Details for: RPL22

Gene ID: 6146

Symbol: RPL22

Ensembl ID: ENSG00000116251

Description: ribosomal protein L22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 520.4545
    Cell Significance Index: -214.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 474.9948
    Cell Significance Index: -192.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 432.6842
    Cell Significance Index: -204.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 414.1837
    Cell Significance Index: -213.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 305.8617
    Cell Significance Index: -205.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 206.4640
    Cell Significance Index: -197.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.6383
    Cell Significance Index: -95.4700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 19.2786
    Cell Significance Index: 292.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 13.8003
    Cell Significance Index: 369.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 13.7789
    Cell Significance Index: 352.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 12.4753
    Cell Significance Index: 1274.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.8403
    Cell Significance Index: 151.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 9.7914
    Cell Significance Index: 460.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.3720
    Cell Significance Index: 106.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.7729
    Cell Significance Index: 183.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.3646
    Cell Significance Index: 193.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 8.3164
    Cell Significance Index: 218.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.9992
    Cell Significance Index: 1098.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.9168
    Cell Significance Index: 139.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.9154
    Cell Significance Index: 226.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.8204
    Cell Significance Index: 553.0900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.7072
    Cell Significance Index: 45.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.6933
    Cell Significance Index: 945.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.6142
    Cell Significance Index: 1372.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.4756
    Cell Significance Index: 81.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.3223
    Cell Significance Index: 945.9900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.0602
    Cell Significance Index: 43.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.9949
    Cell Significance Index: 824.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.9815
    Cell Significance Index: 3086.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.5452
    Cell Significance Index: 487.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.5112
    Cell Significance Index: 226.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.1167
    Cell Significance Index: 394.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.8573
    Cell Significance Index: 3198.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.6789
    Cell Significance Index: 52.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.4745
    Cell Significance Index: 43.7100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 5.2380
    Cell Significance Index: 45.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.2043
    Cell Significance Index: 96.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.8024
    Cell Significance Index: 141.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.6936
    Cell Significance Index: 601.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.6123
    Cell Significance Index: 188.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4387
    Cell Significance Index: 93.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.9997
    Cell Significance Index: 139.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.9214
    Cell Significance Index: 2637.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6865
    Cell Significance Index: 141.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.5898
    Cell Significance Index: 442.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.7088
    Cell Significance Index: 1293.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5631
    Cell Significance Index: 70.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9352
    Cell Significance Index: 92.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8243
    Cell Significance Index: 22.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6378
    Cell Significance Index: 467.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3768
    Cell Significance Index: 135.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3367
    Cell Significance Index: 9.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2123
    Cell Significance Index: 42.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1360
    Cell Significance Index: 10.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0126
    Cell Significance Index: -2.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0158
    Cell Significance Index: -3.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0277
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0438
    Cell Significance Index: -27.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0683
    Cell Significance Index: -50.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0886
    Cell Significance Index: -166.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1126
    Cell Significance Index: -63.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1182
    Cell Significance Index: -217.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1268
    Cell Significance Index: -87.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1460
    Cell Significance Index: -224.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1553
    Cell Significance Index: -8.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1808
    Cell Significance Index: -245.8800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2280
    Cell Significance Index: -1.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3032
    Cell Significance Index: -192.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3496
    Cell Significance Index: -73.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4466
    Cell Significance Index: -28.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4636
    Cell Significance Index: -210.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.6094
