Details for: RPL19

Gene ID: 6143

Symbol: RPL19

Ensembl ID: ENSG00000108298

Description: ribosomal protein L19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 759.3684
    Cell Significance Index: -312.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 720.7012
    Cell Significance Index: -292.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 645.2137
    Cell Significance Index: -304.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 619.2052
    Cell Significance Index: -318.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 455.6780
    Cell Significance Index: -305.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 311.4032
    Cell Significance Index: -297.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.1783
    Cell Significance Index: -88.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 20.3263
    Cell Significance Index: 519.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.5716
    Cell Significance Index: 1692.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 16.1824
    Cell Significance Index: 432.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.8042
    Cell Significance Index: 648.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.3183
    Cell Significance Index: 297.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.7334
    Cell Significance Index: 307.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.6815
    Cell Significance Index: 136.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 10.2575
    Cell Significance Index: 356.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.2478
    Cell Significance Index: 236.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.9809
    Cell Significance Index: 176.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.8125
    Cell Significance Index: 1267.7000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 9.6425
    Cell Significance Index: 56.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.9653
    Cell Significance Index: 1231.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.8143
    Cell Significance Index: 1083.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.7827
    Cell Significance Index: 1035.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.7581
    Cell Significance Index: 1578.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.4917
    Cell Significance Index: 96.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.3877
    Cell Significance Index: 593.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.0734
    Cell Significance Index: 4409.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.9901
    Cell Significance Index: 3532.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.8632
    Cell Significance Index: 586.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.7138
    Cell Significance Index: 497.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.1995
    Cell Significance Index: 211.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.9354
    Cell Significance Index: 323.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.8509
    Cell Significance Index: 878.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.8485
    Cell Significance Index: 143.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.3909
    Cell Significance Index: 118.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.6000
    Cell Significance Index: 60.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.9777
    Cell Significance Index: 135.4900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.5363
    Cell Significance Index: 38.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.4232
    Cell Significance Index: 755.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.1276
    Cell Significance Index: 38.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.9050
    Cell Significance Index: 2955.8000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.6154
    Cell Significance Index: 22.2500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.5089
    Cell Significance Index: 9.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.3887
    Cell Significance Index: 177.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.3524
    Cell Significance Index: 174.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.0757
    Cell Significance Index: 304.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.5783
    Cell Significance Index: 2328.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3916
    Cell Significance Index: 474.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3583
    Cell Significance Index: 62.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.5247
    Cell Significance Index: 1117.8800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.4763
    Cell Significance Index: 30.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1254
    Cell Significance Index: 214.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.0162
    Cell Significance Index: 80.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7811
    Cell Significance Index: 40.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4531
    Cell Significance Index: 130.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3269
    Cell Significance Index: 2.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0363
    Cell Significance Index: -68.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1126
    Cell Significance Index: -83.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1472
    Cell Significance Index: -271.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1627
    Cell Significance Index: -32.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1782
    Cell Significance Index: -274.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2325
    Cell Significance Index: -316.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2562
    Cell Significance Index: -144.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2723
    Cell Significance Index: -170.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3141
    Cell Significance Index: -112.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3414
    Cell Significance Index: -216.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3454
    Cell Significance Index: -15.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5893
    Cell Significance Index: -267.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6125
    Cell Significance Index: -129.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.9267
    Cell Significance Index: -150.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1400
    Cell Significance Index: -130.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.2161
    Cell Significance Index: -139.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3216
    Cell Significance Index: -74.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.3726
    Cell Significance Index: -84.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5366
    Cell Significance Index: -26.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6495
    Cell Significance Index: -52.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6860
    Cell Significance Index: -116.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8087
    Cell Significance Index: -262.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.1254
    Cell Significance Index: -35.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.5112
    Cell Significance Index: -158.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.8286
    Cell Significance Index: -17.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.8692
    Cell Significance Index: -298.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.7836
    Cell Significance Index: -290.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.1426
    Cell Significance Index: -56.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.2300
    Cell Significance Index: -284.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.2540
    Cell Significance Index: -260.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.3269
    Cell Significance Index: -64.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -4.4353
    Cell Significance Index: -110.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.5049
    Cell Significance Index: -270.4500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.1294
    Cell Significance Index: -27.9700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -5.3592
    Cell Significance Index: -75.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.4229
    Cell Significance Index: -117.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.9633
    Cell Significance Index: -175.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.1545
    Cell Significance Index: -105.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.5652
    Cell Significance Index: -290.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.5937
    Cell Significance Index: -176.6800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -7.4134
    Cell Significance Index: -95.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.4504
    Cell Significance Index: -273.5000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -7.5500
    Cell Significance Index: -34.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -7.5684
    Cell Significance Index: -90.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -7.8609
    Cell Significance Index: -66.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL19 is a 60S ribosomal protein, which is a structural constituent of the ribosome. It is a highly conserved protein across species, with a high degree of sequence similarity to its counterparts in other organisms. RPL19 is a large protein, consisting of 202 amino acids, and is characterized by its ability to bind to the ribosomal RNA (rRNA) and other ribosomal proteins. The protein is also involved in the regulation of translation elongation, with RPL19 interacting with other ribosomal proteins and factors to facilitate the assembly of the 60S subunit. **Pathways and Functions** RPL19 is involved in several cellular pathways, including: 1. **Translation elongation**: RPL19 plays a crucial role in the translation elongation process, where it interacts with other ribosomal proteins and factors to facilitate the assembly of the 60S subunit. 2. **Cap-dependent translation initiation**: RPL19 is involved in the cap-dependent translation initiation process, where it interacts with the eIF4G protein to facilitate the assembly of the 40S subunit. 3. **Axon guidance**: RPL19 is involved in the axon guidance process, where it interacts with other proteins to facilitate the extension of axons and the formation of synapses. 4. **Response to starvation**: RPL19 is involved in the response to starvation, where it interacts with other proteins to facilitate the regulation of protein synthesis and the mobilization of energy resources. **Clinical Significance** RPL19 has been implicated in various diseases, including: 1. **Cancer**: RPL19 is overexpressed in several types of cancer, including breast cancer, prostate cancer, and lung cancer. 2. **Neurological disorders**: RPL19 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Infectious diseases**: RPL19 has been implicated in infectious diseases, including influenza and HIV-1 infection. The significance of RPL19 in disease development and progression highlights the need for further research into its role in human health and disease. Additionally, the identification of specific mutations or variants in the RPL19 gene that are associated with disease development may provide new therapeutic targets for the treatment of these diseases. **Signaling Pathways and Mechanisms** RPL19 interacts with various signaling pathways and mechanisms, including: 1. **mTOR pathway**: RPL19 interacts with the mTOR pathway to regulate protein synthesis and cell growth. 2. **PI3K/AKT pathway**: RPL19 interacts with the PI3K/AKT pathway to regulate cell survival and apoptosis. 3. **MAPK pathway**: RPL19 interacts with the MAPK pathway to regulate cell proliferation and differentiation. Overall, RPL19 is a critical component of the ribosome, and its dysregulation has been implicated in various diseases. Further research into the role of RPL19 in disease development and progression is necessary to fully understand its significance in human health and disease.

