Details for: SDHD
Gene ID: 6392
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SDHD
Ensembl ID: ENSG00000204370
Description: succinate dehydrogenase complex subunit D
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 42.59rCSI 44.51%PRS 44.1
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CSI 37.83rCSI 44.43%PRS 48.27
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CSI 20.71rCSI 33.4%PRS 53.4
-
CSI 18.97rCSI 61.52%PRS 47.25
-
CSI 17.83rCSI 51.63%PRS 47.01
-
CSI 17.35rCSI 16.73%PRS 35.52
-
CSI 17.05rCSI 17.86%PRS 41.87
-
CSI 16.13rCSI 25.65%PRS 37.88
-
CSI 15.94rCSI 37.9%PRS 56.73
-
CSI 12.15rCSI 11.7%PRS 45.09
-
CSI 10.46rCSI 9.53%PRS 59.6
-
CSI 10.2rCSI 14.63%PRS 51.82
-
CSI 10.12rCSI 58.01%PRS 55.17
-
CSI 8.97rCSI 21.91%PRS 40.66
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CSI 8.75rCSI 38.4%PRS 63.78
-
CSI 8.6rCSI 64.58%PRS 64.7
-
CSI 8.55rCSI 10.65%PRS 55.95
-
CSI 8.36rCSI 6.93%PRS 43.13
-
CSI 8.3rCSI 11.3%PRS 38.15
-
CSI 7.72rCSI 11.98%PRS 54.55
-
CSI 7.61rCSI 9.77%PRS 40.21
-
CSI 7.44rCSI 5.01%PRS 54.82
-
CSI 7.19rCSI 10.99%PRS 60.84
-
CSI 7.16rCSI 14.19%PRS 67.13
-
CSI 7.11rCSI 10.83%PRS 41.35
-
CSI 6.72rCSI 8.93%PRS 49.35
-
CSI 6.55rCSI 9.44%PRS 58.04
-
CSI 6.53rCSI 5.79%PRS 43.66
-
CSI 6.52rCSI 37.93%PRS 55.68
-
CSI 6.06rCSI 6.33%PRS 45.24
-
CSI 6.04rCSI 12.85%PRS 59.56
-
CSI 5.57rCSI 9.82%PRS 53.14
-
CSI 5.47rCSI 7.48%PRS 49.49
-
CSI 5.38rCSI 7.19%PRS 46.08
-
CSI 5.23rCSI 11.51%PRS 58.98
-
CSI 5.02rCSI 13.54%PRS 53.35
-
CSI 4.84rCSI 7.64%PRS 45.6
-
CSI 4.82rCSI 6.06%PRS 58.14
-
CSI 4.79rCSI 13.42%PRS 59.06
-
CSI 4.74rCSI 5.72%PRS 52.39
-
CSI 4.57rCSI 6.7%PRS 55.77
-
CSI 4.56rCSI 3.41%PRS 59.09
-
CSI 4.47rCSI 4.16%PRS 44.39
-
CSI 4.46rCSI 12.79%PRS 62.18
-
CSI 4.46rCSI 4.02%PRS 41.32
-
CSI 4.25rCSI 2.83%PRS 70.24
-
CSI 4.21rCSI 5.83%PRS 49.49
-
CSI 4.15rCSI 5.66%PRS 47.25
-
CSI 4.11rCSI 3.8%PRS 64.62
-
CSI 4.1rCSI 5.93%PRS 60.8
-
CSI 4.09rCSI 18.9%PRS 66.83
-
CSI 4.07rCSI 3.51%PRS 53.05
-
CSI 3.96rCSI 21.38%PRS 59.06
-
CSI 3.88rCSI 7.39%PRS 61.15
-
CSI 3.83rCSI 3.07%PRS 65.89
-
CSI 3.72rCSI 3.02%PRS 45.3
-
CSI 3.66rCSI 18.37%PRS 55.52
-
CSI 3.65rCSI 9.64%PRS 52.15
