Details for: RPL18

Gene ID: 6141

Symbol: RPL18

Ensembl ID: ENSG00000063177

Description: ribosomal protein L18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 696.1565
    Cell Significance Index: -286.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 652.2101
    Cell Significance Index: -264.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 583.4077
    Cell Significance Index: -275.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 562.2829
    Cell Significance Index: -289.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 412.2517
    Cell Significance Index: -276.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 283.3642
    Cell Significance Index: -270.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 40.8961
    Cell Significance Index: -109.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.5835
    Cell Significance Index: 449.2000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 15.4076
    Cell Significance Index: 90.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.2832
    Cell Significance Index: 1561.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.4781
    Cell Significance Index: 387.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.8531
    Cell Significance Index: 164.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.5864
    Cell Significance Index: 591.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.4805
    Cell Significance Index: 301.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.6127
    Cell Significance Index: 304.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.4314
    Cell Significance Index: 241.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.3384
    Cell Significance Index: 1282.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.2833
    Cell Significance Index: 1199.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.7069
    Cell Significance Index: 615.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.6932
    Cell Significance Index: 302.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.6410
    Cell Significance Index: 402.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.5809
    Cell Significance Index: 151.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.3231
    Cell Significance Index: 4545.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.2543
    Cell Significance Index: 1014.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.1908
    Cell Significance Index: 1476.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.0383
    Cell Significance Index: 168.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.0197
    Cell Significance Index: 3545.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.6424
    Cell Significance Index: 569.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.5525
    Cell Significance Index: 85.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.4163
    Cell Significance Index: 217.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.3921
    Cell Significance Index: 871.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.2695
    Cell Significance Index: 468.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.5907
    Cell Significance Index: 71.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.9587
    Cell Significance Index: 162.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.9249
    Cell Significance Index: 308.6200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.6490
    Cell Significance Index: 60.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.2979
    Cell Significance Index: 97.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.0820
    Cell Significance Index: 867.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.7602
    Cell Significance Index: 43.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.6982
    Cell Significance Index: 602.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.9761
    Cell Significance Index: 208.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.7833
    Cell Significance Index: 32.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.6447
    Cell Significance Index: 22.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.5784
    Cell Significance Index: 1951.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5617
    Cell Significance Index: 116.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4210
    Cell Significance Index: 2185.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2752
    Cell Significance Index: 60.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7133
    Cell Significance Index: 340.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6495
    Cell Significance Index: 114.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3933
    Cell Significance Index: 72.3800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.1517
    Cell Significance Index: 24.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0004
    Cell Significance Index: 190.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9401
    Cell Significance Index: 689.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7113
    Cell Significance Index: 204.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6308
    Cell Significance Index: 62.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1273
    Cell Significance Index: 2.1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0939
    Cell Significance Index: 0.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0719
    Cell Significance Index: 14.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0155
    Cell Significance Index: -5.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0493
    Cell Significance Index: -92.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1026
    Cell Significance Index: -75.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1063
    Cell Significance Index: -195.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1318
    Cell Significance Index: -202.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1921
    Cell Significance Index: -261.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2350
    Cell Significance Index: -132.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3263
    Cell Significance Index: -203.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3504
    Cell Significance Index: -222.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5301
    Cell Significance Index: -240.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7076
    Cell Significance Index: -149.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7624
    Cell Significance Index: -46.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8034
