RPS15 | ENSG00000115268 | NCBI 6209

Details for: RPS15

Gene ID: 6209

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPS15

Ensembl ID: ENSG00000115268

Description: ribosomal protein S15

Cell Significance Landscape

Display Count:

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Dna binding
(GO:0003677)
Focal adhesion
(GO:0005925)
Liver regeneration
(GO:0097421)
Mdm2/mdm4 family protein binding
(GO:0097371)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Positive regulation of signal transduction by p53 class mediator
(GO:1901798)
Protein binding
(GO:0005515)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosomal small subunit export from nucleus
(GO:0000056)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Ubiquitin ligase inhibitor activity
(GO:1990948)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 169.33

rCSI 100%

PRS 1.99
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 146.04

rCSI 100%

PRS 4.35
double negative thymocyte CL0002489

CSI 145.34

rCSI 100%

PRS 1.66
hematopoietic stem cell CL0000037

CSI 145.27

rCSI 96.56%

PRS 1.69
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 143.3

rCSI 96.55%

PRS 1.72
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 141.95

rCSI 94.61%

PRS 4.04
naive T cell CL0000898

CSI 138.15

rCSI 96.15%

PRS 2.08
CD4-positive, alpha-beta memory T cell CL0000897

CSI 135.7

rCSI 97.41%

PRS 1.94
plasmacytoid dendritic cell, human CL0001058

CSI 134.82

rCSI 94.13%

PRS 1.5
melanocyte CL0000148

CSI 134.38

rCSI 99.53%

PRS 1.36
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 133.13

rCSI 99.83%

PRS 4.3
class switched memory B cell CL0000972

CSI 132.45

rCSI 98.88%

PRS 2.41
effector CD8-positive, alpha-beta T cell CL0001050

CSI 128.27

rCSI 97.56%

PRS 1.89
group 3 innate lymphoid cell CL0001071

CSI 126.46

rCSI 95.02%

PRS 1.46
T follicular helper cell CL0002038

CSI 125.35

rCSI 93.8%

PRS 2.34
CD4-positive, alpha-beta thymocyte CL0000810

CSI 124.9

rCSI 100%

PRS 2.67
neural crest cell CL0011012

CSI 124.37

rCSI 98.3%

PRS 0.99
common myeloid progenitor CL0000049

CSI 124.07

rCSI 100%

PRS 1.4
epithelial cell of lower respiratory tract CL0002632

CSI 123.75

rCSI 95.94%

PRS 1.35
T-helper 17 cell CL0000899

CSI 123.75

rCSI 98.26%

PRS 2.53
mature T cell CL0002419

CSI 123.12

rCSI 95.77%

PRS 2.04
CD4-positive helper T cell CL0000492

CSI 121.74

rCSI 92.09%

PRS 2
mucosal invariant T cell CL0000940

CSI 121.38

rCSI 98.08%

PRS 3.74
epithelial cell of lung CL0000082

CSI 120.31

rCSI 99.74%

PRS 1.33
bronchus fibroblast of lung CL2000093

CSI 119.34

rCSI 96.97%

PRS 1.49
CD14-low, CD16-positive monocyte CL0002396

CSI 118.51

rCSI 91.31%

PRS 1.28
plasmablast CL0000980

CSI 118.13

rCSI 92.93%

PRS 1.69
intestine goblet cell CL0019031

CSI 115.75

rCSI 100%

PRS 1.43
pro-B cell CL0000826

CSI 115.2

rCSI 95.4%

PRS 1.42
keratinocyte CL0000312

CSI 114.85

rCSI 96.27%

PRS 1.71
early lymphoid progenitor CL0000936

CSI 114.38

rCSI 100%

PRS 1.59
skin fibroblast CL0002620

CSI 114.18

rCSI 98.43%

PRS 2.38
unswitched memory B cell CL0000970

CSI 113.58

rCSI 95.56%

PRS 2.4
naive B cell CL0000788

CSI 111.24

rCSI 95.41%

PRS 4.63
mature B cell CL0000785

CSI 111.24

rCSI 96.7%

PRS 1.75
precursor B cell CL0000817

CSI 110.68

rCSI 96.95%

PRS 1.92
granulocyte monocyte progenitor cell CL0000557

CSI 108.9

rCSI 94.3%

PRS 1.59
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 108.78

rCSI 99.08%

PRS 2.23
fibroblast of lung CL0002553

CSI 107.39

rCSI 99.95%

PRS 1.42
immature B cell CL0000816

CSI 106.53

rCSI 79.15%

PRS 2.13
goblet cell CL0000160

CSI 105.83

rCSI 100%

PRS 1.49
activated CD4-positive, alpha-beta T cell CL0000896

