Details for: RPLP2

Gene ID: 6181

Symbol: RPLP2

Ensembl ID: ENSG00000177600

Description: ribosomal protein lateral stalk subunit P2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 764.4419
    Cell Significance Index: -314.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 612.7539
    Cell Significance Index: -289.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 594.1753
    Cell Significance Index: -305.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 433.1824
    Cell Significance Index: -290.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.0497
    Cell Significance Index: -77.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.1110
    Cell Significance Index: 437.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.4601
    Cell Significance Index: 1681.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 13.7984
    Cell Significance Index: 369.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.9655
    Cell Significance Index: 562.3700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.9780
    Cell Significance Index: 194.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.7073
    Cell Significance Index: 1254.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.3102
    Cell Significance Index: 244.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.7447
    Cell Significance Index: 1576.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.6551
    Cell Significance Index: 1064.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.4901
    Cell Significance Index: 1165.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.3525
    Cell Significance Index: 622.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.8536
    Cell Significance Index: 89.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.6642
    Cell Significance Index: 903.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.5422
    Cell Significance Index: 4118.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.4829
    Cell Significance Index: 348.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.4219
    Cell Significance Index: 524.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.4181
    Cell Significance Index: 950.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.3408
    Cell Significance Index: 255.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.2873
    Cell Significance Index: 152.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.0702
    Cell Significance Index: 3125.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.3200
    Cell Significance Index: 116.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.3113
    Cell Significance Index: 407.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.1230
    Cell Significance Index: 175.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.5044
    Cell Significance Index: 127.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.4937
    Cell Significance Index: 161.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.3351
    Cell Significance Index: 58.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 5.3255
    Cell Significance Index: 4030.9400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.0445
    Cell Significance Index: 31.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 4.8904
    Cell Significance Index: 4415.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.8455
    Cell Significance Index: 827.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.8209
    Cell Significance Index: 131.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.8135
    Cell Significance Index: 61.6500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.5379
    Cell Significance Index: 26.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.0109
    Cell Significance Index: 36.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.5610
    Cell Significance Index: 352.2600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.1770
    Cell Significance Index: 27.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.9670
    Cell Significance Index: 155.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7380
    Cell Significance Index: 73.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8848
    Cell Significance Index: 130.3400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.7115
    Cell Significance Index: 4.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2622
    Cell Significance Index: 250.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1297
    Cell Significance Index: 9.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0905
    Cell Significance Index: 207.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0383
    Cell Significance Index: 29.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5688
    Cell Significance Index: 29.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4723
    Cell Significance Index: 346.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0107
    Cell Significance Index: 2.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0798
    Cell Significance Index: -150.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1254
    Cell Significance Index: -92.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1571
    Cell Significance Index: -289.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1920
    Cell Significance Index: -295.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2130
    Cell Significance Index: -289.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2713
    Cell Significance Index: -152.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2869
    Cell Significance Index: -102.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3049
    Cell Significance Index: -190.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3877
    Cell Significance Index: -246.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6020
    Cell Significance Index: -273.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6875
    Cell Significance Index: -144.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6891
    Cell Significance Index: -112.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8778
    Cell Significance Index: -252.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0291
    Cell Significance Index: -17.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0437
    Cell Significance Index: -64.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1707
    Cell Significance Index: -134.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4411
    Cell Significance Index: -114.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5246
    Cell Significance Index: -85.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.7209
    Cell Significance Index: -196.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8157
    Cell Significance Index: -263.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.2559
    Cell Significance Index: -13.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2819
    Cell Significance Index: -38.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.3367
    Cell Significance Index: -105.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.7151
    Cell Significance Index: -86.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.7748
    Cell Significance Index: -174.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7865
    Cell Significance Index: -290.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.9935
    Cell Significance Index: -74.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.3195
    Cell Significance Index: -49.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.5935
    Cell Significance Index: -275.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.9713
    Cell Significance Index: -243.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.0102
    Cell Significance Index: -86.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.1087
    Cell Significance Index: -276.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.4402
    Cell Significance Index: -60.5800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.2615
    Cell Significance Index: -28.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.8497
    Cell Significance Index: -172.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.9876
    Cell Significance Index: -102.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.0229
    Cell Significance Index: -117.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.0824
    Cell Significance Index: -269.0400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -6.1307
    Cell Significance Index: -44.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -7.0884
    Cell Significance Index: -189.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -7.1037
    Cell Significance Index: -84.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.1440
    Cell Significance Index: -262.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -7.1466
    Cell Significance Index: -251.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -7.3815
    Cell Significance Index: -279.5200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -7.7928
    Cell Significance Index: -48.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -8.0615
    Cell Significance Index: -263.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -8.1123
    Cell Significance Index: -284.1900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -8.1395
    Cell Significance Index: -104.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPLP2 is a 60S acidic ribosomal protein that belongs to the ribosomal protein family. It is composed of 188 amino acids and is highly conserved across species. The protein is characterized by its unique structural features, including a central stalk region and a C-terminal domain that interacts with other ribosomal proteins. RPLP2 is also known for its ability to bind to GTP, which is essential for its function in the translation process. **Pathways and Functions** RPLP2 is involved in several key pathways, including: 1. **Translation elongation**: RPLP2 plays a critical role in the assembly of the 60S ribosomal subunit, which is essential for the elongation phase of translation. 2. **Eukaryotic translation initiation**: RPLP2 is also involved in the initiation phase of translation, where it interacts with other ribosomal proteins to form the 40S ribosomal subunit. 3. **Cytoplasmic translation**: RPLP2 is involved in the translation of mRNAs in the cytoplasm, where it interacts with other ribosomal proteins to form the 60S ribosomal subunit. 4. **Protein synthesis regulation**: RPLP2 is involved in the regulation of protein synthesis, including the translation of mRNAs and the assembly of ribosomes. **Clinical Significance** Dysregulation of RPLP2 has been implicated in various diseases, including: 1. **Cancer**: RPLP2 is overexpressed in several types of cancer, including breast cancer and pancreatic cancer, and is associated with poor prognosis. 2. **Autoimmune disorders**: RPLP2 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders such as multiple sclerosis and rheumatoid arthritis. 3. **Viral infections**: RPLP2 is involved in the translation of viral mRNAs, and its dysregulation has been implicated in viral infections such as influenza and HIV. 4. **Neurological disorders**: RPLP2 has been implicated in the regulation of protein synthesis in the nervous system, and its dysregulation has been linked to neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, RPLP2 is a critical component of the 60S ribosomal subunit, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of RPLP2 in disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 1195373262

Symbol: RLA2_HUMAN

Name: 60S acidic ribosomal protein P2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3323886

Title: Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

PubMed ID: 3323886

DOI: 10.1128/mcb.7.11.4065-4074.1987

PubMed ID: 2153399

Title: A sequence previously identified as metastasis-related encodes an acidic ribosomal phosphoprotein, P2.

PubMed ID: 2153399

DOI: 10.1038/bjc.1990.19

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14997482

Title: Identification and characterization of phosphorylated proteins in the human pituitary.

PubMed ID: 14997482

DOI: 10.1002/pmic.200300584

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20385603

Title: Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk.

PubMed ID: 20385603

DOI: 10.1093/nar/gkq231

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 115
  • Mass: 11665
  • Checksum: B5ECFE2510A756BF
  • Sequence:
  • MRYVASYLLA ALGGNSSPSA KDIKKILDSV GIEADDDRLN KVISELNGKN IEDVIAQGIG 
    KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE ESEESDDDMG FGLFD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.