SEC13 | ENSG00000157020 | NCBI 6396

Details for: SEC13

Gene ID: 6396

Symbol: SEC13

Ensembl ID: ENSG00000157020

Description: SEC13 homolog, nuclear pore and COPII coat complex component

Associated with

Adaptive immune system
(R-HSA-1280218)
Amino acids regulate mtorc1
(R-HSA-9639288)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cellular response to starvation
(R-HSA-9711097)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Copii-mediated vesicle transport
(R-HSA-204005)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective tpr may confer susceptibility towards thyroid papillary carcinoma (tpc)
(R-HSA-5619107)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Export of viral ribonucleoproteins from nucleus
(R-HSA-168274)
Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interactions of vpr with host cellular proteins
(R-HSA-176033)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Late phase of hiv life cycle
(R-HSA-162599)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mhc class ii antigen presentation
(R-HSA-2132295)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Nep/ns2 interacts with the cellular export machinery
(R-HSA-168333)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear import of rev protein
(R-HSA-180746)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Post-translational protein modification
(R-HSA-597592)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Regulation of glucokinase by glucokinase regulatory protein
(R-HSA-170822)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rev-mediated nuclear export of hiv rna
(R-HSA-165054)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Slc transporter disorders
(R-HSA-5619102)
Snrnp assembly
(R-HSA-191859)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of sumoylation proteins
(R-HSA-4085377)
Sumoylation of ubiquitinylation proteins
(R-HSA-3232142)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature mrna derived from an intronless transcript
(R-HSA-159231)
Transport of mature mrnas derived from intronless transcripts
(R-HSA-159234)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Transport of ribonucleoproteins into the host nucleus
(R-HSA-168271)
Transport of the slbp dependant mature mrna
(R-HSA-159230)
Transport of the slbp independent mature mrna
(R-HSA-159227)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Trna processing
(R-HSA-72306)
Trna processing in the nucleus
(R-HSA-6784531)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 250.3452
Cell Significance Index: -38.9400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 148.0819
Cell Significance Index: -37.5600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 108.1934
Cell Significance Index: -44.5700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 101.1921
Cell Significance Index: -41.1100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 99.9634
Cell Significance Index: -47.2000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 91.9739
Cell Significance Index: -47.3100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 70.4075
Cell Significance Index: -47.2500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 43.3206
Cell Significance Index: -41.3600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.1107
Cell Significance Index: -43.2900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.9429
Cell Significance Index: -40.0300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.2999
Cell Significance Index: -44.5900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.9367
Cell Significance Index: -30.5200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.0554
Cell Significance Index: -17.6300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.1635
Cell Significance Index: 45.2900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.0670
Cell Significance Index: 124.0900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.0665
Cell Significance Index: 26.4700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6647
Cell Significance Index: 181.0700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4349
Cell Significance Index: 66.9000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2548
Cell Significance Index: 249.0100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2391
Cell Significance Index: 201.5300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1067
Cell Significance Index: 29.5500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8959
Cell Significance Index: 9.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8855
Cell Significance Index: 104.4300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8422
Cell Significance Index: 24.2700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.7991
Cell Significance Index: 23.4700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7842
Cell Significance Index: 10.7000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7333
Cell Significance Index: 147.1000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5625
Cell Significance Index: 77.2500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5539
Cell Significance Index: 302.4800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5082
Cell Significance Index: 37.8800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5035
Cell Significance Index: 61.9100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5023
Cell Significance Index: 222.0900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5013
Cell Significance Index: 90.3700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.4812
Cell Significance Index: 62.1700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4347
Cell Significance Index: 19.7100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4140
Cell Significance Index: 11.2700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3930
Cell Significance Index: 30.1600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3675
Cell Significance Index: 25.9900
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3458
Cell Significance Index: 6.7500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3450
Cell Significance Index: 11.9900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.3045
Cell Significance Index: 1.8400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3033
Cell Significance Index: 38.8800
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2845
Cell Significance Index: 7.4800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2754
Cell Significance Index: 17.7700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2602
Cell Significance Index: 234.9400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2369
Cell Significance Index: 84.9800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2202
Cell Significance Index: 5.6600
Cell Name: kidney cell (CL1000497)
Fold Change: 0.2054
Cell Significance Index: 1.6400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2014
Cell Significance Index: 10.4600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1476
Cell Significance Index: 102.0700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1468
