RPL10 | ENSG00000147403 | NCBI 6134

Details for: RPL10

Gene ID: 6134

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPL10

Ensembl ID: ENSG00000147403

Description: ribosomal protein L10

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Embryonic brain development
(GO:1990403)
Endoplasmic reticulum
(GO:0005783)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of translation
(GO:0006417)
Rna binding
(GO:0003723)
Smooth endoplasmic reticulum
(GO:0005790)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)
Translation regulator activity
(GO:0045182)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 172.48

rCSI 100%

PRS 1.85
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 149.75

rCSI 99.8%

PRS 3.76
hematopoietic stem cell CL0000037

CSI 147.85

rCSI 98.27%

PRS 1.58
double negative thymocyte CL0002489

CSI 145.32

rCSI 100%

PRS 1.55
T follicular helper cell CL0002038

CSI 144.76

rCSI 100%

PRS 2.17
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 144.31

rCSI 100%

PRS 4.05
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 144.01

rCSI 97.02%

PRS 1.6
plasmacytoid dendritic cell, human CL0001058

CSI 142.39

rCSI 99.42%

PRS 1.39
naive T cell CL0000898

CSI 142.05

rCSI 98.86%

PRS 1.93
CD4-positive, alpha-beta memory T cell CL0000897

CSI 141.55

rCSI 100%

PRS 1.81
immature B cell CL0000816

CSI 141.36

rCSI 100%

PRS 1.98
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 135.47

rCSI 100%

PRS 4
group 3 innate lymphoid cell CL0001071

CSI 133.79

rCSI 100%

PRS 1.36
class switched memory B cell CL0000972

CSI 133.76

rCSI 99.85%

PRS 2.24
melanocyte CL0000148

CSI 133.54

rCSI 98.9%

PRS 1.27
CD4-positive helper T cell CL0000492

CSI 132.55

rCSI 100%

PRS 1.86
mucosal invariant T cell CL0000940

CSI 132.28

rCSI 100%

PRS 3.48
bronchus fibroblast of lung CL2000093

CSI 131.83

rCSI 100%

PRS 1.38
effector CD8-positive, alpha-beta T cell CL0001050

CSI 131.3

rCSI 99.87%

PRS 1.76
neural crest cell CL0011012

CSI 128.45

rCSI 100%

PRS 0.92
T-helper 17 cell CL0000899

CSI 125.98

rCSI 100%

PRS 2.36
epithelial cell of lower respiratory tract CL0002632

CSI 125.75

rCSI 97.49%

PRS 1.26
mature T cell CL0002419

CSI 125.02

rCSI 97.24%

PRS 1.9
CD4-positive, alpha-beta thymocyte CL0000810

CSI 123.68

rCSI 99.07%

PRS 2.49
epithelial cell of lung CL0000082

CSI 122.99

rCSI 100%

PRS 1.23
CD14-low, CD16-positive monocyte CL0002396

CSI 122.44

rCSI 94.33%

PRS 1.19
skin fibroblast CL0002620

CSI 121.84

rCSI 100%

PRS 2.22
pro-B cell CL0000826

CSI 120.99

rCSI 100%

PRS 1.32
keratinocyte CL0000312

CSI 120.11

rCSI 100%

PRS 1.59
mature B cell CL0000785

CSI 118.5

rCSI 100%

PRS 1.63
common myeloid progenitor CL0000049

CSI 118.42

rCSI 95.75%

PRS 1.3
naive B cell CL0000788

CSI 118.23

rCSI 100%

PRS 4.31
early lymphoid progenitor CL0000936

CSI 115.25

rCSI 100%

PRS 1.48
precursor B cell CL0000817

CSI 115.25

rCSI 100%

PRS 1.79
granulocyte monocyte progenitor cell CL0000557

CSI 114.85

rCSI 99.45%

PRS 1.48
unswitched memory B cell CL0000970

CSI 114.58

rCSI 96.4%

PRS 2.23
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 112.2

rCSI 100%

PRS 2.07
plasmablast CL0000980

CSI 110.93

rCSI 87.27%

PRS 1.57
fibroblast of lung CL0002553

CSI 107.11

rCSI 99.69%

PRS 1.32
megakaryocyte-erythroid progenitor cell CL0000050

CSI 106.93

rCSI 96.56%

PRS 1.16
intestine goblet cell CL0019031

CSI 106.22

rCSI 94.28%

PRS 1.33
memory B cell CL0000787

CSI 104.34

rCSI 100%

PRS 5.88
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 102.91

rCSI 100%

PRS 2.12
activated CD4-positive, alpha-beta T cell CL0000896

