Details for: SEC14L1
Gene ID: 6397
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SEC14L1
Ensembl ID: ENSG00000129657
Description: SEC14 like lipid binding 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 35.34rCSI 61.12%PRS 40.86
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CSI 34.61rCSI 58.1%PRS 33.77
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CSI 31.63rCSI 24.88%PRS 57.01
-
CSI 31.25rCSI 24.08%PRS 49.72
-
CSI 28.06rCSI 86.47%PRS 61.17
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CSI 27.77rCSI 100%PRS 48.81
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CSI 27.77rCSI 44.35%PRS 54.47
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CSI 24.39rCSI 33.19%PRS 63.03
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CSI 22.06rCSI 40.44%PRS 68.87
-
CSI 19.7rCSI 28.86%PRS 76.36
-
CSI 19.62rCSI 25.72%PRS 82.19
-
CSI 17.94rCSI 56.1%PRS 37.5
-
CSI 15.45rCSI 76.16%PRS 62.14
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CSI 15.2rCSI 13.49%PRS 49
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CSI 14.35rCSI 29.78%PRS 47.99
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CSI 13.47rCSI 31.42%PRS 73.36
-
CSI 11.53rCSI 52.19%PRS 73.59
-
CSI 11.5rCSI 20.27%PRS 48.07
-
CSI 11.37rCSI 49.33%PRS 65.86
-
CSI 11.26rCSI 62.48%PRS 69.32
-
CSI 10.93rCSI 59.74%PRS 51.41
-
CSI 10.04rCSI 12.88%PRS 48.34
-
CSI 9.97rCSI 28.03%PRS 48.98
-
CSI 9.21rCSI 63.26%PRS 67.1
-
CSI 8.39rCSI 14.81%PRS 32.84
-
CSI 8.38rCSI 10.04%PRS 69.28
-
CSI 7.45rCSI 11.89%PRS 43.98
-
CSI 7.24rCSI 13.67%PRS 60.94
-
CSI 7.07rCSI 50%PRS 42.48
-
CSI 6.94rCSI 20.69%PRS 71.56
-
CSI 6.5rCSI 4.88%PRS 81.1
-
CSI 5.94rCSI 7.94%PRS 73.11
-
CSI 5.82rCSI 20.65%PRS 62.2
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CSI 5.7rCSI 18.9%PRS 52.03
-
CSI 5.7rCSI 4.5%PRS 37.79
-
CSI 5.61rCSI 17.96%PRS 47.15
-
CSI 5.35rCSI 4.83%PRS 47.18
-
CSI 5.23rCSI 41.78%PRS 76.5
-
CSI 5.19rCSI 10.71%PRS 54.84
-
CSI 4.98rCSI 3.69%PRS 43.49
-
CSI 4.98rCSI 36.38%PRS 72.85
-
CSI 4.94rCSI 22.83%PRS 71.99
-
CSI 4.94rCSI 5.29%PRS 48.71
-
CSI 4.9rCSI 3.81%PRS 68.49
-
CSI 4.82rCSI 7.9%PRS 40.44
-
CSI 4.76rCSI 9.49%PRS 68.85
-
CSI 4.75rCSI 4.39%PRS 71
-
CSI 4.61rCSI 5.57%PRS 58.64
-
CSI 4.61rCSI 5.74%PRS 32.1
-
CSI 4.58rCSI 10.22%PRS 57.46
-
CSI 4.48rCSI 10.35%PRS 41.05
-
CSI 4.26rCSI 4.1%PRS 41.05
-
CSI 4.24rCSI 3.19%PRS 54.66
-
CSI 4.12rCSI 3.12%PRS 63.86
-
CSI 4.09rCSI 35.37%PRS 49.86
-
CSI 4.09rCSI 3.04%PRS 64.07
-
CSI 4.06rCSI 6.51%PRS 76.94
-
CSI 4.06rCSI 4.05%PRS 44.38
-
CSI 4.03rCSI 15.08%PRS 42.98
-
CSI 3.98rCSI 3.23%PRS 50.97
-
CSI 3.97rCSI 10.83%PRS 74.94
-
CSI 3.95rCSI 7.53%PRS 67.1
-
