Details for: RPL36A

Gene ID: 6173

Symbol: RPL36A

Ensembl ID: ENSG00000241343

Description: ribosomal protein L36a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 404.5660
    Cell Significance Index: -166.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 356.1151
    Cell Significance Index: -168.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 327.7893
    Cell Significance Index: -168.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 251.1542
    Cell Significance Index: -168.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.9058
    Cell Significance Index: -88.1500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 17.0536
    Cell Significance Index: 100.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 15.7867
    Cell Significance Index: 135.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 11.4765
    Cell Significance Index: 306.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.7854
    Cell Significance Index: 249.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.5614
    Cell Significance Index: 302.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.3825
    Cell Significance Index: 117.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.4698
    Cell Significance Index: 52.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.3292
    Cell Significance Index: 90.5500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 8.3051
    Cell Significance Index: 66.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.1958
    Cell Significance Index: 144.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 8.1288
    Cell Significance Index: 830.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.4427
    Cell Significance Index: 195.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.2856
    Cell Significance Index: 152.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.2796
    Cell Significance Index: 1312.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.2508
    Cell Significance Index: 891.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 6.6242
    Cell Significance Index: 61.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.3607
    Cell Significance Index: 821.7600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 6.2351
    Cell Significance Index: 44.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 6.0487
    Cell Significance Index: 427.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 6.0363
    Cell Significance Index: 283.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.9711
    Cell Significance Index: 765.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 5.8356
    Cell Significance Index: 149.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.7683
    Cell Significance Index: 429.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.0796
    Cell Significance Index: 2245.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.8411
    Cell Significance Index: 664.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.3436
    Cell Significance Index: 42.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.3036
    Cell Significance Index: 114.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.0749
    Cell Significance Index: 362.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1231
    Cell Significance Index: 1917.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0570
    Cell Significance Index: 1123.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.6487
    Cell Significance Index: 281.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5983
    Cell Significance Index: 13.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4192
    Cell Significance Index: 40.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3212
    Cell Significance Index: 85.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2781
    Cell Significance Index: 126.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.0727
    Cell Significance Index: 811.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0682
    Cell Significance Index: 29.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0607
    Cell Significance Index: 201.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.4657
    Cell Significance Index: 53.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4640
    Cell Significance Index: 21.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3311
    Cell Significance Index: 6.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2381
    Cell Significance Index: 7.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1729
    Cell Significance Index: 6.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1025
    Cell Significance Index: 5.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0801
    Cell Significance Index: 2.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0286
    Cell Significance Index: 5.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0597
    Cell Significance Index: -44.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0743
    Cell Significance Index: -139.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0992
    Cell Significance Index: -183.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1127
    Cell Significance Index: -70.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1200
    Cell Significance Index: -184.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1209
    Cell Significance Index: -88.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1264
    Cell Significance Index: -71.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1344
    Cell Significance Index: -21.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1393
    Cell Significance Index: -189.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2163
    Cell Significance Index: -77.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2524
    Cell Significance Index: -160.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2884
    Cell Significance Index: -14.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3439
    Cell Significance Index: -72.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3627
    Cell Significance Index: -164.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3630
    Cell Significance Index: -10.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4181
    Cell Significance Index: -17.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4649
    Cell Significance Index: -28.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6693
    Cell Significance Index: -16.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7154
    Cell Significance Index: -49.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.7588
    Cell Significance Index: -150.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7608
    Cell Significance Index: -35.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9739
    Cell Significance Index: -50.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0678
    Cell Significance Index: -17.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1253
    Cell Significance Index: -163.5800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.1284
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1414
    Cell Significance Index: -130.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.3330
    Cell Significance Index: -69.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3677
    Cell Significance Index: -86.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4382
    Cell Significance Index: -21.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5504
    Cell Significance Index: -161.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.7501
    Cell Significance Index: -138.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.7776
    Cell Significance Index: -10.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.8086
    Cell Significance Index: -138.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9265
    Cell Significance Index: -33.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1352
    Cell Significance Index: -130.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.2531
    Cell Significance Index: -30.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.5025
    Cell Significance Index: -168.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.0183
    Cell Significance Index: -65.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.2135
    Cell Significance Index: -142.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.4689
    Cell Significance Index: -127.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -3.4747
    Cell Significance Index: -35.9700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -3.6127
    Cell Significance Index: -21.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -3.7108
    Cell Significance Index: -55.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.7166
    Cell Significance Index: -109.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.9791
    Cell Significance Index: -150.6800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -4.0058
    Cell Significance Index: -24.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -4.5133
    Cell Significance Index: -158.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -4.5314
    Cell Significance Index: -94.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -4.6379
    Cell Significance Index: -151.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal Protein Function:** RPL36A is a 36-kDa protein that belongs to the ribosomal protein L36 family. It is involved in the assembly and function of the 60S ribosomal subunit, which is responsible for translating mRNA into proteins. 2. **Expression Patterns:** RPL36A is highly expressed in cells involved in immune responses, including professional antigen-presenting cells, monocytes, and T cells. It is also expressed in skeletal muscle satellite cells and fibroblasts of the mammary gland. 3. **Regulation:** RPL36A expression is regulated by various factors, including stress, starvation, and viral infections. It is also influenced by post-transcriptional modifications, such as nonsense-mediated decay (NMD). **Pathways and Functions:** 1. **Translation:** RPL36A plays a crucial role in the translation process, particularly in the elongation phase of protein synthesis. It interacts with other ribosomal proteins to facilitate the assembly and function of the 60S ribosomal subunit. 2. **Stress Response:** RPL36A is involved in the cellular response to stress, including starvation and viral infections. It is activated in response to amino acid deficiency and other stressors, leading to the regulation of protein synthesis. 3. **Immune Response:** RPL36A is highly expressed in cells involved in immune responses, including professional antigen-presenting cells and T cells. It plays a role in the regulation of protein synthesis in response to viral infections and other immune stimuli. 4. **Nonsense-Mediated Decay (NMD):** RPL36A is a target of NMD, a process that regulates the expression of genes with premature stop codons. NMD is enhanced by the exon junction complex (EJC) and is involved in the regulation of protein synthesis. **Clinical Significance:** 1. **Immune Disorders:** Alterations in RPL36A expression have been implicated in various immune disorders, including autoimmune diseases and cancer. 2. **Viral Infections:** RPL36A plays a role in the regulation of protein synthesis in response to viral infections, making it a potential target for antiviral therapies. 3. **Cancer:** RPL36A is involved in the regulation of protein synthesis in cancer cells, making it a potential target for cancer therapies. 4. **Neurological Disorders:** RPL36A has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, highlighting its potential role in the regulation of protein synthesis in the nervous system. In conclusion, RPL36A is a complex gene that plays a critical role in various cellular processes, including translation, stress response, and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of RPL36A regulation and its potential applications in the treatment of immune disorders and cancer.