CSI 101.35

rCSI 93.7%

PRS 2.43
fallopian tube secretory epithelial cell CL4030006

CSI 101.07

rCSI 97.29%

PRS 1.38
small pre-B-II cell CL0000954

CSI 100.1

rCSI 96.26%

PRS 2.9
IgA plasma cell CL0000987

CSI 98.41

rCSI 100%

PRS 2.51
double-positive, alpha-beta thymocyte CL0000809

CSI 97.71

rCSI 99.58%

PRS 1.93
CD8-positive, alpha-beta memory T cell CL0000909

CSI 95.87

rCSI 100%

PRS 4.28
respiratory basal cell CL0002633

CSI 93.24

rCSI 96.58%

PRS 1.55
activated CD8-positive, alpha-beta T cell CL0000906

CSI 92.76

rCSI 91.18%

PRS 3.97
goblet cell CL0000160

CSI 91.59

rCSI 86.55%

PRS 1.38
hematopoietic precursor cell CL0008001

CSI 90.34

rCSI 92.94%

PRS 2.05
intestinal epithelial cell CL0002563

CSI 89.05

rCSI 93.08%

PRS 1.41
alveolar type 1 fibroblast cell CL4028004

CSI 88.83

rCSI 97.29%

PRS 1.55
elicited macrophage CL0000861

CSI 87.5

rCSI 80.34%

PRS 1.5
activated type II NK T cell CL0000931

CSI 87.4

rCSI 98.37%

PRS 2.23
gamma-delta T cell CL0000798

CSI 87.3

rCSI 100%

PRS 13.49
ciliated epithelial cell CL0000067

CSI 86.17

rCSI 75.77%

PRS 0.96
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 85.55

rCSI 98.8%

PRS 1.24
fraction A pre-pro B cell CL0002045

CSI 84

rCSI 96.16%

PRS 2.76
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 83.86

rCSI 100%

PRS 2.31
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 82.57

rCSI 100%

PRS 7.31
CD1c-positive myeloid dendritic cell CL0002399

CSI 82.13

rCSI 99.2%

PRS 1.52
M cell of gut CL0000682

CSI 81.52

rCSI 86.62%

PRS 2.42
pancreatic D cell CL0000173

CSI 81.11

rCSI 79.78%

PRS 1.47
transit amplifying cell of colon CL0009011

CSI 79.1

rCSI 92.9%

PRS 1.62
conventional dendritic cell CL0000990

CSI 77.98

rCSI 65.1%

PRS 4.56
IgG plasma cell CL0000985

CSI 77.21

rCSI 92.49%

PRS 2.3
respiratory suprabasal cell CL4033048

CSI 77.05

rCSI 98.82%

PRS 1.53
B cell CL0000236

CSI 76.98

rCSI 100%

PRS 8.15
common dendritic progenitor CL0001029

CSI 76.83

rCSI 96.42%

PRS 1.68
neuroblast (sensu Vertebrata) CL0000031

CSI 76.49

rCSI 98.16%

PRS 1.34
CD4-positive, alpha-beta T cell CL0000624

CSI 76.42

rCSI 97.8%

PRS 29.15
mature NK T cell CL0000814

CSI 76.11

rCSI 97.35%

PRS 6.17
pulmonary ionocyte CL0017000

CSI 75.78

rCSI 92.25%

PRS 1.68
myofibroblast cell CL0000186

CSI 75.36

rCSI 100%

PRS 1.91
renal alpha-intercalated cell CL0005011

CSI 74.8

rCSI 100%

PRS 1.81
peripheral nervous system neuron CL2000032

CSI 73.44

rCSI 100%

PRS 1.21
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 73.41

rCSI 100%

PRS 3.33
myeloid leukocyte CL0000766

CSI 72.66

rCSI 67.04%

PRS 1.34
extravillous trophoblast CL0008036

CSI 72.35

rCSI 89.5%

PRS 1.17
multi-ciliated epithelial cell CL0005012

CSI 71.77

rCSI 71.63%

PRS 1.11
perivascular cell CL4033054

CSI 71.51

rCSI 97.76%

PRS 1.52
radial glial cell CL0000681

CSI 70.56

rCSI 98.03%

PRS 1.42
enteroendocrine cell CL0000164

CSI 70.23

rCSI 95.97%

PRS 1.47
mesodermal cell CL0000222

CSI 70.02

rCSI 84.04%

PRS 1.33
enteric smooth muscle cell CL0002504

CSI 69.29

rCSI 98.89%

PRS 1.52
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 69.14

rCSI 94.99%

PRS 2.85
endothelial cell of artery CL1000413

CSI 69.07

rCSI 100%

PRS 8.19
CD14-positive monocyte CL0001054

CSI 68.71

rCSI 85.58%

PRS 1.96
promyelocyte CL0000836

CSI 68.49

rCSI 98.79%

PRS 1.84
plasma cell CL0000786

CSI 68.43

rCSI 89.68%

PRS 7.19
club cell CL0000158

CSI 68.22

rCSI 99.93%

PRS 1.57
lung ciliated cell CL1000271

CSI 67.36

rCSI 77.89%

PRS 0.96
pulmonary artery endothelial cell CL1001568

CSI 66.95

rCSI 91.09%

PRS 2.03
