Details for: RPL29

Gene ID: 6159

Symbol: RPL29

Ensembl ID: ENSG00000162244

Description: ribosomal protein L29

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 678.4843
    Cell Significance Index: -279.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 579.4045
    Cell Significance Index: -273.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 554.5455
    Cell Significance Index: -285.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 409.3159
    Cell Significance Index: -274.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.6475
    Cell Significance Index: -106.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.9254
    Cell Significance Index: 457.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.7222
    Cell Significance Index: 393.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 13.2160
    Cell Significance Index: 1350.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.1288
    Cell Significance Index: 617.0400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 12.7659
    Cell Significance Index: 75.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.7258
    Cell Significance Index: 162.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.5144
    Cell Significance Index: 302.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.0529
    Cell Significance Index: 255.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.0536
    Cell Significance Index: 288.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.8306
    Cell Significance Index: 1270.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.3112
    Cell Significance Index: 658.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.2416
    Cell Significance Index: 163.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.2360
    Cell Significance Index: 1268.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.0919
    Cell Significance Index: 315.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.7886
    Cell Significance Index: 183.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.7827
    Cell Significance Index: 95.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.7268
    Cell Significance Index: 1073.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.6951
    Cell Significance Index: 98.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.5981
    Cell Significance Index: 1549.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.5719
    Cell Significance Index: 399.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.0955
    Cell Significance Index: 4421.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.9256
    Cell Significance Index: 590.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.7700
    Cell Significance Index: 3435.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.4981
    Cell Significance Index: 884.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.2481
    Cell Significance Index: 467.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.2001
    Cell Significance Index: 211.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.1218
    Cell Significance Index: 193.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.5923
    Cell Significance Index: 40.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.5321
    Cell Significance Index: 709.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.6782
    Cell Significance Index: 43.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.5471
    Cell Significance Index: 776.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.0167
    Cell Significance Index: 74.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.5952
    Cell Significance Index: 713.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.2503
    Cell Significance Index: 2934.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.0531
    Cell Significance Index: 2310.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.7188
    Cell Significance Index: 268.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4542
    Cell Significance Index: 111.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.4167
    Cell Significance Index: 64.5300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3941
    Cell Significance Index: 19.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0094
    Cell Significance Index: 105.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6938
    Cell Significance Index: 87.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9630
    Cell Significance Index: 183.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.8348
    Cell Significance Index: 612.0900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4934
    Cell Significance Index: 4.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3671
    Cell Significance Index: 105.6300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1201
    Cell Significance Index: 2.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0424
    Cell Significance Index: -31.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0941
    Cell Significance Index: -177.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1690
    Cell Significance Index: -311.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2044
    Cell Significance Index: -314.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2411
    Cell Significance Index: -48.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2469
    Cell Significance Index: -335.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2580
    Cell Significance Index: -145.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3509
    Cell Significance Index: -125.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3783
    Cell Significance Index: -240.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3941
    Cell Significance Index: -246.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4311
    Cell Significance Index: -34.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5538
    Cell Significance Index: -251.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.9099
    Cell Significance Index: -147.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.9461
    Cell Significance Index: -199.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0723
    Cell Significance Index: -122.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1535
    Cell Significance Index: -36.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.3935
    Cell Significance Index: -85.6500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5361
    Cell Significance Index: -26.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6796
    Cell Significance Index: -105.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.7969
    Cell Significance Index: -261.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9554
    Cell Significance Index: -48.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.0365
    Cell Significance Index: -140.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.1116
    Cell Significance Index: -118.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.2068