    Cell Significance Index: -63.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8540
    Cell Significance Index: -47.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0596
    Cell Significance Index: -121.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1172
    Cell Significance Index: -6.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.1921
    Cell Significance Index: -193.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2273
    Cell Significance Index: -39.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4357
    Cell Significance Index: -24.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.6463
    Cell Significance Index: -239.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9980
    Cell Significance Index: -125.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.2351
    Cell Significance Index: -255.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.4234
    Cell Significance Index: -41.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.6215
    Cell Significance Index: -272.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.8792
    Cell Significance Index: -172.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.8969
    Cell Significance Index: -83.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.0945
    Cell Significance Index: -42.2200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -3.2693
    Cell Significance Index: -15.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.4109
    Cell Significance Index: -261.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.4290
    Cell Significance Index: -51.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.6996
    Cell Significance Index: -80.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.7388
    Cell Significance Index: -251.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.9304
    Cell Significance Index: -240.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -4.0309
    Cell Significance Index: -141.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -4.1517
    Cell Significance Index: -103.7800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.2010
    Cell Significance Index: -28.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.4960
    Cell Significance Index: -161.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.2155
    Cell Significance Index: -166.5500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -6.2703
    Cell Significance Index: -38.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.3234
    Cell Significance Index: -279.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -6.6507
    Cell Significance Index: -55.8700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.7270
    Cell Significance Index: -86.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein L18**: RPL18 is a 60S ribosomal protein that belongs to the L18 family, which is involved in the translation elongation process. 2. **Cellular expression**: RPL18 is widely expressed in various cell types, including hematopoietic stem cells, epithelial cells, and immune cells. 3. **Translation elongation**: RPL18 plays a crucial role in the translation elongation process, where it interacts with other ribosomal proteins to facilitate the assembly of the 60S ribosomal subunit. 4. **Stress response**: RPL18 is involved in the cellular response to stress, including amino acid deficiency and hypoxia, through its interaction with the eIF2α kinase, GCN2. **Pathways and Functions:** 1. **Axon guidance**: RPL18 is involved in axon guidance, a process critical for neuronal development and migration. 2. **Cap-dependent translation initiation**: RPL18 interacts with the 60S ribosomal subunit to facilitate cap-dependent translation initiation, a process essential for the translation of mRNAs. 3. **Cytoplasmic translation**: RPL18 is involved in the translation of mRNAs in the cytoplasm, where it interacts with other ribosomal proteins to facilitate the assembly of the 60S ribosomal subunit. 4. **Cellular responses to stimuli**: RPL18 is involved in the cellular response to various stimuli, including stress, hypoxia, and amino acid deficiency. 5. **Influenza infection**: RPL18 is involved in the translation of influenza virus mRNA, where it interacts with the viral RNA to facilitate viral replication. **Clinical Significance:** 1. **Cancer**: RPL18's involvement in cancer development and progression is evident, as it is overexpressed in various types of cancer, including leukemia and lymphoma. 2. **Neurological disorders**: RPL18's role in axon guidance and neuronal development underscores its importance in neurological disorders, such as autism and schizophrenia. 3. **Infectious diseases**: RPL18's involvement in the translation of influenza virus mRNA highlights its potential as a therapeutic target for the treatment of influenza infections. 4. **Regenerative medicine**: RPL18's role in cellular homeostasis and stress response makes it an attractive target for regenerative medicine applications, including tissue engineering and stem cell therapy. In conclusion, RPL18 is a multifaceted protein that plays a crucial role in eukaryotic translation elongation, cellular homeostasis, and disease. Its involvement in various cellular processes, including stress response, axon guidance, and cancer development, underscores its importance in maintaining cellular homeostasis. Further research on RPL18's role in disease will provide valuable insights into its potential as a therapeutic target and its importance in regenerative medicine applications.

Genular Protein ID: 3588064937

Symbol: RL18_HUMAN

Name: 60S ribosomal protein L18

UniProtKB Accession Codes:

Q07020 F8VWC5 Q8WTZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EMDB 82 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 97 PDBsum 97 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8218404

Title: Nucleotide and deduced amino acid sequence of human ribosomal protein L18.

PubMed ID: 8218404

DOI: 10.1016/0167-4781(93)90050-n

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 28280134

Title: Novel and known ribosomal causes of Diamond-Blackfan anaemia identified through comprehensive genomic characterisation.

PubMed ID: 28280134

DOI: 10.1136/jmedgenet-2016-104346

Sequence Information:

  • Length: 188
  • Mass: 21634
  • Checksum: C4E416E7A5329B7C
  • Sequence:
    • MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP 
LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV CALRVTSRAR SRILRAGGKI 
LTFDQLALDS PKGCGTVLLS GPRKGREVYR HFGKAPGTPH SHTKPYVRSK GRKFERARGR 
RASRGYKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.