RPS19 | ENSG00000105372 | NCBI 6223

Details for: RPS19

Gene ID: 6223

Symbol: RPS19

Ensembl ID: ENSG00000105372

Description: ribosomal protein S19

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Defense response to gram-negative bacterium
(GO:0050829)
Erythrocyte differentiation
(GO:0030218)
Extracellular exosome
(GO:0070062)
Fibroblast growth factor binding
(GO:0017134)
Focal adhesion
(GO:0005925)
Identical protein binding
(GO:0042802)
Killing of cells of another organism
(GO:0031640)
Maturation of ssu-rrna
(GO:0030490)
Maturation of ssu-rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000462)
Membrane
(GO:0016020)
Monocyte chemotaxis
(GO:0002548)
Negative regulation of respiratory burst involved in inflammatory response
(GO:0060266)
Nucleolus
(GO:0005730)
Nucleolus organization
(GO:0007000)
Nucleoplasm
(GO:0005654)
Positive regulation of respiratory burst involved in inflammatory response
(GO:0060265)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 851.3461
Cell Significance Index: -350.7100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 753.6853
Cell Significance Index: -306.1900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 683.2758
Cell Significance Index: -322.5900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 652.5848
Cell Significance Index: -335.6800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 482.6815
Cell Significance Index: -323.8900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 326.1349
Cell Significance Index: -311.3800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 23.1964
Cell Significance Index: -62.1400
Cell Name: theca cell (CL0000503)
Fold Change: 20.4118
Cell Significance Index: 119.9200
Cell Name: pro-T cell (CL0000827)
Fold Change: 19.0776
Cell Significance Index: 487.3700
Cell Name: abnormal cell (CL0001061)
Fold Change: 17.7306
Cell Significance Index: 1811.1800
Cell Name: granulosa cell (CL0000501)
Fold Change: 15.8190
Cell Significance Index: 415.9600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 15.2650
Cell Significance Index: 717.4400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 15.0465
Cell Significance Index: 402.4900
Cell Name: lactocyte (CL0002325)
Fold Change: 11.3939
Cell Significance Index: 1472.0200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 10.8413
Cell Significance Index: 191.5800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 10.5813
Cell Significance Index: 303.3200
Cell Name: peg cell (CL4033014)
Fold Change: 10.3682
Cell Significance Index: 239.5400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 10.0895
Cell Significance Index: 350.6100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 9.9890
Cell Significance Index: 113.4800
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 9.4834
Cell Significance Index: 25.4100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 9.4767
Cell Significance Index: 121.3700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 9.3380
Cell Significance Index: 195.4600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.1709
Cell Significance Index: 1259.4200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 8.9654
Cell Significance Index: 634.0700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 8.8867
Cell Significance Index: 3929.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 8.8792
Cell Significance Index: 1091.7800
Cell Name: cell in vitro (CL0001034)
Fold Change: 8.7818
Cell Significance Index: 4795.9500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 8.5868
Cell Significance Index: 1547.9300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.2752
Cell Significance Index: 616.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.2384
Cell Significance Index: 971.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 7.3640
Cell Significance Index: 475.0900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 7.3006
Cell Significance Index: 214.4100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.5438
Cell Significance Index: 71.1400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 6.5403
Cell Significance Index: 40.2500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 6.3730
Cell Significance Index: 117.7900
Cell Name: odontoblast (CL0000060)
Fold Change: 5.5471
Cell Significance Index: 711.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 5.5120
Cell Significance Index: 4172.1200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.4711
Cell Significance Index: 148.9200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 5.0774
Cell Significance Index: 43.6300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.9911
Cell Significance Index: 259.9800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.9156
Cell Significance Index: 229.1900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.6113
Cell Significance Index: 242.1100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.5262
Cell Significance Index: 772.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.5796
Cell Significance Index: 710.3900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.4246
Cell Significance Index: 3092.1900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.3210
Cell Significance Index: 150.5300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.9346
Cell Significance Index: 17.8200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.7688
Cell Significance Index: 202.6400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.3038
Cell Significance Index: 128.9800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1185
Cell Significance Index: 212.8600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.8713
Cell Significance Index: 638.8500
Cell Name: kidney cell (CL1000497)
Fold Change: 0.3970
Cell Significance Index: 3.1700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1595
Cell Significance Index: 4.2600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0696
Cell Significance Index: -3.6200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0852
Cell Significance Index: -160.4100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1313
Cell Significance Index: -97.2400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1507
Cell Significance Index: -277.8800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1894
Cell Significance Index: -291.6300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2459
