Details for: RPL37

Gene ID: 6167

Symbol: RPL37

Ensembl ID: ENSG00000145592

Description: ribosomal protein L37

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 745.5317
    Cell Significance Index: -307.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 618.8434
    Cell Significance Index: -292.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 597.6163
    Cell Significance Index: -307.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 436.8410
    Cell Significance Index: -293.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 72.2509
    Cell Significance Index: -193.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 17.9499
    Cell Significance Index: 1833.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.3431
    Cell Significance Index: 383.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 13.8219
    Cell Significance Index: 353.1100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 12.7192
    Cell Significance Index: 135.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.3634
    Cell Significance Index: 581.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.3510
    Cell Significance Index: 158.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.5872
    Cell Significance Index: 332.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 10.4579
    Cell Significance Index: 193.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 10.0857
    Cell Significance Index: 713.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.9776
    Cell Significance Index: 113.3500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 9.7190
    Cell Significance Index: 83.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.6956
    Cell Significance Index: 1331.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.2306
    Cell Significance Index: 1664.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.1670
    Cell Significance Index: 1127.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.8186
    Cell Significance Index: 3898.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.7485
    Cell Significance Index: 202.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.5349
    Cell Significance Index: 1102.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.4399
    Cell Significance Index: 995.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.9100
    Cell Significance Index: 165.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.7342
    Cell Significance Index: 203.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.5355
    Cell Significance Index: 4115.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.3716
    Cell Significance Index: 343.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.9318
    Cell Significance Index: 516.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.6529
    Cell Significance Index: 117.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.5914
    Cell Significance Index: 844.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.5402
    Cell Significance Index: 421.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.1621
    Cell Significance Index: 66.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.1537
    Cell Significance Index: 167.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.5252
    Cell Significance Index: 162.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.7325
    Cell Significance Index: 43.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.4331
    Cell Significance Index: 756.9800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.3645
    Cell Significance Index: 26.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.0811
    Cell Significance Index: 117.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.5297
    Cell Significance Index: 2671.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.1359
    Cell Significance Index: 108.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.0190
    Cell Significance Index: 2725.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.0404
    Cell Significance Index: 587.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9009
    Cell Significance Index: 377.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8898
    Cell Significance Index: 50.4600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.2879
    Cell Significance Index: 3.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1918
    Cell Significance Index: 226.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0322
    Cell Significance Index: 53.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.8571
    Cell Significance Index: 628.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2075
    Cell Significance Index: 74.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1611
    Cell Significance Index: 11.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0600
    Cell Significance Index: 12.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0438
    Cell Significance Index: -82.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0508
    Cell Significance Index: -4.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1134
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1168
    Cell Significance Index: -86.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1330
    Cell Significance Index: -245.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1656
    Cell Significance Index: -254.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2321
    Cell Significance Index: -315.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2581
    Cell Significance Index: -145.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2652
    Cell Significance Index: -165.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3611
    Cell Significance Index: -229.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3790
    Cell Significance Index: -19.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4712
    Cell Significance Index: -28.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.5149
    Cell Significance Index: -50.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5496
    Cell Significance Index: -249.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6416
    Cell Significance Index: -135.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6672
    Cell Significance Index: -108.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0385
    Cell Significance Index: -118.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0686
