Details for: RPS15

Gene ID: 6209

Symbol: RPS15

Ensembl ID: ENSG00000115268

Description: ribosomal protein S15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 753.6395
    Cell Significance Index: -310.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 621.0886
    Cell Significance Index: -293.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 618.0970
    Cell Significance Index: -317.9400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 439.0764
    Cell Significance Index: -294.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.2198
    Cell Significance Index: -91.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 19.2815
    Cell Significance Index: 492.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.7022
    Cell Significance Index: 1706.1300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 16.5548
    Cell Significance Index: 97.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.9802
    Cell Significance Index: 400.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.5535
    Cell Significance Index: 637.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 13.1565
    Cell Significance Index: 345.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.7791
    Cell Significance Index: 308.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.4101
    Cell Significance Index: 217.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.3920
    Cell Significance Index: 183.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.7531
    Cell Significance Index: 1260.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 9.2549
    Cell Significance Index: 118.5300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.2482
    Cell Significance Index: 56.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.9797
    Cell Significance Index: 1104.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.9445
    Cell Significance Index: 632.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.8766
    Cell Significance Index: 1600.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.8340
    Cell Significance Index: 658.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.8146
    Cell Significance Index: 1210.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.6555
    Cell Significance Index: 98.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.6424
    Cell Significance Index: 453.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.1545
    Cell Significance Index: 3605.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.0637
    Cell Significance Index: 1033.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.8916
    Cell Significance Index: 274.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.8679
    Cell Significance Index: 927.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.6807
    Cell Significance Index: 177.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.6510
    Cell Significance Index: 4178.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.4896
    Cell Significance Index: 349.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.0129
    Cell Significance Index: 76.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.6681
    Cell Significance Index: 181.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.6332
    Cell Significance Index: 122.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.3228
    Cell Significance Index: 407.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.7456
    Cell Significance Index: 810.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.4830
    Cell Significance Index: 131.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.8869
    Cell Significance Index: 176.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.1477
    Cell Significance Index: 2382.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0868
    Cell Significance Index: 28.4300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.0804
    Cell Significance Index: 26.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.9922
    Cell Significance Index: 2701.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.5823
    Cell Significance Index: 68.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3001
    Cell Significance Index: 456.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2314
    Cell Significance Index: 234.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.0445
    Cell Significance Index: 765.8600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.8103
    Cell Significance Index: 16.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7479
    Cell Significance Index: 38.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2768
    Cell Significance Index: 27.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2674
    Cell Significance Index: 53.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2289
    Cell Significance Index: 1.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0559
    Cell Significance Index: -105.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1118
    Cell Significance Index: -40.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1125
    Cell Significance Index: -83.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1647
    Cell Significance Index: -10.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1760
    Cell Significance Index: -324.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2084
    Cell Significance Index: -320.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2437
    Cell Significance Index: -137.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2627
    Cell Significance Index: -357.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2827
    Cell Significance Index: -22.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3228
    Cell Significance Index: -201.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3859
    Cell Significance Index: -245.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5790
    Cell Significance Index: -262.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6395
    Cell Significance Index: -134.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8116
    Cell Significance Index: -233.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.1714
    Cell Significance Index: -190.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.3225
    Cell Significance Index: -151.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3857
    Cell Significance Index: -95.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4045
    Cell Significance Index: -88.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4270
    Cell Significance Index: -24.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5292
    Cell Significance Index: -85.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8460
    Cell Significance Index: -268.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.8976
    Cell Significance Index: -113.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.0226
    Cell Significance Index: -12.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.2288
    Cell Significance Index: -254.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2592
    Cell Significance Index: -37.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.6427
    Cell Significance Index: -66.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7695
    Cell Significance Index: -288.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.9231
    Cell Significance Index: -43.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.9628
    Cell Significance Index: -94.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.5196
    Cell Significance Index: -48.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.5589
    Cell Significance Index: -60.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.7716
    Cell Significance Index: -81.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.8400
    Cell Significance Index: -258.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.8902
    Cell Significance Index: -298.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.9008
    Cell Significance Index: -137.0700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -3.9289
    Cell Significance Index: -10.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.0893
    Cell Significance Index: -250.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.2220
    Cell Significance Index: -62.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.8917
    Cell Significance Index: -173.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.9620
    Cell Significance Index: -32.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.5766
    Cell Significance Index: -189.4900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -7.1706
    Cell Significance Index: -55.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -7.2282
    Cell Significance Index: -93.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.3756
    Cell Significance Index: -326.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.4150
    Cell Significance Index: -272.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -7.5772
    Cell Significance Index: -114.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -8.2020
    Cell Significance Index: -210.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -8.2025
    Cell Significance Index: -268.5500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -8.3206
    Cell Significance Index: -51.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPS15 is a highly conserved protein, with high sequence similarity across species, suggesting its evolutionary importance. It is one of the 40S ribosomal proteins, which form the small subunit of the eukaryotic ribosome. RPS15 is characterized by its ability to bind to the mRNA cap-binding complex and eIFs, facilitating the recruitment of the 40S subunit to the mRNA. This interaction is essential for the initiation of translation, as it enables the scanning of the mRNA for the start codon. **Pathways and Functions:** RPS15 is involved in various cellular processes, including: 1. **Translation initiation:** RPS15 plays a critical role in the initiation of translation, binding to the mRNA cap-binding complex and eIFs to facilitate the recruitment of the 40S subunit. 2. **Stress response:** RPS15 is upregulated in response to stress conditions, such as amino acid deficiency, promoting the translation of stress-responsive genes. 3. **Immune regulation:** RPS15 is expressed in immune cells, including natural T-regulatory cells and CD8-positive T cells, suggesting its involvement in immune responses. 4. **Viral infection:** RPS15 has been shown to interact with viral RNAs, modulating the host translation machinery to facilitate viral replication. 5. **Cellular response to starvation:** RPS15 is upregulated in response to starvation, promoting the translation of genes involved in energy metabolism. **Clinical Significance:** Dysregulation of RPS15 has been implicated in various diseases, including: 1. **Influenza infection:** RPS15 has been shown to interact with influenza viral RNAs, modulating the host translation machinery to facilitate viral replication. 2. **Cancer:** RPS15 is overexpressed in various types of cancer, including breast and lung cancer, suggesting its involvement in tumorigenesis. 3. **Neurological disorders:** RPS15 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of protein synthesis. In conclusion, RPS15 is a multifunctional protein that plays a critical role in eukaryotic translation, immune regulation, and stress response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying RPS15 function and its clinical significance.

