Details for: RPL37A

Gene ID: 6168

Symbol: RPL37A

Ensembl ID: ENSG00000197756

Description: ribosomal protein L37a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 742.9100
    Cell Significance Index: -306.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 644.8748
    Cell Significance Index: -304.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 599.1229
    Cell Significance Index: -308.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 455.6631
    Cell Significance Index: -305.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 75.6105
    Cell Significance Index: -202.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.5985
    Cell Significance Index: 1695.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 14.4379
    Cell Significance Index: 368.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 12.7980
    Cell Significance Index: 342.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.0654
    Cell Significance Index: 520.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.5904
    Cell Significance Index: 278.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.8317
    Cell Significance Index: 1772.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.5960
    Cell Significance Index: 1179.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.5352
    Cell Significance Index: 1231.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.4536
    Cell Significance Index: 1298.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 9.2797
    Cell Significance Index: 79.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.1585
    Cell Significance Index: 647.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.5074
    Cell Significance Index: 196.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.3860
    Cell Significance Index: 3707.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.3582
    Cell Significance Index: 147.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.0599
    Cell Significance Index: 1033.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.9656
    Cell Significance Index: 371.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.7013
    Cell Significance Index: 87.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.6879
    Cell Significance Index: 160.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.6219
    Cell Significance Index: 4162.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.6074
    Cell Significance Index: 566.9700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.9278
    Cell Significance Index: 42.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.8326
    Cell Significance Index: 195.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.8016
    Cell Significance Index: 802.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 6.6641
    Cell Significance Index: 85.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.2790
    Cell Significance Index: 170.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.0462
    Cell Significance Index: 65.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.5903
    Cell Significance Index: 194.2600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.5370
    Cell Significance Index: 32.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.4009
    Cell Significance Index: 49.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.2849
    Cell Significance Index: 340.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.1701
    Cell Significance Index: 882.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.8602
    Cell Significance Index: 255.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.8200
    Cell Significance Index: 3648.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.2879
    Cell Significance Index: 1233.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.2300
    Cell Significance Index: 121.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.6180
    Cell Significance Index: 66.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1543
    Cell Significance Index: 625.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6615
    Cell Significance Index: 21.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.5908
    Cell Significance Index: 2339.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3504
    Cell Significance Index: 62.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1632
    Cell Significance Index: 63.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1451
    Cell Significance Index: 97.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.3336
    Cell Significance Index: 105.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2033
    Cell Significance Index: 62.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.1706
    Cell Significance Index: 858.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7512
    Cell Significance Index: 51.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4010
    Cell Significance Index: 24.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3869
    Cell Significance Index: 77.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3633
    Cell Significance Index: 130.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3522
    Cell Significance Index: 12.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2083
    Cell Significance Index: 11.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1690
    Cell Significance Index: 32.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0730
    Cell Significance Index: -134.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0847
    Cell Significance Index: -130.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1070
    Cell Significance Index: -79.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1280
    Cell Significance Index: -174.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2348
    Cell Significance Index: -132.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2569
    Cell Significance Index: -160.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2926
    Cell Significance Index: -185.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4741
    Cell Significance Index: -215.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5731
    Cell Significance Index: -120.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7047
    Cell Significance Index: -69.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.8628