    Cell Significance Index: -59.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.2004
    Cell Significance Index: -137.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3397
    Cell Significance Index: -42.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.5643
    Cell Significance Index: -12.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.7640
    Cell Significance Index: -30.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8027
    Cell Significance Index: -262.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.0943
    Cell Significance Index: -35.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.2174
    Cell Significance Index: -55.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.2402
    Cell Significance Index: -13.5400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -2.4000
    Cell Significance Index: -14.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.4294
    Cell Significance Index: -153.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -2.5738
    Cell Significance Index: -279.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7324
    Cell Significance Index: -284.5100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.0188
    Cell Significance Index: -62.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.4399
    Cell Significance Index: -263.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.7892
    Cell Significance Index: -254.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.9397
    Cell Significance Index: -241.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.0158
    Cell Significance Index: -54.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.0984
    Cell Significance Index: -61.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.1694
    Cell Significance Index: -90.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.6985
    Cell Significance Index: -282.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.0628
    Cell Significance Index: -223.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -5.5516
    Cell Significance Index: -195.0800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.8392
    Cell Significance Index: -31.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.0982
    Cell Significance Index: -104.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.1478
    Cell Significance Index: -181.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.3160
    Cell Significance Index: -239.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.5886
    Cell Significance Index: -78.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.9565
    Cell Significance Index: -135.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.0688
    Cell Significance Index: -259.4900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -7.1136
    Cell Significance Index: -44.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -7.2537
    Cell Significance Index: -60.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL37 is a highly conserved protein, with high sequence identity among different species. It is a component of the large ribosomal subunit, which is responsible for protein synthesis. RPL37 is involved in the elongation phase of translation, where it interacts with other ribosomal proteins to form the 60S subunit. The protein has a unique structure, with a helical domain and a C-terminal domain that interacts with other proteins. RPL37 is also involved in the regulation of translation initiation, where it interacts with initiation factors to recruit ribosomes to the mRNA. **Pathways and Functions** RPL37 is involved in various biological pathways, including: 1. **Axon guidance**: RPL37 plays a crucial role in the development of the nervous system, where it is involved in the guidance of axons during neuronal migration. 2. **Cap-dependent translation initiation**: RPL37 interacts with initiation factors to recruit ribosomes to the mRNA, initiating translation. 3. **Cellular responses to stimuli**: RPL37 is involved in the regulation of cellular responses to stress, starvation, and other stimuli, where it interacts with signaling pathways to modulate gene expression. 4. **Viral infection pathways**: RPL37 is involved in the translation of viral RNAs, where it interacts with viral proteins to facilitate viral replication. 5. **Protein synthesis**: RPL37 is a critical component of the large ribosomal subunit, where it interacts with other ribosomal proteins to form the 60S subunit, facilitating protein synthesis. **Clinical Significance** Dysregulation of RPL37 has been linked to various diseases, including: 1. **Cancer**: RPL37 has been found to be overexpressed in various types of cancer, where it is involved in the regulation of cell growth and proliferation. 2. **Neurodegenerative disorders**: RPL37 has been implicated in neurodegenerative disorders, such as Alzheimer's disease, where it is involved in the regulation of protein synthesis and clearance. 3. **Infectious diseases**: RPL37 has been found to be involved in the translation of viral RNAs, where it interacts with viral proteins to facilitate viral replication. 4. **Metabolic disorders**: RPL37 has been implicated in metabolic disorders, such as diabetes, where it is involved in the regulation of glucose metabolism. In conclusion, RPL37 is a critical component of the large ribosomal subunit, playing a vital role in protein synthesis, cell growth, and development. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the biology and clinical significance of this gene.

Genular Protein ID: 1456287129

Symbol: RL37_HUMAN

Name: 60S ribosomal protein L37

UniProtKB Accession Codes:

P61927 B2R4H2 P02403 Q6IBB4 Q99883

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 10 EMDB 77 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 92 PDBsum 92 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7545944

Title: Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain.

PubMed ID: 7545944

DOI: 10.1016/0167-4781(94)90197-x

PubMed ID: 7588717

Title: Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37.

PubMed ID: 7588717

DOI: 10.1111/j.1432-1033.1995.tb20874.x

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 97
  • Mass: 11078
  • Checksum: F565A11E983027C9
  • Sequence:
    • MTKGTSSFGK RRNKTHTLCR RCGSKAYHLQ KSTCGKCGYP AKRKRKYNWS AKAKRRNTTG 
TGRMRHLKIV YRRFRHGFRE GTTPKPKRAA VAASSSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.