Details for: S100A9
Gene ID: 6280
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: S100A9
Ensembl ID: ENSG00000163220
Description: S100 calcium binding protein A9
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 61.46rCSI 76.55%PRS 92.54
-
CSI 51.9rCSI 47.65%PRS 91.52
-
CSI 50.75rCSI 76.57%PRS 90.04
-
CSI 50.18rCSI 38.66%PRS 88.56
-
CSI 49.7rCSI 73.68%PRS 93.25
-
CSI 44.84rCSI 58.76%PRS 93.47
-
CSI 41.49rCSI 71.07%PRS 89.48
-
CSI 40.92rCSI 62.5%PRS 85.2
-
CSI 32.85rCSI 77.97%PRS 84.22
-
CSI 31.06rCSI 26.64%PRS 90.25
-
CSI 31.04rCSI 27.19%PRS 90.81
-
CSI 30.15rCSI 29.02%PRS 84.42
-
CSI 30.07rCSI 56.77%PRS 91.64
-
CSI 29.68rCSI 25.7%PRS 88.47
-
CSI 29.63rCSI 35.38%PRS 96.19
-
CSI 29.39rCSI 53.12%PRS 88.25
-
CSI 28.19rCSI 97.08%PRS 92.29
-
CSI 26.54rCSI 42.54%PRS 92.24
-
CSI 23.3rCSI 48.34%PRS 82.64
-
CSI 23.12rCSI 29.06%PRS 92.58
-
CSI 20.63rCSI 17.22%PRS 82.57
-
CSI 18.67rCSI 30.75%PRS 88.42
-
CSI 18.51rCSI 23.67%PRS 91.51
-
CSI 18.38rCSI 21.59%PRS 93.42
-
CSI 17.76rCSI 20.6%PRS 87.63
-
CSI 17.31rCSI 12.16%PRS 94.74
-
CSI 16.39rCSI 25.19%PRS 73.99
-
CSI 16.17rCSI 12.13%PRS 96.45
-
CSI 16.05rCSI 35.33%PRS 88.26
-
CSI 15.4rCSI 27.46%PRS 91.2
-
CSI 15.13rCSI 20.24%PRS 89.3
-
CSI 14.55rCSI 11.82%PRS 84.57
-
CSI 14.39rCSI 32.92%PRS 86.31
-
CSI 13.85rCSI 20.31%PRS 92.58
-
CSI 13.74rCSI 14.34%PRS 84.56
-
CSI 13.22rCSI 16.96%PRS 87.88
-
CSI 13.09rCSI 20.23%PRS 84.06
-
CSI 12.86rCSI 45.12%PRS 91.06
-
CSI 12.82rCSI 16.41%PRS 91.51
-
CSI 12.64rCSI 22.99%PRS 88.71
-
CSI 12.49rCSI 69.86%PRS 84.71
-
CSI 12.06rCSI 18.71%PRS 87.79
-
CSI 11.94rCSI 48.06%PRS 85.03
-
CSI 11.69rCSI 70.71%PRS 93.34
-
CSI 11.59rCSI 10.7%PRS 86.53
-
CSI 11.47rCSI 16.55%PRS 89.47
-
CSI 11.16rCSI 45.94%PRS 90.47
-
CSI 10.98rCSI 72.12%PRS 94.39
-
CSI 10.68rCSI 23.86%PRS 91.15
-
CSI 10.64rCSI 7.9%PRS 93.35
-
CSI 10.47rCSI 8.68%PRS 86.34
-
CSI 10.25rCSI 19.55%PRS 92.66
-
CSI 10.21rCSI 8.59%PRS 95.14
-
CSI 10.01rCSI 7.19%PRS 95.24
-
CSI 9.9rCSI 7.44%PRS 90.01
-
CSI 9.81rCSI 10.17%PRS 88.19
-
CSI 9.61rCSI 12.08%PRS 95.52
-
CSI 9.5rCSI 9.92%PRS 94.17
-
CSI 9.49rCSI 7.36%PRS 88.53
-
CSI 9.28rCSI 26.72%PRS 88.63
-
CSI 9.26rCSI 13.41%PRS 95.01
