RPL37 | ENSG00000145592 | NCBI 6167

Details for: RPL37

Gene ID: 6167

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPL37

Ensembl ID: ENSG00000145592

Description: ribosomal protein L37

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Mdm2/mdm4 family protein binding
(GO:0097371)
Metal ion binding
(GO:0046872)
Positive regulation of signal transduction by p53 class mediator
(GO:1901798)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)
Ubiquitin ligase inhibitor activity
(GO:1990948)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 155.24

rCSI 91.68%

PRS 0.72
hematopoietic stem cell CL0000037

CSI 148.6

rCSI 98.77%

PRS 0.61
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 143.41

rCSI 96.62%

PRS 0.62
double negative thymocyte CL0002489

CSI 141.21

rCSI 98.17%

PRS 0.6
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 139.92

rCSI 93.25%

PRS 1.46
plasmacytoid dendritic cell, human CL0001058

CSI 134.66

rCSI 94.02%

PRS 0.54
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 134.05

rCSI 94.14%

PRS 1.57
naive T cell CL0000898

CSI 130.65

rCSI 90.92%

PRS 0.75
class switched memory B cell CL0000972

CSI 130.32

rCSI 97.29%

PRS 0.87
T follicular helper cell CL0002038

CSI 129.81

rCSI 97.15%

PRS 0.84
immature B cell CL0000816

CSI 129.14

rCSI 95.95%

PRS 0.77
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 125.94

rCSI 94.44%

PRS 1.55
group 3 innate lymphoid cell CL0001071

CSI 125.83

rCSI 94.54%

PRS 0.53
common myeloid progenitor CL0000049

CSI 124.27

rCSI 100%

PRS 0.5
CD4-positive, alpha-beta memory T cell CL0000897

CSI 123.8

rCSI 88.87%

PRS 0.7
neural crest cell CL0011012

CSI 123.63

rCSI 97.72%

PRS 0.36
epithelial cell of lower respiratory tract CL0002632

CSI 120.18

rCSI 93.17%

PRS 0.47
epithelial cell of lung CL0000082

CSI 119.78

rCSI 99.3%

PRS 0.48
CD4-positive helper T cell CL0000492

CSI 118.91

rCSI 89.95%

PRS 0.72
plasmablast CL0000980

CSI 118.18

rCSI 92.97%

PRS 0.61
T-helper 17 cell CL0000899

CSI 117.7

rCSI 93.46%

PRS 0.91
mature T cell CL0002419

CSI 117.62

rCSI 91.48%

PRS 0.72
unswitched memory B cell CL0000970

CSI 115.9

rCSI 97.52%

PRS 0.87
pro-B cell CL0000826

CSI 115.5

rCSI 95.65%

PRS 0.51
mucosal invariant T cell CL0000940

CSI 114.84

rCSI 92.79%

PRS 1.35
keratinocyte CL0000312

CSI 114.69

rCSI 96.14%

PRS 0.62
CD4-positive, alpha-beta thymocyte CL0000810

CSI 114.09

rCSI 91.39%

PRS 0.96
mature B cell CL0000785

CSI 113.8

rCSI 98.93%

PRS 0.63
intestine goblet cell CL0019031

CSI 112.07

rCSI 99.48%

PRS 0.51
granulocyte monocyte progenitor cell CL0000557

CSI 111.07

rCSI 96.18%

PRS 0.57
early lymphoid progenitor CL0000936

CSI 110.45

rCSI 97.01%

PRS 0.57
bronchus fibroblast of lung CL2000093

CSI 110.12

rCSI 89.48%

PRS 0.54
precursor B cell CL0000817

CSI 108.69

rCSI 95.21%

PRS 0.69
CD14-low, CD16-positive monocyte CL0002396

CSI 107.95

rCSI 83.17%

PRS 0.46
megakaryocyte-erythroid progenitor cell CL0000050

CSI 106.9

rCSI 96.54%

PRS 0.45
naive B cell CL0000788

CSI 106.59

rCSI 91.42%

PRS 1.67
skin fibroblast CL0002620

CSI 104.59

rCSI 90.16%

PRS 0.86
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 103.61

rCSI 94.37%

PRS 0.8
