RPS17 | ENSG00000182774 | NCBI 6218

Details for: RPS17

Gene ID: 6218

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPS17

Ensembl ID: ENSG00000182774

Description: ribosomal protein S17

Cell Significance Landscape

Display Count:

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Erythrocyte homeostasis
(GO:0034101)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

T-helper 17 cell CL0000899

CSI 63.01

rCSI 50.03%

PRS 17.39
CD4-positive, alpha-beta thymocyte CL0000810

CSI 61.87

rCSI 49.56%

PRS 17.96
common myeloid progenitor CL0000049

CSI 54.93

rCSI 44.42%

PRS 9.77
early lymphoid progenitor CL0000936

CSI 44.1

rCSI 38.73%

PRS 11.12
granulocyte monocyte progenitor cell CL0000557

CSI 42.63

rCSI 36.91%

PRS 11.01
CD4-positive, alpha-beta memory T cell CL0000897

CSI 41.6

rCSI 29.86%

PRS 13.45
megakaryocyte-erythroid progenitor cell CL0000050

CSI 39.05

rCSI 35.27%

PRS 8.75
pancreatic D cell CL0000173

CSI 38.52

rCSI 37.88%

PRS 10.76
pancreatic A cell CL0000171

CSI 32.6

rCSI 34.16%

PRS 10.55
mucosal invariant T cell CL0000940

CSI 32.44

rCSI 26.21%

PRS 17.87
kidney epithelial cell CL0002518

CSI 32.04

rCSI 61.16%

PRS 23.56
T-helper 1 cell CL0000545

CSI 31.51

rCSI 56.88%

PRS 27.33
CD14-low, CD16-positive monocyte CL0002396

CSI 31.05

rCSI 23.93%

PRS 8.95
colon goblet cell CL0009039

CSI 30.8

rCSI 73.22%

PRS 14.86
extravillous trophoblast CL0008036

CSI 30.06

rCSI 37.19%

PRS 8.68
common dendritic progenitor CL0001029

CSI 29.27

rCSI 36.73%

PRS 12.63
keratinocyte CL0000312

CSI 27.81

rCSI 23.32%

PRS 11.84
placental villous trophoblast CL2000060

CSI 27.47

rCSI 42.45%

PRS 9.27
hematopoietic stem cell CL0000037

CSI 27.06

rCSI 17.99%

PRS 11.8
CD1c-positive myeloid dendritic cell CL0002399

CSI 26.8

rCSI 32.37%

PRS 11.63
promyelocyte CL0000836

CSI 26.76

rCSI 38.6%

PRS 13.79
transit amplifying cell of colon CL0009011

CSI 26.45

rCSI 31.07%

PRS 11.72
enterocyte CL0000584

CSI 25.09

rCSI 40.46%

PRS 15.83
perivascular cell CL4033054

CSI 24.01

rCSI 32.82%

PRS 11.23
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 23.2

rCSI 16.29%

PRS 26.92
basal cell of prostate epithelium CL0002341

CSI 22.94

rCSI 66.36%

PRS 22.15
promonocyte CL0000559

CSI 22.65

rCSI 38.81%

PRS 13.26
conventional dendritic cell CL0000990

CSI 22.47

rCSI 18.76%

PRS 30.01
plasmablast CL0000980

CSI 22.46

rCSI 17.67%

PRS 11.75
neural crest cell CL0011012

CSI 22

rCSI 17.39%

PRS 6.81
immature B cell CL0000816

CSI 21.35

rCSI 15.86%

PRS 14.75
ciliated epithelial cell CL0000067

CSI 21.23

rCSI 18.67%

PRS 7.18
fraction A pre-pro B cell CL0002045

CSI 21.06

rCSI 24.11%

PRS 20.37
CD8-positive, alpha-beta thymocyte CL0000811

CSI 20.97

rCSI 32.7%

PRS 24.23
memory B cell CL0000787

CSI 20.46

rCSI 20.21%

PRS 39.41
stromal cell of ovary CL0002132

CSI 19.81

rCSI 54.43%

PRS 16.43
naive B cell CL0000788

CSI 19.67

rCSI 16.87%

PRS 19.02
pro-B cell CL0000826

CSI 18.75

rCSI 15.53%

PRS 9.9
follicular B cell CL0000843

CSI 18.2

rCSI 66.17%

PRS 40.34
interneuron CL0000099

CSI 17.74

rCSI 35.61%

PRS 7.32
type B pancreatic cell CL0000169

CSI 17.36

rCSI 38.44%

PRS 9.18
precursor B cell CL0000817

CSI 16.9

rCSI 14.8%

PRS 13.19
group 3 innate lymphoid cell CL0001071

CSI 16.85

rCSI 12.66%

PRS 10.23
radial glial cell CL0000681

CSI 16.77

rCSI 23.3%

PRS 10.22
CD8-positive, alpha-beta memory T cell CL0000909

CSI 16.71

rCSI 17.45%

PRS 30.44
CD14-positive, CD16-positive monocyte CL0002397

CSI 15.99

rCSI 20.95%

PRS 13.85
conjunctival epithelial cell CL1000432

CSI 15.72

rCSI 24.01%

PRS 9.91