    Cell Significance Index: -251.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2335
    Cell Significance Index: -37.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.2524
    Cell Significance Index: -33.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.6283
    Cell Significance Index: -273.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.6383
    Cell Significance Index: -15.9400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -2.9026
    Cell Significance Index: -30.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.4346
    Cell Significance Index: -46.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.4470
    Cell Significance Index: -264.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.4752
    Cell Significance Index: -122.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.4842
    Cell Significance Index: -209.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.5920
    Cell Significance Index: -77.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.6251
    Cell Significance Index: -243.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.8667
    Cell Significance Index: -237.0700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.2632
    Cell Significance Index: -37.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.3238
    Cell Significance Index: -156.8100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -5.3604
    Cell Significance Index: -14.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.4174
    Cell Significance Index: -29.5400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -6.0361
    Cell Significance Index: -27.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.4738
    Cell Significance Index: -286.3500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.5165
    Cell Significance Index: -83.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.5346
    Cell Significance Index: -239.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -6.6085
    Cell Significance Index: -55.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.6721
    Cell Significance Index: -114.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.6872
    Cell Significance Index: -79.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.7105
    Cell Significance Index: -179.8100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -7.0806
    Cell Significance Index: -44.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL29 is a small, conserved protein located in the large ribosomal subunit of eukaryotic cells. It is a member of the ribosomal protein L family, which is essential for the assembly and function of ribosomes. The protein is characterized by its ability to bind to RNA, specifically in the 60S ribosomal subunit, where it participates in the translation process. RPL29 is highly expressed in various cell types, including hematopoietic stem cells, myoepithelial cells of the mammary gland, and immune cells such as T cells and natural killer cells. **Pathways and Functions:** RPL29 is involved in multiple cellular processes, including translation, protein synthesis, and cell growth. Its primary function is to participate in the translation process, specifically in the elongation phase, where it works in concert with other ribosomal proteins to facilitate the assembly of the 60S ribosomal subunit. RPL29 is also implicated in the regulation of cellular responses to stimuli, including stress, starvation, and infection. Its expression is modulated by various signaling pathways, including the mTOR (mechanistic target of rapamycin) pathway, which plays a critical role in regulating cell growth and metabolism. One of the most intriguing aspects of RPL29 is its involvement in the regulation of protein synthesis. Research has shown that RPL29 can modulate the expression of specific genes, including those involved in immune responses and cell growth. For example, RPL29 has been shown to regulate the expression of the protein ceruloplasmin, which is involved in copper metabolism and immune function. **Clinical Significance:** RPL29 has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. Its dysregulation has been linked to several conditions, including leukemia, lymphoma, and multiple sclerosis. In cancer, RPL29 has been shown to be overexpressed in various types of tumors, including breast cancer and lung cancer. This overexpression is thought to contribute to the development and progression of cancer by promoting cell growth and survival. In autoimmune disorders, RPL29 has been implicated in the regulation of immune responses. Research has shown that RPL29 can modulate the expression of genes involved in immune function, including those involved in the production of cytokines and antibodies. In infectious diseases, RPL29 has been shown to play a role in the regulation of protein synthesis in response to viral infections. **Conclusion:** In conclusion, RPL29 is a crucial protein that plays a pivotal role in the translation process and cellular responses to stimuli. Its dysregulation has been linked to various diseases, including cancer, autoimmune disorders, and infectious diseases. Further research is needed to fully elucidate the mechanisms by which RPL29 regulates protein synthesis and cellular responses. However, this gene has already shown promise as a potential therapeutic target for the treatment of various diseases. As an expert immunologist, I believe that RPL29 is an area of research that warrants further investigation. Its unique role in the translation process and cellular responses to stimuli makes it an attractive target for the development of novel therapies. By better understanding the functions and pathways of RPL29, we may uncover new avenues for the treatment of various diseases and improve our understanding of the complex relationships between protein synthesis, cellular responses, and disease.

Genular Protein ID: 2719830375

Symbol: RL29_HUMAN

Name: 60S ribosomal protein L29

UniProtKB Accession Codes:

P47914 A8K0H3 B2R4M8 Q6IPY3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 EMBL 9 EMDB 62 Ensembl 6 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 76 PDBsum 76 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8597591

Title: A novel cDNA encoding a human homologue of ribosomal protein L29.

PubMed ID: 8597591

DOI: 10.1016/0167-4781(95)00224-3

PubMed ID: 8662616

Title: cDNA cloning and expression of HIP, a novel cell surface heparan sulfate/heparin-binding protein of human uterine epithelial cells and cell lines.

PubMed ID: 8662616

DOI: 10.1074/jbc.271.20.11817

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 159
  • Mass: 17752
  • Checksum: 2A0C31984EF4FF95
  • Sequence:
    • MAKSKNHTTH NQSRKWHRNG IKKPRSQRYE SLKGVDPKFL RNMRFAKKHN KKGLKKMQAN 
NAKAMSARAE AIKALVKPKE VKPKIPKGVS RKLDRLAYIA HPKLGKRARA RIAKGLRLCR 
PKAKAKAKAK DQTKAQAAAP ASVPAQAPKR TQAPTKASE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.