Details for: RPS14

Gene ID: 6208

Symbol: RPS14

Ensembl ID: ENSG00000164587

Description: ribosomal protein S14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 868.0230
    Cell Significance Index: -357.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 697.5942
    Cell Significance Index: -329.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 676.0692
    Cell Significance Index: -347.7600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 492.9644
    Cell Significance Index: -330.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.8295
    Cell Significance Index: -101.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 20.2394
    Cell Significance Index: 517.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 19.4089
    Cell Significance Index: 1982.6100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 17.1727
    Cell Significance Index: 100.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 16.3892
    Cell Significance Index: 438.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 15.0113
    Cell Significance Index: 394.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 14.1660
    Cell Significance Index: 665.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.5246
    Cell Significance Index: 203.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.2204
    Cell Significance Index: 389.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.8776
    Cell Significance Index: 251.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.7106
    Cell Significance Index: 1383.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.3270
    Cell Significance Index: 132.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.7320
    Cell Significance Index: 110.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.5916
    Cell Significance Index: 1179.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.5373
    Cell Significance Index: 1719.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.3242
    Cell Significance Index: 195.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.3011
    Cell Significance Index: 693.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.2473
    Cell Significance Index: 1269.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.2130
    Cell Significance Index: 651.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.9316
    Cell Significance Index: 4877.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.6037
    Cell Significance Index: 246.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.6023
    Cell Significance Index: 3803.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.2626
    Cell Significance Index: 385.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.8392
    Cell Significance Index: 144.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.7703
    Cell Significance Index: 996.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.4540
    Cell Significance Index: 879.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.9007
    Cell Significance Index: 75.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.8720
    Cell Significance Index: 187.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.4028
    Cell Significance Index: 336.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.3077
    Cell Significance Index: 406.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.8310
    Cell Significance Index: 171.2500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.5747
    Cell Significance Index: 34.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.5162
    Cell Significance Index: 941.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 5.1025
    Cell Significance Index: 3862.2000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.0277
    Cell Significance Index: 34.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.6658
    Cell Significance Index: 33.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6609
    Cell Significance Index: 71.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4327
    Cell Significance Index: 482.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.0694
    Cell Significance Index: 1517.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.5409
    Cell Significance Index: 122.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4803
    Cell Significance Index: 1336.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2752
    Cell Significance Index: 242.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8233
    Cell Significance Index: 42.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8150
    Cell Significance Index: 234.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6976
    Cell Significance Index: 5.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2597
    Cell Significance Index: 11.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0177
    Cell Significance Index: -3.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0411
    Cell Significance Index: -77.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1380
    Cell Significance Index: -102.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1524
    Cell Significance Index: -280.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1938
    Cell Significance Index: -298.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2664
    Cell Significance Index: -362.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3028
    Cell Significance Index: -170.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3344
    Cell Significance Index: -119.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3828
    Cell Significance Index: -243.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3843
    Cell Significance Index: -240.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6146
    Cell Significance Index: -278.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7046
    Cell Significance Index: -69.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.9433
    Cell Significance Index: -198.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0193
    Cell Significance Index: -62.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.3099
    Cell Significance Index: -150.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3864
    Cell Significance Index: -23.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4893
    Cell Significance Index: -83.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.7808
    Cell Significance Index: -289.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9335
    Cell Significance Index: -281.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1708
    Cell Significance Index: -136.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.7080
    Cell Significance Index: -45.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.7282
    Cell Significance Index: -188.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.7624
    Cell Significance Index: -315.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.9511
    Cell Significance Index: -94.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.9817
    Cell Significance Index: -18.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.1399
    Cell Significance Index: -78.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.1503
    Cell Significance Index: -328.0200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -3.3745
    Cell Significance Index: -9.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.8619
    Cell Significance Index: -52.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.9719
    Cell Significance Index: -304.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.1531
    Cell Significance Index: -62.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.6322
    Cell Significance Index: -284.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.8692
    Cell Significance Index: -327.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.9040
    Cell Significance Index: -106.2500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -5.4800
    Cell Significance Index: -114.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.3084
    Cell Significance Index: -185.8100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.5287
    Cell Significance Index: -35.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.6913
    Cell Significance Index: -192.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.9594
    Cell Significance Index: -82.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -7.7440
    Cell Significance Index: -132.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.7572
    Cell Significance Index: -343.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -8.0112
    Cell Significance Index: -294.0900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -8.2932
    Cell Significance Index: -106.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -8.3634
    Cell Significance Index: -163.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -8.4369
    Cell Significance Index: -226.0700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -8.8173
    Cell Significance Index: -63.3200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -9.0011
    Cell Significance Index: -75.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -9.0082
    Cell Significance Index: -294.9300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -9.0857
    Cell Significance Index: -127.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -9.1350
    Cell Significance Index: -320.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPS14 is a highly conserved protein across eukaryotes, with high sequence similarity to other ribosomal proteins. It is a small protein, consisting of only 102 amino acids, and is localized to the cytosol. RPS14 is a key component of the 40S ribosomal subunit, which is responsible for the initiation of translation. It is also involved in the regulation of translation, particularly in response to amino acid deficiency. **Pathways and Functions** RPS14 is involved in several key pathways, including: 1. **Translation Initiation**: RPS14 is essential for the assembly of the 40S ribosomal subunit, which is responsible for the initiation of translation. 2. **Amino Acid Regulation**: RPS14 interacts with the protein kinase GCN2 to modulate translation in response to amino acid deficiency. 3. **mRNA Binding**: RPS14 binds to the 5' untranslated region (UTR) of mRNA, facilitating the recruitment of the small subunit processome to initiate translation. 4. **Ribosome Assembly**: RPS14 is involved in the assembly of the 40S ribosomal subunit, which is necessary for translation. **Clinical Significance** Dysregulation of RPS14 has been implicated in various diseases, including: 1. **Cancer**: Mutations in RPS14 have been associated with certain types of cancer, including leukemia and lymphoma. 2. **Neurodegenerative Diseases**: RPS14 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Infectious Diseases**: RPS14 has been shown to interact with viral proteins, facilitating the replication of certain viruses, including influenza and SARS-CoV-2. In conclusion, RPS14 is a crucial component of the eukaryotic translation machinery, playing a key role in the regulation of translation and the assembly of the 40S ribosomal subunit. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining cellular homeostasis.

Genular Protein ID: 4050521959

Symbol: RS14_HUMAN

Name: 40S ribosomal protein S14

UniProtKB Accession Codes:

P62263 B2R5G5 D3DQG5 P06366 Q5BJI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 81 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 97 PDBsum 97 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 19 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3529092

Title: Homologous ribosomal proteins in bacteria, yeast, and humans.

PubMed ID: 3529092

DOI: 10.1073/pnas.83.18.6907

PubMed ID: 3785212

Title: Primary structure of human ribosomal protein S14 and the gene that encodes it.

PubMed ID: 3785212

DOI: 10.1128/mcb.6.8.2774-2783.1986

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 1549121

Title: Fine-structure map of the human ribosomal protein gene RPS14.

PubMed ID: 1549121

DOI: 10.1128/mcb.12.4.1680-1686.1992

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 151
  • Mass: 16273
  • Checksum: 4F4387F9FADAC278
  • Sequence:
    • MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK ETICRVTGGM 
KVKADRDESS PYAAMLAAQD VAQRCKELGI TALHIKLRAT GGNRTKTPGP GAQSALRALA 
RSGMKIGRIE DVTPIPSDST RRKGGRRGRR L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.