Hofbauer cell CL3000001

CSI 15.67

rCSI 29.59%

PRS 12.28
OFF-bipolar cell CL0000750

CSI 15.56

rCSI 21.27%

PRS 16.58
unswitched memory B cell CL0000970

CSI 15.55

rCSI 13.08%

PRS 16.19
mammary gland epithelial cell CL0002327

CSI 15.16

rCSI 53.18%

PRS 17.94
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 15.12

rCSI 11.34%

PRS 28.65
fibroblast of lung CL0002553

CSI 15.1

rCSI 14.05%

PRS 9.96
epithelial cell CL0000066

CSI 15.08

rCSI 23.18%

PRS 14.14
effector CD8-positive, alpha-beta T cell CL0001050

CSI 14.92

rCSI 11.35%

PRS 12.97
melanocyte CL0000148

CSI 14.73

rCSI 10.91%

PRS 8.89
CD4-positive helper T cell CL0000492

CSI 14.55

rCSI 11.01%

PRS 13.74
mesodermal cell CL0000222

CSI 14.55

rCSI 17.47%

PRS 9.77
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 14.55

rCSI 18.28%

PRS 45.43
mature NK T cell CL0000814

CSI 14.53

rCSI 18.59%

PRS 41.2
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 14.46

rCSI 9.63%

PRS 26.42
dendritic cell CL0000451

CSI 14.13

rCSI 17.41%

PRS 32.34
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 14.05

rCSI 19.91%

PRS 9.28
capillary endothelial cell CL0002144

CSI 13.79

rCSI 25.27%

PRS 45.76
small intestine goblet cell CL1000495

CSI 13.78

rCSI 30.19%

PRS 13.32
ON-bipolar cell CL0000749

CSI 13.58

rCSI 20.19%

PRS 12.2
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 13.51

rCSI 7.98%

PRS 13.65
B cell CL0000236

CSI 13.41

rCSI 17.95%

PRS 44.04
CD14-positive monocyte CL0001054

CSI 13.34

rCSI 16.61%

PRS 14.18
colon epithelial cell CL0011108

CSI 13.07

rCSI 13.69%

PRS 9.2
plasmacytoid dendritic cell CL0000784

CSI 12.99

rCSI 13.16%

PRS 53.33
class switched memory B cell CL0000972

CSI 12.69

rCSI 9.47%

PRS 16.66
pancreatic ductal cell CL0002079

CSI 12.62

rCSI 24.54%

PRS 10.08
activated CD8-positive, alpha-beta T cell CL0000906

CSI 12.57

rCSI 12.35%

PRS 28.64
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 12.46

rCSI 16.97%

PRS 24.13
Schwann cell CL0002573

CSI 12.43

rCSI 35.34%

PRS 12.22
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 12.4

rCSI 14.32%

PRS 8.75
transit amplifying cell CL0009010

CSI 12.4

rCSI 18.96%

PRS 16.07
enteroendocrine cell of colon CL0009042

CSI 12.32

rCSI 57.78%

PRS 26.78
deuterosomal cell CL4033044

CSI 12.27

rCSI 41.47%

PRS 16.84
professional antigen presenting cell CL0000145

CSI 12.15

rCSI 41.84%

PRS 38.77
gamma-delta T cell CL0000798

CSI 12.1

rCSI 14.21%

PRS 62.23
renal interstitial pericyte CL1001318

CSI 12.04

rCSI 33.19%

PRS 9.59
blood vessel endothelial cell CL0000071

CSI 11.97

rCSI 24.84%

PRS 9.86
fallopian tube secretory epithelial cell CL4030006

CSI 11.97

rCSI 11.52%

PRS 10.21
pancreatic acinar cell CL0002064

CSI 11.97

rCSI 15.91%

PRS 10.78
retinal blood vessel endothelial cell CL0002585

CSI 11.9

rCSI 19%

PRS 10.78
mononuclear phagocyte CL0000113

CSI 11.84

rCSI 26.07%

PRS 10.89
erythrocyte CL0000232

CSI 11.28

rCSI 25.6%

PRS 13.82
endocrine cell CL0000163

CSI 11.09

rCSI 56.87%

PRS 41.17
choroid plexus epithelial cell CL0000706

CSI 10.94

rCSI 17.91%

PRS 7.68
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 10.71

rCSI 7.21%

PRS 11.86
neuroblast (sensu Vertebrata) CL0000031

CSI 10.61

rCSI 13.62%

PRS 9.62
retina horizontal cell CL0000745

CSI 10.33

rCSI 15.75%

PRS 9.27
hematopoietic precursor cell CL0008001

CSI 10.13

rCSI 10.42%

PRS 16.08
M cell of gut CL0000682

CSI 9.91

rCSI 10.53%

PRS 17.6
plasmacytoid dendritic cell, human CL0001058

CSI 9.89

rCSI 6.91%

PRS 10.43
T follicular helper cell CL0002038

CSI 9.87

rCSI 7.39%

PRS 16.06
