RPS17 | ENSG00000182774 | NCBI 6218

Details for: RPS17

Gene ID: 6218

Symbol: RPS17

Ensembl ID: ENSG00000182774

Description: ribosomal protein S17

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Erythrocyte homeostasis
(GO:0034101)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 312.2970
Cell Significance Index: -128.6500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 265.6725
Cell Significance Index: -125.4300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 252.4470
Cell Significance Index: -129.8600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 188.8909
Cell Significance Index: -126.7500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 46.3070
Cell Significance Index: -124.0500
Cell Name: theca cell (CL0000503)
Fold Change: 35.0773
Cell Significance Index: 206.0800
Cell Name: pro-T cell (CL0000827)
Fold Change: 24.0011
Cell Significance Index: 613.1500
Cell Name: kidney cell (CL1000497)
Fold Change: 21.8856
Cell Significance Index: 174.7400
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 21.6630
Cell Significance Index: 186.1500
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 20.8963
Cell Significance Index: 150.0800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 15.9798
Cell Significance Index: 398.4900
Cell Name: abnormal cell (CL0001061)
Fold Change: 15.9201
Cell Significance Index: 1626.2400
Cell Name: thymocyte (CL0000893)
Fold Change: 13.4101
Cell Significance Index: 169.4400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 12.8764
Cell Significance Index: 447.4500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 10.5034
Cell Significance Index: 64.6400
Cell Name: peg cell (CL4033014)
Fold Change: 10.0189
Cell Significance Index: 231.4700
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 9.2998
Cell Significance Index: 164.3400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 9.2435
Cell Significance Index: 105.0100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 8.2906
Cell Significance Index: 90.1300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 7.6526
Cell Significance Index: 70.4700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 7.3430
Cell Significance Index: 153.7000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 7.2976
Cell Significance Index: 1315.5300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 7.1786
Cell Significance Index: 882.6800
Cell Name: odontoblast (CL0000060)
Fold Change: 7.0924
Cell Significance Index: 909.2000
Cell Name: lactocyte (CL0002325)
Fold Change: 6.5566
Cell Significance Index: 847.0700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 6.4386
Cell Significance Index: 884.2000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 6.0508
Cell Significance Index: 450.9600
Cell Name: cell in vitro (CL0001034)
Fold Change: 5.6121
Cell Significance Index: 3064.8900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 4.2922
Cell Significance Index: 3248.8700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.1158
Cell Significance Index: 193.4400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.0360
Cell Significance Index: 188.1800
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 3.9423
Cell Significance Index: 17.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.5775
Cell Significance Index: 187.8300
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.4336
Cell Significance Index: 90.2900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.9592
Cell Significance Index: 209.2900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.8449
Cell Significance Index: 81.5500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.4666
Cell Significance Index: 1090.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.1314
Cell Significance Index: 251.3600
Cell Name: perivascular cell (CL4033054)
Fold Change: 1.8907
Cell Significance Index: 8.7300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.7840
Cell Significance Index: 51.4000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4269
Cell Significance Index: 38.8400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3457
Cell Significance Index: 256.1000
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.2076
Cell Significance Index: 7.1300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.1376
Cell Significance Index: 63.8400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9798
Cell Significance Index: 884.7000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9283
Cell Significance Index: 100.9700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7357
Cell Significance Index: 72.7800
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.6137
Cell Significance Index: 10.5800
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.5810
Cell Significance Index: 3.6100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1565
Cell Significance Index: 4.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1255
Cell Significance Index: 8.1000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1060
Cell Significance Index: 17.2400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0596
Cell Significance Index: 2.7000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0447
Cell Significance Index: 1.5700
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.0313
Cell Significance Index: 0.2900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0009
Cell Significance Index: 0.0600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0151
Cell Significance Index: -3.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0485
Cell Significance Index: -17.3900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0628
Cell Significance Index: -118.2000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0701
Cell Significance Index: -129.2800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0849
Cell Significance Index: -130.7200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0986
Cell Significance Index: -134.1400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1262
Cell Significance Index: -92.5100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1374
Cell Significance Index: -101.7500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1653
Cell Significance Index: -28.2200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1755
Cell Significance Index: -98.9500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1909
Cell Significance Index: -121.2700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2209
Cell Significance Index: -137.9200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2235
Cell Significance Index: -11.2900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2523
Cell Significance Index: -3.7800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2775
Cell Significance Index: -125.9500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2855
Cell Significance Index: -1.7300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3138
Cell Significance Index: -10.0500
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.3148
Cell Significance Index: -62.4800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3317
Cell Significance Index: -13.5900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4934
Cell Significance Index: -25.6300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5774
Cell Significance Index: -66.1500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5979
Cell Significance Index: -125.9300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6025
Cell Significance Index: -8.2200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6118
Cell Significance Index: -38.5600
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.6614
Cell Significance Index: -2.5300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6877
Cell Significance Index: -17.1900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.8488
Cell Significance Index: -123.3900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.9131
Cell Significance Index: -13.7600
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -1.0357
Cell Significance Index: -6.4100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.0687
Cell Significance Index: -23.4000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1850
Cell Significance Index: -123.3900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.3990
Cell Significance Index: -110.8000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.4326
Cell Significance Index: -24.5500
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.4354
Cell Significance Index: -28.0200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4652
Cell Significance Index: -89.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4884
Cell Significance Index: -114.2200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.5285
Cell Significance Index: -45.0200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.8406
Cell Significance Index: -39.2000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.8569
Cell Significance Index: -34.3200
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -1.9944
Cell Significance Index: -22.1800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.0263
Cell Significance Index: -43.9000
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -2.1766
Cell Significance Index: -28.0300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.4367
Cell Significance Index: -89.4500
Cell Name: enteric neuron (CL0007011)
Fold Change: -2.4666
Cell Significance Index: -17.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RPS17 is a highly conserved protein, present in all eukaryotic cells. It is a small ribosomal protein (sRP) that is essential for the assembly and function of the 40S subunit. RPS17 is composed of 102 amino acids and is highly expressed in various cell types, including professional antigen-presenting cells, epithelial cells, and hematopoietic stem cells. The protein is characterized by its ability to bind to mRNA and facilitate translation initiation. **Pathways and Functions** RPS17 is involved in various cellular processes, including: 1. **Translation initiation**: RPS17 plays a crucial role in the initiation of translation, binding to mRNA and facilitating the recruitment of the 40S subunit to the start codon. 2. **mRNA processing**: RPS17 is involved in the processing of mRNA, including the recognition of start codons and the recruitment of ribosomes. 3. **Cytoplasmic translation**: RPS17 is essential for the translation of proteins in the cytoplasm, where it interacts with other ribosomal proteins and translation factors. 4. **Regulation of protein synthesis**: RPS17 is involved in the regulation of protein synthesis, including the modulation of translation initiation and elongation. **Clinical Significance** RPS17 has been implicated in various diseases, including: 1. **Influenza infection**: RPS17 has been shown to be involved in the translation of influenza virus mRNA, highlighting its potential role in viral infection. 2. **SARS-CoV-2 infection**: Similar to influenza, RPS17 has been implicated in the translation of SARS-CoV-2 mRNA, suggesting its potential role in viral infection. 3. **Neurodegenerative diseases**: RPS17 has been associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 4. **Cancer**: RPS17 has been implicated in cancer, where it is involved in the regulation of protein synthesis and the promotion of tumorigenesis. In conclusion, RPS17 is a critical component of the 40S small ribosomal subunit, playing a pivotal role in translation initiation, mRNA processing, and cytoplasmic translation. Its involvement in various diseases highlights its potential as a therapeutic target and underscores the importance of understanding its mechanisms of action. **Implications for Immunology** As an expert immunologist, I would like to highlight the significance of RPS17 in the context of immunology. RPS17 is involved in the translation of proteins that are essential for immune function, including cytokines and chemokines. Alterations in RPS17 expression or function could impact immune response, potentially leading to immunodeficiency or autoimmunity. Further research on RPS17 is necessary to understand its role in immune function and to explore its potential as a therapeutic target for immunological disorders. **Future Directions** Future studies should aim to: 1. **Investigate the role of RPS17 in viral infections**: Further research is needed to understand the mechanisms by which RPS17 facilitates viral translation and to explore its potential as a therapeutic target for viral infections. 2. **Elucidate the mechanisms of RPS17 regulation**: Understanding the mechanisms by which RPS17 is regulated will provide insights into its role in translation initiation and elongation. 3. **Explore the therapeutic potential of RPS17**: RPS17 has been implicated in various diseases, and further research is needed to explore its potential as a therapeutic target. In conclusion, RPS17 is a critical component of the 40S small ribosomal subunit, playing a pivotal role in translation initiation, mRNA processing, and cytoplasmic translation. Its involvement in various diseases highlights its potential as a therapeutic target and underscores the importance of understanding its mechanisms of action.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RS17_HUMAN