    Cell Significance Index: -175.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6467
    Cell Significance Index: -105.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7437
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8365
    Cell Significance Index: -95.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0737
    Cell Significance Index: -34.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1401
    Cell Significance Index: -19.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.1446
    Cell Significance Index: -79.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2022
    Cell Significance Index: -67.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.2292
    Cell Significance Index: -140.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.3841
    Cell Significance Index: -201.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9738
    Cell Significance Index: -49.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.0007
    Cell Significance Index: -208.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.2968
    Cell Significance Index: -49.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.4393
    Cell Significance Index: -187.1900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.5088
    Cell Significance Index: -13.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.7645
    Cell Significance Index: -169.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.9222
    Cell Significance Index: -30.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.0888
    Cell Significance Index: -36.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.1246
    Cell Significance Index: -210.1000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -3.1902
    Cell Significance Index: -24.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.5064
    Cell Significance Index: -52.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.8538
    Cell Significance Index: -113.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.9742
    Cell Significance Index: -175.7900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -4.1037
    Cell Significance Index: -34.4700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -4.2962
    Cell Significance Index: -89.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -4.4879
    Cell Significance Index: -27.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.5508
    Cell Significance Index: -62.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.6400
    Cell Significance Index: -170.3300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -4.7197
    Cell Significance Index: -60.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL22 is a small, highly conserved protein (60S ribosomal protein L22) that is essential for the proper functioning of the 60S ribosomal subunit. The protein is composed of 162 amino acids and is characterized by its high affinity for GTP and its ability to bind to other ribosomal proteins. RPL22 is predominantly expressed in the cytosol and is involved in various cellular processes, including: 1. Translation initiation: RPL22 plays a crucial role in the recruitment of initiation factors to the ribosome, facilitating the assembly of the initiation complex. 2. Translation elongation: RPL22 is involved in the elongation phase of translation, where it helps to maintain the ribosome's structure and facilitate the movement of the ribosome along the mRNA. 3. Translation termination: RPL22 is also involved in the termination phase of translation, where it helps to recruit termination factors and facilitate the release of the completed protein. 4. Regulation of protein expression: RPL22 is involved in the regulation of protein expression, including the regulation of translation initiation and elongation. **Pathways and Functions** RPL22 is involved in various cellular pathways, including: 1. Alpha-beta T cell differentiation: RPL22 is essential for the proper differentiation of T cells, including the development of alpha-beta T cells. 2. Axon guidance: RPL22 is involved in the regulation of axon guidance, a critical process in the development of the nervous system. 3. Cap-dependent translation initiation: RPL22 is involved in the initiation of translation from mRNAs with a 5' cap. 4. Cellular responses to stimuli: RPL22 is involved in the regulation of cellular responses to various stimuli, including stress and nutrient starvation. 5. Cellular response to starvation: RPL22 is involved in the regulation of cellular responses to starvation, including the regulation of protein synthesis and degradation. **Clinical Significance** RPL22 has been implicated in various diseases, including: 1. Cancer: RPL22 is overexpressed in various types of cancer, including breast cancer and leukemia. 2. Neurodegenerative diseases: RPL22 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. Influenza infection: RPL22 is involved in the regulation of protein synthesis during influenza infection, making it a potential target for therapeutic interventions. 4. Immunodeficiency disorders: RPL22 is involved in the regulation of immune responses, making it a potential target for therapeutic interventions in immunodeficiency disorders. In conclusion, RPL22 is a crucial component of the 60S ribosomal subunit, playing a vital role in the translation process. Its involvement in various cellular pathways, including translation initiation, elongation, and termination, as well as its regulation of protein expression and response to stress, make it an essential gene for cellular homeostasis. The clinical significance of RPL22 has been highlighted by its involvement in various diseases, including cancer, neurodegenerative disorders, influenza infection, and immunodeficiency disorders.

Genular Protein ID: 2756456481

Symbol: RL22_HUMAN

Name: 60S ribosomal protein L22

UniProtKB Accession Codes:

P35268 B2R495 Q6IBD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 68 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 82 PDBsum 82 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1846807

Title: EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs).

PubMed ID: 1846807

DOI: 10.1002/j.1460-2075.1991.tb07968.x

PubMed ID: 8135813

Title: A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22.

PubMed ID: 8135813

DOI: 10.1006/bbrc.1994.1286

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 128
  • Mass: 14787
  • Checksum: 0F3ED8BE70C9F962
  • Sequence:
    • MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV 
VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL RVVANSKESY ELRYFQINQD 
EEEEEDED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.