inflammatory macrophage CL0000863

CSI 9.86

rCSI 16.84%

PRS 20.12
memory T cell CL0000813

CSI 9.86

rCSI 18.99%

PRS 22.24

pulmonary capillary endothelial cell CL4028001

CSI -18.4

rCSI -35.1%

PRS 15.9%
kidney interstitial alternatively activated macrophage CL1000695

CSI -17.3

rCSI -45.0%

PRS 9.7%
squamous epithelial cell CL0000076

CSI -4.2

rCSI -10.1%

PRS 12.7%
alpha-beta T cell CL0000789

CSI -2.8

rCSI -3.2%

PRS 13.9%
diffuse bipolar 2 cell CL4033028

CSI -1.8

rCSI -14.2%

PRS 10.6%
rod bipolar cell CL0000751

CSI -1.7

rCSI -3.0%

PRS 8.3%
kidney distal convoluted tubule epithelial cell CL1000849

CSI -0.3

rCSI -3.6%

PRS 14.5%
B-1 B cell CL0000819

CSI 0.1

rCSI 2.4%

PRS 48.8%
platelet CL0000233

CSI 0.3

rCSI 1.1%

PRS 23.1%
tracheal goblet cell CL1000329

CSI 0.3

rCSI 0.6%

PRS 20.1%
kidney interstitial cell CL1000500

CSI 0.3

rCSI 5.0%

PRS 59.6%
myeloid leukocyte CL0000766

CSI 0.5

rCSI 0.5%

PRS 10.0%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.5

rCSI 2.8%

PRS 40.1%
immature alpha-beta T cell CL0000790

CSI 0.5

rCSI 7.5%

PRS 79.5%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 0.5

rCSI 4.5%

PRS 19.5%
endothelial cell of arteriole CL1000412

CSI 0.7

rCSI 3.7%

PRS 32.7%
endothelial cell of venule CL1000414

CSI 0.7

rCSI 6.1%

PRS 43.1%
group 3 innate lymphoid cell, human CL0001078

CSI 0.7

rCSI 15.3%

PRS 82.5%
endothelial cell of uterus CL0009095

CSI 0.8

rCSI 5.6%

PRS 27.2%
B-2 B cell CL0000822

CSI 0.9

rCSI 18.2%

PRS 52.0%
glycinergic amacrine cell CL4030028

CSI 0.9

rCSI 2.2%

PRS 10.2%
fibroblast of breast CL4006000

CSI 0.9

rCSI 3.8%

PRS 26.0%
hepatocyte CL0000182

CSI 0.9

rCSI 1.6%

PRS 9.3%
amacrine cell CL0000561

CSI 0.9

rCSI 2.6%

PRS 8.0%
respiratory epithelial cell CL0002368

CSI 0.9

rCSI 5.7%

PRS 32.4%
syncytiotrophoblast cell CL0000525

CSI 0.9

rCSI 2.7%

PRS 19.5%
lung microvascular endothelial cell CL2000016

CSI 1.0

rCSI 19.3%

PRS 32.5%
epithelial cell of lung CL0000082

CSI 1.0

rCSI 0.8%

PRS 9.4%
cardiac muscle cell CL0000746

CSI 1.0

rCSI 1.5%

PRS 7.9%
intestinal epithelial cell CL0002563

CSI 1.1

rCSI 1.1%

PRS 10.5%
lung macrophage CL1001603

CSI 1.1

rCSI 2.4%

PRS 11.2%
bronchiolar smooth muscle cell CL4033017

CSI 1.2

rCSI 18.0%

PRS 31.8%
cytotoxic T cell CL0000910

CSI 1.3

rCSI 7.3%

PRS 14.6%
neural progenitor cell CL0011020

CSI 1.3

rCSI 5.9%

PRS 9.8%
collagen secreting cell CL0000667

CSI 1.4

rCSI 7.8%

PRS 38.3%
transitional stage B cell CL0000818

CSI 1.4

rCSI 4.4%

PRS 28.9%
enterocyte of epithelium of large intestine CL0002071

CSI 1.4

rCSI 7.6%

PRS 18.2%
osteoblast CL0000062

CSI 1.5

rCSI 36.4%

PRS 66.4%
mucus secreting cell CL0000319

CSI 1.5

rCSI 2.4%

PRS 12.8%
BEST4+ enteroycte CL4030026

CSI 1.5

rCSI 1.9%

PRS 10.5%
blood vessel smooth muscle cell CL0019018

CSI 1.6

rCSI 12.7%

PRS 10.3%
decidual natural killer cell, human CL0002343

CSI 1.6

rCSI 16.3%

PRS 62.8%
uterine smooth muscle cell CL0002601

CSI 1.6

rCSI 10.8%

PRS 57.1%
retinal cone cell CL0000573

CSI 1.6

rCSI 2.6%

PRS 7.6%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 1.7

rCSI 19.1%

PRS 38.7%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 1.7

rCSI 7.5%

PRS 35.6%
kidney connecting tubule epithelial cell CL1000768

CSI 1.7

rCSI 4.2%

PRS 7.6%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 1.7

rCSI 10.2%

PRS 22.3%
diffuse bipolar 3b cell CL4033030

CSI 1.7

rCSI 11.5%

PRS 10.8%
mature alpha-beta T cell CL0000791

CSI 1.7

rCSI 6.3%

PRS 17.0%
centrilobular region hepatocyte CL0019029

CSI 1.7

rCSI 4.5%

PRS 16.5%
enteric smooth muscle cell CL0002504

