Details for: RPL27

Gene ID: 6155

Symbol: RPL27

Ensembl ID: ENSG00000131469

Description: ribosomal protein L27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 567.7178
    Cell Significance Index: -233.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 509.9726
    Cell Significance Index: -207.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 472.5043
    Cell Significance Index: -223.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 447.4079
    Cell Significance Index: -230.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 334.1917
    Cell Significance Index: -224.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 221.6722
    Cell Significance Index: -211.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.0792
    Cell Significance Index: -99.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 14.5492
    Cell Significance Index: 371.6900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 14.1067
    Cell Significance Index: 214.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 12.5736
    Cell Significance Index: 1284.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 11.1487
    Cell Significance Index: 298.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 9.2018
    Cell Significance Index: 432.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.2272
    Cell Significance Index: 145.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.7596
    Cell Significance Index: 162.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.4011
    Cell Significance Index: 194.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.3872
    Cell Significance Index: 954.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.2702
    Cell Significance Index: 514.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.1953
    Cell Significance Index: 988.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.8636
    Cell Significance Index: 196.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.8120
    Cell Significance Index: 837.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.7392
    Cell Significance Index: 76.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.6473
    Cell Significance Index: 230.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.5179
    Cell Significance Index: 1174.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.2168
    Cell Significance Index: 463.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.1787
    Cell Significance Index: 2731.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.9694
    Cell Significance Index: 278.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.8696
    Cell Significance Index: 63.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.6341
    Cell Significance Index: 363.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.5558
    Cell Significance Index: 3034.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.1454
    Cell Significance Index: 606.8000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.2965
    Cell Significance Index: 36.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.2556
    Cell Significance Index: 54.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.1324
    Cell Significance Index: 215.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.0920
    Cell Significance Index: 94.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9645
    Cell Significance Index: 107.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.9283
    Cell Significance Index: 115.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.7118
    Cell Significance Index: 475.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.5774
    Cell Significance Index: 66.1200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.5675
    Cell Significance Index: 21.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.1757
    Cell Significance Index: 542.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9385
    Cell Significance Index: 27.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7504
    Cell Significance Index: 21.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.3226
    Cell Significance Index: 1757.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6883
    Cell Significance Index: 167.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2943
    Cell Significance Index: 34.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2438
    Cell Significance Index: 246.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0718
    Cell Significance Index: 48.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9175
    Cell Significance Index: 47.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8015
    Cell Significance Index: 42.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7671
    Cell Significance Index: 145.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7611
    Cell Significance Index: 687.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6339
    Cell Significance Index: 18.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1985
    Cell Significance Index: 145.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0271
    Cell Significance Index: -20.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0896
    Cell Significance Index: -168.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1379
    Cell Significance Index: -254.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1577
    Cell Significance Index: -98.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1670
    Cell Significance Index: -257.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1678
    Cell Significance Index: -33.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1933
    Cell Significance Index: -109.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2076
    Cell Significance Index: -282.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2745
    Cell Significance Index: -98.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3035
    Cell Significance Index: -192.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4451
    Cell Significance Index: -202.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4723
    Cell Significance Index: -99.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.6909
    Cell Significance Index: -198.7900
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.7438
    Cell Significance Index: -4.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.7567
    Cell Significance Index: -123.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8313
    Cell Significance Index: -14.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9079
    Cell Significance Index: -104.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0615
    Cell Significance Index: -121.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1494
    Cell Significance Index: -72.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.2921
    Cell Significance Index: -21.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4390
    Cell Significance Index: -46.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.4672
    Cell Significance Index: -213.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.5021
    Cell Significance Index: -118.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5572
    Cell Significance Index: -95.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.6187
    Cell Significance Index: -9.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6250
    Cell Significance Index: -40.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.0788
    Cell Significance Index: -116.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.1910
    Cell Significance Index: -228.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.3782
    Cell Significance Index: -164.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.6684
    Cell Significance Index: -57.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.7810
    Cell Significance Index: -41.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.0456
    Cell Significance Index: -233.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.1148
    Cell Significance Index: -209.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.2328
    Cell Significance Index: -198.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.3276
    Cell Significance Index: -45.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -4.2114
    Cell Significance Index: -112.8500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.4289
    Cell Significance Index: -24.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.4520
    Cell Significance Index: -131.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.9889
    Cell Significance Index: -220.6700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -4.9922
    Cell Significance Index: -23.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.3338
    Cell Significance Index: -195.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -5.8727
    Cell Significance Index: -36.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.9501
    Cell Significance Index: -49.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -5.9835
    Cell Significance Index: -116.7800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.0242
    Cell Significance Index: -77.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.0469
    Cell Significance Index: -228.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -6.3389
    Cell Significance Index: -162.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL27 is a small, acidic protein with a molecular weight of approximately 17 kDa. It is encoded by the RPL27 gene (ENSG00000131469) and is highly expressed in various cell types, including epithelial cells, myoepithelial cells, and immune cells. RPL27 is a structural component of the 60S ribosomal subunit and plays a crucial role in the process of translation elongation. **Pathways and Functions:** RPL27 is involved in various cellular processes, including: 1. **Translation elongation:** RPL27 is essential for the process of translation elongation, where it interacts with other ribosomal proteins to facilitate the assembly of the 60S ribosomal subunit. 2. **Stress response:** RPL27 is induced in response to cellular stress, including amino acid deficiency, and plays a role in the regulation of protein synthesis. 3. **Immune function:** RPL27 is highly expressed in immune cells, including T cells and dendritic cells, and is involved in the regulation of immune responses. 4. **Cellular responses to stimuli:** RPL27 is activated in response to various stimuli, including cytokines and growth factors, and plays a role in the regulation of cellular responses. **Clinical Significance:** RPL27 has been implicated in various diseases, including: 1. **Cancer:** RPL27 is overexpressed in many types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Neurodegenerative disease:** RPL27 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Autoimmune disease:** RPL27 is involved in the regulation of immune responses and has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. **Conclusion:** RPL27 is a multifunctional protein that plays a critical role in various cellular processes, including translation elongation, stress response, and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of RPL27 and its role in human disease. As our understanding of RPL27 continues to evolve, it is likely that this protein will emerge as a key player in the regulation of cellular responses and the prevention of disease.

Genular Protein ID: 3321254130

Symbol: RL27_HUMAN

Name: 60S ribosomal protein L27

UniProtKB Accession Codes:

P61353 P08526 Q4G0A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 67 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 82 PDBsum 82 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8148381

Title: Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney.

PubMed ID: 8148381

DOI: 10.1016/0167-4781(94)90295-x

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25424902

Title: Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.

PubMed ID: 25424902

DOI: 10.1111/bjh.13229

PubMed ID: 26100019

Title: The DHX33 RNA Helicase Promotes mRNA Translation Initiation.

PubMed ID: 26100019

DOI: 10.1128/mcb.00315-15

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 136
  • Mass: 15798
  • Checksum: 73F4151495029A32
  • Sequence:
    • MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP RKVTAAMGKK 
KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV FRDPALKRKA RREAKVKFEE 
RYKTGKNKWF FQKLRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.