CSI 105.01

rCSI 97.07%

PRS 2.61
megakaryocyte-erythroid progenitor cell CL0000050

CSI 103.89

rCSI 93.82%

PRS 1.25
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 99.2

rCSI 97.42%

PRS 2.28
activated CD8-positive, alpha-beta T cell CL0000906

CSI 98.48

rCSI 96.8%

PRS 4.27
double-positive, alpha-beta thymocyte CL0000809

CSI 96.11

rCSI 97.95%

PRS 2.07
memory B cell CL0000787

CSI 95.99

rCSI 94.79%

PRS 6.32
fallopian tube secretory epithelial cell CL4030006

CSI 95.46

rCSI 91.89%

PRS 1.49
CD8-positive, alpha-beta memory T cell CL0000909

CSI 95.39

rCSI 99.62%

PRS 4.6
elicited macrophage CL0000861

CSI 94.6

rCSI 86.86%

PRS 1.62
respiratory basal cell CL0002633

CSI 93.25

rCSI 96.59%

PRS 1.67
hematopoietic precursor cell CL0008001

CSI 93.2

rCSI 95.89%

PRS 2.23
ciliated epithelial cell CL0000067

CSI 92.6

rCSI 81.43%

PRS 1.04
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 92.52

rCSI 100%

PRS 2.48
small pre-B-II cell CL0000954

CSI 90.14

rCSI 86.68%

PRS 3.12
pancreatic D cell CL0000173

CSI 88.74

rCSI 87.28%

PRS 1.58
alveolar type 1 fibroblast cell CL4028004

CSI 87.86

rCSI 96.23%

PRS 1.67
intestinal epithelial cell CL0002563

CSI 87.08

rCSI 91.02%

PRS 1.52
IgA plasma cell CL0000987

CSI 86.68

rCSI 88.74%

PRS 2.7
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 84.34

rCSI 100%

PRS 7.86
gamma-delta T cell CL0000798

CSI 83.41

rCSI 97.97%

PRS 14.5
CD14-positive monocyte CL0001054

CSI 82.7

rCSI 100%

PRS 2.11
pancreatic A cell CL0000171

CSI 82.49

rCSI 86.41%

PRS 1.54
M cell of gut CL0000682

CSI 81.46

rCSI 86.55%

PRS 2.6
activated type II NK T cell CL0000931

CSI 81.42

rCSI 91.63%

PRS 2.4
CD1c-positive myeloid dendritic cell CL0002399

CSI 81.12

rCSI 97.98%

PRS 1.63
transit amplifying cell of colon CL0009011

CSI 80.8

rCSI 94.9%

PRS 1.74
fraction A pre-pro B cell CL0002045

CSI 79.89

rCSI 91.46%

PRS 2.97
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 78.04

rCSI 90.12%

PRS 1.33
respiratory suprabasal cell CL4033048

CSI 77.14

rCSI 98.93%

PRS 1.65
mature NK T cell CL0000814

CSI 76.72

rCSI 98.13%

PRS 6.64
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 76.3

rCSI 100%

PRS 3.06
CD4-positive, alpha-beta T cell CL0000624

CSI 75.53

rCSI 96.66%

PRS 31.37
common dendritic progenitor CL0001029

CSI 75.5

rCSI 94.75%

PRS 1.8
conventional dendritic cell CL0000990

CSI 75.25

rCSI 62.81%

PRS 4.84
extravillous trophoblast CL0008036

CSI 75.15

rCSI 92.97%

PRS 1.26
B cell CL0000236

CSI 74.81

rCSI 100%

PRS 8.77
pulmonary ionocyte CL0017000

CSI 74.49

rCSI 90.68%

PRS 1.8
mesodermal cell CL0000222

CSI 73.77

rCSI 88.55%

PRS 1.42
secretory cell CL0000151

CSI 72.74

rCSI 75.9%

PRS 1.46
enteroendocrine cell CL0000164

CSI 71.72

rCSI 98%

PRS 1.58
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 70.92

rCSI 96.61%

PRS 3.58
peripheral nervous system neuron CL2000032

CSI 70.85

rCSI 96.53%

PRS 1.3
endothelial cell of artery CL1000413

CSI 70.7

rCSI 100%

PRS 8.8
colon epithelial cell CL0011108

CSI 69.23

rCSI 72.52%

PRS 1.33
common lymphoid progenitor CL0000051

CSI 69.23

rCSI 92.51%

PRS 2.73
mucous neck cell CL0000651

CSI 68.94

rCSI 99.37%

PRS 2.32
myofibroblast cell CL0000186

CSI 68.78

rCSI 95.26%

PRS 2.05
interstitial cell of Cajal CL0002088

CSI 68.35

rCSI 87%

PRS 1.67
promyelocyte CL0000836

CSI 68.04

rCSI 98.13%

PRS 1.98
perivascular cell CL4033054

CSI 67.53

rCSI 92.32%

PRS 1.63
transit amplifying cell CL0009010

CSI 67.26

rCSI 100%

PRS 2.33
pulmonary artery endothelial cell CL1001568

CSI 66.7

rCSI 90.75%

PRS 2.18
dendritic cell CL0000451

CSI 66.47

rCSI 81.9%

PRS 4.73