Cell Significance Index: 5.1600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1266
Cell Significance Index: 24.0900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0792
Cell Significance Index: 13.5200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0667
Cell Significance Index: 1.4200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0585
Cell Significance Index: 90.1300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0575
Cell Significance Index: 78.1900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0499
Cell Significance Index: 93.9800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0469
Cell Significance Index: 35.4700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0353
Cell Significance Index: 65.0800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0123
Cell Significance Index: 7.8400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0081
Cell Significance Index: 0.1400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0179
Cell Significance Index: -0.5000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0213
Cell Significance Index: -1.0000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0281
Cell Significance Index: -20.6300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0298
Cell Significance Index: -3.0400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0330
Cell Significance Index: -14.9800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0506
Cell Significance Index: -37.5100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0540
Cell Significance Index: -1.7300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0679
Cell Significance Index: -38.2900
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0688
Cell Significance Index: -6.8100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0735
Cell Significance Index: -3.8300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0800
Cell Significance Index: -49.9500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0936
Cell Significance Index: -4.1400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0973
Cell Significance Index: -5.4600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1085
Cell Significance Index: -2.0100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1165
Cell Significance Index: -0.9500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1278
Cell Significance Index: -36.7600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1580
Cell Significance Index: -22.9700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1717
Cell Significance Index: -6.5000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1998
Cell Significance Index: -12.5900
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2239
Cell Significance Index: -1.4600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2367
Cell Significance Index: -49.8600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2630
Cell Significance Index: -30.6500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2650
Cell Significance Index: -6.7700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2743
Cell Significance Index: -16.8600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2846
Cell Significance Index: -32.6000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2960
Cell Significance Index: -19.9000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3512
Cell Significance Index: -18.4400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3635
Cell Significance Index: -6.2300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3700
Cell Significance Index: -9.2500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3837
Cell Significance Index: -39.9500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4279
Cell Significance Index: -9.2700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4798
Cell Significance Index: -38.0000
Cell Name: peg cell (CL4033014)
Fold Change: -0.4861
Cell Significance Index: -11.2300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5124
Cell Significance Index: -13.7300
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5358
Cell Significance Index: -7.9100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5499
Cell Significance Index: -8.2400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5534
Cell Significance Index: -33.9300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5800
Cell Significance Index: -15.5200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6714
Cell Significance Index: -6.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Nuclear Pore Complex (NPC) and COPII Coat Complex Component:** SEC13 is a homolog of the NPC and COPII coat complex component, essential for nuclear envelope transport and protein secretion. 2. **Adaptive Immune System:** SEC13 is involved in the adaptive immune system, particularly in antigen presentation, MHC class I and II loading, and cytokine signaling. 3. **Cell Cycle Regulation:** SEC13 regulates the cell cycle, including mitotic anaphase, metaphase, and prophase, ensuring proper chromosome segregation and nuclear envelope reassembly. 4. **Protein Transport:** SEC13 facilitates the transport of proteins, ribonucleoproteins, and lipids across the nuclear envelope, regulating various cellular processes. **Pathways and Functions:** 1. **Adaptive Immune System:** * Antigen presentation: SEC13 regulates the loading of MHC class I and II molecules onto antigen-presenting cells. * Cytokine signaling: SEC13 modulates cytokine signaling, influencing immune responses to infections and inflammation. 2. **Cell Cycle Regulation:** * Mitosis: SEC13 regulates the nuclear envelope breakdown and reassembly during mitosis. * Cell cycle checkpoints: SEC13 ensures proper cell cycle progression by regulating the separation of sister chromatids. 3. **Protein Transport:** * COPII-mediated vesicle transport: SEC13 facilitates the transport of proteins and lipids from the endoplasmic reticulum to the Golgi apparatus. * Nuclear envelope transport: SEC13 regulates the transport of proteins, ribonucleoproteins, and lipids across the nuclear envelope. **Clinical Significance:** SEC13 dysregulation has been implicated in several diseases, including: 1. **Thyroid Papillary Carcinoma (TPC):** Mutations in SEC13 may confer susceptibility to TPC. 2. **Disorders of Transmembrane Transporters:** SEC13 dysregulation can lead to disorders of transmembrane transporters, affecting immune function and cellular homeostasis. 3. **Infectious Diseases:** SEC13 plays a critical role in regulating the transport of viral ribonucleoproteins and lipids, influencing HIV and influenza infections. In conclusion, SEC13 is a crucial component of the nuclear pore complex and COPII coat complex, playing a vital role in immune response, cell cycle regulation, and protein transport. Its dysregulation has significant implications for various diseases, highlighting the importance of SEC13 in maintaining cellular homeostasis and immune function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