Genular Protein ID: 1219281666

Symbol: RS15_HUMAN

Name: 40S ribosomal protein S15

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2821540

Title: Evolutionary conservation of the insulinoma gene rig and its possible function.

PubMed ID: 2821540

DOI: 10.1073/pnas.84.19.6659

PubMed ID: 2159154

Title: Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes.

PubMed ID: 2159154

DOI: 10.1073/pnas.87.9.3594

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1466847

Title: Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid.

PubMed ID: 1466847

DOI: 10.1097/00002030-199210000-00014

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 145
  • Mass: 17040
  • Checksum: CA2C682302C7B387
  • Sequence:
  • MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL 
    RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK TFNQVEIKPE MIGHYLGEFS 
    ITYKPVKHGR PGIGATHSSR FIPLK

Genular Protein ID: 1216274165

Symbol: K7ELC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 152
  • Mass: 17723
  • Checksum: B6EB15A24C6623B0
  • Sequence:
  • MLGRGADLAE VEQKKKRTFR KFTYRGVDLD QLLDMSYEQL MQLYSARQRR RLNRGLRRKQ 
    HSLLKRLRKA KKEAPPMEKP EVVKTHLRDM IILPEMVGSM VGVYNGKTFN QVEIKPEMIG 
    HYLGEFSITY KPVKHGRPGI GATHSSRFIP LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.