effector CD8-positive, alpha-beta T cell CL0001050

CSI 103.39

rCSI 78.64%

PRS 0.68
fallopian tube secretory epithelial cell CL4030006

CSI 102.47

rCSI 98.64%

PRS 0.54
fibroblast of lung CL0002553

CSI 101.36

rCSI 94.33%

PRS 0.51
hematopoietic precursor cell CL0008001

CSI 98.27

rCSI 100%

PRS 0.65
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 97.51

rCSI 95.76%

PRS 0.82
double-positive, alpha-beta thymocyte CL0000809

CSI 97.45

rCSI 99.32%

PRS 0.75
small pre-B-II cell CL0000954

CSI 96.35

rCSI 92.65%

PRS 1.12
ciliated epithelial cell CL0000067

CSI 96.15

rCSI 84.55%

PRS 0.38
activated CD4-positive, alpha-beta T cell CL0000896

CSI 96.06

rCSI 88.81%

PRS 0.94
intestinal epithelial cell CL0002563

CSI 95.44

rCSI 99.75%

PRS 0.55
CD8-positive, alpha-beta memory T cell CL0000909

CSI 94.47

rCSI 98.66%

PRS 1.66
memory B cell CL0000787

CSI 92.31

rCSI 91.15%

PRS 2.28
activated CD8-positive, alpha-beta T cell CL0000906

CSI 88.19

rCSI 86.68%

PRS 1.54
respiratory basal cell CL0002633

CSI 87.91

rCSI 91.06%

PRS 0.6
alveolar type 1 fibroblast cell CL4028004

CSI 85.83

rCSI 94%

PRS 0.59
goblet cell CL0000160

CSI 85.25

rCSI 80.56%

PRS 0.54
fraction A pre-pro B cell CL0002045

CSI 84.9

rCSI 97.19%

PRS 1.07
gamma-delta T cell CL0000798

CSI 84.6

rCSI 99.37%

PRS 5.23
melanocyte CL0000148

CSI 84.05

rCSI 62.25%

PRS 0.48
activated type II NK T cell CL0000931

CSI 83.31

rCSI 93.77%

PRS 0.86
elicited macrophage CL0000861

CSI 80.61

rCSI 74.01%

PRS 0.56
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 80.27

rCSI 92.7%

PRS 0.48
pancreatic D cell CL0000173

CSI 80.08

rCSI 78.76%

PRS 0.57
extravillous trophoblast CL0008036

CSI 78.22

rCSI 96.77%

PRS 0.45
CD4-positive, alpha-beta T cell CL0000624

CSI 78.14

rCSI 100%

PRS 11.44
respiratory suprabasal cell CL4033048

CSI 77.03

rCSI 98.79%

PRS 0.59
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 76.78

rCSI 96.48%

PRS 2.83
pancreatic acinar cell CL0002064

CSI 76.66

rCSI 100%

PRS 0.56
transit amplifying cell of colon CL0009011

CSI 76.5

rCSI 89.84%

PRS 0.63
common dendritic progenitor CL0001029

CSI 75.56

rCSI 94.83%

PRS 0.65
M cell of gut CL0000682

CSI 75.52

rCSI 80.24%

PRS 0.94
mature NK T cell CL0000814

CSI 73.3

rCSI 93.76%

PRS 2.39
neuroblast (sensu Vertebrata) CL0000031

CSI 73.21

rCSI 93.95%

PRS 0.52
CD1c-positive myeloid dendritic cell CL0002399

CSI 73.14

rCSI 88.34%

PRS 0.59
pancreatic A cell CL0000171

CSI 72.24

rCSI 75.68%

PRS 0.55
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 71.3

rCSI 97.13%

PRS 1.29
conventional dendritic cell CL0000990

CSI 70.49

rCSI 58.84%

PRS 1.97
common lymphoid progenitor CL0000051

CSI 70.31

rCSI 93.96%

PRS 0.98
mesodermal cell CL0000222

CSI 69.61

rCSI 83.56%

PRS 0.51
B cell CL0000236

CSI 68.39

rCSI 91.51%

PRS 3.16
promyelocyte CL0000836

CSI 68.16

rCSI 98.31%

PRS 0.71
IgA plasma cell CL0000987

CSI 67.71

rCSI 69.32%

PRS 0.97
perivascular cell CL4033054

CSI 67.66

rCSI 92.49%

PRS 0.59
radial glial cell CL0000681

CSI 67.61

rCSI 93.93%

PRS 0.55
club cell CL0000158

CSI 66.96

rCSI 98.08%

PRS 0.61
enteroendocrine cell CL0000164

CSI 66.91

rCSI 91.43%

PRS 0.57
acinar cell CL0000622