CSI 1.8

rCSI 2.5%

PRS 11.2%
late pro-B cell CL0002048

CSI 1.8

rCSI 4.6%

PRS 30.3%
mesenchymal stem cell CL0000134

CSI 1.9

rCSI 20.8%

PRS 18.0%
cord blood hematopoietic stem cell CL2000095

CSI 1.9

rCSI 36.8%

PRS 62.3%
multi-ciliated epithelial cell CL0005012

CSI 2.0

rCSI 2.0%

PRS 8.5%
renal beta-intercalated cell CL0002201

CSI 2.1

rCSI 4.9%

PRS 12.2%
mesenchymal lymphangioblast CL0005021

CSI 2.1

rCSI 54.7%

PRS 47.4%
parietal cell CL0000162

CSI 2.2

rCSI 18.6%

PRS 52.6%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 2.2

rCSI 5.8%

PRS 28.3%
cerebellar granule cell CL0001031

CSI 2.3

rCSI 3.4%

PRS 9.3%
basal cell of epithelium of trachea CL1000348

CSI 2.3

rCSI 16.4%

PRS 31.0%
pulmonary artery endothelial cell CL1001568

CSI 2.3

rCSI 3.2%

PRS 15.2%
mesenchymal cell CL0008019

CSI 2.5

rCSI 6.2%

PRS 10.0%
renal principal cell CL0005009

CSI 2.5

rCSI 6.4%

PRS 13.7%
epithelial cell of esophagus CL0002252

CSI 2.5

rCSI 24.5%

PRS 36.4%
P/D1 enteroendocrine cell CL0002268

CSI 2.5

rCSI 13.5%

PRS 24.9%
odontoblast CL0000060

CSI 2.5

rCSI 56.8%

PRS 46.1%
myeloid dendritic cell, human CL0001057

CSI 2.5

rCSI 14.2%

PRS 31.4%
double-positive, alpha-beta thymocyte CL0000809

CSI 2.5

rCSI 2.6%

PRS 14.1%
lung neuroendocrine cell CL1000223

CSI 2.5

rCSI 3.8%

PRS 11.3%
peptic cell CL0000155

CSI 2.5

rCSI 25.0%

PRS 30.0%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.6

rCSI 12.9%

PRS 12.9%
eosinophil CL0000771

CSI 2.6

rCSI 17.0%

PRS 25.8%
enteroendocrine cell of small intestine CL0009006

CSI 2.6

rCSI 5.8%

PRS 15.1%
Langerhans cell CL0000453

CSI 2.6

rCSI 4.0%

PRS 17.3%
duct epithelial cell CL0000068

CSI 2.7

rCSI 3.9%

PRS 10.5%
enterocyte of epithelium of small intestine CL1000334

CSI 2.7

rCSI 41.1%

PRS 24.7%
retinal rod cell CL0000604

CSI 2.7

rCSI 4.7%

PRS 10.0%
glutamatergic neuron CL0000679

CSI 2.9

rCSI 5.9%

PRS 10.2%
Bergmann glial cell CL0000644

CSI 2.9

rCSI 4.0%

PRS 10.3%
endocardial cell CL0002350

CSI 3.0

rCSI 14.1%

PRS 13.5%
regular atrial cardiac myocyte CL0002129

CSI 3.0

rCSI 9.7%

PRS 11.0%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 3.1

rCSI 6.9%

PRS 10.4%
epithelial cell of urethra CL1000296

CSI 3.1

rCSI 78.3%

PRS 32.8%
hair follicular keratinocyte CL2000092

CSI 3.1

rCSI 54.6%

PRS 39.7%
Mueller cell CL0000636

CSI 3.2

rCSI 7.3%

PRS 8.9%
pre-conventional dendritic cell CL0002010

CSI 3.2

rCSI 42.3%

PRS 32.7%
adventitial cell CL0002503

CSI 3.2

rCSI 7.7%

PRS 15.6%
epithelial cell of nephron CL1000449

CSI 3.2

rCSI 30.8%

PRS 42.2%
periportal region hepatocyte CL0019026

CSI 3.3

rCSI 12.7%

PRS 14.7%
prostate gland microvascular endothelial cell CL2000059

CSI 3.3

rCSI 78.0%

PRS 34.9%
acinar cell CL0000622

CSI 3.3

rCSI 4.9%

PRS 13.0%
enteroendocrine cell CL0000164

CSI 3.4

rCSI 4.6%

PRS 10.9%
parietal epithelial cell CL1000452

CSI 3.4

rCSI 9.0%

PRS 9.0%
goblet cell CL0000160

CSI 3.4

rCSI 3.2%

PRS 10.3%
megakaryocyte CL0000556

CSI 3.4

rCSI 14.8%

PRS 17.9%
glioblast CL0000030

CSI 3.4

rCSI 5.5%

PRS 8.5%
colon macrophage CL0009038

CSI 3.4

rCSI 15.8%

PRS 21.0%
Merkel cell CL0000242

CSI 3.5

rCSI 80.6%

