Details for: RPL15

Gene ID: 6138

Symbol: RPL15

Ensembl ID: ENSG00000174748

Description: ribosomal protein L15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 785.2819
    Cell Significance Index: -323.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 704.1107
    Cell Significance Index: -286.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 653.5378
    Cell Significance Index: -308.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 609.5626
    Cell Significance Index: -313.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 461.7731
    Cell Significance Index: -309.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 301.7357
    Cell Significance Index: -288.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.7324
    Cell Significance Index: -76.9700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 21.5642
    Cell Significance Index: 126.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 20.2633
    Cell Significance Index: 517.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 15.5612
    Cell Significance Index: 236.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 13.4158
    Cell Significance Index: 1370.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 13.2902
    Cell Significance Index: 349.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 13.2519
    Cell Significance Index: 354.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 13.1999
    Cell Significance Index: 458.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.9905
    Cell Significance Index: 610.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.9177
    Cell Significance Index: 228.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.8948
    Cell Significance Index: 192.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.4344
    Cell Significance Index: 118.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.8787
    Cell Significance Index: 1276.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.4786
    Cell Significance Index: 271.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 9.2830
    Cell Significance Index: 118.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.7818
    Cell Significance Index: 461.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.7210
    Cell Significance Index: 649.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.6556
    Cell Significance Index: 1064.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.5928
    Cell Significance Index: 1180.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.5849
    Cell Significance Index: 198.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.4420
    Cell Significance Index: 1521.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.9133
    Cell Significance Index: 4321.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.7934
    Cell Significance Index: 551.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.7369
    Cell Significance Index: 84.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.4708
    Cell Significance Index: 3303.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.4694
    Cell Significance Index: 880.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.2372
    Cell Significance Index: 466.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.1349
    Cell Significance Index: 914.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.1310
    Cell Significance Index: 332.4800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.6093
    Cell Significance Index: 40.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.0061
    Cell Significance Index: 163.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.7147
    Cell Significance Index: 87.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.6117
    Cell Significance Index: 135.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.3527
    Cell Significance Index: 743.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.4867
    Cell Significance Index: 93.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3348
    Cell Significance Index: 661.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.2764
    Cell Significance Index: 26.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9483
    Cell Significance Index: 27.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.8580
    Cell Significance Index: 2163.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.1833
    Cell Significance Index: 867.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.9247
    Cell Significance Index: 105.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.5628
    Cell Significance Index: 44.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4653
    Cell Significance Index: 93.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3606
    Cell Significance Index: 18.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3377
    Cell Significance Index: 97.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2684
    Cell Significance Index: 51.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0511
    Cell Significance Index: 18.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0584
    Cell Significance Index: -52.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0788
    Cell Significance Index: -148.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1117
    Cell Significance Index: -82.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1709
    Cell Significance Index: -315.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2014
    Cell Significance Index: -310.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2526
    Cell Significance Index: -142.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2593
    Cell Significance Index: -352.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2644
    Cell Significance Index: -165.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4071
    Cell Significance Index: -258.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6071
    Cell Significance Index: -127.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6168
    Cell Significance Index: -279.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7488
    Cell Significance Index: -74.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9911
    Cell Significance Index: -60.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.0338
    Cell Significance Index: -168.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1168
    Cell Significance Index: -127.9500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.3598