alternatively activated macrophage CL0000890

CSI 66.44

rCSI 83.53%

PRS 2.19
granulocyte CL0000094

CSI 66.36

rCSI 100%

PRS 1.78
lung ciliated cell CL1000271

CSI 65.96

rCSI 76.27%

PRS 1.03
multi-ciliated epithelial cell CL0005012

CSI 65.71

rCSI 65.58%

PRS 1.2
neuroblast (sensu Vertebrata) CL0000031

CSI 64.97

rCSI 83.38%

PRS 1.44
IgG plasma cell CL0000985

CSI 64.49

rCSI 77.25%

PRS 2.47

pvalb GABAergic cortical interneuron CL4023018

CSI -53.8

rCSI -66.9%

PRS 0.9%
sst GABAergic cortical interneuron CL4023017

CSI -46.5

rCSI -59.9%

PRS 1.0%
VIP GABAergic cortical interneuron CL4023016

CSI -43.9

rCSI -52.5%

PRS 1.0%
astrocyte of the cerebral cortex CL0002605

CSI -27.8

rCSI -62.3%

PRS 0.9%
adipocyte CL0000136

CSI -22.0

rCSI -28.2%

PRS 1.9%
GABAergic neuron CL0000617

CSI -20.7

rCSI -69.2%

PRS 1.6%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI -19.5

rCSI -34.5%

PRS 0.9%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -19.2

rCSI -68.9%

PRS 0.8%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -19.2

rCSI -46.5%

PRS 0.9%
inhibitory interneuron CL0000498

CSI -18.9

rCSI -43.7%

PRS 1.5%
cerebral cortex neuron CL0010012

CSI -18.7

rCSI -76.2%

PRS 2.1%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -18.3

rCSI -33.2%

PRS 1.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI -18.1

rCSI -30.4%

PRS 1.0%
L6b glutamatergic cortical neuron CL4023038

CSI -16.8

rCSI -52.4%

PRS 1.0%
kidney collecting duct principal cell CL1001431

CSI -15.0

rCSI -75.4%

PRS 10.2%
sncg GABAergic cortical interneuron CL4023015

CSI -11.1

rCSI -17.9%

PRS 1.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -10.8

rCSI -33.8%

PRS 1.1%
erythroid lineage cell CL0000764

CSI -10.6

rCSI -68.4%

PRS 4.1%
kidney collecting duct intercalated cell CL1001432

CSI -10.4

rCSI -74.2%

PRS 6.6%
Bergmann glial cell CL0000644

CSI -9.6

rCSI -13.1%

PRS 1.6%
epicardial adipocyte CL1000309

CSI -9.5

rCSI -30.9%

PRS 2.7%
mature microglial cell CL0002629

CSI -8.7

rCSI -36.3%

PRS 5.4%
glutamatergic neuron CL0000679

CSI -8.6

rCSI -17.7%

PRS 1.8%
kidney interstitial alternatively activated macrophage CL1000695

CSI -8.6

rCSI -22.3%

PRS 1.8%
exhausted T cell CL0011025

CSI -8.5

rCSI -100.0%

PRS 8.3%
OFFx cell CL4033036

CSI -8.4

rCSI -39.7%

PRS 4.4%
cerebral cortex endothelial cell CL1001602

CSI -8.0

rCSI -13.9%

PRS 1.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI -7.2

rCSI -27.2%

PRS 1.0%
S cone cell CL0003050

CSI -6.7

rCSI -29.3%

PRS 1.8%
central nervous system neuron CL2000029

CSI -6.1

rCSI -44.7%

PRS 0.7%
rod bipolar cell CL0000751

CSI -5.8

rCSI -10.5%

PRS 1.3%
cell of skeletal muscle CL0000188

CSI -5.7

rCSI -62.3%

PRS 10.2%
mature astrocyte CL0002627

CSI -5.5

rCSI -23.1%

PRS 3.8%
invaginating midget bipolar cell CL4033034

CSI -5.2

rCSI -30.6%

PRS 3.8%
pulmonary capillary endothelial cell CL4028001

CSI -5.2

rCSI -9.8%

PRS 2.3%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -5.2

rCSI -30.3%

PRS 1.1%
regular ventricular cardiac myocyte CL0002131

CSI -5.0

rCSI -31.4%

PRS 1.2%
renal interstitial pericyte CL1001318

CSI -5.0

rCSI -13.8%

PRS 1.6%
diffuse bipolar 1 cell CL4033027

CSI -4.7

rCSI -35.6%

PRS 4.0%
starburst amacrine cell CL0004232

CSI -4.7

rCSI -39.6%

PRS 4.4%
endocrine cell CL0000163

CSI -4.5

rCSI -22.9%

PRS 6.7%
cerebellar granule cell CL0001031

CSI -3.9

rCSI -5.7%

PRS 1.6%
glycinergic amacrine cell CL4030028

CSI -3.6

rCSI -9.4%

PRS 2.3%
flat midget bipolar cell CL4033033

CSI -3.5

rCSI -24.6%

PRS 4.0%
diffuse bipolar 6 cell CL4033032

CSI -3.4

rCSI -18.0%

PRS 4.8%
cardiac endothelial cell CL0010008

CSI -3.1

rCSI -12.4%

PRS 1.8%