mucous neck cell CL0000651

CSI 66.94

rCSI 96.49%

PRS 2.16
plasmacytoid dendritic cell CL0000784

CSI 66.56

rCSI 67.42%

PRS 8.89
CD8-positive, alpha-beta thymocyte CL0000811

CSI 66.09

rCSI 100%

PRS 3.47
classical monocyte CL0000860

CSI 65.38

rCSI 96.92%

PRS 16.16

adipocyte CL0000136

CSI -57.3

rCSI -73.5%

PRS 1.8%
sst GABAergic cortical interneuron CL4023017

CSI -55.6

rCSI -71.7%

PRS 0.9%
vascular leptomeningeal cell CL4023051

CSI -51.7

rCSI -90.7%

PRS 1.1%
pvalb GABAergic cortical interneuron CL4023018

CSI -51.5

rCSI -64.1%

PRS 0.8%
Bergmann glial cell CL0000644

CSI -31.4

rCSI -42.9%

PRS 1.5%
kidney collecting duct principal cell CL1001431

CSI -31.1

rCSI -100.0%

PRS 9.5%
inhibitory interneuron CL0000498

CSI -30.4

rCSI -70.1%

PRS 1.4%
astrocyte of the cerebral cortex CL0002605

CSI -29.9

rCSI -66.9%

PRS 0.9%
cardiac neuron CL0010022

CSI -27.7

rCSI -88.8%

PRS 1.1%
VIP GABAergic cortical interneuron CL4023016

CSI -24.9

rCSI -29.8%

PRS 0.9%
kidney collecting duct intercalated cell CL1001432

CSI -21.4

rCSI -100.0%

PRS 6.2%
mature microglial cell CL0002629

CSI -18.5

rCSI -76.8%

PRS 5.2%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -18.0

rCSI -64.9%

PRS 0.8%
GABAergic neuron CL0000617

CSI -17.9

rCSI -59.9%

PRS 1.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI -17.3

rCSI -29.0%

PRS 0.9%
mature astrocyte CL0002627

CSI -16.8

rCSI -71.3%

PRS 3.8%
cerebral cortex neuron CL0010012

CSI -16.4

rCSI -66.7%

PRS 1.9%
contractile cell CL0000183

CSI -15.4

rCSI -45.4%

PRS 1.2%
L6b glutamatergic cortical neuron CL4023038

CSI -15.3

rCSI -47.8%

PRS 0.9%
kidney interstitial alternatively activated macrophage CL1000695

CSI -15.2

rCSI -39.7%

PRS 1.7%
erythroid lineage cell CL0000764

CSI -14.6

rCSI -93.9%

PRS 3.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI -13.8

rCSI -24.3%

PRS 0.8%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -12.6

rCSI -39.4%

PRS 1.0%
fibroblast of cardiac tissue CL0002548

CSI -12.3

rCSI -59.0%

PRS 0.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -12.3

rCSI -29.9%

PRS 0.9%
glutamatergic neuron CL0000679

CSI -11.9

rCSI -24.5%

PRS 1.6%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -10.6

rCSI -19.3%

PRS 1.6%
cerebellar granule cell CL0001031

CSI -10.3

rCSI -15.2%

PRS 1.5%
epicardial adipocyte CL1000309

CSI -9.9

rCSI -32.4%

PRS 2.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI -8.5

rCSI -32.0%

PRS 1.0%
regular ventricular cardiac myocyte CL0002131

CSI -8.4

rCSI -52.2%

PRS 1.2%
OFFx cell CL4033036

CSI -8.0

rCSI -37.5%

PRS 4.1%
sncg GABAergic cortical interneuron CL4023015

CSI -7.7

rCSI -12.4%

PRS 1.1%
squamous epithelial cell CL0000076

CSI -6.8

rCSI -16.1%

PRS 1.8%
rod bipolar cell CL0000751

CSI -6.6

rCSI -11.9%

PRS 1.2%
retinal bipolar neuron CL0000748

CSI -6.5

rCSI -12.1%

PRS 1.1%
cell of skeletal muscle CL0000188

CSI -6.4

rCSI -69.6%

PRS 9.3%
hepatic stellate cell CL0000632

CSI -6.3

rCSI -23.7%

PRS 1.2%
neural cell CL0002319

CSI -6.3

rCSI -23.7%

PRS 3.2%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI -5.9

rCSI -51.3%

PRS 3.8%
invaginating midget bipolar cell CL4033034

CSI -5.9

rCSI -34.8%

PRS 3.6%
diffuse bipolar 6 cell CL4033032

CSI -5.8

rCSI -30.4%

PRS 4.4%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -4.8

rCSI -28.3%

PRS 1.0%
renal interstitial pericyte CL1001318

CSI -3.8

rCSI -10.5%

PRS 1.5%
cardiac muscle cell CL0000746

CSI -3.7

rCSI -5.3%

PRS 1.2%
diffuse bipolar 1 cell CL4033027

CSI -3.3

rCSI -24.4%

PRS 3.6%
endothelial cell of vascular tree CL0002139

CSI -3.1

rCSI -17.0%

PRS 3.7%
