Details for: RPS15

Gene ID: 6209

Symbol: RPS15

Ensembl ID: ENSG00000115268

Description: ribosomal protein S15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.42
    Marker Score: 3621
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.22
    Marker Score: 30531
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.75
    Marker Score: 77257
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.71
    Marker Score: 11966
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.7
    Marker Score: 4136
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.57
    Marker Score: 2860
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.41
    Marker Score: 7048
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.39
    Marker Score: 15724
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.29
    Marker Score: 4139
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.26
    Marker Score: 52069.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.18
    Marker Score: 8893
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.17
    Marker Score: 2670
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.16
    Marker Score: 3896
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.1
    Marker Score: 4341
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.1
    Marker Score: 3651
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.08
    Marker Score: 7823
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.05
    Marker Score: 171804
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 5.03
    Marker Score: 4487
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.87
    Marker Score: 15354
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.8
    Marker Score: 12206
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.77
    Marker Score: 252052
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.74
    Marker Score: 2037
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.72
    Marker Score: 24813
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.59
    Marker Score: 1095.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.56
    Marker Score: 2052
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.55
    Marker Score: 12204
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.53
    Marker Score: 5033
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.5
    Marker Score: 251785
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.49
    Marker Score: 59225
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.48
    Marker Score: 1457
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.45
    Marker Score: 15803
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.43
    Marker Score: 5345
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.42
    Marker Score: 26857
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.4
    Marker Score: 2837
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.4
    Marker Score: 2675
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.39
    Marker Score: 50987
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.35
    Marker Score: 4104.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.31
    Marker Score: 11914
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.28
    Marker Score: 3045
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.28
    Marker Score: 27278.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.26
    Marker Score: 10397
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.24
    Marker Score: 11900.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.22
    Marker Score: 4078
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.21
    Marker Score: 4915
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.19
    Marker Score: 2457
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.17
    Marker Score: 9491
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.16
    Marker Score: 5132.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.13
    Marker Score: 30755
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.12
    Marker Score: 10053
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.1
    Marker Score: 3221
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.09
    Marker Score: 3669
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.09
    Marker Score: 17545.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.09
    Marker Score: 6020
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.09
    Marker Score: 3485
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.08
    Marker Score: 26580
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.07
    Marker Score: 7654
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.04
    Marker Score: 10191
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 4.03
    Marker Score: 10046
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.03
    Marker Score: 923.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.03
    Marker Score: 4334
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.02
    Marker Score: 4294
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 4.02
    Marker Score: 1835
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.01
    Marker Score: 3947
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 4
    Marker Score: 1053.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 4
    Marker Score: 3557
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.98
    Marker Score: 1088.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.97
    Marker Score: 1463
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.95
    Marker Score: 4758.5
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.91
    Marker Score: 1110.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.9
    Marker Score: 2713
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.9
    Marker Score: 1097.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.9
    Marker Score: 3191
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.89
    Marker Score: 1419
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.88
    Marker Score: 3409.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.87
    Marker Score: 4281
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.87
    Marker Score: 3327
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.85
    Marker Score: 3621
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.84
    Marker Score: 3389
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.84
    Marker Score: 1990
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.82
    Marker Score: 1586
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.82
    Marker Score: 1712.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.82
    Marker Score: 3406.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.82
    Marker Score: 2568
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.82
    Marker Score: 1256
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.8
    Marker Score: 1219
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.79
    Marker Score: 3148.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.78
    Marker Score: 2176
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.78
    Marker Score: 1077
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.77
    Marker Score: 3820
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.75
    Marker Score: 4295.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.75
    Marker Score: 2485
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.75
    Marker Score: 2837
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.75
    Marker Score: 5447
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.74
    Marker Score: 5418
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.74
    Marker Score: 2063
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.74
    Marker Score: 869.5
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.73
    Marker Score: 988
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.73
    Marker Score: 5930
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.72
    Marker Score: 924.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.72
    Marker Score: 22052.5

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Other Information

**Key characteristics** * The gene is located on chromosome 15q21.1. * It is a large gene with a size of approximately 1.5 million base pairs. * It encodes for a protein of 571 amino acids. * The protein is a component of the ribosome. **Pathways and functions** * The RPS15 gene is involved in the translation of mRNA in eukaryotic cells. * It is a key regulator of protein synthesis. * It is involved in the initiation of translation. * It is also involved in the termination of translation. **Clinical significance** * Mutations in the RPS15 gene have been linked to a number of human diseases, including cancer, diabetes, and heart disease. * These mutations can disrupt the normal function of the ribosome, leading to the production of abnormal proteins that can cause disease. * Targeting the RPS15 gene has been investigated as a potential treatment for these diseases. **Additional information** * The RPS15 gene is also involved in the regulation of apoptosis (programmed cell death). * It is a well-studied gene, and there are many research papers available on its function. * The protein encoded by the RPS15 gene is a key player in the translation of mRNA.

Genular Protein ID: 1219281666

Symbol: RS15_HUMAN

Name: 40S ribosomal protein S15

UniProtKB Accession Codes:

P62841 A5D8V9 P11174 Q3KRA1 Q9UDC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 63 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 82 PDBsum 78 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2821540

Title: Evolutionary conservation of the insulinoma gene rig and its possible function.

PubMed ID: 2821540

DOI: 10.1073/pnas.84.19.6659

PubMed ID: 2159154

Title: Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes.

PubMed ID: 2159154

DOI: 10.1073/pnas.87.9.3594

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1466847

Title: Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid.

PubMed ID: 1466847

DOI: 10.1097/00002030-199210000-00014

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 145
  • Mass: 17040
  • Checksum: CA2C682302C7B387
  • Sequence:
    • MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL 
RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS 
ITYKPVKHGR PGIGATHSSR FIPLK

Genular Protein ID: 1216274165

Symbol: K7ELC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ELC2

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 4 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 IntAct 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 152
  • Mass: 17723
  • Checksum: B6EB15A24C6623B0
  • Sequence:
    • MLGRGADLAE VEQKKKRTFR KFTYRGVDLD QLLDMSYEQL MQLYSARQRR RLNRGLRRKQ 
HSLLKRLRKA KKEAPPMEKP EVVKTHLRDM IILPEMVGSM VGVYNGKTFN QVEIKPEMIG 
HYLGEFSITY KPVKHGRPGI GATHSSRFIP LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.