retinal bipolar neuron CL0000748

CSI -3.0

rCSI -5.6%

PRS 1.2%
periportal region hepatocyte CL0019026

CSI -2.7

rCSI -10.4%

PRS 2.5%
platelet CL0000233

CSI -2.6

rCSI -10.7%

PRS 4.5%
squamous epithelial cell CL0000076

CSI -1.3

rCSI -3.2%

PRS 1.9%
melanocyte of skin CL1000458

CSI -1.3

rCSI -1.8%

PRS 1.2%
diffuse bipolar 2 cell CL4033028

CSI -1.2

rCSI -9.6%

PRS 4.3%
cord blood hematopoietic stem cell CL2000095

CSI -1.2

rCSI -23.6%

PRS 12.4%
cardiac blood vessel endothelial cell CL0010006

CSI -1.2

rCSI -8.3%

PRS 5.2%
direct pathway medium spiny neuron CL4023026

CSI -1.1

rCSI -25.4%

PRS 0.8%
indirect pathway medium spiny neuron CL4023029

CSI -0.3

rCSI -8.3%

PRS 1.1%
basal cell of epidermis CL0002187

CSI -0.1

rCSI -0.2%

PRS 2.0%
endothelial cell of vascular tree CL0002139

CSI 0.4

rCSI 2.1%

PRS 3.9%
immature innate lymphoid cell CL0001082

CSI 0.5

rCSI 13.9%

PRS 27.2%
ON midget ganglion cell CL4033046

CSI 0.5

rCSI 11.1%

PRS 1.9%
diffuse bipolar 3b cell CL4033030

CSI 0.7

rCSI 4.3%

PRS 4.0%
neural cell CL0002319

CSI 1.0

rCSI 3.6%

PRS 3.4%
OFF midget ganglion cell CL4033047

CSI 1.3

rCSI 26.2%

PRS 2.1%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.4

rCSI 12.4%

PRS 4.1%
endocardial cell CL0002350

CSI 1.6

rCSI 7.7%

PRS 2.6%
cardiac muscle cell CL0000746

CSI 1.9

rCSI 2.7%

PRS 1.3%
diffuse bipolar 3a cell CL4033029

CSI 2.0

rCSI 13.6%

PRS 3.7%
kidney loop of Henle epithelial cell CL1000909

CSI 2.3

rCSI 47.4%

PRS 13.9%
primordial germ cell CL0000670

CSI 2.5

rCSI 12.5%

PRS 11.5%
GABAergic amacrine cell CL4030027

CSI 2.6

rCSI 8.8%

PRS 2.2%
fast muscle cell CL0000190

CSI 2.7

rCSI 10.4%

PRS 9.0%
tracheobronchial goblet cell CL0019003

CSI 2.7

rCSI 43.2%

PRS 36.9%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 2.9

rCSI 88.5%

PRS 20.5%
group 3 innate lymphoid cell, human CL0001078

CSI 2.9

rCSI 60.4%

PRS 28.8%
helper T cell CL0000912

CSI 2.9

rCSI 4.1%

PRS 2.3%
H2 horizontal cell CL0004218

CSI 3.0

rCSI 14.8%

PRS 3.0%
cholangiocyte CL1000488

CSI 3.0

rCSI 18.1%

PRS 3.4%
hepatic pit cell CL2000054

CSI 3.2

rCSI 44.3%

PRS 18.8%
odontoblast CL0000060

CSI 3.3

rCSI 73.6%

PRS 8.6%
professional antigen presenting cell CL0000145

CSI 3.3

rCSI 11.3%

PRS 6.5%
pluripotent stem cell CL0002248

CSI 3.3

rCSI 98.4%

PRS 3.6%
slow muscle cell CL0000189

CSI 3.3

rCSI 44.5%

PRS 20.1%
neuron CL0000540

CSI 3.4

rCSI 9.0%

PRS 2.2%
cytotoxic T cell CL0000910

CSI 3.4

rCSI 19.5%

PRS 2.3%
forebrain neuroblast CL1000042

CSI 3.6

rCSI 38.5%

PRS 22.5%
mesenchymal lymphangioblast CL0005021

CSI 3.6

rCSI 95.6%

PRS 8.3%
regular atrial cardiac myocyte CL0002129

CSI 3.7

rCSI 11.8%

PRS 1.8%
B-1 B cell CL0000819

CSI 3.8

rCSI 97.6%

PRS 9.0%
osteoblast CL0000062

CSI 3.8

rCSI 95.4%

PRS 14.3%
epithelial cell of urethra CL1000296

CSI 3.9

rCSI 97.1%

PRS 5.1%
renal intercalated cell CL0005010

CSI 3.9

rCSI 34.5%

PRS 13.9%
Merkel cell CL0000242

CSI 4.0

rCSI 92.9%

PRS 10.6%
prostate gland microvascular endothelial cell CL2000059

CSI 4.1

rCSI 96.9%

PRS 5.4%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 4.1

rCSI 43.0%

PRS 2.5%
hepatic stellate cell CL0000632

CSI 4.1

rCSI 15.3%

PRS 1.3%
retinal cone cell CL0000573

CSI 4.1

rCSI 6.6%

PRS 1.1%
kidney connecting tubule principal cell CL4030018

CSI 4.1

rCSI 29.9%

PRS 22.6%
lung microvascular endothelial cell CL2000016

CSI 4.4

rCSI 84.0%

PRS 5.2%
epithelial cell of proximal tubule segment 3 CL4030011

CSI 4.4

rCSI 34.9%

PRS 20.4%
enteric neuron CL0007011

CSI 4.6

rCSI 67.3%