SEC13-like protein 1
A8MWR8_HUMAN

Genular Protein ID: 2224607514

Symbol: SEC13_HUMAN

Name: SEC13-like protein 1

UniProtKB Accession Codes:

P55735 A8MV37 B4DXJ1 Q5BJF0 Q9BRM6 Q9BUG7

Database IDs:

Citations:

PubMed ID: 7987303

Title: Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6.

PubMed ID: 7987303

DOI: 10.1093/hmg/3.8.1281

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8972206

Title: The mammalian homolog of yeast Sec13p is enriched in the intermediate compartment and is essential for protein transport from the endoplasmic reticulum to the Golgi apparatus.

PubMed ID: 8972206

DOI: 10.1128/mcb.17.1.256

PubMed ID: 14517296

Title: Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex.

PubMed ID: 14517296

DOI: 10.1128/mcb.23.20.7271-7284.2003

PubMed ID: 16495487

Title: Human Sec31B: a family of new mammalian orthologues of yeast Sec31p that associate with the COPII coat.

PubMed ID: 16495487

DOI: 10.1242/jcs.02751

PubMed ID: 16957052

Title: The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A.

PubMed ID: 16957052

DOI: 10.1091/mbc.e06-05-0444

PubMed ID: 17428803

Title: Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum.

PubMed ID: 17428803

DOI: 10.1074/jbc.m611237200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19638414

Title: Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

PubMed ID: 19638414

DOI: 10.1242/jcs.044032

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22355596

Title: Characterization of human Sec16B: indications of specialized, non-redundant functions.

PubMed ID: 22355596

DOI: 10.1038/srep00077

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25263562

Title: The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

PubMed ID: 25263562

DOI: 10.1016/j.celrep.2014.09.014

PubMed ID: 25457612

Title: Sestrins inhibit mTORC1 kinase activation through the GATOR complex.

PubMed ID: 25457612

DOI: 10.1016/j.celrep.2014.10.019

PubMed ID: 23723238

Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

PubMed ID: 23723238

DOI: 10.1126/science.1232044

PubMed ID: 25201882

Title: Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.

PubMed ID: 25201882

DOI: 10.15252/embj.201487807

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26972053

Title: The CASTOR proteins are arginine sensors for the mTORC1 pathway.

PubMed ID: 26972053

DOI: 10.1016/j.cell.2016.02.035

PubMed ID: 27487210

Title: Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.

PubMed ID: 27487210

DOI: 10.1038/nature19079

PubMed ID: 28199306

Title: KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

PubMed ID: 28199306

DOI: 10.1038/nature21423

PubMed ID: 36528027

Title: Ring domains are essential for GATOR2-dependent mTORC1 activation.

PubMed ID: 36528027

DOI: 10.1016/j.molcel.2022.11.021

PubMed ID: 18160040

Title: Architecture of a coat for the nuclear pore membrane.

PubMed ID: 18160040

DOI: 10.1016/j.cell.2007.11.038

PubMed ID: 35831510

Title: Structure of the nutrient-sensing hub GATOR2.

PubMed ID: 35831510

DOI: 10.1038/s41586-022-04939-z

Sequence Information:

Length: 322
Mass: 35541
Checksum: 18E29627D87FB3DD
Sequence:

MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV 
WQVAWAHPMY GNILASCSYD RKVIIWREEN GTWEKSHEHA GHDSSVNSVC WAPHDYGLIL 
ACGSSDGAIS LLTYTGEGQW EVKKINNAHT IGCNAVSWAP AVVPGSLIDH PSGQKPNYIK 
RFASGGCDNL IKLWKEEEDG QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV 
FIWTCDDASS NTWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI 
SDVNKGQGSV SASVTEGQQN EQ

Genular Protein ID: 2087090862

Symbol: A8MWR8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MWR8

Database IDs:

Sequence Information:

Length: 194
Mass: 21416
Checksum: 70C8607278A85300
Sequence:

MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV 
WQVAWAHPMY GNILASCSYD RKVIIWREEN GTWEKSHEHA GHDSSVNSVC WAPHDYGLIL 
ACGSSDGAIS LLTYTGEGQW EVKKINNAHT VSPSPAFRAV RAPALPRVCC SLPRGWHGRV 
PAGQWAGEWS ADQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SEC13

Associated with

Cells (max top 100)

Other Information

Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6. PubMed ID: 7987303

Large-scale concatenation cDNA sequencing. PubMed ID: 9110174

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

The mammalian homolog of yeast Sec13p is enriched in the intermediate compartment and is essential for protein transport from the endoplasmic reticulum to the Golgi apparatus. PubMed ID: 8972206

Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex. PubMed ID: 14517296

Human Sec31B: a family of new mammalian orthologues of yeast Sec31p that associate with the COPII coat. PubMed ID: 16495487

The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A. PubMed ID: 16957052

Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum. PubMed ID: 17428803

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER. PubMed ID: 19638414

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Characterization of human Sec16B: indications of specialized, non-redundant functions. PubMed ID: 22355596

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. PubMed ID: 25263562

Sestrins inhibit mTORC1 kinase activation through the GATOR complex. PubMed ID: 25457612

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. PubMed ID: 23723238

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. PubMed ID: 25201882

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The CASTOR proteins are arginine sensors for the mTORC1 pathway. PubMed ID: 26972053

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. PubMed ID: 27487210

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. PubMed ID: 28199306

Ring domains are essential for GATOR2-dependent mTORC1 activation. PubMed ID: 36528027

Architecture of a coat for the nuclear pore membrane. PubMed ID: 18160040

Structure of the nutrient-sensing hub GATOR2. PubMed ID: 35831510