Details for: RPLP1

Gene ID: 6176

Symbol: RPLP1

Ensembl ID: ENSG00000137818

Description: ribosomal protein lateral stalk subunit P1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 7.77
    Marker Score: 4381
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 7.22
    Marker Score: 30122
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 6.82
    Marker Score: 3857
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.37
    Marker Score: 31275
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 6.15
    Marker Score: 4639
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 6.06
    Marker Score: 4273
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 5.99
    Marker Score: 4558
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.99
    Marker Score: 106283
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.94
    Marker Score: 79764
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.89
    Marker Score: 4271
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.81
    Marker Score: 12177
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.69
    Marker Score: 2926
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.61
    Marker Score: 2898
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.57
    Marker Score: 18258
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.49
    Marker Score: 16017
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.49
    Marker Score: 7146
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.48
    Marker Score: 4667
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.45
    Marker Score: 2009
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.37
    Marker Score: 13639
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.31
    Marker Score: 52555
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.19
    Marker Score: 4156
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.17
    Marker Score: 3327.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.14
    Marker Score: 3682
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.12
    Marker Score: 174340
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 5.01
    Marker Score: 26317
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.99
    Marker Score: 1191
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.89
    Marker Score: 7525
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.87
    Marker Score: 2093
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.85
    Marker Score: 15320
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.85
    Marker Score: 12987.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.79
    Marker Score: 17025
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.79
    Marker Score: 253091
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.77
    Marker Score: 4118
  • Cell Name: glial cell (CL0000125)
    Fold Change: 4.75
    Marker Score: 5219
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 4.69
    Marker Score: 2425
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.63
    Marker Score: 4153
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.62
    Marker Score: 5131
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.61
    Marker Score: 3488
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.59
    Marker Score: 256702
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.54
    Marker Score: 1475
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.52
    Marker Score: 59578
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.51
    Marker Score: 7733
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.49
    Marker Score: 4006
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.48
    Marker Score: 5231
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.46
    Marker Score: 27073
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.45
    Marker Score: 1019
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.4
    Marker Score: 51188
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.4
    Marker Score: 2678
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 4.4
    Marker Score: 10960
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.4
    Marker Score: 3129
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.39
    Marker Score: 28014
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 4.36
    Marker Score: 1955
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.35
    Marker Score: 10979
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.35
    Marker Score: 5368
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.33
    Marker Score: 11957
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 4.32
    Marker Score: 4172
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.3
    Marker Score: 5193
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.28
    Marker Score: 10454.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.28
    Marker Score: 4036.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.27
    Marker Score: 5147
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.26
    Marker Score: 2497
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.25
    Marker Score: 11927
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.25
    Marker Score: 4106
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.22
    Marker Score: 31448
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 4.22
    Marker Score: 1824
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 4.22
    Marker Score: 982
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.21
    Marker Score: 27412
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 4.2
    Marker Score: 1184
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 4.19
    Marker Score: 1189
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.15
    Marker Score: 6030
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.15
    Marker Score: 9454
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.14
    Marker Score: 3251
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 4.13
    Marker Score: 4840
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.13
    Marker Score: 36206
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 4.1
    Marker Score: 1019
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.1
    Marker Score: 1085
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.09
    Marker Score: 7689
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.09
    Marker Score: 6022
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.09
    Marker Score: 4398
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17504
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.08
    Marker Score: 3477
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.06
    Marker Score: 1828
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 4.06
    Marker Score: 1303
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 4.06
    Marker Score: 2824
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.05
    Marker Score: 1156
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.05
    Marker Score: 5863
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 4.05
    Marker Score: 1680
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.04
    Marker Score: 4319
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 4.03
    Marker Score: 3550
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 4.02
    Marker Score: 875
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 4.02
    Marker Score: 1466
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4
    Marker Score: 993
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3933
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.99
    Marker Score: 3436
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 3.99
    Marker Score: 1035
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 3.99
    Marker Score: 980
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.99
    Marker Score: 1021
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 3.98
    Marker Score: 1198
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.98
    Marker Score: 1178
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.98
    Marker Score: 1048

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Other Information

**Key characteristics:** * RPLP1 is a large protein with a molecular weight of approximately 100 kDa. * It is a key component of the 60S ribosomal subunit. * RPLP1 is expressed in a variety of cell types, including epithelial cells, myoepithelial cells, and cancer cells. **Pathways and functions:** * RPLP1 is involved in the initiation of protein synthesis by binding to the initiator tRNA and facilitating the binding of the ribosome to the start codon of the mRNA. * It is also involved in the elongation of protein synthesis by interacting with the peptidyltransferase centre of the ribosome and facilitating the transfer of amino acids to the growing polypeptide chain. * RPLP1 is also involved in the regulation of protein translation by interacting with the mRNA and modulating its stability and translation efficiency. **Clinical significance:** * Mutations in RPLP1 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * RPLP1 is a potential target for cancer therapy. **Other important points:** * RPLP1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a well-characterized protein that has been extensively studied in model organisms.

Genular Protein ID: 334476783

Symbol: RLA1_HUMAN

Name: 60S acidic ribosomal protein P1

UniProtKB Accession Codes:

P05386 A6NIB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3323886

Title: Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

PubMed ID: 3323886

DOI: 10.1128/mcb.7.11.4065-4074.1987

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14997482

Title: Identification and characterization of phosphorylated proteins in the human pituitary.

PubMed ID: 14997482

DOI: 10.1002/pmic.200300584

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 22135285

Title: Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex.

PubMed ID: 22135285

DOI: 10.1093/nar/gkr1143

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 114
  • Mass: 11514
  • Checksum: 4C282AB8DCA079C8
  • Sequence:
    • MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA LANVNIGSLI 
CNVGAGGPAP AAGAAPAGGP APSTAAAPAE EKKVEAKKEE SEESDDDMGF GLFD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.