PRS 60.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPS17](/details-gene/6218) (Ribosomal Protein S17) is a protein-coding gene located on chromosome 15q25.2 that encodes a structural component of the 40S small ribosomal subunit. As an integral part of the cellular translation machinery, [RPS17](/details-gene/6218) plays a fundamental role in [ribosomal small subunit biogenesis](/details-ontology/GO:0042274), [rRNA processing](/details-ontology/GO:0006364), and [cytoplasmic translation](/details-ontology/GO:0002181). Its expression is particularly significant in highly proliferative and metabolically active cells, including hematopoietic progenitors and specialized immune cells such as [T-helper 17 cell](/details-cell/CL0000899). Clinically, heterozygous mutations in the [RPS17](/details-gene/6218) gene are a known cause of Diamond-Blackfan anemia ([180472](https://omim.org/entry/180472)), a congenital ribosomopathy characterized by red cell aplasia and developmental abnormalities [Link](https://doi.org/10.1002/humu.20608). ## Cellular Roles and Expression Landscape The expression profile of [RPS17](/details-gene/6218) underscores its essential function in protein synthesis, with its significance being highest in cells undergoing rapid division or with high secretory demands. **Overall**, [RPS17](/details-gene/6218) shows prominent significance in hematopoietic lineages, particularly in progenitor populations like [common myeloid progenitor](/details-cell/CL0000049) (CSI: 54.93), [early lymphoid progenitor](/details-cell/CL0000936) (CSI: 44.10), and [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 39.05). This pattern is consistent with the high translational activity required to support cell division and differentiation. Beyond progenitors, [RPS17](/details-gene/6218) is a key marker in highly specialized and active immune cell populations. It is most significant in [T-helper 17 cell](/details-cell/CL0000899) (CSI: 63.01) and developing [CD4-positive, alpha-beta thymocyte](/details-cell/CL0000810) (CSI: 61.87), cells known for their robust cytokine production and proliferative capacity. Its high significance extends to other metabolically active secretory cells, such as [pancreatic D cell](/details-cell/CL0000173) and [pancreatic A cell](/details-cell/CL0000171), which are responsible for hormone synthesis. Conversely, the gene's significance is markedly lower in terminally differentiated or structurally-focused cells. It is identified as an anti-marker in cell types like [pulmonary capillary endothelial cell](/details-cell/CL4028001) (CSI: -18.41) and [squamous epithelial cell](/details-cell/CL0000076) (CSI: -4.24). This suggests that while [RPS17](/details-gene/6218) is ubiquitously expressed, its relative importance is substantially reduced in quiescent cells with lower protein synthesis requirements, highlighting its role as a marker for cellular activity rather than just lineage. ## Pathways and Molecular Function The functional annotations for [RPS17](/details-gene/6218) confirm its central role in protein metabolism. As a core molecular component, it is a [structural constituent of ribosome](/details-ontology/GO:0003735) and is involved in nearly all stages of protein synthesis. Its function begins in the [nucleolus](/details-ontology/GO:0005730) with [rrna processing](/details-ontology/R-HSA-72312) and the assembly of the [small-subunit processome](/details-ontology/GO:0032040), followed by its role in the [cytosolic ribosome](/details-ontology/GO:0022626). Reactome pathway analysis places [RPS17](/details-gene/6218) at the heart of [Translation](/details-pathway/R-HSA-72766), from [cap-dependent translation initiation](/details-pathway/R-HSA-72737) to [peptide chain elongation](/details-pathway/R-HSA-156902) and [eukaryotic translation termination](/details-pathway/R-HSA-72764). This fundamental role makes it a critical factor in broad biological programs such as [Developmental biology](/details-pathway/R-HSA-1266738) and [Cellular responses