-
CSI 8.83rCSI 5.88%PRS 93.56
-
CSI 8.78rCSI 23.12%PRS 93.77
-
CSI 8.71rCSI 19.01%PRS 89.8
-
CSI 8.6rCSI 19.31%PRS 94.13
-
CSI 8.52rCSI 8.37%PRS 94.94
-
CSI 8.48rCSI 10.24%PRS 91.56
-
CSI 8.46rCSI 11.72%PRS 81.68
-
CSI 8.23rCSI 5.72%PRS 94.57
-
CSI 8.12rCSI 6.72%PRS 87.46
-
CSI 8.1rCSI 6.05%PRS 94.25
-
CSI 8.07rCSI 9.98%PRS 83.67
-
CSI 8.02rCSI 8.01%PRS 79.62
-
CSI 8.01rCSI 12.79%PRS 88.51
-
CSI 7.89rCSI 11.55%PRS 89.48
-
CSI 7.74rCSI 5.22%PRS 95.42
-
CSI 7.73rCSI 11.32%PRS 80.29
-
CSI 7.65rCSI 9.43%PRS 86.52
-
CSI 7.12rCSI 9.53%PRS 83
-
CSI 7.03rCSI 10.75%PRS 90.95
-
CSI 6.98rCSI 4.12%PRS 96.78
-
CSI 6.98rCSI 6.13%PRS 89.38
-
CSI 6.87rCSI 8.36%PRS 90.35
-
CSI 6.49rCSI 5.25%PRS 87.31
-
CSI 6.46rCSI 14.67%PRS 84.77
-
CSI 6.01rCSI 17.41%PRS 84.41
-
CSI 5.91rCSI 5.38%PRS 94.56
-
CSI 5.72rCSI 5.33%PRS 86.28
-
CSI 5.68rCSI 56.13%PRS 87.21
-
CSI 5.33rCSI 22.1%PRS 82.24
-
CSI 5.32rCSI 6.15%PRS 78.73
-
CSI 5.29rCSI 8.08%PRS 93.61
-
CSI 5.24rCSI 5.17%PRS 93.75
-
CSI 5.14rCSI 7.06%PRS 96.26
-
CSI 5.09rCSI 8.03%PRS 86.37
-
CSI 5.04rCSI 4.22%PRS 87.23
-
CSI 5.01rCSI 3.81%PRS 95.27
-
CSI 4.77rCSI 5.11%PRS 87.27
-
CSI 4.74rCSI 20.59%PRS 88.65
-
CSI 4.66rCSI 18.62%PRS 90.37
-
CSI 0.6rCSI 3.1%PRS 95.6%
-
CSI 0.7rCSI 3.8%PRS 94.9%
-
CSI 0.7rCSI 16.2%PRS 93.1%
-
CSI 0.9rCSI 2.9%PRS 81.4%
-
CSI 1.2rCSI 3.3%PRS 89.2%
-
CSI 1.3rCSI 2.2%PRS 83.2%
-
CSI 1.5rCSI 8.4%PRS 88.9%
-
CSI 1.5rCSI 1.8%PRS 92.4%
-
CSI 1.5rCSI 7.1%PRS 93.8%
-
CSI 1.5rCSI 9.4%PRS 90.6%
-
CSI 1.6rCSI 3.3%PRS 93.1%
-
CSI 1.6rCSI 4.0%PRS 85.8%
-
CSI 1.7rCSI 1.5%PRS 75.5%
-
CSI 1.7rCSI 8.4%PRS 91.0%
-
CSI 1.7rCSI 30.2%PRS 91.4%
-
CSI 1.8rCSI 6.6%PRS 96.7%
-
CSI 1.8rCSI 12.8%PRS 88.1%
-
CSI 1.9rCSI 1.4%PRS 94.7%
-
CSI 1.9rCSI 3.5%PRS 92.6%
-
CSI 1.9rCSI 2.7%PRS 84.4%
-
CSI 2.1rCSI 5.5%PRS 90.5%
-
CSI 2.2rCSI 5.8%PRS 86.6%
-
CSI 2.3rCSI 1.6%PRS 88.7%
-
CSI 2.3rCSI 11.5%PRS 94.5%
-
CSI 2.4rCSI 3.7%PRS 92.1%
-
CSI 2.4rCSI 2.2%PRS 83.9%
-
CSI 2.5rCSI 3.1%PRS 91.8%
-
CSI 2.5rCSI 3.9%PRS 91.7%
-
CSI 2.7rCSI 29.3%PRS 92.6%
-
CSI 2.8rCSI 30.4%PRS 90.5%
-
CSI 2.9rCSI 6.0%PRS 91.1%
-
CSI 3.4rCSI 3.2%PRS 83.4%
-
CSI 3.4rCSI 3.6%PRS 82.9%
-
