Details for: RPL19

Gene ID: 6143

Symbol: RPL19

Ensembl ID: ENSG00000108298

Description: ribosomal protein L19

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.28
    Marker Score: 3541.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.11
    Marker Score: 29997.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.81
    Marker Score: 12175
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.78
    Marker Score: 77652
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.51
    Marker Score: 4315.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.49
    Marker Score: 3982
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.39
    Marker Score: 15729
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.39
    Marker Score: 2781
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.37
    Marker Score: 2761.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.3
    Marker Score: 52501
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.29
    Marker Score: 1949
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.24
    Marker Score: 3377
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.19
    Marker Score: 8901
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 5.18
    Marker Score: 3653
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.09
    Marker Score: 6633
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.03
    Marker Score: 2843.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.03
    Marker Score: 171062
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.02
    Marker Score: 7732
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.99
    Marker Score: 4458
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.94
    Marker Score: 3542
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.86
    Marker Score: 15330
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.78
    Marker Score: 12155
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.77
    Marker Score: 4067
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.77
    Marker Score: 252236
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.71
    Marker Score: 24756
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.65
    Marker Score: 1110.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.63
    Marker Score: 19304
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.62
    Marker Score: 3490
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.59
    Marker Score: 1971
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.58
    Marker Score: 3488.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.51
    Marker Score: 252250
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.49
    Marker Score: 4995
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.48
    Marker Score: 59032
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.46
    Marker Score: 11955.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.46
    Marker Score: 1450
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.39
    Marker Score: 26701
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.39
    Marker Score: 51056
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.38
    Marker Score: 2665
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.34
    Marker Score: 15424
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.31
    Marker Score: 2297
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.31
    Marker Score: 11894
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.24
    Marker Score: 11892
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.24
    Marker Score: 4096
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 4.22
    Marker Score: 1892
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.2
    Marker Score: 10270
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.19
    Marker Score: 2457.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.18
    Marker Score: 2971
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.17
    Marker Score: 31034.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.15
    Marker Score: 9461.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.13
    Marker Score: 4826
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.11
    Marker Score: 3229
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.11
    Marker Score: 941.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.1
    Marker Score: 10002
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.09
    Marker Score: 3670
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17508
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.08
    Marker Score: 6007
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.07
    Marker Score: 3472
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.04
    Marker Score: 4347
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.04
    Marker Score: 7589
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.03
    Marker Score: 26243
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 4.02
    Marker Score: 1057.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.01
    Marker Score: 4279.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.01
    Marker Score: 4945
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4
    Marker Score: 3937.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.98
    Marker Score: 9924
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.97
    Marker Score: 25333
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.96
    Marker Score: 9975
  • Cell Name: glial cell (CL0000125)
    Fold Change: 3.95
    Marker Score: 4347
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.94
    Marker Score: 1110.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.93
    Marker Score: 3220
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.92
    Marker Score: 3441.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.91
    Marker Score: 4586
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.89
    Marker Score: 3672
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.89
    Marker Score: 1104.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.89
    Marker Score: 2614
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.87
    Marker Score: 3414
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.86
    Marker Score: 4274
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.86
    Marker Score: 1409
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.86
    Marker Score: 4649.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.85
    Marker Score: 4650
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.85
    Marker Score: 3311
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.84
    Marker Score: 3611
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.83
    Marker Score: 1014
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.82
    Marker Score: 1090
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.81
    Marker Score: 3860
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.81
    Marker Score: 5508
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.8
    Marker Score: 3159.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.8
    Marker Score: 1968.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.8
    Marker Score: 3388
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.8
    Marker Score: 1735
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.79
    Marker Score: 1963
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.79
    Marker Score: 3370
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.77
    Marker Score: 938.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.77
    Marker Score: 1241.5
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.77
    Marker Score: 877.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.76
    Marker Score: 2847
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.76
    Marker Score: 1112
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.75
    Marker Score: 32889.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.74
    Marker Score: 4282
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.74
    Marker Score: 2601

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Other Information

**Key characteristics:** * RPL19 is a large protein with a molecular weight of approximately 120 kDa. * It is a key component of the ribosome, where it is involved in the assembly and elongation of polypeptide chains. * RPL19 is also involved in the processing of mRNA, where it is responsible for removing a processing signal from the pre-mRNA. * It is a highly expressed protein in epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, and CD38-negative naive B cells. * It is also expressed in malignant cells, thyroid follicular cells, activated CD8-positive, alpha-beta T cells, NKp46-positive innate lymphoid cells, and human professional antigen-presenting cells. **Pathways and functions:** * RPL19 is involved in the translation of mRNA from the 5' cap to the stop codon. * It is a key component of the ribosome, where it is involved in the assembly and elongation of polypeptide chains. * It is also involved in the processing of mRNA, where it is responsible for removing a processing signal from the pre-mRNA. * RPL19 is a regulator of gene expression, as it can be targeted for degradation by the nonsense-mediated decay (nmd) pathway. * It is also involved in the regulation of cellular responses to stimuli and stress. **Clinical significance:** RPL19 is a potential therapeutic target for a variety of diseases. It is expressed in high levels in cancer cells, where it is involved in the translation of mRNA that is required for the growth and survival of cancer cells. Inhibition of RPL19 has been shown to inhibit cancer cell growth and metastasis.

Genular Protein ID: 3344646804

Symbol: RL19_HUMAN

Name: 60S ribosomal protein L19

UniProtKB Accession Codes:

P84098 B2R4K2 P14118 P22908 Q502Y6 Q7Z6E4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 9 EMDB 58 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 76 PDBsum 72 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1598220

Title: Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19.

PubMed ID: 1598220

DOI: 10.1093/nar/20.10.2598

PubMed ID: 8095182

Title: High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2.

PubMed ID: 8095182

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 196
  • Mass: 23466
  • Checksum: 4AF506393E526216
  • Sequence:
    • MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR 
ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR ILRRLLRRYR ESKKIDRHMY 
HSLYLKVKGN VFKNKRILME HIHKLKADKA RKKLLADQAE ARRSKTKEAR KRREERLQAK 
KEEIIKTLSK EEETKK

Genular Protein ID: 2003483060

Symbol: J3KTE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KTE4

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 3 GO 6 Gene3D 2 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 194
  • Mass: 23248
  • Checksum: 02BAB54372D2186C
  • Sequence:
    • MLRLQKRLAS SVLRCGKKKV WLDPNETNEI ANANSRQQIR KLIKDGLIIR KPVTVHSRAR 
CRKNTLARRK GRHMGIGKRK GTANARMPEK VTWMRRMRIL RRLLRRYRES KKIDRHMYHS 
LYLKVKGNVF KNKRILMEHI HKLKADKARK KLLADQAEAR RSKTKEARKR REERLQAKKE 
EIIKTLSKEE ETKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.