Details for: RPL12

Gene ID: 6136

Symbol: RPL12

Ensembl ID: ENSG00000197958

Description: ribosomal protein L12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.77
    Marker Score: 3817
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.13
    Marker Score: 30116
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.75
    Marker Score: 12060
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.73
    Marker Score: 76987
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.62
    Marker Score: 4075
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.56
    Marker Score: 2856
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.4
    Marker Score: 4226
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.36
    Marker Score: 6980
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.3
    Marker Score: 52471
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.26
    Marker Score: 15349
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.15
    Marker Score: 1900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.15
    Marker Score: 8827
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.06
    Marker Score: 3623
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.01
    Marker Score: 170601
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5
    Marker Score: 7704.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.95
    Marker Score: 3735
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.9
    Marker Score: 4372
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.84
    Marker Score: 15286
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.79
    Marker Score: 4084
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.79
    Marker Score: 25181
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.78
    Marker Score: 3374.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.76
    Marker Score: 251460
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.66
    Marker Score: 2404
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.51
    Marker Score: 1939
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.49
    Marker Score: 4990
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.49
    Marker Score: 2892
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.48
    Marker Score: 250454
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.45
    Marker Score: 58690
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.45
    Marker Score: 1062
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.43
    Marker Score: 26901
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.42
    Marker Score: 1436
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.39
    Marker Score: 51029
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.35
    Marker Score: 2648
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.28
    Marker Score: 11817
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.22
    Marker Score: 1901.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.22
    Marker Score: 11841
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.2
    Marker Score: 26814
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.2
    Marker Score: 10250
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.18
    Marker Score: 4042
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.17
    Marker Score: 9505
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.17
    Marker Score: 31052
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.14
    Marker Score: 2425
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.09
    Marker Score: 17536
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.08
    Marker Score: 6006
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.07
    Marker Score: 3473
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.07
    Marker Score: 7647
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.06
    Marker Score: 9906
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.05
    Marker Score: 26423
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.05
    Marker Score: 3174.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.04
    Marker Score: 2155
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.03
    Marker Score: 4306
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4
    Marker Score: 10728
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3934
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.99
    Marker Score: 3547
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.97
    Marker Score: 14091
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.96
    Marker Score: 2817
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.94
    Marker Score: 4109
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 3.93
    Marker Score: 794
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.93
    Marker Score: 4591
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.9
    Marker Score: 894
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.89
    Marker Score: 4801
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.86
    Marker Score: 3161
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.85
    Marker Score: 1760
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.84
    Marker Score: 3612
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.84
    Marker Score: 2673
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.83
    Marker Score: 2917
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.82
    Marker Score: 1977
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.82
    Marker Score: 1393
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.81
    Marker Score: 4211
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.8
    Marker Score: 1251
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.79
    Marker Score: 2552
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.79
    Marker Score: 3331
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.78
    Marker Score: 4328
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.78
    Marker Score: 1064
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.78
    Marker Score: 1072
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.77
    Marker Score: 992
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.77
    Marker Score: 1029
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.76
    Marker Score: 4049
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.75
    Marker Score: 1679
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.75
    Marker Score: 3617.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.74
    Marker Score: 5440
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.74
    Marker Score: 3300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.73
    Marker Score: 3326.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.73
    Marker Score: 2145
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.72
    Marker Score: 24197
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.72
    Marker Score: 9452
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.72
    Marker Score: 2813
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.72
    Marker Score: 3087
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.72
    Marker Score: 2100
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.71
    Marker Score: 3768
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.69
    Marker Score: 3191
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.69
    Marker Score: 9187
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.68
    Marker Score: 2439
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.68
    Marker Score: 2156
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.67
    Marker Score: 5843
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.66
    Marker Score: 8299
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.63
    Marker Score: 846
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.62
    Marker Score: 4246
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.62
    Marker Score: 8729
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.61
    Marker Score: 957.5

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Other Information

**Key characteristics:** - RPL12 is a large protein with a molecular weight of approximately 120 kDa. - It is a key component of the ribosome, which is the cellular machinery responsible for protein synthesis. - RPL12 is expressed in a variety of cell types, including epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, and CD38-negative naive B cells. **Pathways and functions:** - RPL12 is involved in the initiation of protein translation. - It is a key component of the ribosome, which is the cellular machinery responsible for protein synthesis. - RPL12 is also involved in the regulation of translation initiation. - It is a key factor in the initiation of protein translation in eukaryotic cells. **Clinical significance:** - Mutations in RPL12 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. - These diseases are characterized by abnormal protein translation, which can lead to the formation of abnormal proteins that can cause disease. - Targeting RPL12 has been explored as a potential therapeutic strategy for these diseases.

Genular Protein ID: 3963943269

Symbol: RL12_HUMAN

Name: 60S ribosomal protein L12

UniProtKB Accession Codes:

P30050 Q5VVV2 Q6PB27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 36 EPD 1 Ensembl 2 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 41 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441690

Title: The primary structure of human ribosomal protein L12.

PubMed ID: 8441690

DOI: 10.1093/nar/21.3.749

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 165
  • Mass: 17819
  • Checksum: 7EFD783A8ED350F9
  • Sequence:
    • MPPKFDPNEI KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT GDWKGLRITV 
KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH SGNITFDEIV NIARQMRHRS 
LARELSGTIK EILGTAQSVG CNVDGRHPHD IIDDINSGAV ECPAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.