-
CSI 3.64rCSI 3.34%PRS 51.99
-
CSI 3.61rCSI 4.59%PRS 49.84
-
CSI 3.59rCSI 2.83%PRS 50.97
-
CSI 3.52rCSI 3.25%PRS 45.5
-
CSI 3.38rCSI 5.42%PRS 72.87
-
CSI 3.37rCSI 9.77%PRS 36.23
-
CSI 3.36rCSI 3.17%PRS 45.51
-
CSI 3.35rCSI 5.35%PRS 48.38
-
CSI 3.26rCSI 5.81%PRS 60.02
-
CSI 3.25rCSI 2.7%PRS 45.52
-
CSI 3.2rCSI 2.43%PRS 55.89
-
CSI 3.17rCSI 2.38%PRS 76.5
-
CSI 3.14rCSI 2.18%PRS 53.07
-
CSI 3.14rCSI 2.42%PRS 43.44
-
CSI 3.12rCSI 16.78%PRS 59.91
-
CSI 3.1rCSI 2.41%PRS 45.02
-
CSI 3.08rCSI 6.13%PRS 62.37
-
CSI 3.06rCSI 4.36%PRS 47.24
-
CSI 3.04rCSI 3.99%PRS 57.56
-
CSI 3.04rCSI 3.03%PRS 38.99
-
CSI 3rCSI 4.01%PRS 52.96
-
CSI 2.97rCSI 15.6%PRS 59.21
-
CSI 2.93rCSI 45.29%PRS 70.02
-
CSI 2.78rCSI 2.88%PRS 50.39
-
CSI 2.73rCSI 2.28%PRS 49.53
-
CSI 2.72rCSI 2.39%PRS 34.08
-
CSI 2.64rCSI 3.27%PRS 40.57
-
CSI 2.64rCSI 4.03%PRS 53.79
-
CSI 2.6rCSI 1.86%PRS 57.4
-
CSI 2.6rCSI 5.05%PRS 46.65
-
CSI 2.6rCSI 2.67%PRS 62.21
-
CSI 2.57rCSI 5.73%PRS 51.12
-
CSI 2.54rCSI 7%PRS 41.41
-
CSI 2.51rCSI 2.66%PRS 59.51
-
CSI 2.47rCSI 1.46%PRS 59.61
-
CSI 2.41rCSI 2.37%PRS 46.97
-
CSI 2.4rCSI 3.08%PRS 49.29
-
CSI 2.36rCSI 3.82%PRS 43.07
-
CSI 2.34rCSI 1.95%PRS 64.87
-
CSI 2.29rCSI 6.12%PRS 37.68
-
CSI 2.29rCSI 4.59%PRS 34.75
-
CSI 2.26rCSI 4.98%PRS 48.51
-
CSI 0.1rCSI 0.8%PRS 56.7%
-
CSI 0.2rCSI 4.3%PRS 67.4%
-
CSI 0.2rCSI 1.8%PRS 81.8%
-
CSI 0.3rCSI 1.3%PRS 66.8%
-
CSI 0.3rCSI 3.9%PRS 69.1%
-
CSI 0.3rCSI 1.3%PRS 69.9%
-
CSI 0.3rCSI 7.2%PRS 91.3%
-
CSI 0.3rCSI 3.4%PRS 45.8%
-
CSI 0.3rCSI 2.7%PRS 39.3%
-
CSI 0.3rCSI 3.4%PRS 71.3%
-
CSI 0.4rCSI 1.5%PRS 60.9%
-
CSI 0.4rCSI 3.9%PRS 65.0%
-
CSI 0.4rCSI 3.4%PRS 74.9%
-
CSI 0.4rCSI 3.0%PRS 62.9%
-
CSI 0.5rCSI 0.8%PRS 64.0%
-
CSI 0.5rCSI 1.0%PRS 33.3%
-
CSI 0.5rCSI 3.2%PRS 68.2%
-
CSI 0.5rCSI 2.1%PRS 64.9%
-
CSI 0.6rCSI 7.4%PRS 77.2%
-
CSI 0.6rCSI 1.8%PRS 52.1%
-
CSI 0.6rCSI 6.0%PRS 71.1%
-
CSI 0.6rCSI 3.7%PRS 69.0%
-
CSI 0.6rCSI 3.4%PRS 75.9%
-
CSI 0.6rCSI 5.6%PRS 89.6%
-
CSI 0.7rCSI 3.5%PRS 68.4%
-
CSI 0.7rCSI 3.1%PRS 43.3%
-
CSI 0.7rCSI 3.5%PRS 56.4%
-
CSI 0.7rCSI 1.1%PRS 46.6%
-
CSI 0.7rCSI 1.2%PRS 35.6%
-
CSI 0.7rCSI 1.6%PRS 42.0%
-
CSI 0.8rCSI 3.1%PRS 66.0%
-