Genular Protein ID: 1985324850

Symbol: RS17_HUMAN

Name: N/A

UniProtKB Accession Codes:

P08708 B2R4U4 P0CW22

Database IDs:

Citations:

PubMed ID: 3529092

Title: Homologous ribosomal proteins in bacteria, yeast, and humans.

PubMed ID: 3529092

DOI: 10.1073/pnas.83.18.6907

PubMed ID: 3240863

Title: The transcriptionally active human ribosomal protein S17 gene.

PubMed ID: 3240863

DOI: 10.1016/0378-1119(88)90109-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 17647292

Title: Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia.

PubMed ID: 17647292

DOI: 10.1002/humu.20608

PubMed ID: 19061985

Title: Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients.

PubMed ID: 19061985

DOI: 10.1016/j.ajhg.2008.11.004

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 135
Mass: 15550
Checksum: 299AD605C5401325
Sequence:

MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR 
IQRGPVRGIS IKLQEEERER RDNYVPEVSA LDQEIIEVDP DTKEMLKLLD FGSLSNLQVT 
QPTVGMNFKT PRGPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS17

Associated with

Cells (max top 100)

Other Information

Homologous ribosomal proteins in bacteria, yeast, and humans. PubMed ID: 3529092

The transcriptionally active human ribosomal protein S17 gene. PubMed ID: 3240863

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. PubMed ID: 17647292

Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. PubMed ID: 19061985

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797