Details for: RPL7A

Gene ID: 6130

Symbol: RPL7A

Ensembl ID: ENSG00000148303

Description: ribosomal protein L7a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 678.0231
    Cell Significance Index: -279.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 647.4348
    Cell Significance Index: -263.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 587.0403
    Cell Significance Index: -277.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 559.8722
    Cell Significance Index: -287.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 414.7404
    Cell Significance Index: -278.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 280.9919
    Cell Significance Index: -268.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 50.8052
    Cell Significance Index: -136.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 18.9007
    Cell Significance Index: 482.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 15.8328
    Cell Significance Index: 202.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.5574
    Cell Significance Index: 1487.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 13.2556
    Cell Significance Index: 306.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.8337
    Cell Significance Index: 603.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.6439
    Cell Significance Index: 333.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.0679
    Cell Significance Index: 384.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.7158
    Cell Significance Index: 281.7700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.4170
    Cell Significance Index: 61.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.9204
    Cell Significance Index: 112.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.5001
    Cell Significance Index: 1304.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.4274
    Cell Significance Index: 197.3300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 9.2415
    Cell Significance Index: 98.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.0646
    Cell Significance Index: 1171.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.0164
    Cell Significance Index: 1108.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.9142
    Cell Significance Index: 630.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.8809
    Cell Significance Index: 1600.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.4701
    Cell Significance Index: 4625.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.1893
    Cell Significance Index: 381.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.0818
    Cell Significance Index: 87.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.8502
    Cell Significance Index: 3470.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.6972
    Cell Significance Index: 136.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.6521
    Cell Significance Index: 902.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.6363
    Cell Significance Index: 224.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.4832
    Cell Significance Index: 557.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.2343
    Cell Significance Index: 466.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.5031
    Cell Significance Index: 177.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.4448
    Cell Significance Index: 55.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.4022
    Cell Significance Index: 692.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.1976
    Cell Significance Index: 887.5200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.0088
    Cell Significance Index: 30.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.7426
    Cell Significance Index: 247.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.2357
    Cell Significance Index: 39.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.8355
    Cell Significance Index: 70.8900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 3.7122
    Cell Significance Index: 77.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.6511
    Cell Significance Index: 2006.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1262
    Cell Significance Index: 1919.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.9339
    Cell Significance Index: 221.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8565
    Cell Significance Index: 96.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7704
    Cell Significance Index: 351.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7044
    Cell Significance Index: 89.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.4099
    Cell Significance Index: 1033.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2049
    Cell Significance Index: 9.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1726
    Cell Significance Index: 53.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0040
    Cell Significance Index: 191.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.9761
    Cell Significance Index: 77.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3062
    Cell Significance Index: 61.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2220
    Cell Significance Index: 25.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1356
    Cell Significance Index: 3.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0534
    Cell Significance Index: -100.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1143
    Cell Significance Index: -41.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1198
    Cell Significance Index: -88.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1237
    Cell Significance Index: -228.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1361
    Cell Significance Index: -7.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1482
    Cell Significance Index: -228.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2056
    Cell Significance Index: -279.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2112
    Cell Significance Index: -10.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2494
    Cell Significance Index: -140.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2851
    Cell Significance Index: -178.0500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3046
    Cell Significance Index: -2.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3456
    Cell Significance Index: -219.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3930
    Cell Significance Index: -38.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3967
    Cell Significance Index: -16.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5208
    Cell Significance Index: -236.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6591
    Cell Significance Index: -138.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.8592
    Cell Significance Index: -139.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.9717
    Cell Significance Index: -279.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3047
    Cell Significance Index: -82.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3457
    Cell Significance Index: -43.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.6418
    Cell Significance Index: -238.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.6647
    Cell Significance Index: -27.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.7246
    Cell Significance Index: -29.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.4953
    Cell Significance Index: -259.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.7071
    Cell Significance Index: -187.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.1903
    Cell Significance Index: -79.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.4464
    Cell Significance Index: -206.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.5708
    Cell Significance Index: -274.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.8984
    Cell Significance Index: -239.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.3832
    Cell Significance Index: -94.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -4.4655
    Cell Significance Index: -26.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.7098
    Cell Significance Index: -70.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.8044
    Cell Significance Index: -65.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.4074
    Cell Significance Index: -159.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -5.7591
    Cell Significance Index: -202.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.8504
    Cell Significance Index: -69.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.8744
    Cell Significance Index: -259.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.9228
    Cell Significance Index: -49.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.1999
    Cell Significance Index: -178.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.3649
    Cell Significance Index: -233.6500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.5173
    Cell Significance Index: -83.9300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.8056
    Cell Significance Index: -37.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -6.8108
    Cell Significance Index: -70.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -6.8352
    Cell Significance Index: -223.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL7A is a 60S ribosomal protein that is essential for the translation process. It is a member of the L7A family of ribosomal proteins, which are conserved across eukaryotes. RPL7A is a small protein that is highly conserved among different species, suggesting its critical role in fundamental cellular processes. The protein is localized to the cytosol and is involved in the maturation of the 60S ribosomal subunit. **Pathways and Functions** RPL7A is involved in various cellular pathways, including: 1. **Translation**: RPL7A is a key component of the 60S ribosomal subunit, which is responsible for the elongation phase of translation. 2. **Protein synthesis**: RPL7A is involved in the synthesis of proteins, which is essential for cell growth, differentiation, and survival. 3. **Stress response**: RPL7A is activated in response to stress, including amino acid deficiency, which triggers the activation of the unfolded protein response (UPR). 4. **Cellular responses to stimuli**: RPL7A is involved in the regulation of gene expression in response to various stimuli, including cytokines and growth factors. 5. **Nonsense-mediated decay (NMD)**: RPL7A is involved in the regulation of NMD, a process that prevents the translation of aberrant mRNAs. **Clinical Significance** RPL7A dysregulation has been implicated in various diseases, including: 1. **Cancer**: RPL7A is overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Infectious diseases**: RPL7A is involved in the translation of viral mRNAs, and its dysregulation has been implicated in viral infections, including influenza. 3. **Neurological disorders**: RPL7A has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders**: RPL7A is involved in the regulation of glucose metabolism, and its dysregulation has been implicated in metabolic disorders, including diabetes. In conclusion, RPL7A is a critical component of the 60S ribosomal subunit, involved in various cellular processes, including translation, protein synthesis, and stress response. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 2573499590

