Gene RPL37A - ENSG00000197756 | NCBI Gene ID: 6168

Details for: RPL37A

Gene ID: 6168

Symbol: RPL37A

Ensembl ID: ENSG00000197756

Description: ribosomal protein L37a

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Metal ion binding
(GO:0046872)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 6.9
Marker Score: 3889
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 6.7
Marker Score: 27914
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.14
Marker Score: 4807
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.12
Marker Score: 30055
Cell Name: endocardial cell (CL0002350)
Fold Change: 5.84
Marker Score: 3302
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 5.84
Marker Score: 4441
Cell Name: acinar cell (CL0000622)
Fold Change: 5.76
Marker Score: 4061
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 5.69
Marker Score: 4296
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 5.61
Marker Score: 99524
Cell Name: malignant cell (CL0001064)
Fold Change: 5.59
Marker Score: 75144
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 5.4
Marker Score: 2789.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.37
Marker Score: 6997
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.37
Marker Score: 3896
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.35
Marker Score: 2748
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.32
Marker Score: 1962
Cell Name: mature T cell (CL0002419)
Fold Change: 5.25
Marker Score: 52030
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.13
Marker Score: 8794
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.08
Marker Score: 14813
Cell Name: taste receptor cell (CL0000209)
Fold Change: 5.03
Marker Score: 4345
Cell Name: chromaffin cell (CL0000166)
Fold Change: 5.01
Marker Score: 7044.5
Cell Name: naive B cell (CL0000788)
Fold Change: 5
Marker Score: 4465
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.94
Marker Score: 168191
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.82
Marker Score: 10104
Cell Name: theca cell (CL0000503)
Fold Change: 4.82
Marker Score: 3452
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.76
Marker Score: 25029
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.68
Marker Score: 3988
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.66
Marker Score: 14698.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.65
Marker Score: 1112
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.64
Marker Score: 7147
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.61
Marker Score: 243874
Cell Name: naive T cell (CL0000898)
Fold Change: 4.59
Marker Score: 2957
Cell Name: endocrine cell (CL0000163)
Fold Change: 4.57
Marker Score: 2363
Cell Name: glial cell (CL0000125)
Fold Change: 4.48
Marker Score: 4927
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.45
Marker Score: 58671
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.44
Marker Score: 1442
Cell Name: memory T cell (CL0000813)
Fold Change: 4.43
Marker Score: 1903.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 4.37
Marker Score: 2986
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.37
Marker Score: 4852
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.36
Marker Score: 2651
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.3
Marker Score: 26108
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.29
Marker Score: 11846
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.28
Marker Score: 10465
Cell Name: blood cell (CL0000081)
Fold Change: 4.23
Marker Score: 49227
Cell Name: hepatoblast (CL0005026)
Fold Change: 4.23
Marker Score: 13851
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.22
Marker Score: 236146
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.19
Marker Score: 11743
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.17
Marker Score: 5042
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.16
Marker Score: 9480
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 4.15
Marker Score: 4330
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.15
Marker Score: 10544
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.12
Marker Score: 2414
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 4.11
Marker Score: 942
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.11
Marker Score: 3874.5
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 4.09
Marker Score: 10193
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 4.09
Marker Score: 5046
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.06
Marker Score: 26492
Cell Name: supporting cell (CL0000630)
Fold Change: 4.06
Marker Score: 7635
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.06
Marker Score: 3460
Cell Name: club cell (CL0000158)
Fold Change: 4.05
Marker Score: 4726
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.03
Marker Score: 10807
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.03
Marker Score: 2150
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.03
Marker Score: 3159
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.03
Marker Score: 4299
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4
Marker Score: 3862
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.99
Marker Score: 17109
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.98
Marker Score: 3921
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.97
Marker Score: 5768
Cell Name: fibroblast (CL0000057)
Fold Change: 3.95
Marker Score: 3813
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.95
Marker Score: 14015
Cell Name: reticular cell (CL0000432)
Fold Change: 3.92
Marker Score: 1430
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.89
Marker Score: 4691
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.89
Marker Score: 1751
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.86
Marker Score: 2000
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.86
Marker Score: 3403
Cell Name: stromal cell (CL0000499)
Fold Change: 3.85
Marker Score: 4516.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.85
Marker Score: 4142
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.85
Marker Score: 1093
Cell Name: granulocyte (CL0000094)
Fold Change: 3.85
Marker Score: 1725
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.84
Marker Score: 1095
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.84
Marker Score: 1016
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.83
Marker Score: 1262
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.81
Marker Score: 1003
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.8
Marker Score: 944
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.79
Marker Score: 3399
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.79
Marker Score: 1067
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.78
Marker Score: 3257
Cell Name: paneth cell (CL0000510)
Fold Change: 3.78
Marker Score: 2630
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.78
Marker Score: 2541
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.78
Marker Score: 24086
Cell Name: memory B cell (CL0000787)
Fold Change: 3.76
Marker Score: 2842
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.75
Marker Score: 3117
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.75
Marker Score: 2469
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 3.74
Marker Score: 1055
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 3.74
Marker Score: 1558
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.73
Marker Score: 3329.5
Cell Name: microglial cell (CL0000129)
Fold Change: 3.71
Marker Score: 6759
Cell Name: S cone cell (CL0003050)
Fold Change: 3.71
Marker Score: 1114
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.7
Marker Score: 1691
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.7
Marker Score: 2476
Cell Name: papillary tips cell (CL1000597)
Fold Change: 3.7
Marker Score: 746

