Details for: SAFB

Gene ID: 6294

Symbol: SAFB

Ensembl ID: ENSG00000160633

Description: scaffold attachment factor B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 296.8911
    Cell Significance Index: -46.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 181.3964
    Cell Significance Index: -46.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 135.4541
    Cell Significance Index: -55.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.0215
    Cell Significance Index: -53.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 108.6750
    Cell Significance Index: -44.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.9336
    Cell Significance Index: -50.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.7142
    Cell Significance Index: -53.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.5361
    Cell Significance Index: -44.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.1653
    Cell Significance Index: -50.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.3805
    Cell Significance Index: -46.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5538
    Cell Significance Index: -41.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3044
    Cell Significance Index: -52.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0202
    Cell Significance Index: -21.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0543
    Cell Significance Index: 1854.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8295
    Cell Significance Index: 48.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5215
    Cell Significance Index: 165.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3436
    Cell Significance Index: 266.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3298
    Cell Significance Index: 266.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0122
    Cell Significance Index: 124.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9501
    Cell Significance Index: 27.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9427
    Cell Significance Index: 52.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9193
    Cell Significance Index: 41.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8569
    Cell Significance Index: 154.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8192
    Cell Significance Index: 22.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7285
    Cell Significance Index: 261.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7172
    Cell Significance Index: 37.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6666
    Cell Significance Index: 91.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6477
    Cell Significance Index: 18.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6275
    Cell Significance Index: 48.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5996
    Cell Significance Index: 414.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5829
    Cell Significance Index: 68.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5793
    Cell Significance Index: 14.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5629
    Cell Significance Index: 307.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5139
    Cell Significance Index: 33.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4996
    Cell Significance Index: 23.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4554
    Cell Significance Index: 23.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4149
    Cell Significance Index: 25.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4053
    Cell Significance Index: 8.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3871
    Cell Significance Index: 13.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3821
    Cell Significance Index: 19.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3785
    Cell Significance Index: 10.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3653
    Cell Significance Index: 161.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2982
    Cell Significance Index: 20.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2920
    Cell Significance Index: 28.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2883
    Cell Significance Index: 7.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1997
    Cell Significance Index: 9.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1914
    Cell Significance Index: 24.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1581
    Cell Significance Index: 20.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1302
    Cell Significance Index: 4.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1298
    Cell Significance Index: 244.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1148
    Cell Significance Index: 2.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0838
    Cell Significance Index: 5.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0694
    Cell Significance Index: 13.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0649
    Cell Significance Index: 99.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0610
    Cell Significance Index: 27.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0585
    Cell Significance Index: 107.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0470
    Cell Significance Index: 3.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0450
    Cell Significance Index: 28.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0261
    Cell Significance Index: 35.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0212
    Cell Significance Index: 1.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0133
    Cell Significance Index: -0.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0230
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0259
    Cell Significance Index: -4.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0394
    Cell Significance Index: -29.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0589
    Cell Significance Index: -43.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0820
    Cell Significance Index: -46.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0863
    Cell Significance Index: -14.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0867
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0967
    Cell Significance Index: -60.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1021
    Cell Significance Index: -1.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1372
    Cell Significance Index: -6.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1571
    Cell Significance Index: -45.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1776
    Cell Significance Index: -25.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1834
    Cell Significance Index: -3.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2575
    Cell Significance Index: -30.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2800
    Cell Significance Index: -58.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2980
    Cell Significance Index: -11.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3057
    Cell Significance Index: -35.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3187
    Cell Significance Index: -6.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3422
    Cell Significance Index: -35.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3473
    Cell Significance Index: -4.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3584
    Cell Significance Index: -4.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3602
    Cell Significance Index: -7.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4107
    Cell Significance Index: -9.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5318
    Cell Significance Index: -42.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5545
    Cell Significance Index: -3.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5742
    Cell Significance Index: -16.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5887
    Cell Significance Index: -15.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6598
    Cell Significance Index: -5.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6733
    Cell Significance Index: -41.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6753
    Cell Significance Index: -18.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6881
    Cell Significance Index: -8.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7095
    Cell Significance Index: -15.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8414
    Cell Significance Index: -24.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8717
    Cell Significance Index: -12.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8861
    Cell Significance Index: -9.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8884
    Cell Significance Index: -16.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8979
    Cell Significance Index: -20.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0765
    Cell Significance Index: -34.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Scaffold function:** SAFB acts as a scaffold protein, facilitating the assembly of transcriptional complexes and chromatin-associated proteins. 2. **Chromatin organization:** SAFB regulates chromatin structure and organization, influencing gene expression and transcriptional control. 3. **Transcriptional regulation:** SAFB interacts with transcriptional regulators, modulating the activity of RNA polymerase II and other transcriptional machinery. 4. **Sumoylation:** SAFB is involved in sumoylation, a post-translational modification that regulates protein function and stability. 5. **Cell-type specificity:** SAFB expression is detected in various cell types, including GABAergic neurons, oogonial cells, and skeletal muscle satellite stem cells. **Pathways and Functions:** 1. **Chromatin binding:** SAFB binds to chromatin, regulating chromatin structure and organization. 2. **Intracellular estrogen receptor signaling:** SAFB interacts with estrogen receptor signaling pathways, modulating gene expression and transcriptional control. 3. **Sumoylation:** SAFB is involved in sumoylation, a post-translational modification that regulates protein function and stability. 4. **Regulation of mRNA processing:** SAFB regulates mRNA processing, influencing the stability and translation of target mRNAs. 5. **Regulation of transcription by RNA polymerase II:** SAFB interacts with RNA polymerase II, modulating the activity of this transcriptional machinery. **Clinical Significance:** 1. **Neurological disorders:** SAFB's involvement in GABAergic neuron function and chromatin organization may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** SAFB's expression in various cancer types, including breast cancer and leukemia, suggests its potential role in tumorigenesis and cancer progression. 3. **Developmental biology:** SAFB's involvement in the development of oogonial cells and skeletal muscle satellite stem cells highlights its importance in cellular differentiation and development. 4. **Estrogen receptor signaling:** SAFB's interaction with estrogen receptor signaling pathways may contribute to the regulation of estrogen-dependent gene expression and tissue development. In conclusion, Scaffold Attachment Factor B (SAFB) is a multifunctional protein that plays a crucial role in regulating gene expression, chromatin organization, and transcriptional control. Its involvement in various signaling pathways and its expression in multiple cell types underscore its importance in cellular processes. Further research is needed to fully elucidate SAFB's functions and its role in various diseases.