Cell Significance Index: -334.2900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2584
Cell Significance Index: -92.7000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2632
Cell Significance Index: -52.8000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2868
Cell Significance Index: -161.7600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.3260
Cell Significance Index: -203.5800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.4307
Cell Significance Index: -273.5200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5551
Cell Significance Index: -34.1200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.6572
Cell Significance Index: -298.2600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.7759
Cell Significance Index: -163.4200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.9034
Cell Significance Index: -31.7500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.9186
Cell Significance Index: -149.4000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9953
Cell Significance Index: -55.8500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.0842
Cell Significance Index: -18.6900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -1.1398
Cell Significance Index: -327.9400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2475
Cell Significance Index: -98.8000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.4653
Cell Significance Index: -46.9300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.9780
Cell Significance Index: -287.5200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.2688
Cell Significance Index: -37.9700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -2.5150
Cell Significance Index: -287.0800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.7560
Cell Significance Index: -173.7000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.9343
Cell Significance Index: -305.5300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -3.1275
Cell Significance Index: -78.1800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -3.4091
Cell Significance Index: -235.7600
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -3.9687
Cell Significance Index: -82.7700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -4.0123
Cell Significance Index: -60.1200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.0166
Cell Significance Index: -270.0800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.0491
Cell Significance Index: -310.7300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -4.0675
Cell Significance Index: -244.1900
Cell Name: Sertoli cell (CL0000216)
Fold Change: -4.4858
Cell Significance Index: -62.9200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.5342
Cell Significance Index: -277.9900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.8740
Cell Significance Index: -105.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -5.6434
Cell Significance Index: -162.6000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -5.8525
Cell Significance Index: -79.8500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -6.3190
Cell Significance Index: -108.2900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -6.3398
Cell Significance Index: -138.8200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -6.3835
Cell Significance Index: -188.0200
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -6.6901
Cell Significance Index: -36.4800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -6.8928
Cell Significance Index: -41.6500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -7.4317
Cell Significance Index: -88.5900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -7.4982
Cell Significance Index: -331.6700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -7.7610
Cell Significance Index: -284.9000
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -8.3328
Cell Significance Index: -107.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** RPS19 is a highly conserved protein, with a high degree of sequence similarity across species. It is a component of the 40S ribosomal subunit, which is responsible for the initiation and elongation of protein synthesis. RPS19 interacts with various factors, including eIFs and the cap-binding complex, to facilitate the recognition of start codons and the recruitment of initiation factors. Additionally, RPS19 has been shown to play a role in the regulation of immune responses, including the activation of the antimicrobial humoral immune response and the modulation of host translation machinery in response to viral infections. **Pathways and Functions:** RPS19 is involved in several key pathways, including: 1. **Translation Initiation:** RPS19 interacts with eIFs and the cap-binding complex to facilitate the recognition of start codons and the recruitment of initiation factors. 2. **Antimicrobial Humoral Immune Response:** RPS19 has been shown to play a role in the activation of the antimicrobial humoral immune response, including the production of antimicrobial peptides. 3. **Viral Infection:** RPS19 has been implicated in the modulation of host translation machinery in response to viral infections, including SARS-CoV-1 and SARS-CoV-2. 4. **Immune Regulation:** RPS19 has been shown to play a role in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. **Clinical Significance:** RPS19 has been implicated in various diseases, including: 1. **Infectious Diseases:** RPS19 has been shown to play a role in the regulation of host translation machinery in response to viral infections, including SARS-CoV-1 and SARS-CoV-2. 2. **Cancer:** RPS19 has been implicated in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. 3. **Neurological Disorders:** RPS19 has been shown to play a role in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. In conclusion, RPS19 is a critical component of the 40S ribosomal subunit, playing a vital role in the regulation of protein synthesis and immune response. Its involvement in various diseases highlights the importance of RPS19 in maintaining immune homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which RPS19 regulates immune responses and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S19

Genular Protein ID: 309396336

Symbol: RS19_HUMAN

Name: 40S ribosomal protein S19

UniProtKB Accession Codes:

P39019

Database IDs:

Citations:

PubMed ID: 1339304

Title: Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation.