CSI 66.48

rCSI 97.49%

PRS 0.68
granulocyte CL0000094

CSI 66.1

rCSI 100%

PRS 0.64
multi-ciliated epithelial cell CL0005012

CSI 65.84

rCSI 65.71%

PRS 0.43
mucous neck cell CL0000651

CSI 65.64

rCSI 94.61%

PRS 0.84
myeloid dendritic cell CL0000782

CSI 65.57

rCSI 95%

PRS 0.75
myeloid leukocyte CL0000766

CSI 64.25

rCSI 59.27%

PRS 0.52
placental villous trophoblast CL2000060

CSI 64.12

rCSI 99.08%

PRS 0.49
epithelial cell CL0000066

CSI 63.73

rCSI 97.93%

PRS 0.75
intermediate monocyte CL0002393

CSI 63.56

rCSI 95.9%

PRS 0.5
secretory cell CL0000151

CSI 63.49

rCSI 66.25%

PRS 0.53
endothelial cell of artery CL1000413

CSI 63.06

rCSI 92.4%

PRS 3.17
Langerhans cell CL0000453

CSI 62.98

rCSI 96.19%

PRS 0.9
transit amplifying cell CL0009010

CSI 62.94

rCSI 96.27%

PRS 0.84
interstitial cell of Cajal CL0002088

CSI 62.91

rCSI 80.08%

PRS 0.6
alternatively activated macrophage CL0000890

CSI 62.67

rCSI 78.79%

PRS 0.79
dendritic cell, human CL0001056

CSI 62.59

rCSI 96.13%

PRS 0.59

retinal bipolar neuron CL0000748

CSI -35.0

rCSI -65.5%

PRS 0.4%
sncg GABAergic cortical interneuron CL4023015

CSI -33.3

rCSI -53.5%

PRS 0.4%
inhibitory interneuron CL0000498

CSI -31.4

rCSI -72.4%

PRS 0.5%
cerebral cortex neuron CL0010012

CSI -30.7

rCSI -100.0%

PRS 0.8%
sst GABAergic cortical interneuron CL4023017

CSI -29.5

rCSI -38.0%

PRS 0.3%
mature astrocyte CL0002627

CSI -25.9

rCSI -100.0%

PRS 1.6%
adipocyte CL0000136

CSI -25.6

rCSI -32.8%

PRS 0.7%
pvalb GABAergic cortical interneuron CL4023018

CSI -23.9

rCSI -29.7%

PRS 0.3%
vascular leptomeningeal cell CL4023051

CSI -23.0

rCSI -40.2%

PRS 0.4%
VIP GABAergic cortical interneuron CL4023016

CSI -22.7

rCSI -27.1%

PRS 0.3%
astrocyte of the cerebral cortex CL0002605

CSI -22.0

rCSI -49.4%

PRS 0.4%
GABAergic neuron CL0000617

CSI -20.6

rCSI -69.0%

PRS 0.6%
kidney interstitial alternatively activated macrophage CL1000695

CSI -20.2

rCSI -52.6%

PRS 0.6%
rod bipolar cell CL0000751

CSI -20.2

rCSI -36.3%

PRS 0.5%
neural cell CL0002319

CSI -18.2

rCSI -68.8%

PRS 1.2%
lamp5 GABAergic cortical interneuron CL4023011

CSI -17.2

rCSI -28.9%

PRS 0.4%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -16.9

rCSI -41.1%

PRS 0.3%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -14.0

rCSI -100.0%

PRS 10.3%
L6b glutamatergic cortical neuron CL4023038

CSI -13.5

rCSI -42.3%

PRS 0.3%
endocrine cell CL0000163

CSI -13.4

rCSI -68.7%

PRS 2.0%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -13.3

rCSI -24.2%

PRS 0.7%
kidney interstitial fibroblast CL1000692

CSI -13.1

rCSI -69.7%

PRS 5.2%
OFFx cell CL4033036

CSI -13.0

rCSI -61.2%

PRS 1.8%
kidney collecting duct principal cell CL1001431

CSI -12.4

rCSI -62.4%

PRS 3.6%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI -12.4

rCSI -29.6%

PRS 0.6%
glutamatergic neuron CL0000679

CSI -11.2

rCSI -22.9%

PRS 0.6%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -10.5

rCSI -37.7%

PRS 0.3%
near-projecting glutamatergic cortical neuron CL4023012

CSI -10.4

rCSI -39.3%

PRS 0.4%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -9.4

rCSI -29.5%

PRS 0.4%
diffuse bipolar 6 cell CL4033032

CSI -9.3

rCSI -49.1%