Genular Protein ID: 228700606

Symbol: SAFB1_HUMAN

Name: Scaffold attachment factor B1

UniProtKB Accession Codes:

Q15424 A0AV56 B7Z5B6 B7ZLP6 F5H0H3 O60406 Q59HH8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9328833

Title: Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells.

PubMed ID: 9328833

DOI: 10.1002/(sici)1097-4644(19971101)67:2<275::aid-jcb13>3.3.co;2-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8600450

Title: Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA.

PubMed ID: 8600450

DOI: 10.1093/nar/24.5.843

PubMed ID: 9671816

Title: SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements.

PubMed ID: 9671816

DOI: 10.1093/nar/26.15.3542

PubMed ID: 11509566

Title: Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B.

PubMed ID: 11509566

DOI: 10.1074/jbc.m104755200

PubMed ID: 12660241

Title: SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor.

PubMed ID: 12660241

DOI: 10.1074/jbc.m212988200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19674106

Title: The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.

PubMed ID: 19674106

DOI: 10.1111/j.1742-4658.2009.07217.x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21527249

Title: Co-repressor activity of scaffold attachment factor B1 requires sumoylation.

PubMed ID: 21527249

DOI: 10.1016/j.bbrc.2011.04.040

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22693546

Title: Sequence-specific binding of recombinant Zbed4 to DNA: insights into Zbed4 participation in gene transcription and its association with other proteins.

PubMed ID: 22693546

DOI: 10.1371/journal.pone.0035317

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27731383

Title: FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.

PubMed ID: 27731383

DOI: 10.1038/srep35195

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 915
  • Mass: 102642
  • Checksum: E865940BC7783C4A
  • Sequence:
    • MAETLSGLGD SGAAGAAALS SASSETGTRR LSDLRVIDLR AELRKRNVDS SGNKSVLMER 
LKKAIEDEGG NPDEIEITSE GNKKTSKRSS KGRKPEEEGV EDNGLEENSG DGQEDVETSL 
ENLQDIDIMD ISVLDEAEID NGSVADCVED DDADNLQESL SDSRELVEGE MKELPEQLQE 
HAIEDKETIN NLDTSSSDFT ILQEIEEPSL EPENEKILDI LGETCKSEPV KEESSELEQP 
FAQDTSSVGP DRKLAEEEDL FDSAHPEEGD LDLASESTAH AQSSKADSLL AVVKREPAEQ 
PGDGERTDCE PVGLEPAVEQ SSAASELAEA SSEELAEAPT EAPSPEARDS KEDGRKFDFD 
ACNEVPPAPK ESSTSEGADQ KMSSPEDDSD TKRLSKEEKG RSSCGRNFWV SGLSSTTRAT 
DLKNLFSKYG KVVGAKVVTN ARSPGARCYG FVTMSTAEEA TKCINHLHKT ELHGKMISVE 
KAKNEPVGKK TSDKRDSDGK KEKSSNSDRS TNLKRDDKCD RKDDAKKGDD GSGEKSKDQD 
DQKPGPSERS RATKSGSRGT ERTVVMDKSK GVPVISVKTS GSKERASKSQ DRKSASREKR 
SVVSFDKVKE PRKSRDSESH SRVRERSERE QRMQAQWERE ERERLEIARE RLAFQRQRLE 
RERMERERLE RERMHVEHER RREQERIHRE REELRRQQEL RYEQERRPAV RRPYDLDRRD 
DAYWPEAKRA ALDERYHSDF NRQDRFHDFD HRDRGRYPDH SVDRREGSRS MMGEREGQHY 
PERHGGPERH GRDSRDGWGG YGSDKRMSEG RGLPPPPRRD WGDHGRREDD RSWQGTADGG 
MMDRDHKRWQ GGERSMSGHS GPGHMMNRGG MSGRGSFAPG GASRGHPIPH GGMQGGFGGQ 
SRGSRPSDAR FTRRY