ON parasol ganglion cell CL4033052

CSI -3.1

rCSI -43.5%

PRS 1.3%
S cone cell CL0003050

CSI -2.9

rCSI -12.6%

PRS 1.7%
periportal region hepatocyte CL0019026

CSI -2.8

rCSI -11.0%

PRS 2.3%
cardiac endothelial cell CL0010008

CSI -2.6

rCSI -10.3%

PRS 1.6%
diffuse bipolar 4 cell CL4033031

CSI -2.5

rCSI -28.2%

PRS 4.7%
flat midget bipolar cell CL4033033

CSI -2.1

rCSI -14.8%

PRS 3.7%
starburst amacrine cell CL0004232

CSI -2.0

rCSI -16.8%

PRS 4.2%
indirect pathway medium spiny neuron CL4023029

CSI -1.5

rCSI -35.7%

PRS 1.1%
direct pathway medium spiny neuron CL4023026

CSI -1.5

rCSI -35.0%

PRS 0.8%
exhausted T cell CL0011025

CSI -1.4

rCSI -23.3%

PRS 7.7%
platelet CL0000233

CSI -1.3

rCSI -5.6%

PRS 4.2%
endocrine cell CL0000163

CSI -1.3

rCSI -6.5%

PRS 6.2%
cord blood hematopoietic stem cell CL2000095

CSI -1.2

rCSI -23.3%

PRS 11.4%
glycinergic amacrine cell CL4030028

CSI -1.2

rCSI -3.1%

PRS 2.2%
professional antigen presenting cell CL0000145

CSI -0.7

rCSI -2.4%

PRS 6.0%
neuron CL0000540

CSI -0.1

rCSI -0.3%

PRS 2.0%
ON midget ganglion cell CL4033046

CSI 0.3

rCSI 6.1%

PRS 1.8%
immature innate lymphoid cell CL0001082

CSI 0.7

rCSI 22.4%

PRS 25.3%
regular atrial cardiac myocyte CL0002129

CSI 0.8

rCSI 2.5%

PRS 1.7%
OFF midget ganglion cell CL4033047

CSI 1.1

rCSI 22.8%

PRS 1.9%
cerebral cortex endothelial cell CL1001602

CSI 1.2

rCSI 2.0%

PRS 1.0%
GABAergic amacrine cell CL4030027

CSI 1.2

rCSI 4.2%

PRS 2.0%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.2

rCSI 13.2%

PRS 2.4%
diffuse bipolar 2 cell CL4033028

CSI 1.3

rCSI 10.3%

PRS 4.0%
H1 horizontal cell CL0004217

CSI 1.5

rCSI 5.9%

PRS 4.0%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 1.6

rCSI 9.2%

PRS 8.4%
cholangiocyte CL1000488

CSI 1.6

rCSI 9.7%

PRS 3.2%
endocardial cell CL0002350

CSI 1.8

rCSI 8.6%

PRS 2.4%
fast muscle cell CL0000190

CSI 2.0

rCSI 7.9%

PRS 8.5%
tracheobronchial goblet cell CL0019003

CSI 2.2

rCSI 35.1%

PRS 34.4%
parietal epithelial cell CL1000452

CSI 2.6

rCSI 7.1%

PRS 1.4%
hepatic pit cell CL2000054

CSI 2.8

rCSI 38.5%

PRS 17.8%
diffuse bipolar 3b cell CL4033030

CSI 2.9

rCSI 19.3%

PRS 3.6%
odontoblast CL0000060

CSI 3.0

rCSI 67.2%

PRS 8.0%
kidney resident macrophage CL1000698

CSI 3.1

rCSI 61.0%

PRS 35.6%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 3.1

rCSI 96.8%

PRS 19.1%
H2 horizontal cell CL0004218

CSI 3.2

rCSI 15.7%

PRS 2.8%
group 3 innate lymphoid cell, human CL0001078

CSI 3.2

rCSI 68.1%

PRS 26.5%
retinal ganglion cell CL0000740

CSI 3.3

rCSI 7.2%

PRS 1.0%
pluripotent stem cell CL0002248

CSI 3.3

rCSI 97.5%

PRS 3.4%
neutrophil CL0000775

CSI 3.4

rCSI 19.0%

PRS 5.5%
cardiac blood vessel endothelial cell CL0010006

CSI 3.5

rCSI 25.0%

PRS 4.9%
diffuse bipolar 3a cell CL4033029

CSI 3.6

rCSI 24.7%

PRS 3.5%
forebrain neuroblast CL1000042

CSI 3.6

rCSI 39.4%

PRS 21.3%
mesenchymal lymphangioblast CL0005021

CSI 3.7

rCSI 97.3%

PRS 7.7%
B-1 B cell CL0000819

CSI 3.8

rCSI 97.6%

PRS 8.4%
Merkel cell CL0000242

CSI 3.9

rCSI 89.9%

PRS 9.8%
epithelial cell of urethra CL1000296

CSI 3.9

rCSI 97.6%

PRS 4.7%
renal intercalated cell CL0005010

CSI 3.9

rCSI 34.7%

PRS 12.8%
osteoblast CL0000062

CSI 4.0

rCSI 98.6%

PRS 13.3%
kidney connecting tubule principal cell CL4030018

CSI 4.1

rCSI 29.5%

PRS 21.4%
slow muscle cell CL0000189

CSI 4.1

rCSI 54.3%

PRS 19.5%
prostate gland microvascular endothelial cell CL2000059

CSI 4.1

rCSI 97.6%