PRS 2.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -8.5

rCSI -50.1%

PRS 0.4%
invaginating midget bipolar cell CL4033034

CSI -8.1

rCSI -47.7%

PRS 1.6%
central nervous system neuron CL2000029

CSI -7.9

rCSI -57.8%

PRS 0.3%
erythroid lineage cell CL0000764

CSI -7.8

rCSI -50.3%

PRS 1.5%
renal interstitial pericyte CL1001318

CSI -7.4

rCSI -20.5%

PRS 0.5%
starburst amacrine cell CL0004232

CSI -7.3

rCSI -61.6%

PRS 1.9%
diffuse bipolar 2 cell CL4033028

CSI -7.1

rCSI -54.8%

PRS 1.6%
cell of skeletal muscle CL0000188

CSI -6.5

rCSI -70.6%

PRS 2.9%
pulmonary capillary endothelial cell CL4028001

CSI -6.5

rCSI -12.4%

PRS 0.8%
flat midget bipolar cell CL4033033

CSI -6.2

rCSI -44.4%

PRS 1.7%
exhausted T cell CL0011025

CSI -5.4

rCSI -91.8%

PRS 3.1%
diffuse bipolar 3b cell CL4033030

CSI -5.4

rCSI -35.9%

PRS 1.5%
diffuse bipolar 3a cell CL4033029

CSI -5.3

rCSI -35.9%

PRS 1.4%
squamous epithelial cell CL0000076

CSI -4.9

rCSI -11.5%

PRS 0.7%
glycinergic amacrine cell CL4030028

CSI -4.7

rCSI -12.3%

PRS 0.9%
H2 horizontal cell CL0004218

CSI -4.5

rCSI -22.5%

PRS 1.1%
cerebellar granule cell CL0001031

CSI -3.3

rCSI -4.8%

PRS 0.6%
ON midget ganglion cell CL4033046

CSI -3.1

rCSI -63.7%

PRS 0.7%
kidney granular cell CL0000648

CSI -3.0

rCSI -42.8%

PRS 7.7%
cardiac endothelial cell CL0010008

CSI -2.9

rCSI -11.7%

PRS 0.6%
OFF midget ganglion cell CL4033047

CSI -2.8

rCSI -56.7%

PRS 0.8%
kidney collecting duct intercalated cell CL1001432

CSI -2.7

rCSI -19.3%

PRS 2.4%
hepatic stellate cell CL0000632

CSI -2.6

rCSI -9.8%

PRS 0.5%
H1 horizontal cell CL0004217

CSI -2.6

rCSI -10.1%

PRS 1.6%
cardiac blood vessel endothelial cell CL0010006

CSI -2.4

rCSI -16.8%

PRS 2.1%
cord blood hematopoietic stem cell CL2000095

CSI -1.6

rCSI -30.7%

PRS 3.3%
endothelial cell of vascular tree CL0002139

CSI -1.6

rCSI -8.7%

PRS 1.5%
Purkinje cell CL0000121

CSI -1.1

rCSI -14.6%

PRS 5.3%
kidney resident macrophage CL1000698

CSI -0.6

rCSI -11.3%

PRS 13.7%
periportal region hepatocyte CL0019026

CSI -0.5

rCSI -2.1%

PRS 0.9%
platelet CL0000233

CSI -0.5

rCSI -2.0%

PRS 1.6%
GABAergic amacrine cell CL4030027

CSI 0.7

rCSI 2.3%

PRS 0.8%
immature innate lymphoid cell CL0001082

CSI 1.0

rCSI 31.6%

PRS 10.2%
amacrine cell CL0000561

CSI 1.2

rCSI 3.5%

PRS 0.5%
tracheobronchial goblet cell CL0019003

CSI 1.5

rCSI 24.5%

PRS 12.8%
neuron CL0000540

CSI 1.6

rCSI 4.2%

PRS 1.0%
endocardial cell CL0002350

CSI 1.8

rCSI 8.7%

PRS 0.9%
renal intercalated cell CL0005010

CSI 2.0

rCSI 17.6%

PRS 4.0%
Bergmann glial cell CL0000644

CSI 2.3

rCSI 3.1%

PRS 0.6%
serous secreting cell CL0000313

CSI 2.5

rCSI 12.5%

PRS 2.6%
direct pathway medium spiny neuron CL4023026

CSI 2.5

rCSI 59.7%

PRS 0.4%
neutrophil CL0000775

CSI 2.5

rCSI 14.1%

PRS 2.1%
choroid plexus epithelial cell CL0000706

CSI 2.6

rCSI 4.3%

PRS 0.4%
cerebral cortex endothelial cell CL1001602

CSI 2.7

rCSI 4.6%

PRS 0.4%
macula densa epithelial cell CL1000850

CSI 2.7

rCSI 38.4%

PRS 10.3%
indirect pathway medium spiny neuron CL4023029

CSI 2.8

rCSI 66.5%

PRS 0.4%
forebrain neuroblast CL1000042

CSI 2.8

rCSI 30.7%

PRS 8.5%
basal cell of epidermis CL0002187

