Details for: RPL10

Gene ID: 6134

Symbol: RPL10

Ensembl ID: ENSG00000147403

Description: ribosomal protein L10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 997.9667
    Cell Significance Index: -411.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 813.0938
    Cell Significance Index: -383.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 766.3711
    Cell Significance Index: -394.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 574.9214
    Cell Significance Index: -385.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.2986
    Cell Significance Index: -94.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 22.3841
    Cell Significance Index: 571.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 21.2801
    Cell Significance Index: 2173.7600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 18.6808
    Cell Significance Index: 109.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 15.9501
    Cell Significance Index: 749.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 14.5510
    Cell Significance Index: 186.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 14.4001
    Cell Significance Index: 378.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.3745
    Cell Significance Index: 384.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.2332
    Cell Significance Index: 379.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 13.0709
    Cell Significance Index: 230.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 12.2970
    Cell Significance Index: 427.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 12.1883
    Cell Significance Index: 255.1200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 12.0778
    Cell Significance Index: 32.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 11.5744
    Cell Significance Index: 1495.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.8763
    Cell Significance Index: 123.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 10.1225
    Cell Significance Index: 1390.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.0293
    Cell Significance Index: 231.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 10.0102
    Cell Significance Index: 707.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.8498
    Cell Significance Index: 1211.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.5027
    Cell Significance Index: 175.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.4995
    Cell Significance Index: 1712.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.4519
    Cell Significance Index: 704.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 9.1257
    Cell Significance Index: 4034.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 9.0911
    Cell Significance Index: 1165.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 9.0472
    Cell Significance Index: 4940.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.0412
    Cell Significance Index: 1066.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.4654
    Cell Significance Index: 248.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 8.3421
    Cell Significance Index: 538.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.0496
    Cell Significance Index: 87.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 7.6846
    Cell Significance Index: 5816.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.9163
    Cell Significance Index: 363.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.6638
    Cell Significance Index: 967.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.1394
    Cell Significance Index: 139.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.8805
    Cell Significance Index: 227.5500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 4.1948
    Cell Significance Index: 87.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 2.7741
    Cell Significance Index: 219.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.7725
    Cell Significance Index: 2032.7800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.5556
    Cell Significance Index: 15.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4285
    Cell Significance Index: 481.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0379
    Cell Significance Index: 1840.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9646
    Cell Significance Index: 194.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.8650
    Cell Significance Index: 213.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0740
    Cell Significance Index: 204.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2693
    Cell Significance Index: 2.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1528
    Cell Significance Index: 4.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0827
    Cell Significance Index: 16.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0411
    Cell Significance Index: -77.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1612
    Cell Significance Index: -119.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1633
    Cell Significance Index: -301.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1684
    Cell Significance Index: -60.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1871
    Cell Significance Index: -288.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2748
    Cell Significance Index: -373.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3298
    Cell Significance Index: -185.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3674
    Cell Significance Index: -229.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4323
    Cell Significance Index: -274.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5658
    Cell Significance Index: -31.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.7164
    Cell Significance Index: -325.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7766
    Cell Significance Index: -163.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9235
    Cell Significance Index: -63.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0432
    Cell Significance Index: -119.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1849
    Cell Significance Index: -72.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.2026
    Cell Significance Index: -62.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3238
    Cell Significance Index: -22.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.7505
    Cell Significance Index: -284.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.0202
    Cell Significance Index: -91.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.2251
    Cell Significance Index: -323.4500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -2.3521
    Cell Significance Index: -18.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.5968
    Cell Significance Index: -43.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.7316
    Cell Significance Index: -87.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.4874
    Cell Significance Index: -363.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -3.5794
    Cell Significance Index: -225.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.0925
    Cell Significance Index: -314.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.6826
    Cell Significance Index: -281.1200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -4.7155
    Cell Significance Index: -40.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.9753
    Cell Significance Index: -334.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -5.5683
    Cell Significance Index: -341.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -5.7386
    Cell Significance Index: -143.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -6.8468
    Cell Significance Index: -149.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.9668
    Cell Significance Index: -119.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -7.0919
    Cell Significance Index: -84.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -7.2704
    Cell Significance Index: -108.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -7.7001
    Cell Significance Index: -226.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -8.1496
    Cell Significance Index: -111.1900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -8.9273
    Cell Significance Index: -64.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -8.9789
    Cell Significance Index: -329.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -8.9853
    Cell Significance Index: -397.4400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -9.0247
    Cell Significance Index: -49.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -9.1777
    Cell Significance Index: -55.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -10.1880
    Cell Significance Index: -261.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -10.4309
    Cell Significance Index: -107.9800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -10.5381
    Cell Significance Index: -135.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -10.5491
    Cell Significance Index: -88.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -10.5729
    Cell Significance Index: -229.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -10.6133
    Cell Significance Index: -401.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -10.7327
    Cell Significance Index: -309.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -11.2123
    Cell Significance Index: -367.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL10 is a highly conserved protein across species, with a high sequence similarity to its counterparts in other eukaryotes. It is a part of the 60S large ribosomal subunit, which is responsible for the translation of mRNAs into proteins. RPL10 has a unique structure, consisting of a single polypeptide chain with a molecular weight of approximately 14 kDa. It is highly hydrophobic and contains a characteristic helix-loop-helix (HLH) motif, which is essential for its function. **Pathways and Functions** RPL10 is involved in various cellular pathways, including: 1. **Translation regulation**: RPL10 plays a crucial role in regulating translation initiation and elongation. It interacts with other ribosomal proteins to ensure accurate translation of mRNAs. 2. **Protein synthesis**: RPL10 is necessary for the synthesis of proteins, including those involved in immune responses, cell signaling, and metabolism. 3. **Response to stress**: RPL10 is involved in the response to cellular stress, including amino acid deficiency, oxidative stress, and viral infections. 4. **Cellular responses to stimuli**: RPL10 is responsive to various cellular stimuli, including growth factors, cytokines, and stress signals. **Clinical Significance** Dysregulation of RPL10 has been implicated in various diseases, including: 1. **Infectious diseases**: RPL10 has been shown to play a role in the translation of viral mRNAs, such as influenza virus. 2. **Metabolic disorders**: RPL10 has been implicated in metabolic disorders, including diabetes and obesity. 3. **Cancer**: RPL10 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 4. **Neurological disorders**: RPL10 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells** RPL10 is highly expressed in various cell types, including: 1. **Professional antigen-presenting cells**: RPL10 is highly expressed in dendritic cells and macrophages, which are essential for immune responses. 2. **Cardiac muscle cells**: RPL10 is highly expressed in cardiac muscle cells, which are responsible for heart function. 3. **Skeletal muscle satellite cells**: RPL10 is highly expressed in skeletal muscle satellite cells, which are responsible for muscle regeneration. 4. **Malignant cells**: RPL10 is overexpressed in various types of cancer, including breast, lung, and colon cancer. **Proteins** The protein encoded by the RPL10 gene is a homolog of the laminin receptor, which is involved in cellular adhesion and signaling.

