Details for: RPLP2

Gene ID: 6181

Symbol: RPLP2

Ensembl ID: ENSG00000177600

Description: ribosomal protein lateral stalk subunit P2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.36
    Marker Score: 3584
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 5.96
    Marker Score: 29279
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.83
    Marker Score: 4229.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.79
    Marker Score: 77856
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.63
    Marker Score: 2895
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.63
    Marker Score: 11804
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.42
    Marker Score: 15819
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.31
    Marker Score: 52562
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.29
    Marker Score: 6887
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.29
    Marker Score: 2729
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.29
    Marker Score: 1949
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 5.24
    Marker Score: 3695
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.22
    Marker Score: 3361
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.2
    Marker Score: 4165
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.98
    Marker Score: 2817
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.94
    Marker Score: 4208
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.92
    Marker Score: 7573
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.87
    Marker Score: 3493
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.87
    Marker Score: 165785
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.86
    Marker Score: 12345
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.84
    Marker Score: 15261
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.83
    Marker Score: 2078
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.82
    Marker Score: 20103.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.82
    Marker Score: 25315
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.8
    Marker Score: 3652
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.75
    Marker Score: 251041.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.63
    Marker Score: 1107
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.56
    Marker Score: 3571
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.56
    Marker Score: 1482
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.56
    Marker Score: 5062
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.49
    Marker Score: 59164
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.48
    Marker Score: 250408
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.43
    Marker Score: 26918
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.41
    Marker Score: 3939
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.38
    Marker Score: 2666
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.38
    Marker Score: 50907
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.38
    Marker Score: 3780
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.37
    Marker Score: 7505
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.32
    Marker Score: 11945
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.29
    Marker Score: 27369
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.27
    Marker Score: 4980
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.24
    Marker Score: 11885
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.24
    Marker Score: 10346.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.23
    Marker Score: 2483
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.17
    Marker Score: 4026
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.16
    Marker Score: 9468
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 4.1
    Marker Score: 1771
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.09
    Marker Score: 938
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 4.09
    Marker Score: 952
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.08
    Marker Score: 5932
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17492
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.07
    Marker Score: 3196.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.07
    Marker Score: 3467
  • Cell Name: glial cell (CL0000125)
    Fold Change: 4.06
    Marker Score: 4460
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.04
    Marker Score: 4986
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.04
    Marker Score: 26316
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.03
    Marker Score: 30007
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.02
    Marker Score: 7553
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.02
    Marker Score: 4842
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.02
    Marker Score: 4289
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 4.01
    Marker Score: 2740
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3933
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.97
    Marker Score: 14114
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.95
    Marker Score: 9847.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.94
    Marker Score: 3504
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.93
    Marker Score: 3526.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.93
    Marker Score: 5793
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.92
    Marker Score: 3376
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.92
    Marker Score: 2026
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.91
    Marker Score: 4206.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.89
    Marker Score: 3674
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.88
    Marker Score: 1093
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.88
    Marker Score: 1101
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.87
    Marker Score: 4678
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.86
    Marker Score: 1410
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.86
    Marker Score: 3401
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.85
    Marker Score: 2909
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.84
    Marker Score: 1730.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.83
    Marker Score: 1715
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.82
    Marker Score: 1090
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.81
    Marker Score: 4213
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.81
    Marker Score: 1972.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.81
    Marker Score: 3395
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.8
    Marker Score: 1007
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.78
    Marker Score: 4433
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.78
    Marker Score: 940
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.77
    Marker Score: 10114
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.77
    Marker Score: 2081
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.77
    Marker Score: 3129
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.76
    Marker Score: 1716
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.76
    Marker Score: 1236
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.75
    Marker Score: 4291
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.75
    Marker Score: 2197
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.74
    Marker Score: 2478
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.74
    Marker Score: 1105
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.74
    Marker Score: 5945
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.73
    Marker Score: 2595
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 3.73
    Marker Score: 1051
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.72
    Marker Score: 5385
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.71
    Marker Score: 1190

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Other Information

**Key characteristics:** - It is a transmembrane protein with a molecular weight of approximately 150 kDa. - It is expressed in various cell types, including epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, activated CD8+ T cells, malignant cells, natural T-regulatory cells, and human mature T cells. - It is a key regulator of translation initiation and elongation by interacting with the ribosome. **Pathways and functions:** - RPLP2 is involved in the initiation of protein synthesis by interacting with the 5' cap of mRNA through its N-terminal domain. - It forms a complex with the eukaryotic translation initiation factor eIF4B and recruits it to the ribosome. - It also interacts with the eIF2 complex, which is responsible for recruiting the elongation factors. - RPLP2 is also involved in the termination of translation by interacting with the release factors on the ribosome. - It facilitates the release of the completed polypeptide chain from the ribosome. **Clinical significance:** - Mutations in RPLP2 have been linked to several human diseases, including cancer and autoimmune disorders. - In cancer, RPLP2 mutations can lead to the activation of oncogenes and the proliferation of cancer cells. - RPLP2 inhibitors are being investigated as potential therapeutic agents for cancer and other diseases that are characterized by abnormal protein synthesis.

Genular Protein ID: 1195373262

Symbol: RLA2_HUMAN

Name: 60S acidic ribosomal protein P2

UniProtKB Accession Codes:

P05387 Q6FG96

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3323886

Title: Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

PubMed ID: 3323886

DOI: 10.1128/mcb.7.11.4065-4074.1987

PubMed ID: 2153399

Title: A sequence previously identified as metastasis-related encodes an acidic ribosomal phosphoprotein, P2.

PubMed ID: 2153399

DOI: 10.1038/bjc.1990.19

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14997482

Title: Identification and characterization of phosphorylated proteins in the human pituitary.

PubMed ID: 14997482

DOI: 10.1002/pmic.200300584

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20385603

Title: Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk.

PubMed ID: 20385603

DOI: 10.1093/nar/gkq231

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 115
  • Mass: 11665
  • Checksum: B5ECFE2510A756BF
  • Sequence:
    • MRYVASYLLA ALGGNSSPSA KDIKKILDSV GIEADDDRLN KVISELNGKN IEDVIAQGIG 
KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE ESEESDDDMG FGLFD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.