CSI 0.9rCSI 1.7%PRS 74.4%
-
CSI 0.9rCSI 3.1%PRS 60.1%
-
CSI 0.9rCSI 1.2%PRS 57.4%
-
CSI 0.9rCSI 2.6%PRS 59.1%
-
CSI 0.9rCSI 3.3%PRS 77.4%
-
CSI 0.9rCSI 2.4%PRS 49.6%
-
CSI 1.0rCSI 1.1%PRS 42.7%
-
CSI 1.0rCSI 2.1%PRS 64.0%
-
CSI 1.0rCSI 1.4%PRS 65.4%
-
CSI 1.0rCSI 0.9%PRS 54.0%
-
CSI 1.0rCSI 3.6%PRS 63.6%
-
CSI 1.0rCSI 2.4%PRS 46.8%
-
CSI 1.0rCSI 1.5%PRS 47.6%
-
CSI 1.0rCSI 1.8%PRS 35.6%
-
CSI 1.1rCSI 3.1%PRS 67.2%
-
CSI 1.1rCSI 3.1%PRS 62.2%
-
CSI 1.1rCSI 2.9%PRS 52.9%
-
CSI 1.2rCSI 1.5%PRS 54.2%
-
CSI 1.2rCSI 2.7%PRS 43.2%
-
CSI 1.2rCSI 3.0%PRS 40.6%
-
CSI 1.2rCSI 4.2%PRS 80.1%
-
CSI 1.2rCSI 1.8%PRS 61.8%
-
CSI 1.3rCSI 2.0%PRS 51.5%
-
CSI 1.3rCSI 1.5%PRS 67.2%
-
CSI 1.4rCSI 1.9%PRS 44.1%
-
CSI 1.4rCSI 1.8%PRS 66.8%
-
CSI 1.4rCSI 2.1%PRS 49.2%
-
CSI 1.4rCSI 2.1%PRS 45.2%
-
CSI 1.4rCSI 3.4%PRS 54.8%
-
CSI 1.4rCSI 3.9%PRS 60.0%
-
CSI 1.4rCSI 1.1%PRS 66.6%
-
CSI 1.4rCSI 1.4%PRS 68.5%
-
CSI 1.5rCSI 3.0%PRS 66.7%
-
CSI 1.5rCSI 1.8%PRS 47.3%
-
CSI 1.5rCSI 3.8%PRS 40.9%
-
CSI 1.5rCSI 4.3%PRS 62.1%
-
CSI 1.5rCSI 2.9%PRS 67.8%
-
CSI 1.5rCSI 5.2%PRS 75.9%
-
CSI 1.5rCSI 3.2%PRS 42.5%
-
CSI 1.5rCSI 2.9%PRS 54.8%
-
CSI 1.5rCSI 3.3%PRS 54.5%
-
CSI 1.6rCSI 1.7%PRS 42.6%
-
CSI 1.6rCSI 2.3%PRS 62.1%
-
CSI 1.6rCSI 1.8%PRS 35.0%
-
CSI 1.6rCSI 1.2%PRS 57.8%
-
CSI 1.6rCSI 2.7%PRS 53.8%
-
CSI 1.6rCSI 1.7%PRS 57.6%
-
CSI 1.7rCSI 4.1%PRS 42.6%
-
CSI 1.7rCSI 3.1%PRS 78.1%
-
CSI 1.7rCSI 4.3%PRS 35.4%
-
CSI 1.7rCSI 2.6%PRS 71.5%
-
CSI 1.7rCSI 1.9%PRS 61.0%
-
CSI 1.7rCSI 1.5%PRS 48.3%
-
CSI 1.7rCSI 1.8%PRS 63.0%
-
CSI 1.7rCSI 2.5%PRS 54.5%
-
CSI 1.8rCSI 2.3%PRS 42.6%
-
CSI 1.8rCSI 9.2%PRS 79.6%
-
CSI 1.8rCSI 2.6%PRS 41.6%
-
CSI 1.8rCSI 2.2%PRS 52.1%
-
CSI 1.8rCSI 2.8%PRS 42.5%
-
CSI 1.8rCSI 31.9%PRS 78.1%
-
CSI 1.9rCSI 4.5%PRS 62.4%
-
CSI 1.9rCSI 1.4%PRS 63.0%
-
CSI 1.9rCSI 3.0%PRS 55.2%
-
CSI 1.9rCSI 3.2%PRS 70.6%
-
CSI 1.9rCSI 2.8%PRS 47.2%
-
CSI 1.9rCSI 6.8%PRS 57.2%
-
CSI 1.9rCSI 1.9%PRS 59.9%
-
CSI 2.0rCSI 3.5%PRS 38.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 199115780
Symbol: DHSD_HUMAN
Name: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9533030
Title: Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23.
