Details for: RPLP1

Gene ID: 6176

Symbol: RPLP1

Ensembl ID: ENSG00000137818

Description: ribosomal protein lateral stalk subunit P1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1003.5499
    Cell Significance Index: -413.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 899.9965
    Cell Significance Index: -365.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 813.3056
    Cell Significance Index: -383.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 784.5676
    Cell Significance Index: -403.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 574.6755
    Cell Significance Index: -385.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 389.7594
    Cell Significance Index: -372.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 46.3929
    Cell Significance Index: -124.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 25.7654
    Cell Significance Index: 391.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 21.5018
    Cell Significance Index: 549.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 19.6149
    Cell Significance Index: 2003.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 18.5728
    Cell Significance Index: 496.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 15.2056
    Cell Significance Index: 714.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 14.4563
    Cell Significance Index: 267.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.9924
    Cell Significance Index: 315.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.9406
    Cell Significance Index: 342.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 11.1678
    Cell Significance Index: 2013.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 11.1584
    Cell Significance Index: 1372.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 10.7489
    Cell Significance Index: 760.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 10.7413
    Cell Significance Index: 4748.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.6823
    Cell Significance Index: 136.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.5852
    Cell Significance Index: 1367.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 10.1232
    Cell Significance Index: 5528.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 10.0661
    Cell Significance Index: 750.2200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 9.9575
    Cell Significance Index: 26.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.8327
    Cell Significance Index: 1350.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 9.7417
    Cell Significance Index: 7373.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.6304
    Cell Significance Index: 1135.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.1510
    Cell Significance Index: 161.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.1299
    Cell Significance Index: 103.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.0484
    Cell Significance Index: 209.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.9394
    Cell Significance Index: 55.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.4639
    Cell Significance Index: 1085.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.4010
    Cell Significance Index: 291.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.6584
    Cell Significance Index: 224.9200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.1727
    Cell Significance Index: 42.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.0984
    Cell Significance Index: 148.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.7486
    Cell Significance Index: 435.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.6837
    Cell Significance Index: 181.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.7443
    Cell Significance Index: 301.6000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 5.5807
    Cell Significance Index: 47.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.5135
    Cell Significance Index: 50.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.4261
    Cell Significance Index: 252.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.8817
    Cell Significance Index: 833.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.5140
    Cell Significance Index: 120.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.4908
    Cell Significance Index: 233.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.1761
    Cell Significance Index: 45.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 2.6034
    Cell Significance Index: 206.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.5852
    Cell Significance Index: 1895.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5367
    Cell Significance Index: 503.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4661
    Cell Significance Index: 2226.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1443
    Cell Significance Index: 217.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0046
    Cell Significance Index: 99.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0134
    Cell Significance Index: 25.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0701
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1779
    Cell Significance Index: -131.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1980
    Cell Significance Index: -365.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2459
    Cell Significance Index: -378.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2612
    Cell Significance Index: -11.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.3263
    Cell Significance Index: -443.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3453
    Cell Significance Index: -123.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3701
    Cell Significance Index: -235.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3756
    Cell Significance Index: -211.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3799
    Cell Significance Index: -76.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3983
    Cell Significance Index: -248.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6547
    Cell Significance Index: -297.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6565
    Cell Significance Index: -106.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7700
    Cell Significance Index: -47.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.9258
    Cell Significance Index: -195.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -1.0503