Genular Protein ID: 3344646804

Symbol: RL19_HUMAN

Name: 60S ribosomal protein L19

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1598220

Title: Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19.

PubMed ID: 1598220

DOI: 10.1093/nar/20.10.2598

PubMed ID: 8095182

Title: High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2.

PubMed ID: 8095182

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 196
  • Mass: 23466
  • Checksum: 4AF506393E526216
  • Sequence:
  • MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR 
    ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR ILRRLLRRYR ESKKIDRHMY 
    HSLYLKVKGN VFKNKRILME HIHKLKADKA RKKLLADQAE ARRSKTKEAR KRREERLQAK 
    KEEIIKTLSK EEETKK

Genular Protein ID: 2003483060

Symbol: J3KTE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 194
  • Mass: 23248
  • Checksum: 02BAB54372D2186C
  • Sequence:
  • MLRLQKRLAS SVLRCGKKKV WLDPNETNEI ANANSRQQIR KLIKDGLIIR KPVTVHSRAR 
    CRKNTLARRK GRHMGIGKRK GTANARMPEK VTWMRRMRIL RRLLRRYRES KKIDRHMYHS 
    LYLKVKGNVF KNKRILMEHI HKLKADKARK KLLADQAEAR RSKTKEARKR REERLQAKKE 
    EIIKTLSKEE ETKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.