Details for: S100A9
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 154.8103
Cell Significance Index: -24.0800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 136.5303
Cell Significance Index: -34.6300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 86.5339
Cell Significance Index: -35.1600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 77.2232
Cell Significance Index: -39.7200 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 71.4115
Cell Significance Index: 188.3800 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 52.1402
Cell Significance Index: 448.0400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 37.8426
Cell Significance Index: -36.1300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 26.6553
Cell Significance Index: 492.6600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 18.6166
Cell Significance Index: -57.1800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.6652
Cell Significance Index: -20.5500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.9634
Cell Significance Index: -35.3700 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 6.8861
Cell Significance Index: 45.7100 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 5.9013
Cell Significance Index: 39.1500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.6321
Cell Significance Index: 137.1000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.5191
Cell Significance Index: 70.4000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.4754
Cell Significance Index: 22.8000 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.1953
Cell Significance Index: 154.4200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1224
Cell Significance Index: 213.5900 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.9311
Cell Significance Index: 3.8800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8693
Cell Significance Index: 384.3200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.8033
Cell Significance Index: 10.9600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7559
Cell Significance Index: 74.7800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6941
Cell Significance Index: 125.1300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6533
Cell Significance Index: 589.9200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6148
Cell Significance Index: 75.6000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4632
Cell Significance Index: 21.7700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.4512
Cell Significance Index: 341.5500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4312
Cell Significance Index: 20.1100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4123
Cell Significance Index: 11.0100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3881
Cell Significance Index: 63.1200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3125
Cell Significance Index: 8.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3057
Cell Significance Index: 60.6700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.2641
Cell Significance Index: 3.0000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2052
Cell Significance Index: 10.6600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1800
Cell Significance Index: 19.5800 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.0333
Cell Significance Index: 0.3100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0085
Cell Significance Index: -0.5200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0100
Cell Significance Index: -0.3500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0135
Cell Significance Index: -3.8800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0170
Cell Significance Index: -9.2600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0184
Cell Significance Index: -34.6300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0296
Cell Significance Index: -0.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0430
Cell Significance Index: -31.5000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0465
Cell Significance Index: -1.9000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0503
Cell Significance Index: -2.5400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0524
Cell Significance Index: -0.8100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0569
Cell Significance Index: -42.1700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0584
Cell Significance Index: -37.1000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0596
Cell Significance Index: -37.2300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0754
Cell Significance Index: -42.5500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0831
Cell Significance Index: -1.8000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0835
Cell Significance Index: -5.7800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0859
Cell Significance Index: -39.0000 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0931
Cell Significance Index: -1.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1014
Cell Significance Index: -10.3600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1036
Cell Significance Index: -37.1600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1043
Cell Significance Index: -0.6300 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1557
Cell Significance Index: -1.2700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1592
Cell Significance Index: -5.1000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1798
Cell Significance Index: -8.1500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1956
Cell Significance Index: -41.2000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1982
Cell Significance Index: -39.7500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1992
Cell Significance Index: -5.7400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2328
Cell Significance Index: -17.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2408
Cell Significance Index: -41.1100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2410
Cell Significance Index: -5.0000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2491
Cell Significance Index: -36.2100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2509
Cell Significance Index: -34.4600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.2579
Cell Significance Index: -15.4800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2986
Cell Significance Index: -34.8000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3085
Cell Significance Index: -36.3800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3243
Cell Significance Index: -37.1500 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3303
Cell Significance Index: -8.0000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3359
Cell Significance Index: -34.9700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3409
Cell Significance Index: -7.2600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.3503
Cell Significance Index: -44.9000 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: -0.3671
Cell Significance Index: -1.6900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4505
Cell Significance Index: -29.0700 - Cell Name: blood cell (CL0000081)
Fold Change: -0.4541
Cell Significance Index: -3.8700 - Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.4679
Cell Significance Index: -4.0900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4971
Cell Significance Index: -38.1500 - Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
Fold Change: -0.5031
Cell Significance Index: -4.8400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5457
Cell Significance Index: -36.6900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5714
Cell Significance Index: -35.1200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6086
Cell Significance Index: -43.0400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.6191
Cell Significance Index: -9.3300 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.6742
Cell Significance Index: -5.9400 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.7154
Cell Significance Index: -4.4500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7494
Cell Significance Index: -42.0500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7633
Cell Significance Index: -28.0200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8070
Cell Significance Index: -23.7700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8097
Cell Significance Index: -42.5100 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.9412
Cell Significance Index: -13.7700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9500
Cell Significance Index: -24.4200 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.9516
Cell Significance Index: -12.6500 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.9939
Cell Significance Index: -9.4400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.0807
Cell Significance Index: -30.9800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.1386
Cell Significance Index: -39.5700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -1.1449
Cell Significance Index: -36.2100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.1869
Cell Significance Index: -41.5800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3919054124
Symbol: S10A9_HUMAN
Name: Protein S100-A9
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3313057
Title: Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis.