Symbol: RL7A_HUMAN

Name: 60S ribosomal protein L7a

UniProtKB Accession Codes:

P62424 P11518 Q5T8U4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EMDB 84 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 99 PDBsum 99 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2966065

Title: Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences.

PubMed ID: 2966065

DOI: 10.1002/j.1460-2075.1988.tb02794.x

PubMed ID: 1756182

Title: The organization and expression of the human L7a ribosomal protein gene.

PubMed ID: 1756182

DOI: 10.1016/0167-4781(91)90218-b

PubMed ID: 8482538

Title: Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene.

PubMed ID: 8482538

DOI: 10.1016/0378-1119(93)90371-9

PubMed ID: 1696715

Title: A human cellular sequence implicated in trk oncogene activation is DNA damage inducible.

PubMed ID: 1696715

DOI: 10.1073/pnas.87.16.6039

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17507929

Title: MicroRNA silencing through RISC recruitment of eIF6.

PubMed ID: 17507929

DOI: 10.1038/nature05841

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 266
  • Mass: 29996
  • Checksum: 54EF43F221D9F704
  • Sequence:
    • MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY 
IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH KYRPETKQEK KQRLLARAEK 
KAAGKGDVPT KRPPVLRAGV NTVTTLVENK KAQLVVIAHD VDPIELVVFL PALCRKMGVP 
YCIIKGKARL GRLVHRKTCT TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN 
VLGPKSVARI AKLEKAKAKE LATKLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.