Details for: MRPL23

Gene ID: 6150

Symbol: MRPL23

Ensembl ID: ENSG00000214026

Description: mitochondrial ribosomal protein L23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.4239
    Cell Significance Index: -22.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.8212
    Cell Significance Index: -28.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.0851
    Cell Significance Index: -37.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.6786
    Cell Significance Index: -32.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.2330
    Cell Significance Index: -37.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.4363
    Cell Significance Index: -37.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.8052
    Cell Significance Index: -33.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.2508
    Cell Significance Index: -36.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7984
    Cell Significance Index: -38.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9832
    Cell Significance Index: -24.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2489
    Cell Significance Index: -16.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.9461
    Cell Significance Index: 272.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.9341
    Cell Significance Index: 458.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.8519
    Cell Significance Index: 626.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1186
    Cell Significance Index: 91.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2384
    Cell Significance Index: 30.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2007
    Cell Significance Index: 99.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9774
    Cell Significance Index: 29.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8663
    Cell Significance Index: 50.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5192
    Cell Significance Index: 70.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3978
    Cell Significance Index: 72.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3746
    Cell Significance Index: 10.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2643
    Cell Significance Index: 27.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2026
    Cell Significance Index: 34.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1102
    Cell Significance Index: 82.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0896
    Cell Significance Index: 595.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0760
    Cell Significance Index: 139.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0643
    Cell Significance Index: 75.2700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0215
    Cell Significance Index: 8.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9972
    Cell Significance Index: 136.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9809
    Cell Significance Index: 97.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8785
    Cell Significance Index: 56.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8539
    Cell Significance Index: 377.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7487
    Cell Significance Index: 127.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7027
    Cell Significance Index: 634.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6253
    Cell Significance Index: 16.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6227
    Cell Significance Index: 179.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6065
    Cell Significance Index: 109.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5916
    Cell Significance Index: 27.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5604
    Cell Significance Index: 29.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4709
    Cell Significance Index: 57.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4600
    Cell Significance Index: 58.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4476
    Cell Significance Index: 9.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3486
    Cell Significance Index: 3.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3069
    Cell Significance Index: 7.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3065
    Cell Significance Index: 58.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2829
    Cell Significance Index: 17.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1927
    Cell Significance Index: 38.2500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1732
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1594
    Cell Significance Index: 5.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1489
    Cell Significance Index: 7.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1259
    Cell Significance Index: 95.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1187
    Cell Significance Index: 3.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0999
    Cell Significance Index: 1.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0556
    Cell Significance Index: 6.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0546
    Cell Significance Index: 10.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0378
    Cell Significance Index: 1.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0172
    Cell Significance Index: 0.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0110
    Cell Significance Index: 1.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0086
    Cell Significance Index: 6.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0191
    Cell Significance Index: -0.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0197
    Cell Significance Index: -36.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0223
    Cell Significance Index: -34.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0265
    Cell Significance Index: -36.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0282
    Cell Significance Index: -0.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0370
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0390
    Cell Significance Index: -28.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0430
    Cell Significance Index: -27.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0505
    Cell Significance Index: -18.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0529
    Cell Significance Index: -29.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0678
    Cell Significance Index: -30.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0751
    Cell Significance Index: -46.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1076
    Cell Significance Index: -4.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1236
    Cell Significance Index: -1.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1300
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1527
    Cell Significance Index: -17.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1593
    Cell Significance Index: -4.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1958
    Cell Significance Index: -41.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2285
    Cell Significance Index: -33.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2936
    Cell Significance Index: -23.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3602
    Cell Significance Index: -37.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3651
    Cell Significance Index: -6.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3706
    Cell Significance Index: -4.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4081
    Cell Significance Index: -25.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4324
    Cell Significance Index: -5.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4666
    Cell Significance Index: -16.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5217
    Cell Significance Index: -40.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5452
    Cell Significance Index: -30.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5785
    Cell Significance Index: -14.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5984
    Cell Significance Index: -11.0600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6185
    Cell Significance Index: -10.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6834
    Cell Significance Index: -20.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6898
    Cell Significance Index: -30.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7776
    Cell Significance Index: -22.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7777
    Cell Significance Index: -28.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7810
    Cell Significance Index: -27.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8235
    Cell Significance Index: -31.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9385
    Cell Significance Index: -29.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9641
    Cell Significance Index: -31.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL23 is a mitochondrial ribosomal protein, specifically part of the large subunit of the mitochondrial ribosome. It is highly conserved across species and has a distinct molecular weight of approximately 39 kDa. The protein is expressed in a wide range of cell types, including respiratory basal cells, pancreatic acinar cells, and epithelial cells, highlighting its fundamental role in cellular homeostasis. MRPL23 is also notable for its ability to bind to RNA, suggesting its involvement in the translation process. **Pathways and Functions:** MRPL23 is integral to several critical pathways that regulate mitochondrial function, including: 1. **Mitochondrial translation:** MRPL23 is essential for the translation of mitochondrial mRNAs, which are necessary for the synthesis of mitochondrial proteins involved in energy production. 2. **Mitochondrial elongation:** MRPL23 plays a crucial role in the elongation phase of mitochondrial translation, where it helps to facilitate the assembly of the ribosome and the translation of mRNAs. 3. **Mitochondrial initiation and termination:** MRPL23 is also involved in the initiation and termination phases of mitochondrial translation, ensuring the accurate translation of mRNAs. **Clinical Significance:** Dysregulation of MRPL23 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Mutations in MRPL23 have been associated with neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, highlighting its role in maintaining mitochondrial function and energy homeostasis. 2. **Metabolic disorders:** MRPL23 has been linked to metabolic disorders, such as type 2 diabetes and metabolic syndrome, where mitochondrial dysfunction is a key contributing factor. 3. **Cancer:** Alterations in MRPL23 expression have been observed in various types of cancer, suggesting its role in tumorigenesis and cancer progression. In conclusion, MRPL23 is a critical protein that plays a vital role in maintaining mitochondrial function and energy homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic targets. As an immunologist, it is essential to recognize the significance of MRPL23 in immune cell function and its potential role in autoimmune diseases and immune-related disorders.

Genular Protein ID: 3676728752

Symbol: RM23_HUMAN

Name: 39S ribosomal protein L23, mitochondrial

UniProtKB Accession Codes:

Q16540 A8MT29 Q96Q71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 57 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8541832

Title: A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues.

PubMed ID: 8541832

DOI: 10.1093/hmg/4.9.1499

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 153
  • Mass: 17781
  • Checksum: 7277C03CA224ED50
  • Sequence:
    • MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR VDLRNYLEGI 
YNVPVAAVRT RVQHGSNKRR DHRNVRIKKP DYKVAYVQLA HGQTFTFPDL FPEKDESPEG 
SAADDLYSML EEERQQRQSS DPRRGGVPSW FGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.