Genular Protein ID: 228832646

Symbol: B7ZLP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLP5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 914
  • Mass: 102581
  • Checksum: C015B16E66F08F2E
  • Sequence:
    • MAETLSGLGD SGAAGAAALS SASSETGTRR LSDLRVIDLR AELRKRNVDS SGNKSVLMER 
LKKAIEDEGG NPDEIEITSE GNKKTSKRSS KGRKPEEEGV EDNGLEENSG DGQEDVETSL 
ENLQDIDIMD ISVLDEAEID NGSVADCVED DDADNLQESL SDSRELVEGE MKELPEQLQE 
HAIEDKETIN NLDTSSSDFT ILQEIEEPSL EPENEKILDI LGETCKSEPV KEESSELEQP 
FAQDTSSVGP DRKLAEEEDL FDSAHPEEGD LDLASESTAH AQSSKADSLL AVVKREPAEQ 
PGDGERTDCE PVGLEPAVEQ SSAASELAEA SSEELAEAPT EAPSPEARDS KEDGRKFDFD 
ACNEVPPAPK ESSTSEGADQ KMSSPEDDSD TKRLSKEEKG RSSCGRNFWV SGLSSTTRAT 
DLKNLFSKYG KVVGAKVVTN ARSPGARCYG FVTMSTAEEA TKCINHLHKT ELHGKMISVE 
KAKNEPVGKK TSDKRDSDGK KEKSSNSDRS TNLKRDDKCD RKDDAKKGDD GSGEKSKDQD 
DQKPGPSERS RATKSGSRGT ERTVVMDKSK GVPVISVKTS GSKERASKSQ DRKSASREKR 
SVVSFDKVKE PRKSRDSESH RVRERSEREQ RMQAQWEREE RERLEIARER LAFQRQRLER 
ERMERERLER ERMHVEHERR REQERIHRER EELRRQQELR YEQERRPAVR RPYDLDRRDD 
AYWPEAKRAA LDERYHSDFN RQDRFHDFDH RDRGRYPDHS VDRREGSRSM MGEREGQHYP 
ERHGGPERHG RDSRDGWGGY GSDKRMSEGR GLPPPPRRDW GDHGRREDDR SWQGTADGGM 
MDRDHKRWQG GERSMSGHSG PGHMMNRGGM SGRGSFAPGG ASRGHPIPYG GMQGGFGGQS 
RGSRPSDARF TRRY

Genular Protein ID: 2967678626

Symbol: B7Z2F6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2F6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 759
  • Mass: 86100
  • Checksum: E57439CBF54028F2
  • Sequence:
    • MKVVILTKLK LPPRETRKHQ RGLAKIEDKE TINNLDTSSS DFTILQEIEE PSLEPENEKI 
LDILGETCKS EPVKEESSEL EQPFAQDTSS VGPDRKLAEE EDLFDSAHPE EGDLDLASES 
TAHAQSSKAD SLLAVVKREP AEQPGDGERT DCEPVGLEPA VEQSSAASEL AEASSEELAE 
APTEAPSPEA RDSKEDGRKF DFDACNEVPP APKESSTSEG ADQKMSSPED DSDTKRLSKE 
EKGRSSCGRN FWVSGLSSTT RATDLKNLFS KYGKVVGAKV VTNARSPGAR CYGFVTMSTA 
EEATKCINHL HKTELHGKMI SVEKAKNEPV GKKTSDKRDS DGKKEKSSNS DRSTNLKRDD 
KCDRKDDAKK GDDGSGEKSK DQDDQKPGPS ERSRATKSGS RGTERTVVMD KSKGVPVISV 
KTSGSKERAS KSQDRKSASR EKRSVVSFDK VKEPRKSRDS ESHRVRERSE REQRMQAQWE 
REERERLEIA RERLAFQRQR LERERMERER LERERMHVEH ERRREQERIH REREELRRQQ 
ELRYEQERRP AVRRPYDLDR RDDAYWPEAK RAALDERYHS DFNRQDRFHD FDHRDRGRYP 
DHSVDRREGS RSMMGEREGQ HYPERHGGPE RHGRDSRDGW GGYGSDKRMS EGRGLPPPPR 
GRRDWGDHGR REDDRSWQGT ADGGMMDRDH KRWQGGERSM SGHSGPGHMM NRGGMSGRGS 
FAPGGASRGH PIPHGGMQGG FGGQSRGSRP SDARFTRRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.