PRS 4.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPS15](/details-gene/6209) is a protein-coding gene located on chromosome 19p13.3 that encodes the 40S ribosomal protein S15, a core structural component of the small ribosomal subunit. As an integral part of the cellular translation machinery, [RPS15](/details-gene/6209) plays a fundamental role in protein synthesis. Its expression profile reflects this essential function, with high significance observed in metabolically active and highly proliferative cell types, particularly within the hematopoietic and immune systems. These include various T cell subsets such as [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904)s, B cells, natural killer cells, and [hematopoietic stem cell](/details-cell/CL0000037)s. Beyond its canonical role in translation, functional annotations suggest its involvement in p53 signaling and rRNA processing, highlighting its broader role in cellular homeostasis and stress responses. ## Cellular Roles and Expression Landscape The expression landscape of [RPS15](/details-gene/6209) underscores its critical importance in cells requiring high translational capacity for growth, proliferation, and function. **Overall**, the gene shows the highest significance in a wide array of immune cells. It is a top marker in both naive and memory lymphocyte populations, including [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) (CSI: 169.33), [naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900) (CSI: 146.04), and [class switched memory B cell](/details-cell/CL0000972) (CSI: 132.45). Its high significance in progenitor cells like [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 145.27) and developing lymphocytes such as the [double negative thymocyte](/details-cell/CL0002489) (CSI: 145.34) is consistent with the extensive protein synthesis required for cell division and differentiation. This expression pattern aligns with early research characterizing its human homolog as having features of a housekeeping gene essential for cellular maintenance [Link](https://doi.org/10.1073/pnas.87.9.3594). Conversely, [RPS15](/details-gene/6209) exhibits very low significance in several terminally differentiated, non-proliferative cell types. Its expression is markedly low across numerous neuronal subtypes, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: -53.80) and [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: -46.46), as well as in structural cells like the [adipocyte](/details-cell/CL0000136) (CSI: -21.95). This contrast reinforces the conclusion that the primary role of [RPS15](/details-gene/6209) is tied to dynamic cellular processes like proliferation and robust protein secretion, rather than the maintenance of quiescent or terminally differentiated states. ## Pathways and Molecular Function The functional annotations for [RPS15](/details-gene/6209) confirm its central role in protein metabolism. As a core molecular function, it is a [structural constituent of ribosome](/details-gene/GO:0003735), located within the [cytosolic small ribosomal subunit](/details-cell/GO:0022627). This structural role is essential for the biological process of [translation](/details-gene/GO:0006412) and the biogenesis of the ribosome itself, including [ribosomal small subunit assembly](/details-gene/GO:0000028) and [rRNA processing](/details-gene/GO:0006364). These functions are reflected in numerous Reactome pathways, such as [Metabolism of proteins](/content/detail/R-HSA-392499) and the detailed steps of translation, including [Eukaryotic translation initiation](/content/detail/R-HSA-72613) ([R-HSA-72613](https://reactome.org/content/detail/R-HSA-72613)) and [Eukaryotic translation elongation](/content/detail/R-HSA-156842) ([R-HSA-156842](https://reactome.org/content/detail/R-HSA-156842)). Beyond