    Cell Significance Index: -302.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3263
    Cell Significance Index: -91.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5445
    Cell Significance Index: -86.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.7473
    Cell Significance Index: -200.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9073
    Cell Significance Index: -32.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.0366
    Cell Significance Index: -232.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.2120
    Cell Significance Index: -321.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.6250
    Cell Significance Index: -165.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.1316
    Cell Significance Index: -100.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -3.2487
    Cell Significance Index: -54.3700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.5777
    Cell Significance Index: -74.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.5958
    Cell Significance Index: -374.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.8040
    Cell Significance Index: -291.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.9068
    Cell Significance Index: -97.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.9855
    Cell Significance Index: -24.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -4.3843
    Cell Significance Index: -126.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.5000
    Cell Significance Index: -270.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.5765
    Cell Significance Index: -62.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -5.3997
    Cell Significance Index: -363.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -5.4137
    Cell Significance Index: -331.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -5.7684
    Cell Significance Index: -202.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -6.2774
    Cell Significance Index: -50.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -7.4956
    Cell Significance Index: -112.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -7.5105
    Cell Significance Index: -89.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -8.1105
    Cell Significance Index: -238.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -8.3163
    Cell Significance Index: -180.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -8.4147
    Cell Significance Index: -164.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -8.4271
    Cell Significance Index: -372.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -8.6961
    Cell Significance Index: -233.0200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -8.7285
    Cell Significance Index: -47.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -9.1987
    Cell Significance Index: -157.6400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -9.7298
    Cell Significance Index: -125.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein function**: RPLP1 is a structural component of the large ribosomal subunit, which is responsible for protein synthesis. 2. **Translation regulation**: RPLP1 is involved in the regulation of translation initiation, elongation, and termination, ensuring accurate protein synthesis. 3. **Cellular localization**: RPLP1 is found in the cytosol, where it interacts with other ribosomal proteins and factors to regulate translation. 4. **Stress response**: RPLP1 is upregulated in response to cellular stress, such as amino acid deficiency, and plays a role in the activation of stress response pathways. 5. **Cellular differentiation**: RPLP1 is involved in the regulation of cellular differentiation, particularly in the development of the nervous system and the pancreas. **Pathways and Functions:** 1. **Translation initiation**: RPLP1 interacts with other ribosomal proteins and initiation factors to regulate the assembly of the ribosome and the initiation of translation. 2. **Translation elongation**: RPLP1 is involved in the regulation of translation elongation, ensuring accurate protein synthesis and preventing aberrant translation. 3. **Stress response**: RPLP1 is activated in response to cellular stress, triggering the activation of stress response pathways, including the unfolded protein response (UPR) and the integrated stress response (ISR). 4. **Cellular differentiation**: RPLP1 plays a role in the regulation of cellular differentiation, particularly in the development of the nervous system and the pancreas. 5. **Signaling pathways**: RPLP1 interacts with signaling molecules, such as the receptor tyrosine kinase, to regulate cellular processes, including cell growth and differentiation. **Clinical Significance:** Dysregulation of RPLP1 has been implicated in various diseases, including: 1. **Cancer**: RPLP1 is overexpressed in certain types of cancer, including pancreatic cancer and leukemia, and may contribute to tumorigenesis and cancer progression. 2. **Neurodegenerative diseases**: RPLP1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to protein misfolding and aggregation. 3. **Metabolic disorders**: RPLP1 is involved in the regulation of protein synthesis and may contribute to metabolic disorders, such as diabetes and obesity. In conclusion, RPLP1 is a multifaceted gene that plays a critical role in eukaryotic translation and cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of RPLP1 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the functions of RPLP1 and its role in disease pathogenesis.

Genular Protein ID: 334476783

Symbol: RLA1_HUMAN

Name: 60S acidic ribosomal protein P1

UniProtKB Accession Codes:

P05386 A6NIB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3323886

Title: Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

PubMed ID: 3323886

DOI: 10.1128/mcb.7.11.4065-4074.1987

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14997482

Title: Identification and characterization of phosphorylated proteins in the human pituitary.

PubMed ID: 14997482

DOI: 10.1002/pmic.200300584

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 22135285

Title: Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex.

PubMed ID: 22135285

DOI: 10.1093/nar/gkr1143

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 114
  • Mass: 11514
  • Checksum: 4C282AB8DCA079C8
  • Sequence:
    • MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA LANVNIGSLI 
CNVGAGGPAP AAGAAPAGGP APSTAAAPAE EKKVEAKKEE SEESDDDMGF GLFD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.