PRS 5.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPL10](/details-gene/6134) is a protein-coding gene that encodes ribosomal protein L10, a core component of the large 60S ribosomal subunit. Its fundamental role is to provide structural integrity to the ribosome and participate in the essential cellular process of protein synthesis, or '[translation](/details-go/GO:0006412)'. Beyond this canonical housekeeping function, evidence suggests [RPL10](/details-gene/6134) has critical extra-ribosomal roles, particularly in development. Mutations in the gene are associated with several X-linked neurodevelopmental disorders, including syndromic mental retardation and autism ([300847](https://omim.org/entry/300847), [300998](https://omim.org/entry/300998)). Consistent with its role in protein synthesis, its expression is highest in metabolically active and highly proliferative cell types, most notably within the hematopoietic and lymphoid lineages, such as in [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) and [hematopoietic stem cell](/details-cell/CL0000037). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [RPL10](/details-gene/6134) highlights its importance in cells requiring robust protein synthesis machinery for proliferation, differentiation, and effector function. The gene's significance is most pronounced across the immune system, with top scores in numerous lymphoid cell subsets. These include various T cells like [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900), and [T follicular helper cell](/details-cell/CL0002038), as well as [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939), and both [immature B cell](/details-cell/CL0000816) and [class switched memory B cell](/details-cell/CL0000972). High significance in progenitor populations, such as [hematopoietic stem cell](/details-cell/CL0000037), underscores its role in the fundamental processes of cell growth and lineage commitment. In stark contrast, [RPL10](/details-gene/6134) expression is markedly low in many terminally differentiated and quiescent cell types. This is particularly evident in the nervous system, where it is an anti-marker for various mature neuronal subtypes, including [sst GABAergic cortical interneuron](/details-cell/CL4023017) and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), as well as glial cells like [Bergmann glial cell](/details-cell/CL0000644). Low expression is also noted in specialized cells such as [adipocyte](/details-cell/CL0000136). This dichotomy suggests that while [RPL10](/details-gene/6134) is essential for building and maintaining highly active cells, its expression may be actively downregulated in terminally differentiated cells with lower or more specialized metabolic demands. ## Pathways and Molecular Function As its name implies, the primary molecular function of [RPL10](/details-gene/6134) is as a '[structural constituent of ribosome](/details-go/GO:0003735)'. It is a key player in the intricate process of protein synthesis, as reflected by its annotation in numerous related biological processes, including '[cytoplasmic translation](/details-go/GO:0002181)' and '[regulation of translation](/details-go/GO:0006417)'. Reactome pathways further detail its involvement in all stages of this process, from '[Eukaryotic translation initiation](/details-pathway/R-HSA-72613)' and '[Peptide chain elongation](/details-pathway/R-HSA-156902)' to '[Eukaryotic translation termination](/details-pathway/R-HSA-72764)'. Beyond its role in the ribosome, functional annotations indicate significant extra-ribosomal functions that may explain its connection to specific pathologies. Its involvement in '[embryonic brain development](/details-go/GO:1990403)', further supported by the '[Nervous