to stress](/details-pathway/R-HSA-2262752). Notably, its involvement in numerous viral infection pathways, including [Influenza infection](/details-pathway/R-HSA-168255) and [Sars-cov-2 infection](/details-pathway/R-HSA-9694516), highlights its role as a key piece of host machinery that is often co-opted by viruses to facilitate their replication via [Viral mrna translation](/details-pathway/R-HSA-192823). ## Research Directions The association of [RPS17](/details-gene/6218) with Diamond-Blackfan Anemia (DBA) provides a clear clinical context, while its expression patterns suggest specific cellular vulnerabilities to its haploinsufficiency. **Proposed Hypotheses:** 1. Given the exceptionally high significance of [RPS17](/details-gene/6218) in [T-helper 17 cell](/details-cell/CL0000899) and other T cell progenitors, DBA-causing mutations may disproportionately impair the development and effector function of these high-demand immune subsets, potentially contributing to the immune dysregulation observed in some DBA patients. 2. The high significance of [RPS17](/details-gene/6218) in erythroid progenitors ([megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050)) suggests that these cells are uniquely sensitive to ribosomal stress. It can be hypothesized that [RPS17](/details-gene/6218) haploinsufficiency specifically in this lineage triggers a p53-dependent apoptotic program, leading to the characteristic pure red cell aplasia of DBA, while other hematopoietic lineages are less affected. 3. The ubiquitous involvement of [RPS17](/details-gene/6218) in viral translation pathways suggests it may be a critical host dependency factor. We hypothesize that specific viral proteins interact directly with [RPS17](/details-gene/6218) to enhance the translation of viral transcripts, and that disrupting this interaction could represent a broad-spectrum antiviral strategy. **Experimental Approach:** To test the hypothesis that [RPS17](/details-gene/6218) insufficiency impairs Th17 cell function (Hypothesis 1), a robust *in vitro* model could be employed. Primary naive CD4+ T cells could be isolated from a heterozygous `Rps17+/-` mouse model (mimicking DBA) and wild-type littermate controls. These cells would be cultured under Th17-polarizing conditions (e.g., TGF-β, IL-6, anti-IFNγ, anti-IL4). The efficiency of Th17 differentiation could be quantified by flow cytometry for the master transcription factor RORγt and intracellular IL-17A. Supernatants could be analyzed by ELISA to measure the secretion of key Th17 effector cytokines (IL-17A, IL-17F, IL-22). Further, RNA-sequencing of the resulting cells would reveal transcriptomic alterations and pinpoint downstream pathways dysregulated by reduced [RPS17](/details-gene/6218) dosage during T cell activation and differentiation. **Therapeutic Potential:** As an essential and ubiquitously expressed ribosomal protein, [RPS17](/details-gene/6218) is not a suitable target for therapeutic **inhibition**, as this would likely cause severe, widespread cellular toxicity. However, in the context of DBA, a disease of haploinsufficiency, the therapeutic goal is **restoration** of function. Gene therapy approaches aimed at reintroducing a functional copy of [RPS17](/details-gene/6218) into hematopoietic stem cells represent a potential curative strategy. Furthermore, understanding the precise downstream pathways that are disrupted by [RPS17](/details-gene/6218) deficiency, such as p53 activation, could uncover more druggable targets to ameliorate the disease phenotype.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

