Details for: RPL12

Gene ID: 6136

Symbol: RPL12

Ensembl ID: ENSG00000197958

Description: ribosomal protein L12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 702.5651
    Cell Significance Index: -289.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 597.7896
    Cell Significance Index: -282.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 567.1527
    Cell Significance Index: -291.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.4877
    Cell Significance Index: -87.0300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 22.8331
    Cell Significance Index: 134.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 16.9399
    Cell Significance Index: 432.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.9611
    Cell Significance Index: 1630.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 15.9200
    Cell Significance Index: 425.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 14.3318
    Cell Significance Index: 673.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.0371
    Cell Significance Index: 154.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.8662
    Cell Significance Index: 274.1500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 11.3183
    Cell Significance Index: 69.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.2642
    Cell Significance Index: 296.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 11.1612
    Cell Significance Index: 789.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 11.0157
    Cell Significance Index: 1423.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.6758
    Cell Significance Index: 188.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.5590
    Cell Significance Index: 302.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.9578
    Cell Significance Index: 113.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.6783
    Cell Significance Index: 1329.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.4977
    Cell Significance Index: 1712.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.4870
    Cell Significance Index: 1166.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 9.2104
    Cell Significance Index: 4072.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.1078
    Cell Significance Index: 678.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.7377
    Cell Significance Index: 303.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.7251
    Cell Significance Index: 4765.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.4958
    Cell Significance Index: 177.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.0899
    Cell Significance Index: 377.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.9926
    Cell Significance Index: 942.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.4204
    Cell Significance Index: 80.6700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 7.2536
    Cell Significance Index: 62.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.8424
    Cell Significance Index: 200.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.3554
    Cell Significance Index: 172.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.2979
    Cell Significance Index: 807.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.0451
    Cell Significance Index: 390.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.9088
    Cell Significance Index: 109.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.1957
    Cell Significance Index: 887.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.1055
    Cell Significance Index: 47.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.5142
    Cell Significance Index: 3416.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.9592
    Cell Significance Index: 2671.9400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 2.2267
    Cell Significance Index: 46.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1910
    Cell Significance Index: 99.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5995
    Cell Significance Index: 42.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3619
    Cell Significance Index: 70.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1949
    Cell Significance Index: 227.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0523
    Cell Significance Index: 55.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9402
    Cell Significance Index: 689.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6515
    Cell Significance Index: 45.0500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5148
    Cell Significance Index: 4.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1959
    Cell Significance Index: 38.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1434
    Cell Significance Index: 41.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0571
    Cell Significance Index: -107.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1096
    Cell Significance Index: -81.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1574
    Cell Significance Index: -290.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1871
    Cell Significance Index: -288.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2363
    Cell Significance Index: -321.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2414
    Cell Significance Index: -136.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2486
    Cell Significance Index: -24.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2679
    Cell Significance Index: -167.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3362
    Cell Significance Index: -26.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3559
    Cell Significance Index: -57.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3651
    Cell Significance Index: -231.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.5101
    Cell Significance Index: -182.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5127
    Cell Significance Index: -232.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5874
    Cell Significance Index: -123.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.8770
    Cell Significance Index: -175.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9392
    Cell Significance Index: -30.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0634
    Cell Significance Index: -121.8300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5790
    Cell Significance Index: -27.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.7617
    Cell Significance Index: -256.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.8057
    Cell Significance Index: -30.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.8185
    Cell Significance Index: -207.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0309
    Cell Significance Index: -128.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.2047
    Cell Significance Index: -135.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.2268
    Cell Significance Index: -133.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.4657
    Cell Significance Index: -138.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.6283
    Cell Significance Index: -15.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.6742
    Cell Significance Index: -278.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.2308
    Cell Significance Index: -80.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.4701
    Cell Significance Index: -266.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.5137
    Cell Significance Index: -47.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.7240
    Cell Significance Index: -55.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.9738
    Cell Significance Index: -243.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.2408
    Cell Significance Index: -285.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.9957
    Cell Significance Index: -108.2300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.0616
    Cell Significance Index: -27.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -5.1302
    Cell Significance Index: -147.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.4060
    Cell Significance Index: -159.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -5.8402
    Cell Significance Index: -75.2100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -5.9473
    Cell Significance Index: -27.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.1550
    Cell Significance Index: -272.2500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -6.4296
    Cell Significance Index: -39.9500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -6.6049
    Cell Significance Index: -55.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -6.6313
    Cell Significance Index: -233.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.7155
    Cell Significance Index: -246.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.9703
    Cell Significance Index: -136.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -7.1117
    Cell Significance Index: -73.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -7.3435
    Cell Significance Index: -278.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -7.3446
    Cell Significance Index: -188.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -7.4047
    Cell Significance Index: -198.4100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -7.6011
    Cell Significance Index: -54.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein L12**: RPL12 is a 60S ribosomal protein that forms part of the large ribosomal subunit, essential for protein synthesis. 2. **Highly conserved**: RPL12 is highly conserved across species, suggesting its critical function in maintaining cellular homeostasis. 3. **Multiple isoforms**: Alternative splicing of the RPL12 gene generates multiple isoforms, which may have distinct functions or expression patterns. 4. **Cell-type specific expression**: RPL12 is expressed in various cell types, including epithelial cells, immune cells, and cancer cells. **Pathways and Functions:** 1. **Translation**: RPL12 is involved in the translation process, specifically in the elongation phase, where it interacts with other ribosomal proteins to facilitate protein synthesis. 2. **Stress response**: RPL12 is activated in response to cellular stress, including amino acid deficiency, hypoxia, and viral infections, promoting the translation of stress-related genes. 3. **Viral infection pathways**: RPL12 plays a critical role in the translation of viral RNAs, facilitating the replication and expression of viral genes. 4. **Immune response**: RPL12 is expressed in immune cells, where it regulates the translation of immune-related genes and modulates the immune response. 5. **Cytoskeleton organization**: RPL12 interacts with cytoskeletal proteins, influencing the organization and dynamics of the cytoskeleton. **Clinical Significance:** Dysregulation of RPL12 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RPL12 has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: RPL12 mutations have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Infectious diseases**: RPL12 plays a critical role in the translation of viral RNAs, making it a potential target for antiviral therapies. 4. **Metabolic disorders**: RPL12 is involved in the regulation of amino acid metabolism, suggesting its potential role in metabolic disorders, such as diabetes and obesity. In conclusion, RPL12 is a multifunctional protein that plays a critical role in various cellular processes, including translation, stress response, and viral infection pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of RPL12 in maintaining cellular homeostasis and responding to environmental challenges. Further research is needed to elucidate the mechanisms underlying RPL12's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3963943269

Symbol: RL12_HUMAN

Name: 60S ribosomal protein L12

UniProtKB Accession Codes:

P30050 Q5VVV2 Q6PB27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 36 Ensembl 2 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 41 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441690

Title: The primary structure of human ribosomal protein L12.

PubMed ID: 8441690

DOI: 10.1093/nar/21.3.749

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

Sequence Information:

  • Length: 165
  • Mass: 17819
  • Checksum: 7EFD783A8ED350F9
  • Sequence:
    • MPPKFDPNEI KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT GDWKGLRITV 
KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH SGNITFDEIV NIARQMRHRS 
LARELSGTIK EILGTAQSVG CNVDGRHPHD IIDDINSGAV ECPAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.