system development](/details-pathway/R-HSA-9675108)' and '[Axon guidance](/details-pathway/R-HSA-422475)' pathways, aligns with the clinical manifestations of its mutation. Furthermore, its role in processes like '[negative regulation of apoptotic process](/details-go/GO:0043066)' is consistent with its high expression in lymphocytes and stem cells, where the precise control of cell survival is critical for development and homeostasis. Several studies also suggest a role for [RPL10](/details-gene/6134) as a putative tumor suppressor, potentially regulating proto-oncogenes ([Link](https://doi.org/10.1074/jbc.m201859200)). ## Research Directions The data for [RPL10](/details-gene/6134) presents a compelling profile of a gene with both a ubiquitous housekeeping function and highly specific roles in development and disease. This duality provides fertile ground for future investigation. **Proposed Hypotheses:** 1. **Hypothesis on Neurodevelopment:** The apparent contradiction between the critical role of [RPL10](/details-gene/6134) in brain development (evidenced by OMIM associations) and its low expression in mature neurons suggests its function is temporally regulated. We hypothesize that high [RPL10](/details-gene/6134) expression is essential for the proliferation and migration of neural progenitor cells, but its subsequent downregulation is a necessary step for terminal neuronal differentiation and synaptic maturation. 2. **Hypothesis on Tumor Suppression:** Based on literature suggesting a tumor suppressor role ([Link](https://doi.org/10.1074/jbc.m201859200)) and its association with ovarian cancer ([Link](https://doi.org/10.4161/cbt.5.5.2610)), we hypothesize that loss-of-function mutations or epigenetic silencing of [RPL10](/details-gene/6134) contribute to tumorigenesis not by globally impairing translation, but by disrupting the translation of a specific subset of mRNAs or by ablating an extra-ribosomal signaling function that controls cell growth and apoptosis. **Key Experimental Approach:** To test the hypothesis regarding neurodevelopment, one could employ a directed differentiation protocol using human induced pluripotent stem cells (iPSCs) to generate cortical neurons. By using a CRISPR interference (CRISPRi) system with a doxycycline-inducible guide RNA, [RPL10](/details-gene/6134) expression could be specifically knocked down at distinct stages of differentiation (progenitor stage, migrating neuroblast stage, and post-mitotic neuron stage). The impact on cell proliferation (Ki67 staining), differentiation efficiency (marker expression via scRNA-seq), and functional maturation (patch-clamp electrophysiology) would reveal the stage-specific requirements for [RPL10](/details-gene/6134). **Therapeutic Potential:** Direct systemic targeting of [RPL10](/details-gene/6134) is unlikely to be a viable therapeutic strategy due to its essential role in protein synthesis in all cells, which would likely lead to unacceptable toxicity. However, its characterization as a putative tumor suppressor suggests a different approach. In cancers characterized by the loss of [RPL10](/details-gene/6134) function, therapeutic strategies could focus on *restoring* its activity. This might involve developing small molecules that stabilize mutant [RPL10](/details-gene/6134) protein or, more speculatively, using gene therapy approaches to reintroduce a functional copy of the gene into tumor cells. Therefore, therapeutic intervention would likely involve activation or restoration rather than inhibition.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Laminin receptor homolog