this canonical function, [RPS15](/details-gene/6209) is implicated in cellular regulation and disease. It is annotated with functions such as [DNA binding](/details-gene/GO:0003677) and involvement in the [positive regulation of signal transduction by p53 class mediator](/details-gene/GO:1901798), suggesting a role in cellular surveillance and stress response pathways. Furthermore, its inclusion in pathways related to viral infection, such as [Sars-cov-2 modulates host translation machinery](/content/detail/R-HSA-9754678) ([R-HSA-9754678](https://reactome.org/content/detail/R-HSA-9754678)) and [Influenza infection](/content/detail/R-HSA-168255) ([R-HSA-168255](https://reactome.org/content/detail/R-HSA-168255)), highlights how this fundamental cellular component can be co-opted by pathogens to facilitate their replication. ## Research Directions The ubiquitous and essential nature of [RPS15](/details-gene/6209) makes its dysregulation a potential factor in various pathologies, particularly those characterized by altered cell growth and proliferation. **Testable Hypotheses:** 1. Given the high significance of [RPS15](/details-gene/6209) in hematopoietic stem cells and its role in ribosome biogenesis—a pathway frequently dysregulated in cancer—it is hypothesized that mutations or copy number variations in [RPS15](/details-gene/6209) could be a contributing factor in the development of myelodysplastic syndromes or acute myeloid leukemia by altering translational fidelity or capacity, thereby favoring the production of oncoproteins. 2. Considering its critical role in lymphocyte populations, it is plausible that germline mutations leading to [RPS15](/details-gene/6209) haploinsufficiency may impair immune cell development and function, leading to specific immunodeficiency syndromes. Such mutations could disrupt the rapid protein synthesis required for lymphocyte activation and clonal expansion in response to pathogens. **Proposed Experiment:** To test the first hypothesis regarding the role of [RPS15](/details-gene/6209) in hematological malignancies, one could employ a CRISPR-Cas9 based approach in a relevant cell line (e.g., K562) or primary human CD34+ cells to introduce specific mutations found in patients or to modulate its expression levels. Subsequent analysis using ribosome profiling (Ribo-seq) would reveal changes in the landscape of translated mRNAs, identifying specific oncoproteins whose synthesis is preferentially affected. In parallel, cellular assays would assess changes in proliferation, differentiation capacity, and apoptosis rates, while xenotransplantation of these engineered cells into immunocompromised mice could validate their leukemogenic potential *in vivo*. **Therapeutic Potential:** As a core component of the ribosome, [RPS15](/details-gene/6209) itself is a challenging therapeutic target for direct inhibition due to the high risk of on-target toxicity in healthy, proliferating cells. However, many cancers exhibit a dependency on elevated protein synthesis, a state known as "translation addiction." This suggests that the broader pathway of ribosome biogenesis could be a viable therapeutic avenue. Instead of directly targeting [RPS15](/details-gene/6209), therapeutic strategies might focus on inhibiting upstream regulators of ribosome production or exploiting synthetic lethal interactions in cancer cells with [RPS15](/details-gene/6209) mutations. Therefore, inhibition of the pathway, rather than direct inhibition of the protein, would be the more promising therapeutic strategy.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S15
K7ELC2_HUMAN