CSI 3.5rCSI 4.1%PRS 95.3%
-
CSI 3.5rCSI 4.8%PRS 96.9%
-
CSI 3.5rCSI 2.7%PRS 94.7%
-
CSI 3.7rCSI 17.1%PRS 94.3%
-
CSI 3.8rCSI 7.4%PRS 87.9%
-
CSI 3.9rCSI 3.0%PRS 89.1%
-
CSI 4.2rCSI 26.9%PRS 91.0%
-
CSI 4.3rCSI 18.5%PRS 89.8%
-
CSI 4.6rCSI 9.6%PRS 81.0%
-
CSI 4.7rCSI 18.6%PRS 90.4%
-
CSI 4.7rCSI 20.6%PRS 88.7%
-
CSI 4.8rCSI 5.1%PRS 87.3%
-
CSI 5.0rCSI 3.8%PRS 95.3%
-
CSI 5.0rCSI 4.2%PRS 87.2%
-
CSI 5.1rCSI 8.0%PRS 86.4%
-
CSI 5.1rCSI 7.1%PRS 96.3%
-
CSI 5.2rCSI 5.2%PRS 93.8%
-
CSI 5.3rCSI 8.1%PRS 93.6%
-
CSI 5.3rCSI 6.2%PRS 78.7%
-
CSI 5.3rCSI 22.1%PRS 82.2%
-
CSI 5.7rCSI 56.1%PRS 87.2%
-
CSI 5.7rCSI 5.3%PRS 86.3%
-
CSI 5.9rCSI 5.4%PRS 94.6%
-
CSI 6.0rCSI 17.4%PRS 84.4%
-
CSI 6.5rCSI 14.7%PRS 84.8%
-
CSI 6.5rCSI 5.3%PRS 87.3%
-
CSI 6.9rCSI 8.4%PRS 90.4%
-
CSI 7.0rCSI 6.1%PRS 89.4%
-
CSI 7.0rCSI 4.1%PRS 96.8%
-
CSI 7.0rCSI 10.8%PRS 91.0%
-
CSI 7.1rCSI 9.5%PRS 83.0%
-
CSI 7.7rCSI 9.4%PRS 86.5%
-
CSI 7.7rCSI 11.3%PRS 80.3%
-
CSI 7.7rCSI 5.2%PRS 95.4%
-
CSI 7.9rCSI 11.6%PRS 89.5%
-
CSI 8.0rCSI 12.8%PRS 88.5%
-
CSI 8.0rCSI 8.0%PRS 79.6%
-
CSI 8.1rCSI 10.0%PRS 83.7%
-
CSI 8.1rCSI 6.1%PRS 94.3%
-
CSI 8.1rCSI 6.7%PRS 87.5%
-
CSI 8.2rCSI 5.7%PRS 94.6%
-
CSI 8.5rCSI 11.7%PRS 81.7%
-
CSI 8.5rCSI 10.2%PRS 91.6%
-
CSI 8.5rCSI 8.4%PRS 94.9%
-
CSI 8.6rCSI 19.3%PRS 94.1%
-
CSI 8.7rCSI 19.0%PRS 89.8%
-
CSI 8.8rCSI 23.1%PRS 93.8%
-
CSI 8.8rCSI 5.9%PRS 93.6%
-
CSI 9.3rCSI 13.4%PRS 95.0%
-
CSI 9.3rCSI 26.7%PRS 88.6%
-
CSI 9.5rCSI 7.4%PRS 88.5%
-
CSI 9.5rCSI 9.9%PRS 94.2%
-
CSI 9.6rCSI 12.1%PRS 95.5%
-
CSI 9.8rCSI 10.2%PRS 88.2%
-
CSI 9.9rCSI 7.4%PRS 90.0%
-
CSI 10.0rCSI 7.2%PRS 95.2%
-
CSI 10.2rCSI 8.6%PRS 95.1%
-
CSI 10.3rCSI 19.6%PRS 92.7%
-
CSI 10.5rCSI 8.7%PRS 86.3%
-
CSI 10.6rCSI 7.9%PRS 93.4%
-
CSI 10.7rCSI 23.9%PRS 91.2%
-
CSI 11.0rCSI 72.1%PRS 94.4%
-
CSI 11.2rCSI 45.9%PRS 90.5%
-
CSI 11.5rCSI 16.6%PRS 89.5%
-
CSI 11.6rCSI 10.7%PRS 86.5%
-
CSI 11.7rCSI 70.7%PRS 93.3%
-
CSI 11.9rCSI 48.1%PRS 85.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3919054124
Symbol: S10A9_HUMAN
Name: Protein S100-A9
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3313057
Title: Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis.
