Details for: MRPL12

Gene ID: 6182

Symbol: MRPL12

Ensembl ID: ENSG00000262814

Description: mitochondrial ribosomal protein L12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.5123
    Cell Significance Index: -28.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.0831
    Cell Significance Index: -26.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.1442
    Cell Significance Index: -38.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.0994
    Cell Significance Index: -38.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.9616
    Cell Significance Index: -38.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.3603
    Cell Significance Index: -36.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2813
    Cell Significance Index: -32.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7864
    Cell Significance Index: -38.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9799
    Cell Significance Index: -24.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7070
    Cell Significance Index: 45.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.6132
    Cell Significance Index: 12.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5909
    Cell Significance Index: 110.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3565
    Cell Significance Index: 61.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3218
    Cell Significance Index: 38.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2667
    Cell Significance Index: 59.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2403
    Cell Significance Index: 74.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2389
    Cell Significance Index: 26.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1685
    Cell Significance Index: 60.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1493
    Cell Significance Index: 81.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0403
    Cell Significance Index: 568.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8095
    Cell Significance Index: 12.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8032
    Cell Significance Index: 144.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7949
    Cell Significance Index: 18.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7809
    Cell Significance Index: 345.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7594
    Cell Significance Index: 93.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6999
    Cell Significance Index: 201.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6701
    Cell Significance Index: 31.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6699
    Cell Significance Index: 86.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6357
    Cell Significance Index: 41.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5713
    Cell Significance Index: 15.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5681
    Cell Significance Index: 42.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5642
    Cell Significance Index: 6.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5592
    Cell Significance Index: 76.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5405
    Cell Significance Index: 17.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5254
    Cell Significance Index: 474.3800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4899
    Cell Significance Index: 4.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4417
    Cell Significance Index: 15.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3900
    Cell Significance Index: 4.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3649
    Cell Significance Index: 3.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3259
    Cell Significance Index: 6.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3254
    Cell Significance Index: 52.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3098
    Cell Significance Index: 8.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2726
    Cell Significance Index: 51.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2591
    Cell Significance Index: 44.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2585
    Cell Significance Index: 13.5700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1769
    Cell Significance Index: 1.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1503
    Cell Significance Index: 5.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1379
    Cell Significance Index: 17.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1215
    Cell Significance Index: 12.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0934
    Cell Significance Index: 70.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0555
    Cell Significance Index: 3.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0461
    Cell Significance Index: 1.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0417
    Cell Significance Index: 30.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0225
    Cell Significance Index: 0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0196
    Cell Significance Index: 3.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0051
    Cell Significance Index: -0.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0211
    Cell Significance Index: -7.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0479
    Cell Significance Index: -33.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0488
    Cell Significance Index: -36.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0530
    Cell Significance Index: -29.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0653
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0815
    Cell Significance Index: -50.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0858
    Cell Significance Index: -8.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1231
    Cell Significance Index: -1.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1261
    Cell Significance Index: -14.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1405
    Cell Significance Index: -63.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1711
    Cell Significance Index: -20.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1762
    Cell Significance Index: -20.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1911
    Cell Significance Index: -37.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2140
    Cell Significance Index: -45.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2405
    Cell Significance Index: -2.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2802
    Cell Significance Index: -21.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2918
    Cell Significance Index: -42.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2933
    Cell Significance Index: -23.2300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.4609
    Cell Significance Index: -3.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4840
    Cell Significance Index: -27.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5103
    Cell Significance Index: -8.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5269
    Cell Significance Index: -15.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5398
    Cell Significance Index: -33.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5657
    Cell Significance Index: -14.1400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5739
    Cell Significance Index: -5.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5931
    Cell Significance Index: -17.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6827
    Cell Significance Index: -41.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7061
    Cell Significance Index: -20.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7559
    Cell Significance Index: -11.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7990
    Cell Significance Index: -14.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8182
    Cell Significance Index: -36.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8712
    Cell Significance Index: -31.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8798
    Cell Significance Index: -23.1400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9363
    Cell Significance Index: -14.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9624
    Cell Significance Index: -36.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0057
    Cell Significance Index: -35.2300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.0586
    Cell Significance Index: -26.4400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.0945
    Cell Significance Index: -6.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0996
    Cell Significance Index: -36.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -1.1102
    Cell Significance Index: -15.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1511
    Cell Significance Index: -36.6600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -1.1783
    Cell Significance Index: -6.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.2315
    Cell Significance Index: -38.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL12 is a mitochondrial ribosomal protein that belongs to the L12 family of ribosomal proteins. It is a small protein, consisting of 39 amino acids, and is encoded by the ENSG00000262814 gene. MRPL12 is highly expressed in cells with high energy demands, such as respiratory basal cells, hepatocytes, and erythroid progenitor cells. It is also present in other cell types, including stratified epithelial cells, fetal cardiomyocytes, and placental villous trophoblasts. **Pathways and Functions:** MRPL12 is involved in various mitochondrial translation pathways, including: 1. **Mitochondrial translation elongation**: MRPL12 is required for the accurate elongation of mitochondrial mRNAs, ensuring the proper synthesis of mitochondrial proteins. 2. **Mitochondrial translation initiation**: MRPL12 plays a role in the initiation of mitochondrial translation, facilitating the recruitment of ribosomal subunits to the mitochondrial ribosome. 3. **Mitochondrial translation termination**: MRPL12 is involved in the termination of mitochondrial translation, ensuring the proper release of completed proteins. 4. **Mitochondrial protein degradation**: MRPL12 is also involved in the regulation of mitochondrial protein degradation, influencing the activity of proteases involved in protein quality control. **Clinical Significance:** Dysregulation of MRPL12 has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the MRPL12 gene have been associated with mitochondrial disorders, such as MELAS syndrome and Kearns-Sayre syndrome. 2. **Cancer**: Alterations in MRPL12 expression have been observed in various types of cancer, including breast cancer and lung cancer. 3. **Neurodegenerative diseases**: MRPL12 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, MRPL12 is a critical component of the mitochondrial translation machinery, playing a vital role in the synthesis of mitochondrial proteins. Its dysregulation has been implicated in various diseases, highlighting the importance of MRPL12 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which MRPL12 regulates mitochondrial protein synthesis and its role in disease pathology.

Genular Protein ID: 3170056916

Symbol: RM12_HUMAN

Name: 39S ribosomal protein L12, mitochondrial

UniProtKB Accession Codes:

P52815 Q969U0 Q9HCA2 Q9UQJ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 24 Ensembl 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626705

Title: A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein.

PubMed ID: 8626705

DOI: 10.1074/jbc.271.19.11468

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19103604

Title: hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis.

PubMed ID: 19103604

DOI: 10.1074/jbc.m807797200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22003127

Title: Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription.

PubMed ID: 22003127

DOI: 10.1073/pnas.1108852108

PubMed ID: 23603806

Title: Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency.

PubMed ID: 23603806

DOI: 10.1016/j.bbadis.2013.04.014

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27184847

Title: APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest.

PubMed ID: 27184847

DOI: 10.1016/j.celrep.2016.04.064

Sequence Information:

  • Length: 198
  • Mass: 21348
  • Checksum: 7F26BEDE9218CEF0
  • Sequence:
    • MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG APLDNAPKEY 
PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM GGVMSGAVPA AAAQEAVEED 
IPIAKERTHF TVRLTEAKPV DKVKLIKEIK NYIQGINLVQ AKKLVESLPQ EIKANVAKAE 
AEKIKAALEA VGGTVVLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.