Details for: TSPAN31

Gene ID: 6302

Symbol: TSPAN31

Ensembl ID: ENSG00000135452

Description: tetraspanin 31

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 178.5333
    Cell Significance Index: -27.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.2051
    Cell Significance Index: -25.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.9219
    Cell Significance Index: -30.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.7302
    Cell Significance Index: -28.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.3836
    Cell Significance Index: -22.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.6624
    Cell Significance Index: -26.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.9750
    Cell Significance Index: -22.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8232
    Cell Significance Index: -28.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9329
    Cell Significance Index: -23.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1844
    Cell Significance Index: -28.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5641
    Cell Significance Index: -17.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.5171
    Cell Significance Index: 72.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8812
    Cell Significance Index: 305.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5254
    Cell Significance Index: 41.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0089
    Cell Significance Index: 52.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9044
    Cell Significance Index: 57.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8529
    Cell Significance Index: 99.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7929
    Cell Significance Index: 6.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7339
    Cell Significance Index: 100.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7049
    Cell Significance Index: 86.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6952
    Cell Significance Index: 36.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6769
    Cell Significance Index: 122.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6055
    Cell Significance Index: 28.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5183
    Cell Significance Index: 283.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5125
    Cell Significance Index: 11.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4779
    Cell Significance Index: 12.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4248
    Cell Significance Index: 29.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4106
    Cell Significance Index: 26.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4011
    Cell Significance Index: 8.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3695
    Cell Significance Index: 26.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3653
    Cell Significance Index: 72.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3477
    Cell Significance Index: 16.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3388
    Cell Significance Index: 3.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3362
    Cell Significance Index: 67.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3154
    Cell Significance Index: 60.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2838
    Cell Significance Index: 36.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2784
    Cell Significance Index: 20.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2760
    Cell Significance Index: 122.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2718
    Cell Significance Index: 12.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1932
    Cell Significance Index: 24.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1583
    Cell Significance Index: 2.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1422
    Cell Significance Index: 14.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1260
    Cell Significance Index: 45.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1156
    Cell Significance Index: 6.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0942
    Cell Significance Index: 1.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0868
    Cell Significance Index: 3.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0868
    Cell Significance Index: 60.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0767
    Cell Significance Index: 2.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0126
    Cell Significance Index: 1.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0103
    Cell Significance Index: 19.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0076
    Cell Significance Index: 5.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0070
    Cell Significance Index: 0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0019
    Cell Significance Index: 2.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0037
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0221
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0301
    Cell Significance Index: -22.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0310
    Cell Significance Index: -14.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0363
    Cell Significance Index: -0.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0449
    Cell Significance Index: -25.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0486
    Cell Significance Index: -13.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0517
    Cell Significance Index: -32.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0550
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0582
    Cell Significance Index: -6.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0657
    Cell Significance Index: -1.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1153
    Cell Significance Index: -4.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1237
    Cell Significance Index: -9.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1282
    Cell Significance Index: -18.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1484
    Cell Significance Index: -31.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1495
    Cell Significance Index: -2.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1534
    Cell Significance Index: -3.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1554
    Cell Significance Index: -4.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1668
    Cell Significance Index: -1.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1753
    Cell Significance Index: -4.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1784
    Cell Significance Index: -4.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1791
    Cell Significance Index: -5.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1940
    Cell Significance Index: -5.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2047
    Cell Significance Index: -2.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2393
    Cell Significance Index: -16.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2498
    Cell Significance Index: -4.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2590
    Cell Significance Index: -26.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2918
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2972
    Cell Significance Index: -23.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3254
    Cell Significance Index: -19.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3778
    Cell Significance Index: -16.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4356
    Cell Significance Index: -6.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4468
    Cell Significance Index: -8.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4592
    Cell Significance Index: -17.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4646
    Cell Significance Index: -11.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4670
    Cell Significance Index: -23.6000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4706
    Cell Significance Index: -5.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4930
    Cell Significance Index: -3.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4981
    Cell Significance Index: -12.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5497
    Cell Significance Index: -20.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5536
    Cell Significance Index: -14.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5565
    Cell Significance Index: -16.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5597
    Cell Significance Index: -22.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TSPAN31 exhibits several key characteristics that distinguish it from other tetraspanins: 1. **Expression Pattern**: TSPAN31 is widely expressed in various cell types, including immune cells (myeloid leukocyte), epithelial cells (bladder urothelial cell, luminal epithelial cell of mammary gland), and neural cells (cerebral cortex GABAergic interneuron, forebrain radial glial cell). 2. **Cellular Localization**: TSPAN31 is predominantly localized to the plasma membrane, where it interacts with other proteins to regulate cellular processes. 3. **Protein Binding**: TSPAN31 interacts with various proteins, including other tetraspanins, integrins, and adhesion molecules, to regulate cell-cell interactions and signaling. 4. **Membrane Organization**: TSPAN31 plays a role in maintaining the structural integrity of the plasma membrane and regulating membrane organization. **Pathways and Functions** TSPAN31 is involved in several key pathways and functions, including: 1. **Positive Regulation of Cell Population Proliferation**: TSPAN31 regulates cell proliferation by interacting with other proteins to activate signaling pathways that promote cell growth and division. 2. **Protein Binding**: TSPAN31 interacts with various proteins to regulate protein-protein interactions, which are crucial for maintaining cellular homeostasis and regulating signaling pathways. 3. **Membrane Organization**: TSPAN31 plays a role in maintaining the structural integrity of the plasma membrane and regulating membrane organization, which is essential for cellular processes such as cell-cell interactions and signaling. 4. **Immune Regulation**: TSPAN31 is involved in regulating immune responses, including the activation of immune cells and the regulation of inflammatory responses. **Clinical Significance** TSPAN31 has several clinical implications, including: 1. **Cancer**: Aberrant expression of TSPAN31 has been observed in various types of cancer, including breast cancer and bladder cancer. TSPAN31 may play a role in regulating cell proliferation and tumor progression. 2. **Autoimmune Diseases**: TSPAN31 is involved in regulating immune responses and may play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders**: TSPAN31 is expressed in neural cells and may play a role in regulating neuronal function and behavior, which is relevant to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TSPAN31 is a multifaceted protein that plays a crucial role in regulating various cellular processes, including immune response, cell proliferation, and differentiation. Further studies are needed to fully elucidate the functions and clinical significance of TSPAN31, but its significance in cancer, autoimmune diseases, and neurological disorders highlights its importance as a potential therapeutic target.