Genular Protein ID: 3019187403

Symbol: RL10_HUMAN

Name: Laminin receptor homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1658743

Title: The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells.

PubMed ID: 1658743

DOI: 10.1093/nar/19.20.5763

PubMed ID: 1303197

Title: Identification and characterization of a new gene in the human Xq28 region.

PubMed ID: 1303197

DOI: 10.1093/hmg/1.4.269

PubMed ID: 1339145

Title: Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28.

PubMed ID: 1339145

DOI: 10.1093/hmg/1.7.529

PubMed ID: 12138090

Title: QM, a putative tumor suppressor, regulates proto-oncogene c-Yes.

PubMed ID: 12138090

DOI: 10.1074/jbc.m201859200

PubMed ID: 16627977

Title: Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer.

PubMed ID: 16627977

DOI: 10.4161/cbt.5.5.2610

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1534224

Title: cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene.

PubMed ID: 1534224

DOI: 10.1016/s0006-291x(05)80005-1

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18258260

Title: Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold.

PubMed ID: 18258260

DOI: 10.1016/j.jmb.2008.01.003

PubMed ID: 16940977

Title: Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism.

PubMed ID: 16940977

DOI: 10.1038/sj.mp.4001883

PubMed ID: 21567917

Title: Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder.

PubMed ID: 21567917

DOI: 10.1002/ajmg.a.33977

PubMed ID: 25316788

Title: A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans.

PubMed ID: 25316788

DOI: 10.1534/genetics.114.168211

PubMed ID: 25846674

Title: RPL10 mutation segregating in a family with X-linked syndromic Intellectual Disability.

PubMed ID: 25846674

DOI: 10.1002/ajmg.a.37094

PubMed ID: 26290468

Title: A novel mutation in RPL10 (Ribosomal Protein L10) causes X-Linked intellectual disability, cerebellar hypoplasia, and spondylo-epiphyseal dysplasia.

PubMed ID: 26290468

DOI: 10.1002/humu.22860

Sequence Information:

  • Length: 214
  • Mass: 24577
  • Checksum: 0860CECC8BF674FE
  • Sequence:
  • MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL 
    SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG 
    KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE 
    FEDMVAEKRL IPDGCGVKYI PSRGPLDKWR ALHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.