Genular Protein ID: 1219281666

Symbol: RS15_HUMAN

Name: 40S ribosomal protein S15

UniProtKB Accession Codes:

P62841 A5D8V9 P11174 Q3KRA1 Q9UDC2

Database IDs:

Citations:

PubMed ID: 2821540

Title: Evolutionary conservation of the insulinoma gene rig and its possible function.

PubMed ID: 2821540

DOI: 10.1073/pnas.84.19.6659

PubMed ID: 2159154

Title: Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes.

PubMed ID: 2159154

DOI: 10.1073/pnas.87.9.3594

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1466847

Title: Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid.

PubMed ID: 1466847

DOI: 10.1097/00002030-199210000-00014

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 145
Mass: 17040
Checksum: CA2C682302C7B387
Sequence:

MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL 
RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS 
ITYKPVKHGR PGIGATHSSR FIPLK

Genular Protein ID: 1216274165

Symbol: K7ELC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ELC2

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

Length: 152
Mass: 17723
Checksum: B6EB15A24C6623B0
Sequence:

MLGRGADLAE VEQKKKRTFR KFTYRGVDLD QLLDMSYEQL MQLYSARQRR RLNRGLRRKQ 
HSLLKRLRKA KKEAPPMEKP EVVKTHLRDM IILPEMVGSM VGVYNGKTFN QVEIKPEMIG 
HYLGEFSITY KPVKHGRPGI GATHSSRFIP LK

Details for: RPS15

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Evolutionary conservation of the insulinoma gene rig and its possible function. PubMed ID: 2821540

Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes. PubMed ID: 2159154

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid. PubMed ID: 1466847

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

PubMed ID: 2821540

PubMed ID: 2159154

PubMed ID: 15489334

PubMed ID: 1466847

PubMed ID: 8706699

PubMed ID: 14654843

PubMed ID: 19413330

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 24524803

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 28112733

PubMed ID: 23636399

PubMed ID: 11237011

PubMed ID: 15057824

PubMed ID: 15496913

PubMed ID: 19413330

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 28112733