Details for: RPL17

Gene ID: 6139

Symbol: RPL17

Ensembl ID: ENSG00000265681

Description: ribosomal protein L17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 307.9496
    Cell Significance Index: -145.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 291.2214
    Cell Significance Index: -149.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 217.3401
    Cell Significance Index: -145.8400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 25.1472
    Cell Significance Index: 216.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.1270
    Cell Significance Index: -59.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 18.9933
    Cell Significance Index: 438.8100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 17.5591
    Cell Significance Index: 103.1600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 17.1695
    Cell Significance Index: 123.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.2329
    Cell Significance Index: 379.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 11.8164
    Cell Significance Index: 134.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 11.0233
    Cell Significance Index: 101.5100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 8.9215
    Cell Significance Index: 41.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.8956
    Cell Significance Index: 1093.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.8283
    Cell Significance Index: 1591.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.8127
    Cell Significance Index: 258.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.7130
    Cell Significance Index: 111.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.7199
    Cell Significance Index: 203.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.0053
    Cell Significance Index: 898.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 5.9128
    Cell Significance Index: 603.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.7813
    Cell Significance Index: 62.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.7177
    Cell Significance Index: 98.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.4130
    Cell Significance Index: 520.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.9008
    Cell Significance Index: 503.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.3852
    Cell Significance Index: 159.1000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.2138
    Cell Significance Index: 25.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8052
    Cell Significance Index: 209.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.7567
    Cell Significance Index: 73.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.7030
    Cell Significance Index: 47.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6829
    Cell Significance Index: 368.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.6333
    Cell Significance Index: 186.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5399
    Cell Significance Index: 1122.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3454
    Cell Significance Index: 81.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.9799
    Cell Significance Index: 50.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 1.8977
    Cell Significance Index: 1185.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8803
    Cell Significance Index: 186.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4312
    Cell Significance Index: 41.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3435
    Cell Significance Index: 75.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2794
    Cell Significance Index: 218.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0508
    Cell Significance Index: 64.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9669
    Cell Significance Index: 528.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8626
    Cell Significance Index: 173.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8468
    Cell Significance Index: 23.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4634
    Cell Significance Index: 8.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4629
    Cell Significance Index: 29.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3854
    Cell Significance Index: 347.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3331
    Cell Significance Index: 63.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2446
    Cell Significance Index: 87.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1637
    Cell Significance Index: 123.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1304
    Cell Significance Index: 14.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1060
    Cell Significance Index: 2.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0520
    Cell Significance Index: -1.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0563
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0713
    Cell Significance Index: -134.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0881
    Cell Significance Index: -162.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1051
    Cell Significance Index: -161.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1232
    Cell Significance Index: -167.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1253
    Cell Significance Index: -70.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1268
    Cell Significance Index: -4.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1566
    Cell Significance Index: -114.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1843
    Cell Significance Index: -20.0500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2108
    Cell Significance Index: -1.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2301
    Cell Significance Index: -146.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2354
    Cell Significance Index: -11.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2677
    Cell Significance Index: -77.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3021
    Cell Significance Index: -63.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3257
    Cell Significance Index: -147.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3454
    Cell Significance Index: -56.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4249
    Cell Significance Index: -17.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4972
    Cell Significance Index: -23.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6557
    Cell Significance Index: -75.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7097
    Cell Significance Index: -32.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.7182
    Cell Significance Index: -142.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8339
    Cell Significance Index: -52.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8399
    Cell Significance Index: -58.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9596
    Cell Significance Index: -16.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0164
    Cell Significance Index: -147.7500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.2609
    Cell Significance Index: -7.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2907
    Cell Significance Index: -99.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.2950
    Cell Significance Index: -67.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2951
    Cell Significance Index: -68.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3660
    Cell Significance Index: -142.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4490
    Cell Significance Index: -36.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.7268
    Cell Significance Index: -136.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.9309
    Cell Significance Index: -51.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1403
    Cell Significance Index: -131.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -2.1779
    Cell Significance Index: -32.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.2883
    Cell Significance Index: -54.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -2.4548
    Cell Significance Index: -37.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.6784
    Cell Significance Index: -118.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.6801
    Cell Significance Index: -139.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.9198
    Cell Significance Index: -43.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9878
    Cell Significance Index: -64.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.1235
    Cell Significance Index: -92.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.3087
    Cell Significance Index: -121.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.3612
    Cell Significance Index: -127.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -3.4316
    Cell Significance Index: -112.3500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -3.5273
    Cell Significance Index: -21.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -3.5357
    Cell Significance Index: -75.3000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -3.6076
    Cell Significance Index: -23.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL17 is a 60S ribosomal protein, specifically located in the large subunit of the ribosome. It is composed of 173 amino acids and exhibits a characteristic ribosomal binding motif. The protein's structure allows it to bind to ribosomal RNA and other ribosomal proteins, contributing to the assembly and function of the ribosome. RPL17 is also involved in the regulation of translation initiation and elongation, particularly in response to stress and starvation. **Pathways and Functions:** RPL17 is involved in several key pathways, including: 1. **Translation**: RPL17 plays a crucial role in the translation process, regulating the assembly and function of ribosomes. 2. **Stress Response**: RPL17 is activated in response to stress and starvation, contributing to the regulation of protein synthesis and cellular homeostasis. 3. **Signaling**: RPL17 interacts with signaling molecules, including the eukaryotic translation initiation factor 2 alpha (eIF2α), to regulate the translation of specific mRNAs. 4. **Immune Response**: RPL17 is expressed in immune cells, where it plays a role in the regulation of protein synthesis and the presentation of antigens to T cells. **Clinical Significance:** Dysregulation of RPL17 has been implicated in various diseases, including: 1. **Influenza Infection**: RPL17 is involved in the regulation of viral RNA transcription and replication, making it a potential target for therapeutic intervention. 2. **Cancer**: Alterations in RPL17 expression have been observed in various types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Neurodegenerative Diseases**: RPL17 has been implicated in the regulation of protein synthesis and the presentation of antigens to T cells, making it a potential target for therapeutic intervention in neurodegenerative diseases. In conclusion, RPL17 is a critical component of the 60S ribosomal subunit, playing a pivotal role in the translation process and cellular homeostasis. Its involvement in multiple cellular pathways, including stress response, signaling, and immune response, underscores its importance in maintaining cellular homeostasis. Further research is needed to elucidate the role of RPL17 in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1325350968

Symbol: RL17_HUMAN

Name: 60S ribosomal protein L17

UniProtKB Accession Codes:

P18621 B2R4H3 B4E3C2 B5ME31 J3QL51 Q3KQW2 Q6NZ54 Q7M4M5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 79 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 95 PDBsum 95 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2402465

Title: A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui.

PubMed ID: 2402465

DOI: 10.1093/nar/18.17.5301

PubMed ID: 1793733

Title: Isolation and characterization of a complementary DNA (PD-1) differentially expressed by human pancreatic ductal cell tumors.

PubMed ID: 1793733

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 184
  • Mass: 21397
  • Checksum: 2FC595DD74ED1CA0
  • Sequence:
    • MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD VTLQKQCVPF 
RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES NAELKGLDVD SLVIEHIQVN 
KAPKMRRRTY RAHGRINPYM SSPCHIEMIL TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL 
MARE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.