PubMed ID: 9533030
DOI: 10.1159/000134700
PubMed ID: 10482792
Title: Characterization of the human SDHD gene encoding the small subunit of cytochrome b (cybS) in mitochondrial succinate-ubiquinone oxidoreductase.
PubMed ID: 10482792
PubMed ID: 16303743
Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
PubMed ID: 16303743
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 37098072
Title: Structure of the human respiratory complex II.
PubMed ID: 37098072
PubMed ID: 11156372
Title: Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma.
PubMed ID: 11156372
PubMed ID: 10657297
Title: Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.
PubMed ID: 10657297
PubMed ID: 11343322
Title: Novel mutations and the emergence of a common mutation in the SDHD gene causing familial paraganglioma.
PubMed ID: 11343322
DOI: 10.1002/ajmg.1270
PubMed ID: 11391796
Title: Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss.
PubMed ID: 11391796
DOI: 10.1002/gcc.1142
PubMed ID: 11391798
Title: Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene.
PubMed ID: 11391798
DOI: 10.1002/gcc.1144
PubMed ID: 11526495
Title: Germline SDHD mutation in paraganglioma of the spinal cord.
PubMed ID: 11526495
PubMed ID: 12007193
Title: Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas.
PubMed ID: 12007193
DOI: 10.1002/gcc.10081
PubMed ID: 14500403
Title: Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.
PubMed ID: 14500403
PubMed ID: 12000816
Title: Germ-line mutations in nonsyndromic pheochromocytoma.
PubMed ID: 12000816
DOI: 10.1056/nejmoa020152
PubMed ID: 12696072
Title: G12S and H50R variations are polymorphisms in the SDHD gene.
PubMed ID: 12696072
DOI: 10.1002/gcc.10212
PubMed ID: 15328326
Title: Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.
PubMed ID: 15328326
PubMed ID: 15032977
Title: SDHD mutation analysis in seven German patients with sporadic carotid body paraganglioma: one novel mutation, no Dutch founder mutation and further evidence that G12S is a polymorphism.
PubMed ID: 15032977
PubMed ID: 17804857
Title: Familial gastrointestinal stromal tumors and germ-line mutations.
PubMed ID: 17804857
DOI: 10.1056/nejmc071191
PubMed ID: 18678321
Title: Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes.
PubMed ID: 18678321
PubMed ID: 18987736
Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
PubMed ID: 18987736
DOI: 10.1038/nature07485
PubMed ID: 24367056
Title: Mutations in SDHD lead to autosomal recessive encephalomyopathy and isolated mitochondrial complex II deficiency.
PubMed ID: 24367056
PubMed ID: 26008905
Title: A recessive homozygous p.Asp92Gly SDHD mutation causes prenatal cardiomyopathy and a severe mitochondrial complex II deficiency.
PubMed ID: 26008905
Sequence Information:
- Length: 159
- Mass: 17043
- Checksum: 6B1AA94831C8C3B6
- Sequence:
MAVLWRLSAV CGALGGRALL LRTPVVRPAH ISAFLQDRPI PEWCGVQHIH LSPSHHSGSK AASLHWTSER VVSVLLLGLL PAAYLNPCSA MDYSLAAALT LHGHWGLGQV VTDYVHGDAL QKAAKAGLLA LSALTFAGLC YFNYHDVGIC KAVAMLWKL
Genular Protein ID: 4206575651
Symbol: A0A0S2Z4H7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 85
- Mass: 9720
- Checksum: 590AF9A98DD8AE76
- Sequence:
MAVLWRLSAV CGALGGRALL LRTPVVRPAH ISAFLQDRPI PEWCGVQHIH LSPSHHWALD KLLLTMFMGM PCRKLPRQGF WHFQL