    Cell Significance Index: -140.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8783
    Cell Significance Index: -28.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.9989
    Cell Significance Index: -108.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0669
    Cell Significance Index: -122.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.3241
    Cell Significance Index: -151.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3399
    Cell Significance Index: -84.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.6093
    Cell Significance Index: -233.9300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.6658
    Cell Significance Index: -12.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.8026
    Cell Significance Index: -27.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9949
    Cell Significance Index: -34.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.0482
    Cell Significance Index: -35.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.1463
    Cell Significance Index: -35.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7860
    Cell Significance Index: -290.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.0719
    Cell Significance Index: -18.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.1872
    Cell Significance Index: -244.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.3371
    Cell Significance Index: -45.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.5544
    Cell Significance Index: -239.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.1402
    Cell Significance Index: -253.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.1690
    Cell Significance Index: -90.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.9441
    Cell Significance Index: -218.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -5.1438
    Cell Significance Index: -128.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.4561
    Cell Significance Index: -65.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -5.8717
    Cell Significance Index: -157.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.1624
    Cell Significance Index: -181.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.2280
    Cell Significance Index: -235.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.7362
    Cell Significance Index: -247.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.7551
    Cell Significance Index: -131.8400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -6.8428
    Cell Significance Index: -31.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -7.1835
    Cell Significance Index: -60.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -7.2465
    Cell Significance Index: -173.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -7.3625
    Cell Significance Index: -241.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -7.4591
    Cell Significance Index: -191.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Role:** RPL37A is a structural component of the 60S ribosomal subunit, which is responsible for protein synthesis and translation. 2. **Regulation of Translation:** RPL37A regulates the translation process through interactions with other ribosomal proteins and factors, influencing the accuracy and efficiency of protein synthesis. 3. **Stress Response:** RPL37A is involved in the cellular response to stress, including amino acid deficiency and hypoxia, through the activation of the eIF2α kinases (e.g., GCN2). 4. **Cellular Homeostasis:** RPL37A maintains cellular homeostasis by regulating the expression of genes involved in cell growth, differentiation, and metabolism. 5. **Disease Association:** RPL37A has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions. **Pathways and Functions:** 1. **Cap-dependent Translation Initiation:** RPL37A is involved in the initiation of translation, where it interacts with other ribosomal proteins to form the 60S subunit. 2. **Eukaryotic Translation Elongation:** RPL37A regulates the elongation phase of translation, ensuring the accurate and efficient synthesis of proteins. 3. **Cellular Responses to Stimuli:** RPL37A is activated in response to cellular stress, including amino acid deficiency and hypoxia, through the activation of eIF2α kinases. 4. **Metabolism:** RPL37A regulates metabolic pathways, including amino acid metabolism, protein synthesis, and RNA processing. 5. **Selenocysteine Synthesis:** RPL37A is involved in the synthesis of selenocysteine, an essential amino acid for the functioning of selenoproteins. **Clinical Significance:** Dysregulation of RPL37A has been implicated in various diseases, including: 1. **Cancer:** RPL37A is overexpressed in certain types of cancer, including pancreatic cancer and glioblastoma. 2. **Metabolic Disorders:** RPL37A is associated with metabolic disorders, such as insulin resistance and type 2 diabetes. 3. **Neurological Conditions:** RPL37A has been linked to neurological conditions, including Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases:** RPL37A is involved in the regulation of viral infection pathways, including influenza and HIV. In conclusion, RPL37A is a multifunctional protein that plays a critical role in eukaryotic translation, cellular homeostasis, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which RPL37A regulates cellular processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2095948031

Symbol: RL37A_HUMAN

Name: 60S ribosomal protein L37a

UniProtKB Accession Codes:

P61513 P12751 Q6FGF5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 68 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 83 PDBsum 83 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1437567

Title: Primary sequence of the human ribosomal protein L37a.

PubMed ID: 1437567

DOI: 10.1093/nar/20.20.5475

PubMed ID: 8479924

Title: Human ribosomal protein S20 cDNA sequence.

PubMed ID: 8479924

DOI: 10.1093/nar/21.7.1672

PubMed ID: 8224875

Title: Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines.

PubMed ID: 8224875

DOI: 10.1016/0378-1119(93)90209-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 92
  • Mass: 10275
  • Checksum: 7122AF87B0E24CF6
  • Sequence:
    • MAKRTKKVGI VGKYGTRYGA SLRKMVKKIE ISQHAKYTCS FCGKTKMKRR AVGIWHCGSC 
MKTVAGGAWT YNTTSAVTVK SAIRRLKELK DQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.