Genular Protein ID: 3019187403

Symbol: RL10_HUMAN

Name: Laminin receptor homolog

UniProtKB Accession Codes:

P27635 A3KQT0 D3DWW6 Q16470 Q2HXT7 Q53FH7 Q6FGN8 Q8TDA5

Database IDs:

Citations:

PubMed ID: 1658743

Title: The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells.

PubMed ID: 1658743

DOI: 10.1093/nar/19.20.5763

PubMed ID: 1303197

Title: Identification and characterization of a new gene in the human Xq28 region.

PubMed ID: 1303197

DOI: 10.1093/hmg/1.4.269

PubMed ID: 1339145

Title: Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28.

PubMed ID: 1339145

DOI: 10.1093/hmg/1.7.529

PubMed ID: 12138090

Title: QM, a putative tumor suppressor, regulates proto-oncogene c-Yes.

PubMed ID: 12138090

DOI: 10.1074/jbc.m201859200

PubMed ID: 16627977

Title: Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer.

PubMed ID: 16627977

DOI: 10.4161/cbt.5.5.2610

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1534224

Title: cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene.

PubMed ID: 1534224

DOI: 10.1016/s0006-291x(05)80005-1

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18258260

Title: Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold.

PubMed ID: 18258260

DOI: 10.1016/j.jmb.2008.01.003

PubMed ID: 16940977

Title: Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism.

PubMed ID: 16940977

DOI: 10.1038/sj.mp.4001883

PubMed ID: 21567917

Title: Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder.

PubMed ID: 21567917

DOI: 10.1002/ajmg.a.33977

PubMed ID: 25316788

Title: A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans.

PubMed ID: 25316788

DOI: 10.1534/genetics.114.168211

PubMed ID: 25846674

Title: RPL10 mutation segregating in a family with X-linked syndromic Intellectual Disability.

PubMed ID: 25846674

DOI: 10.1002/ajmg.a.37094

PubMed ID: 26290468

Title: A novel mutation in RPL10 (Ribosomal Protein L10) causes X-Linked intellectual disability, cerebellar hypoplasia, and spondylo-epiphyseal dysplasia.

PubMed ID: 26290468

DOI: 10.1002/humu.22860

Sequence Information:

Length: 214
Mass: 24577
Checksum: 0860CECC8BF674FE
Sequence:

MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL 
SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG 
KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE 
FEDMVAEKRL IPDGCGVKYI PSRGPLDKWR ALHS

Details for: RPL10

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. PubMed ID: 1658743

Identification and characterization of a new gene in the human Xq28 region. PubMed ID: 1303197

Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28. PubMed ID: 1339145

QM, a putative tumor suppressor, regulates proto-oncogene c-Yes. PubMed ID: 12138090

Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer. PubMed ID: 16627977

Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. PubMed ID: 8733135

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene. PubMed ID: 1534224

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. PubMed ID: 12962325

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. PubMed ID: 18258260

Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. PubMed ID: 16940977

Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. PubMed ID: 21567917

A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans. PubMed ID: 25316788

RPL10 mutation segregating in a family with X-linked syndromic Intellectual Disability. PubMed ID: 25846674

A novel mutation in RPL10 (Ribosomal Protein L10) causes X-Linked intellectual disability, cerebellar hypoplasia, and spondylo-epiphyseal dysplasia. PubMed ID: 26290468