PubMed ID: 1339304

PubMed ID: 9988267

Title: The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia.

PubMed ID: 9988267

DOI: 10.1038/5951

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15075082

Title: Molecular basis of Diamond-Blackfan anemia: new findings from the Italian registry and a review of the literature.

PubMed ID: 15075082

PubMed ID: 16990592

Title: Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits.

PubMed ID: 16990592

DOI: 10.1182/blood-2006-07-038232

PubMed ID: 17517689

Title: Missense mutations associated with Diamond-Blackfan anemia affect the assembly of ribosomal protein S19 into the ribosome.

PubMed ID: 17517689

DOI: 10.1093/hmg/ddm120

PubMed ID: 18412286

Title: RPS19 mutations in patients with Diamond-Blackfan anemia.

PubMed ID: 18412286

DOI: 10.1002/humu.20752

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20844026

Title: Interaction of hantavirus nucleocapsid protein with ribosomal protein S19.

PubMed ID: 20844026

DOI: 10.1128/jvi.01388-10

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25062117

Title: Ribosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism.

PubMed ID: 25062117

DOI: 10.1042/bj20140449

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

PubMed ID: 10590074

Title: Mutations in ribosomal protein S19 gene and Diamond Blackfan anemia: wide variations in phenotypic expression.

PubMed ID: 10590074

PubMed ID: 11112378

Title: Diamond-Blackfan anemia: report of seven further mutations in the RPS19 gene and evidence of mutation heterogeneity in the Italian population.

PubMed ID: 11112378

DOI: 10.1006/bcmd.2000.0324

PubMed ID: 12586610

Title: Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology.

PubMed ID: 12586610

DOI: 10.1182/blood-2002-12-3878

PubMed ID: 12750732

Title: Ten novel Diamond-Blackfan anemia mutations and three polymorphisms within the rps19 gene.

PubMed ID: 12750732

DOI: 10.1038/sj.thj.6200230

PubMed ID: 15384984

Title: RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations.

PubMed ID: 15384984

DOI: 10.1111/j.1365-2141.2004.05152.x

Sequence Information:

Length: 145
Mass: 16060
Checksum: 181F2DB898E56E41
Sequence:

MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST 
ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG 
RKLTPQGQRD LDRIAGQVAA ANKKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS19

Associated with

Cells (max top 100)

Other Information

Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation. PubMed ID: 1339304

The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia. PubMed ID: 9988267

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Molecular basis of Diamond-Blackfan anemia: new findings from the Italian registry and a review of the literature. PubMed ID: 15075082

Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits. PubMed ID: 16990592

Missense mutations associated with Diamond-Blackfan anemia affect the assembly of ribosomal protein S19 into the ribosome. PubMed ID: 17517689

RPS19 mutations in patients with Diamond-Blackfan anemia. PubMed ID: 18412286

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Interaction of hantavirus nucleocapsid protein with ribosomal protein S19. PubMed ID: 20844026

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

A new system for naming ribosomal proteins. PubMed ID: 24524803

Ribosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism. PubMed ID: 25062117

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797

Mutations in ribosomal protein S19 gene and Diamond Blackfan anemia: wide variations in phenotypic expression. PubMed ID: 10590074

Diamond-Blackfan anemia: report of seven further mutations in the RPS19 gene and evidence of mutation heterogeneity in the Italian population. PubMed ID: 11112378

Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology. PubMed ID: 12586610

Ten novel Diamond-Blackfan anemia mutations and three polymorphisms within the rps19 gene. PubMed ID: 12750732

RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations. PubMed ID: 15384984