CSI 2.9

rCSI 5.1%

PRS 0.8%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 3.0

rCSI 91.6%

PRS 7.7%
odontoblast CL0000060

CSI 3.0

rCSI 67.3%

PRS 3.1%
B-1 B cell CL0000819

CSI 3.0

rCSI 77.2%

PRS 3.2%
slow muscle cell CL0000189

CSI 3.0

rCSI 40.0%

PRS 8.1%
Merkel cell CL0000242

CSI 3.1

rCSI 70.9%

PRS 3.8%
retinal ganglion cell CL0000740

CSI 3.1

rCSI 7.0%

PRS 0.4%
hepatic pit cell CL2000054

CSI 3.2

rCSI 44.1%

PRS 7.2%
pluripotent stem cell CL0002248

CSI 3.3

rCSI 98.8%

PRS 1.3%
uterine smooth muscle cell CL0002601

CSI 3.5

rCSI 22.9%

PRS 4.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 3.6

rCSI 6.3%

PRS 0.3%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 3.6

rCSI 31.1%

PRS 1.5%
mesenchymal lymphangioblast CL0005021

CSI 3.7

rCSI 97.4%

PRS 2.9%
kidney loop of Henle epithelial cell CL1000909

CSI 3.8

rCSI 80.5%

PRS 4.1%
cone retinal bipolar cell CL0000752

CSI 3.8

rCSI 49.9%

PRS 3.8%
osteoblast CL0000062

CSI 3.8

rCSI 95.1%

PRS 4.9%
epithelial cell of urethra CL1000296

CSI 3.8

rCSI 96.6%

PRS 1.8%
kidney connecting tubule principal cell CL4030018

CSI 3.9

rCSI 28.5%

PRS 8.1%
eye photoreceptor cell CL0000287

CSI 4.0

rCSI 45.1%

PRS 2.2%
prostate gland microvascular endothelial cell CL2000059

CSI 4.1

rCSI 97.5%

PRS 2.0%
lung microvascular endothelial cell CL2000016

CSI 4.2

rCSI 80.3%

PRS 1.9%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 4.2

rCSI 44.2%

PRS 0.9%
fast muscle cell CL0000190

CSI 4.3

rCSI 16.9%

PRS 3.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPL37](/details-gene/6167) (Ribosomal Protein L37) is a protein-coding gene located on chromosome 5p13.1. It encodes a core component of the 60S large ribosomal subunit, making it a fundamental element of the cell's protein synthesis machinery. As a [structural constituent of the ribosome](/details-ontology/GO:0003735), it plays an essential role in the process of [translation](/details-ontology/GO:0006412). Expression data reveals that **Overall**, [RPL37](/details-gene/6167) shows particularly high significance in highly proliferative and metabolically active cell populations, most notably within the hematopoietic system, including [hematopoietic stem cells](/details-cell/CL0000037) and various lymphocyte subsets like [central memory CD4-positive, alpha-beta T cells](/details-cell/CL0000904). Functional annotations also suggest potential extra-ribosomal roles, including involvement in the p53 signaling pathway through its interaction with MDM2 family proteins ([GO:0097371](/details-ontology/GO:0097371)). ## Cellular Roles and Expression Landscape The expression profile of [RPL37](/details-gene/6167) highlights its critical role in cells requiring high rates of protein synthesis for proliferation, differentiation, and effector functions. **Overall**, the gene exhibits its highest significance in a broad range of immune cells. This includes both the lymphoid lineage, such as [central memory CD4-positive, alpha-beta T cells](/details-cell/CL0000904) (CSI: 155.24), [central memory CD8-positive, alpha-beta T cells](/details-cell/CL0000907), and [naive T cells](/details-cell/CL0000898), as well as progenitor cells like [hematopoietic