PubMed ID: 3313057
DOI: 10.1038/330080a0
PubMed ID: 3405210
Title: Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.
PubMed ID: 3405210
PubMed ID: 2656677
Title: A protein containing the cystic fibrosis antigen is an inhibitor of protein kinases.
PubMed ID: 2656677
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2478889
Title: Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.
PubMed ID: 2478889
DOI: 10.1038/342189a0
PubMed ID: 2776242
Title: Amino acid sequences of 60B8 antigens induced in HL-60 cells by 1,25-dihydroxyvitamin D3. The antigens are identical with macrophage-related protein-14 and -8.
PubMed ID: 2776242
DOI: 10.1248/cpb.37.1576
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 8423249
Title: In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.
PubMed ID: 8423249
PubMed ID: 9083090
Title: Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway.
PubMed ID: 9083090
PubMed ID: 11708798
Title: The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes.
PubMed ID: 11708798
PubMed ID: 12626582
Title: Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion.
PubMed ID: 12626582
PubMed ID: 15331440
Title: MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes.
PubMed ID: 15331440
PubMed ID: 15598812
Title: Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells.
PubMed ID: 15598812
PubMed ID: 15642721
Title: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.
PubMed ID: 15642721
PubMed ID: 15905572
Title: Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils.
PubMed ID: 15905572
PubMed ID: 16258195
Title: Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity.
PubMed ID: 16258195
DOI: 10.1155/mi.2005.280
PubMed ID: 18786929
Title: Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9.
PubMed ID: 18786929
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 20523765
Title: Anti-infective protective properties of S100 calgranulins.
PubMed ID: 20523765
PubMed ID: 19534726
Title: A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway.
PubMed ID: 19534726
DOI: 10.1042/bj20090465
PubMed ID: 19835859
Title: S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis.
PubMed ID: 19835859
PubMed ID: 19087201
Title: Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation.
PubMed ID: 19087201
PubMed ID: 19122197
Title: Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion.
PubMed ID: 19122197
PubMed ID: 19451397
Title: The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer.
PubMed ID: 19451397
DOI: 10.1189/jlb.1008647
PubMed ID: 19402754
Title: Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides.
PubMed ID: 19402754
PubMed ID: 19935772
Title: S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.
PubMed ID: 19935772
DOI: 10.1038/cr.2009.129
PubMed ID: 19935766
PubMed ID: 20103766
Title: Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism.
PubMed ID: 20103766
DOI: 10.1189/jlb.1009676
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 20213444
Title: Inflammation-associated S100 proteins: new mechanisms that regulate function.
PubMed ID: 20213444
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21325622
Title: Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.
PubMed ID: 21325622
PubMed ID: 22095980
Title: S100A8 and S100A9 in cardiovascular biology and disease.
PubMed ID: 22095980
PubMed ID: 22804476
Title: Induction of nuclear factor-kappaB responses by the S100A9 protein is Toll-like receptor-4-dependent.
PubMed ID: 22804476
PubMed ID: 21487906
Title: Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction.
PubMed ID: 21487906
PubMed ID: 22489132
Title: Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes.
PubMed ID: 22489132
DOI: 10.3390/ijms13032893
PubMed ID: 21912088
Title: S100A8 and S100A9: new insights into their roles in malignancy.
PubMed ID: 21912088
DOI: 10.1159/000330095
PubMed ID: 22808130
Title: Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation.
PubMed ID: 22808130
PubMed ID: 22457725
Title: MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization.
PubMed ID: 22457725
PubMed ID: 22363402
Title: Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway.
PubMed ID: 22363402
PubMed ID: 25417112
Title: Target-selective protein S-nitrosylation by sequence motif recognition.
PubMed ID: 25417112
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26296369
Title: Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation.
PubMed ID: 26296369
DOI: 10.1096/fj.15-273987
PubMed ID: 11851337
Title: The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process.
PubMed ID: 11851337
PubMed ID: 17553524
Title: The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins.
PubMed ID: 17553524
Sequence Information:
- Length: 114
- Mass: 13242
- Checksum: C3BE19729E14C078
- Sequence:
MTCKMSQLER NIETIINTFH QYSVKLGHPD TLNQGEFKEL VRKDLQNFLK KENKNEKVIE HIMEDLDTNA DKQLSFEEFI MLMARLTWAS HEKMHEGDEG PGHHHKPGLG EGTP