Genular Protein ID: 171230180

Symbol: TSN31_HUMAN

Name: Tetraspanin-31

UniProtKB Accession Codes:

Q12999 O00577 Q53X76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8134123

Title: SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins.

PubMed ID: 8134123

PubMed ID: 9192850

Title: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.

PubMed ID: 9192850

DOI: 10.1006/geno.1997.4727

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 210
  • Mass: 23053
  • Checksum: 8A1FF8CC5319755E
  • Sequence:
    • MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI AVGVFLLLIA 
VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN RSKQTDVINA SWWVMSNKTR 
DELERSFDCC GLFNLTTLYQ QDYDFCTAIC KSQSPTCQMC GEKFLKHSDE ALKILGGVGL 
FFSFTEILGV WLAMRFRNQK DPRANPSAFL

Genular Protein ID: 2814650044

Symbol: F8VWE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VWE0

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 127
  • Mass: 14325
  • Checksum: DBB73B0C7AFC12D1
  • Sequence:
    • MVCGGFACSK NALCALNVVY MTDVINASWW VMSNKTRDEL ERSFDCCGLF NLTTLYQQDY 
DFCTAICKSQ SPTCQMCGEK FLKHSDEALK ILGGVGLFFS FTEILGVWLA MRFRNQKDPR 
ANPSAFL

Genular Protein ID: 489665760

Symbol: B4DFJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFJ7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 132
  • Mass: 15075
  • Checksum: 7B2F132D23755610
  • Sequence:
    • MIILGLVFIF QFVISCSCLA INRSKQTDVI NASWWVMSNK TRDELERSFD CCGLFNLTTL 
YQQDYDFCTA ICKSQSPTCQ MCGEKFLKHS DEALKILGGV GLFFSFTEIL GVWLAMRFRN 
QKDPRANPSA FL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.