RS17_HUMAN

Genular Protein ID: 1985324850

Symbol: RS17_HUMAN

Name: N/A

UniProtKB Accession Codes:

P08708 B2R4U4 P0CW22

Database IDs:

Citations:

PubMed ID: 3529092

Title: Homologous ribosomal proteins in bacteria, yeast, and humans.

PubMed ID: 3529092

DOI: 10.1073/pnas.83.18.6907

PubMed ID: 3240863

Title: The transcriptionally active human ribosomal protein S17 gene.

PubMed ID: 3240863

DOI: 10.1016/0378-1119(88)90109-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 17647292

Title: Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia.

PubMed ID: 17647292

DOI: 10.1002/humu.20608

PubMed ID: 19061985

Title: Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients.

PubMed ID: 19061985

DOI: 10.1016/j.ajhg.2008.11.004

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 135
Mass: 15550
Checksum: 299AD605C5401325
Sequence:

MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR 
IQRGPVRGIS IKLQEEERER RDNYVPEVSA LDQEIIEVDP DTKEMLKLLD FGSLSNLQVT 
QPTVGMNFKT PRGPV

Details for: RPS17

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Homologous ribosomal proteins in bacteria, yeast, and humans. PubMed ID: 3529092

The transcriptionally active human ribosomal protein S17 gene. PubMed ID: 3240863

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. PubMed ID: 17647292

Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. PubMed ID: 19061985

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797