Hover over a box to see details here...

**Key characteristics**: * RPL37A is a 60S ribosomal protein. * It is encoded by the ENSG00000197756 gene. * It is a transmembrane protein that is expressed in the cytoplasm. * It is involved in the initiation of protein translation. **Pathways and functions**: * RPL37A is involved in the initiation of protein translation by binding to the 5' cap of mRNA. * It then recruits the initiator complex to the start codon. * Once the ribosome has assembled on the mRNA, RPL37A releases the cap-dependent complex. **Clinical significance**: * Mutations in RPL37A have been linked to several human diseases, including pancreatitis, lung cancer, and breast cancer. * These mutations can lead to the loss of function of RPL37A, which can result in the initiation of translation before the correct start codon. * This can lead to the production of abnormal proteins that can be harmful to cells. **Additional notes**: * RPL37A is a relatively conserved protein. * It is a member of the Ribosomal Protein Large Subunit family. * It is a highly expressed protein in the human body.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L37a

Genular Protein ID: 2095948031

Symbol: RL37A_HUMAN

Name: 60S ribosomal protein L37a

UniProtKB Accession Codes:

P61513 P12751 Q6FGF5

Database IDs:

Citations:

PubMed ID: 1437567

Title: Primary sequence of the human ribosomal protein L37a.

PubMed ID: 1437567

DOI: 10.1093/nar/20.20.5475

PubMed ID: 8479924

Title: Human ribosomal protein S20 cDNA sequence.

PubMed ID: 8479924

DOI: 10.1093/nar/21.7.1672

PubMed ID: 8224875

Title: Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines.

PubMed ID: 8224875

DOI: 10.1016/0378-1119(93)90209-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 92
Mass: 10275
Checksum: 7122AF87B0E24CF6
Sequence:

MAKRTKKVGI VGKYGTRYGA SLRKMVKKIE ISQHAKYTCS FCGKTKMKRR AVGIWHCGSC 
MKTVAGGAWT YNTTSAVTVK SAIRRLKELK DQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPL37A

Associated with

Cells (max top 100)

Other Information

Primary sequence of the human ribosomal protein L37a. PubMed ID: 1437567

Human ribosomal protein S20 cDNA sequence. PubMed ID: 8479924

Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines. PubMed ID: 8224875

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547