Details for: MRPS12

Gene ID: 6183

Symbol: MRPS12

Ensembl ID: ENSG00000128626

Description: mitochondrial ribosomal protein S12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 174.6116
    Cell Significance Index: -27.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.6424
    Cell Significance Index: -25.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.0304
    Cell Significance Index: -35.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.3911
    Cell Significance Index: -34.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.8180
    Cell Significance Index: -34.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.3675
    Cell Significance Index: -32.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 10.5578
    Cell Significance Index: 263.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7144
    Cell Significance Index: -34.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9311
    Cell Significance Index: -24.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9395
    Cell Significance Index: -18.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.0747
    Cell Significance Index: 31.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8309
    Cell Significance Index: 16.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4648
    Cell Significance Index: 76.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4645
    Cell Significance Index: 43.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4056
    Cell Significance Index: 38.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3720
    Cell Significance Index: 168.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2622
    Cell Significance Index: 227.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2564
    Cell Significance Index: 686.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2351
    Cell Significance Index: 87.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1487
    Cell Significance Index: 53.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0565
    Cell Significance Index: 73.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0128
    Cell Significance Index: 23.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0042
    Cell Significance Index: 163.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9985
    Cell Significance Index: 64.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9591
    Cell Significance Index: 113.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9297
    Cell Significance Index: 42.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9067
    Cell Significance Index: 10.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9049
    Cell Significance Index: 42.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9037
    Cell Significance Index: 12.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8640
    Cell Significance Index: 382.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8620
    Cell Significance Index: 64.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7440
    Cell Significance Index: 96.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6971
    Cell Significance Index: 95.7300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6470
    Cell Significance Index: 5.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6353
    Cell Significance Index: 9.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5322
    Cell Significance Index: 4.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4552
    Cell Significance Index: 13.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3900
    Cell Significance Index: 12.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3596
    Cell Significance Index: 9.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2876
    Cell Significance Index: 7.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2610
    Cell Significance Index: 6.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2192
    Cell Significance Index: 11.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2190
    Cell Significance Index: 43.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1972
    Cell Significance Index: 33.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1966
    Cell Significance Index: 37.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1553
    Cell Significance Index: 9.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1190
    Cell Significance Index: 15.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1185
    Cell Significance Index: 107.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0959
    Cell Significance Index: 3.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0816
    Cell Significance Index: 59.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0574
    Cell Significance Index: 43.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0523
    Cell Significance Index: 10.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0047
    Cell Significance Index: 0.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0044
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0144
    Cell Significance Index: -27.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0187
    Cell Significance Index: -1.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0230
    Cell Significance Index: -42.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0277
    Cell Significance Index: -42.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0316
    Cell Significance Index: -43.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0395
    Cell Significance Index: -29.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0412
    Cell Significance Index: -14.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0442
    Cell Significance Index: -24.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0458
    Cell Significance Index: -29.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0488
    Cell Significance Index: -2.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0715
    Cell Significance Index: -32.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0748
    Cell Significance Index: -46.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0845
    Cell Significance Index: -0.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0902
    Cell Significance Index: -2.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0919
    Cell Significance Index: -26.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1051
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1164
    Cell Significance Index: -13.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1357
    Cell Significance Index: -15.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1472
    Cell Significance Index: -4.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1502
    Cell Significance Index: -5.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1518
    Cell Significance Index: -12.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1832
    Cell Significance Index: -38.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2045
    Cell Significance Index: -29.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2207
    Cell Significance Index: -4.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2888
    Cell Significance Index: -7.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2903
    Cell Significance Index: -6.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3010
    Cell Significance Index: -23.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3185
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3295
    Cell Significance Index: -34.3100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4166
    Cell Significance Index: -5.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4216
    Cell Significance Index: -7.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4397
    Cell Significance Index: -26.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4535
    Cell Significance Index: -2.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4619
    Cell Significance Index: -7.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4680
    Cell Significance Index: -26.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4753
    Cell Significance Index: -4.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6172
    Cell Significance Index: -18.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6926
    Cell Significance Index: -10.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7101
    Cell Significance Index: -7.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7513
    Cell Significance Index: -26.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7608
    Cell Significance Index: -27.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7823
    Cell Significance Index: -9.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7962
    Cell Significance Index: -35.2200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8260
    Cell Significance Index: -14.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8566
    Cell Significance Index: -28.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8905
    Cell Significance Index: -28.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPS12 is a mitochondrial ribosomal protein that belongs to the S12 family of ribosomal proteins. It is a 28-kDa protein that is highly conserved across species, suggesting its critical importance in mitochondrial function. The protein is composed of a single polypeptide chain with a molecular weight of 28 kDa. MRPS12 is specifically localized to the mitochondrial small ribosomal subunit, where it interacts with other ribosomal proteins to form the 40S subunit. **Pathways and Functions:** MRPS12 is involved in various mitochondrial translation pathways, including: 1. **Mitochondrial translation initiation**: MRPS12 plays a crucial role in the initiation of mitochondrial translation by interacting with the mitochondrial translation initiation factor, MTIF2. 2. **Mitochondrial translation elongation**: MRPS12 is involved in the elongation phase of mitochondrial translation, where it interacts with the mitochondrial translation elongation factor, MTSF1. 3. **Mitochondrial translation termination**: MRPS12 is required for the termination of mitochondrial translation, where it interacts with the mitochondrial translation termination factor, MTSF2. In addition to its role in mitochondrial translation, MRPS12 is also involved in other cellular processes, including: 1. **Protein binding**: MRPS12 interacts with various proteins, including ribosomal proteins, translation factors, and mitochondrial proteins. 2. **Ribosome biogenesis**: MRPS12 is required for the biogenesis of mitochondrial ribosomes, where it interacts with other ribosomal proteins and mitochondrial proteins. 3. **Structural constituent of ribosome**: MRPS12 is a structural component of the mitochondrial ribosome, where it interacts with other ribosomal proteins to form the 40S subunit. **Clinical Significance:** Dysregulation of MRPS12 has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the MRPS12 gene have been associated with mitochondrial disorders, such as Mitorpia, a rare genetic disorder characterized by progressive muscle weakness and wasting. 2. **Neurodegenerative diseases**: MRPS12 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction is a key contributing factor. 3. **Cancer**: MRPS12 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer, where it may contribute to tumorigenesis and cancer progression. In conclusion, MRPS12 is a critical component of the mitochondrial ribosome, playing a pivotal role in mitochondrial function and disease. Further research is needed to fully understand the mechanisms by which MRPS12 regulates mitochondrial translation and to identify potential therapeutic targets for the treatment of mitochondrial disorders and cancer.

Genular Protein ID: 44800638

Symbol: RT12_HUMAN

Name: 28S ribosomal protein S12, mitochondrial

UniProtKB Accession Codes:

O15235 Q53X98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 41 Ensembl 6 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9434165

Title: Metazoan nuclear genes for mitoribosomal protein S12.

PubMed ID: 9434165

DOI: 10.1016/s0378-1119(97)00521-0

PubMed ID: 9790755

Title: Characterization of the human mitochondrial ribosomal S12 gene.

PubMed ID: 9790755

DOI: 10.1006/geno.1998.5448

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 138
  • Mass: 15173
  • Checksum: 893FD2CA1C7187A7
  • Sequence:
    • MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG 
VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH TLQEHQIVLV EGGRTQDLPG 
VKLTVVRGKY DCGHVQKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.