    Cell Significance Index: -28.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.5721
    Cell Significance Index: -71.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6293
    Cell Significance Index: -91.4300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.6817
    Cell Significance Index: -28.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.8087
    Cell Significance Index: -30.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.9089
    Cell Significance Index: -61.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9266
    Cell Significance Index: -280.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1385
    Cell Significance Index: -134.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.2526
    Cell Significance Index: -13.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.3166
    Cell Significance Index: -66.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.4562
    Cell Significance Index: -127.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.9997
    Cell Significance Index: -312.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.4805
    Cell Significance Index: -234.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.8887
    Cell Significance Index: -298.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -4.2347
    Cell Significance Index: -292.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.2522
    Cell Significance Index: -72.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.3588
    Cell Significance Index: -59.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -4.5867
    Cell Significance Index: -161.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.9273
    Cell Significance Index: -302.0900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -5.1583
    Cell Significance Index: -44.3300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.3078
    Cell Significance Index: -38.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.4478
    Cell Significance Index: -81.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.6250
    Cell Significance Index: -165.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -5.8793
    Cell Significance Index: -121.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -6.0769
    Cell Significance Index: -131.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.3547
    Cell Significance Index: -170.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.4930
    Cell Significance Index: -77.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.6894
    Cell Significance Index: -295.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.0759
    Cell Significance Index: -259.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -7.1264
    Cell Significance Index: -178.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -7.9411
    Cell Significance Index: -300.7100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -7.9463
    Cell Significance Index: -36.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL15 is a 40-kDa protein that belongs to the 60S ribosomal protein family. It is a highly conserved protein across species, with a high degree of sequence similarity to its counterparts in other eukaryotes. RPL15 is a structural component of the 60S ribosomal subunit, which is responsible for the translation of messenger RNA (mRNA) into proteins. The protein is synthesized in the cytosol and is transported to the nucleus, where it associates with the 60S ribosomal subunit. RPL15 is also involved in the regulation of protein synthesis, responding to changes in amino acid availability and responding to stress signals. **Pathways and Functions** RPL15 is involved in various cellular pathways, including: 1. **Translation**: RPL15 is a key component of the 60S ribosomal subunit, which is responsible for the translation of mRNA into proteins. 2. **Protein Synthesis**: RPL15 is essential for the accurate assembly and functioning of the ribosome, which is responsible for protein synthesis. 3. **Response to Stress**: RPL15 responds to stress signals, such as amino acid deficiency and ethanol exposure, which can impact protein synthesis and cellular homeostasis. 4. **Ribosome Biogenesis**: RPL15 is involved in the regulation of ribosome biogenesis, responding to changes in gene expression and cellular metabolism. 5. **Regulation of Gene Expression**: RPL15 regulates the expression of genes involved in protein synthesis, including the translation of specific mRNAs. **Clinical Significance** RPL15 has been implicated in various diseases, including: 1. **Influenza Infection**: RPL15 has been shown to play a role in the replication of influenza virus, highlighting its importance in viral infections. 2. **Neurodegenerative Diseases**: RPL15 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where protein misfolding and aggregation are major contributors to disease pathology. 3. **Cancer**: RPL15 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer, where it may contribute to tumorigenesis and cancer progression. 4. **Immune Diseases**: RPL15 has been implicated in immune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to disease pathology. In conclusion, RPL15 is a crucial component of the 60S ribosomal subunit, playing a pivotal role in the translation process and protein synthesis. Its involvement in various cellular pathways and diseases highlights its importance in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the role of RPL15 in these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 549259437

Symbol: RL15_HUMAN

Name: 60S ribosomal protein L15

UniProtKB Accession Codes:

P61313 P39030 P41051 Q5U0C0 Q642I1 Q6IPX6 Q8WYP2 Q96C44 Q9H2E5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 15 EMDB 78 Ensembl 7 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 93 PDBsum 93 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21612406

Title: A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells.

PubMed ID: 21612406

DOI: 10.1089/dna.2010.1149

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 23812780

Title: Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia.

PubMed ID: 23812780

DOI: 10.1007/s00439-013-1326-z

Sequence Information:

  • Length: 204
  • Mass: 24146
  • Checksum: A6E3AD1A76C9506F
  • Sequence:
    • MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR LGYKAKQGYV 
IYRIRVRRGG RKRPVPKGAT YGKPVHHGVN QLKFARSLQS VAEERAGRHC GALRVLNSYW 
VGEDSTYKFF EVILIDPFHK AIRRNPDTQW ITKPVHKHRE MRGLTSAGRK SRGLGKGHKF 
HHTIGGSRRA AWRRRNTLQL HRYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.