stem cells](/details-cell/CL0000037) (CSI: 148.60). Its high significance extends to innate immune cells, including [CD16-positive, CD56-dim natural killer cells, human](/details-cell/CL0000939), and antigen-presenting cells like [plasmacytoid dendritic cells, human](/details-cell/CL0001058). This pattern is consistent with the high demand for protein production during immune cell development and activation. In stark contrast, [RPL37](/details-gene/6167) shows very low to negative significance in terminally differentiated, non-proliferative cell types. Its expression is least significant in various neuronal populations, including [retinal bipolar neurons](/details-cell/CL0000748) (CSI: -34.99) and multiple types of [GABAergic cortical interneurons](/details-cell/CL4023015), as well as structural cells like [adipocytes](/details-cell/CL0000136). This sharp distinction suggests that while [RPL37](/details-gene/6167) is a ubiquitous housekeeping gene, its expression levels are tightly regulated and correspond to the translational demands of specific cell lineages, being most prominent in the immune system and least prominent in the nervous system. ## Pathways and Molecular Function The primary function of [RPL37](/details-gene/6167) is its integral role in protein biosynthesis. As a component of the cytosolic large ribosomal subunit ([GO:0022625](/details-ontology/GO:0022625)), it is fundamentally involved in nearly all aspects of mRNA translation, as detailed in Reactome pathways such as [Eukaryotic translation initiation](/details-pathway/R-HSA-72613), [Peptide chain elongation](/details-pathway/R-HSA-156902), and [Eukaryotic translation termination](/details-pathway/R-HSA-72764). Its high expression in lymphocytes is directly consistent with its involvement in the [Metabolism of proteins](/details-pathway/R-HSA-392499), which is massively upregulated during an immune response. Beyond its canonical role in the ribosome, functional annotations suggest extra-ribosomal functions for [RPL37](/details-gene/6167). The gene is associated with [Mdm2/mdm4 family protein binding](/details-ontology/GO:0097371) and [positive regulation of signal transduction by p53 class mediator](/details-ontology/GO:1901798). This suggests that, like other ribosomal proteins, [RPL37](/details-gene/6167) may act as a cellular stress sensor. Under conditions of ribosomal stress, free [RPL37](/details-gene/6167) might bind to and inhibit the E3 ubiquitin ligase MDM2, leading to the stabilization of the p53 tumor suppressor. This places [RPL37](/details-gene/6167) at the critical intersection of protein synthesis, cell cycle control, and cellular stress responses ([R-HSA-2262752](https://reactome.org/content/detail/R-HSA-2262752)). ## Research Directions The widespread and essential nature of [RPL37](/details-gene/6167) in translation, combined with its specific regulatory functions, opens several avenues for future research. ### Testable Hypotheses 1. **Hypothesis 1: Role in Hematopoietic Lineage Commitment:** Given its high significance in [hematopoietic stem cells](/details-cell/CL0000037) and its differential expression across various immune lineages, the precise expression level of [RPL37](/details-gene/6167) may function as a rheostat controlling translational capacity, thereby influencing lineage commitment decisions during hematopoiesis. 