Details for: RPL35A

Gene ID: 6165

Symbol: RPL35A

Ensembl ID: ENSG00000182899

Description: ribosomal protein L35a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 712.4207
    Cell Significance Index: -293.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 595.7774
    Cell Significance Index: -281.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 570.2730
    Cell Significance Index: -293.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 43.5745
    Cell Significance Index: -116.7300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 18.6808
    Cell Significance Index: 109.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 16.0584
    Cell Significance Index: 410.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.6123
    Cell Significance Index: 1492.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 13.2513
    Cell Significance Index: 169.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 13.0526
    Cell Significance Index: 349.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.9694
    Cell Significance Index: 609.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 12.4815
    Cell Significance Index: 328.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.8895
    Cell Significance Index: 340.8200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.6497
    Cell Significance Index: 205.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.0150
    Cell Significance Index: 209.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.9779
    Cell Significance Index: 1289.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.5561
    Cell Significance Index: 332.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.1667
    Cell Significance Index: 1258.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.0128
    Cell Significance Index: 102.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.7749
    Cell Significance Index: 620.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.7036
    Cell Significance Index: 648.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.0117
    Cell Significance Index: 3542.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.9702
    Cell Significance Index: 980.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.9659
    Cell Significance Index: 184.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.7522
    Cell Significance Index: 1397.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.6409
    Cell Significance Index: 979.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.5108
    Cell Significance Index: 4101.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.3790
    Cell Significance Index: 80.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.3463
    Cell Significance Index: 135.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.2700
    Cell Significance Index: 857.3500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.7259
    Cell Significance Index: 41.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.3599
    Cell Significance Index: 296.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.0346
    Cell Significance Index: 389.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.6479
    Cell Significance Index: 153.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.9573
    Cell Significance Index: 145.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.7356
    Cell Significance Index: 37.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.6738
    Cell Significance Index: 245.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.6413
    Cell Significance Index: 792.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.3629
    Cell Significance Index: 2545.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2357
    Cell Significance Index: 443.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9731
    Cell Significance Index: 18.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6684
    Cell Significance Index: 44.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5768
    Cell Significance Index: 1423.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5063
    Cell Significance Index: 149.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0214
    Cell Significance Index: 194.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9286
    Cell Significance Index: 680.8700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4527
    Cell Significance Index: 3.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3248
    Cell Significance Index: 16.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0646
    Cell Significance Index: -121.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1167
    Cell Significance Index: -86.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1529
    Cell Significance Index: -281.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1821
    Cell Significance Index: -280.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2370
    Cell Significance Index: -133.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2415
    Cell Significance Index: -328.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2552
    Cell Significance Index: -91.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2654
    Cell Significance Index: -165.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3187
    Cell Significance Index: -14.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3386
    Cell Significance Index: -26.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3533
    Cell Significance Index: -224.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5425
    Cell Significance Index: -246.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5779
    Cell Significance Index: -121.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8071
    Cell Significance Index: -232.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.2184
    Cell Significance Index: -139.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.2346
    Cell Significance Index: -141.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2373
    Cell Significance Index: -69.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.2493
    Cell Significance Index: -76.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3507
    Cell Significance Index: -43.2600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5407
    Cell Significance Index: -26.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5936
    Cell Significance Index: -26.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.6719
    Cell Significance Index: -271.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.7904
    Cell Significance Index: -260.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.8260
    Cell Significance Index: -115.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.8689
    Cell Significance Index: -129.2500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.6494
    Cell Significance Index: -55.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.6921
    Cell Significance Index: -280.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.7525
    Cell Significance Index: -16.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.7539
    Cell Significance Index: -165.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.4664
    Cell Significance Index: -86.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.5798
    Cell Significance Index: -274.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.8666
    Cell Significance Index: -259.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.8701
    Cell Significance Index: -57.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.9649
    Cell Significance Index: -139.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.1181
    Cell Significance Index: -252.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.1670
    Cell Significance Index: -71.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.3947
    Cell Significance Index: -59.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -4.4908
    Cell Significance Index: -129.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.6458
    Cell Significance Index: -100.6500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.9956
    Cell Significance Index: -27.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.7333
    Cell Significance Index: -168.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.9389
    Cell Significance Index: -262.6900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -6.2949
    Cell Significance Index: -29.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.4443
    Cell Significance Index: -76.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.7901
    Cell Significance Index: -249.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.8967
    Cell Significance Index: -184.8000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -7.0240
    Cell Significance Index: -90.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -7.1771
    Cell Significance Index: -271.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -7.6753
    Cell Significance Index: -149.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -7.9902
    Cell Significance Index: -261.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -7.9970
    Cell Significance Index: -120.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -8.1230
    Cell Significance Index: -284.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL35A is a conserved gene that encodes a 60S ribosomal protein, which is a crucial component of the eukaryotic ribosome. The protein is highly expressed in various cell types, including epithelial cells, myoepithelial cells, and immune cells. RPL35A has been implicated in several cellular processes, including translation, protein synthesis, and cellular stress response. The protein's structure consists of a conserved domain, which is essential for its function in ribosome biogenesis and translation. **Pathways and Functions:** RPL35A is involved in multiple cellular pathways, including: 1. **Translation**: RPL35A plays a crucial role in translation initiation, elongation, and termination. The protein is essential for the assembly and function of the 60S ribosomal subunit, which is responsible for protein synthesis. 2. **Stress Response**: RPL35A is involved in the cellular response to stress, including starvation, hypoxia, and oxidative stress. The protein helps to regulate the expression of genes involved in stress response and survival. 3. **Axon Guidance**: RPL35A has been implicated in axon guidance, a critical process in neuronal development. The protein is involved in the regulation of axon outgrowth and guidance. 4. **Cap-Dependent Translation Initiation**: RPL35A is essential for cap-dependent translation initiation, a process that regulates the translation of mRNAs. **Clinical Significance:** RPL35A has been implicated in several human diseases, including: 1. **Influenza Infection**: RPL35A has been shown to play a critical role in the replication and transcription of influenza viral RNA. 2. **Neurodegenerative Diseases**: RPL35A has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: RPL35A has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 4. **Immune Response**: RPL35A has been implicated in the regulation of immune responses, including the activation of CD8+ T cells and the regulation of cytokine production. In conclusion, RPL35A is a multifaceted gene that plays a critical role in various cellular processes, including translation, stress response, and development. The gene's involvement in human diseases highlights the importance of RPL35A in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which RPL35A regulates cellular processes and to develop therapeutic strategies for the treatment of diseases associated with this gene.

Genular Protein ID: 2397693344

Symbol: RL35A_HUMAN

Name: 60S ribosomal protein L35a

UniProtKB Accession Codes:

P18077 Q08ES9 Q9BVN7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 EMBL 8 EMDB 80 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 95 PDBsum 95 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2388839

Title: cDNA encoding the human homologue of rat ribosomal protein L35a.

PubMed ID: 2388839

DOI: 10.1093/nar/18.15.4600

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8786106

Title: The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter.

PubMed ID: 8786106

DOI: 10.1006/geno.1996.0093

PubMed ID: 18535205

Title: Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia.

PubMed ID: 18535205

DOI: 10.1182/blood-2008-02-140012

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 110
  • Mass: 12538
  • Checksum: F32E4A26A25E79E8
  • Sequence:
    • MSGRLWSKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV YKAKNNTVTP 
GGKPNKTRVI WGKVTRAHGN SGMVRAKFRS NLPAKAIGHR IRVMLYPSRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.