PubMed ID: 3313057
DOI: 10.1038/330080a0
PubMed ID: 3405210
Title: Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation.
PubMed ID: 3405210
PubMed ID: 2656677
Title: A protein containing the cystic fibrosis antigen is an inhibitor of protein kinases.
PubMed ID: 2656677
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2478889
Title: Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.
PubMed ID: 2478889
DOI: 10.1038/342189a0
PubMed ID: 2776242
Title: Amino acid sequences of 60B8 antigens induced in HL-60 cells by 1,25-dihydroxyvitamin D3. The antigens are identical with macrophage-related protein-14 and -8.
PubMed ID: 2776242
DOI: 10.1248/cpb.37.1576
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 8423249
Title: In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.
PubMed ID: 8423249
PubMed ID: 9083090
Title: Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway.
PubMed ID: 9083090
PubMed ID: 11708798
Title: The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes.
PubMed ID: 11708798
PubMed ID: 12626582
Title: Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion.
PubMed ID: 12626582
PubMed ID: 15331440
Title: MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes.
PubMed ID: 15331440
PubMed ID: 15598812
Title: Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells.
PubMed ID: 15598812
PubMed ID: 15642721
Title: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.
PubMed ID: 15642721
PubMed ID: 15905572
Title: Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils.
PubMed ID: 15905572
PubMed ID: 16258195
Title: Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity.
PubMed ID: 16258195
DOI: 10.1155/mi.2005.280
PubMed ID: 18786929
Title: Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9.
PubMed ID: 18786929
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 20523765
Title: Anti-infective protective properties of S100 calgranulins.
PubMed ID: 20523765
PubMed ID: 19534726
Title: A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway.
PubMed ID: 19534726
DOI: 10.1042/bj20090465
PubMed ID: 19835859
Title: S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis.
PubMed ID: 19835859
PubMed ID: 19087201
Title: Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation.
PubMed ID: 19087201
PubMed ID: 19122197
Title: Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion.
PubMed ID: 19122197
PubMed ID: 19451397
Title: The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer.
PubMed ID: 19451397
DOI: 10.1189/jlb.1008647
PubMed ID: 19402754
Title: Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides.
PubMed ID: 19402754
PubMed ID: 19935772
Title: S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.
PubMed ID: 19935772
DOI: 10.1038/cr.2009.129
PubMed ID: 19935766
PubMed ID: 20103766
Title: Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism.
PubMed ID: 20103766
DOI: 10.1189/jlb.1009676
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 20213444
Title: Inflammation-associated S100 proteins: new mechanisms that regulate function.
PubMed ID: 20213444
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21325622
Title: Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.
PubMed ID: 21325622
PubMed ID: 22095980
Title: S100A8 and S100A9 in cardiovascular biology and disease.
PubMed ID: 22095980
PubMed ID: 22804476
Title: Induction of nuclear factor-kappaB responses by the S100A9 protein is Toll-like receptor-4-dependent.
PubMed ID: 22804476
PubMed ID: 21487906
Title: Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction.
PubMed ID: 21487906
PubMed ID: 22489132
Title: Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes.
PubMed ID: 22489132
DOI: 10.3390/ijms13032893
PubMed ID: 21912088
Title: S100A8 and S100A9: new insights into their roles in malignancy.
PubMed ID: 21912088
DOI: 10.1159/000330095
PubMed ID: 22808130
Title: Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation.
PubMed ID: 22808130
PubMed ID: 22457725
Title: MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization.
PubMed ID: 22457725
PubMed ID: 22363402
Title: Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway.
PubMed ID: 22363402
PubMed ID: 25417112
Title: Target-selective protein S-nitrosylation by sequence motif recognition.
PubMed ID: 25417112
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26296369
Title: Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation.
PubMed ID: 26296369
DOI: 10.1096/fj.15-273987
PubMed ID: 11851337
Title: The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process.
PubMed ID: 11851337
PubMed ID: 17553524
Title: The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins.
PubMed ID: 17553524
Sequence Information:
- Length: 114
- Mass: 13242
- Checksum: C3BE19729E14C078
- Sequence:
MTCKMSQLER NIETIINTFH QYSVKLGHPD TLNQGEFKEL VRKDLQNFLK KENKNEKVIE HIMEDLDTNA DKQLSFEEFI MLMARLTWAS HEKMHEGDEG PGHHHKPGLG EGTP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.