2. **Hypothesis 2: Extra-ribosomal Function in Immune Cell Apoptosis:** The annotated interaction with the p53 pathway suggests that [RPL37](/details-gene/6167) has an extra-ribosomal role in regulating immune cell fate. Under conditions of cellular stress (e.g., viral infection or nutrient deprivation), free cytosolic [RPL37](/details-gene/6167) may bind and inhibit MDM2, stabilizing p53 and promoting apoptosis in activated lymphocytes to ensure proper immune homeostasis. ### Experimental Approach To test the second hypothesis, one could utilize an immune cell line, such as Jurkat T cells. Ribosomal stress could be induced using low-dose Actinomycin D. The interaction between endogenous [RPL37](/details-gene/6167) and MDM2 could then be assessed via co-immunoprecipitation followed by Western blotting. Concurrently, levels of p53 and its downstream targets (e.g., p21, PUMA) would be measured to confirm pathway activation. A definitive test would involve creating an [RPL37](/details-gene/6167) knockout in these cells using CRISPR-Cas9 and demonstrating that the p53-mediated apoptotic response to ribosomal stress is abrogated. ### Therapeutic Potential As a core component of the ribosome, [RPL37](/details-gene/6167) is an inherently challenging therapeutic target for inhibition due to the high likelihood of severe, on-target toxicity across all healthy tissues. However, its role as a potential regulator of the MDM2-p53 axis presents a more nuanced possibility. Instead of targeting the protein directly, strategies aimed at modulating its specific extra-ribosomal interactions could be explored, though this remains highly speculative. More immediately, the expression level of [RPL37](/details-gene/6167) could serve as a valuable prognostic biomarker in diseases characterized by dysregulated protein synthesis, such as certain cancers or autoimmune disorders, where it may reflect cellular proliferation rates and metabolic activity.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L37

Genular Protein ID: 1456287129

Symbol: RL37_HUMAN

Name: 60S ribosomal protein L37

UniProtKB Accession Codes:

P61927 B2R4H2 P02403 Q6IBB4 Q99883

Database IDs:

Citations:

PubMed ID: 7545944

Title: Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain.

PubMed ID: 7545944

DOI: 10.1016/0167-4781(94)90197-x

PubMed ID: 7588717

Title: Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37.

PubMed ID: 7588717

DOI: 10.1111/j.1432-1033.1995.tb20874.x

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 97
Mass: 11078
Checksum: F565A11E983027C9
Sequence:

MTKGTSSFGK RRNKTHTLCR RCGSKAYHLQ KSTCGKCGYP AKRKRKYNWS AKAKRRNTTG 
TGRMRHLKIV YRRFRHGFRE GTTPKPKRAA VAASSSS

Details for: RPL37

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain. PubMed ID: 7545944

Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37. PubMed ID: 7588717

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

A new system for naming ribosomal proteins. PubMed ID: 24524803

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547