Genular Protein ID: 3518761018

Symbol: RL36A_HUMAN

Name: 60S ribosomal protein L36a

UniProtKB Accession Codes:

P83881 P09896 P10661 Q08ES5 Q5J9I6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 39 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 62 PDBsum 62 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9110171

Title: Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains.

PubMed ID: 9110171

DOI: 10.1101/gr.7.4.315

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 106
  • Mass: 12441
  • Checksum: AE3308265D70BD26
  • Sequence:
    • MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGKRR YDRKQSGYGG QTKPIFRKKA 
KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK GQVIQF

Genular Protein ID: 1211693924

Symbol: J3KQN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KQN4

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 EMDB 19 Ensembl 3 GO 7 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 18 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 32820719

Title: An ER translocon for multi-pass membrane protein biogenesis.

PubMed ID: 32820719

DOI: 10.7554/elife.56889

PubMed ID: 32687489

Title: Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.

PubMed ID: 32687489

DOI: 10.1371/journal.pbio.3000780

PubMed ID: 36302773

Title: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

PubMed ID: 36302773

DOI: 10.1038/s41467-022-34097-9

PubMed ID: 36259929

Title: A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.

PubMed ID: 36259929

DOI: 10.1158/2159-8290.cd-22-0210

PubMed ID: 37020024

Title: mRNA decoding in human is kinetically and structurally distinct from bacteria.

PubMed ID: 37020024

DOI: 10.1038/s41586-023-05908-w

Sequence Information:

  • Length: 142
  • Mass: 16378
  • Checksum: 88394FFBA30632CB
  • Sequence:
    • MIAPTDSHEE VRSGTSYILP FASRFLSFRA DSAHASMVNV PKTRRTFCKK CGKHQPHKVT 
QYKKGKDSLY AQGKRRYDRK QSGYGGQTKP IFRKKAKTTK KIVLRLECVE PNCRSKRMLA 
IKRCKHFELG GDKKRKGQVI QF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.