CSI 3.91rCSI 8.65%PRS 48.03
-
CSI 3.86rCSI 4.23%PRS 54.18
-
CSI 3.79rCSI 2.52%PRS 74.47
-
CSI 3.74rCSI 2.61%PRS 52.7
-
CSI 3.72rCSI 4.87%PRS 64.14
-
CSI 3.71rCSI 2.82%PRS 62.69
-
CSI 3.67rCSI 3.76%PRS 67.87
-
CSI 3.67rCSI 17.57%PRS 49.34
-
CSI 3.57rCSI 13.58%PRS 42.66
-
CSI 3.56rCSI 2.47%PRS 60.28
-
CSI 3.56rCSI 6.23%PRS 42.55
-
CSI 3.55rCSI 9.77%PRS 46.6
-
CSI 3.48rCSI 3.42%PRS 66.42
-
CSI 3.47rCSI 2.92%PRS 68.07
-
CSI 3.46rCSI 14.08%PRS 61.7
-
CSI 3.45rCSI 3.18%PRS 51.43
-
CSI 3.43rCSI 2.66%PRS 51.18
-
CSI 3.43rCSI 3.52%PRS 68.54
-
CSI 3.38rCSI 65.3%PRS 72.18
-
CSI 3.34rCSI 4.16%PRS 61.69
-
CSI 3.34rCSI 2.49%PRS 68.42
-
CSI 3.34rCSI 14.83%PRS 49.48
-
CSI 3.27rCSI 5.03%PRS 50.28
-
CSI 3.26rCSI 3.92%PRS 48.37
-
CSI 3.25rCSI 9.34%PRS 69.35
-
CSI 3.22rCSI 3.36%PRS 50.95
-
CSI 3.18rCSI 2.79%PRS 55.82
-
CSI 3.17rCSI 14.1%PRS 88.11
-
CSI 3.11rCSI 7.06%PRS 55.73
-
CSI 3.08rCSI 3.68%PRS 71.07
-
CSI 3.03rCSI 4.91%PRS 48.35
-
CSI 3.02rCSI 2.17%PRS 64.17
-
CSI 2.96rCSI 4.37%PRS 55.82
-
CSI 2.95rCSI 2.6%PRS 39.16
-
CSI 2.93rCSI 70.07%PRS 33.24
-
CSI 2.92rCSI 1.73%PRS 66.87
-
CSI 2.89rCSI 3.96%PRS 45.68
-
CSI 2.88rCSI 2.68%PRS 50.12
-
CSI 0.3rCSI 6.5%PRS 72.6%
-
CSI 0.3rCSI 3.7%PRS 82.2%
-
CSI 0.4rCSI 1.6%PRS 66.0%
-
CSI 0.5rCSI 3.0%PRS 42.6%
-
CSI 0.5rCSI 1.5%PRS 35.1%
-
CSI 0.5rCSI 3.8%PRS 37.9%
-
CSI 0.5rCSI 2.1%PRS 70.3%
-
CSI 0.5rCSI 1.9%PRS 32.5%
-
CSI 0.5rCSI 3.2%PRS 73.5%
-
CSI 0.6rCSI 2.7%PRS 72.1%
-
CSI 0.6rCSI 1.8%PRS 41.2%
-
CSI 0.6rCSI 6.8%PRS 69.2%
-
CSI 0.7rCSI 5.9%PRS 37.6%
-
CSI 0.7rCSI 1.5%PRS 68.4%
-
CSI 0.7rCSI 2.3%PRS 38.6%
-
CSI 0.8rCSI 4.4%PRS 35.2%
-
CSI 0.8rCSI 2.0%PRS 63.7%
-
CSI 0.8rCSI 1.7%PRS 37.9%
-
CSI 0.8rCSI 1.9%PRS 38.9%
-
CSI 0.8rCSI 1.3%PRS 61.4%
-
CSI 0.8rCSI 1.6%PRS 52.7%
-
CSI 0.8rCSI 1.6%PRS 39.6%
-
CSI 0.9rCSI 7.5%PRS 74.3%
-
CSI 0.9rCSI 2.9%PRS 58.1%
-
CSI 0.9rCSI 3.0%PRS 65.1%
-
CSI 0.9rCSI 1.3%PRS 47.0%
-
CSI 0.9rCSI 1.5%PRS 40.7%
-
CSI 1.0rCSI 1.5%PRS 55.2%
-
CSI 1.0rCSI 1.0%PRS 56.4%
-
CSI 1.0rCSI 5.6%PRS 61.0%
-
CSI 1.0rCSI 2.3%PRS 59.8%
-
CSI 1.0rCSI 1.2%PRS 60.6%
-
CSI 1.0rCSI 3.4%PRS 37.5%
-
CSI 1.1rCSI 1.4%PRS 55.2%
-
CSI 1.1rCSI 2.7%PRS 40.4%
-
CSI 1.1rCSI 2.3%PRS 39.9%
-
CSI 1.1rCSI 2.6%PRS 69.0%
-
CSI 1.1rCSI 2.9%PRS 42.5%
-
CSI 1.1rCSI 0.9%PRS 73.0%
-
CSI 1.2rCSI 2.2%PRS 66.8%
-
CSI 1.2rCSI 3.1%PRS 55.0%
-
CSI 1.2rCSI 3.1%PRS 46.1%
-
CSI 1.2rCSI 6.8%PRS 79.5%
-
CSI 1.3rCSI 1.9%PRS 67.8%
-
CSI 1.4rCSI 5.1%PRS 34.6%
-
CSI 1.4rCSI 5.3%PRS 67.2%
-
CSI 1.4rCSI 6.0%PRS 43.0%
-
CSI 1.4rCSI 33.6%PRS 74.0%
-
CSI 1.4rCSI 5.2%PRS 70.3%
-
CSI 1.5rCSI 3.6%PRS 48.3%
-
CSI 1.5rCSI 2.7%PRS 43.4%
-
CSI 1.5rCSI 3.9%PRS 71.9%
-
CSI 1.5rCSI 1.9%PRS 52.9%
-
CSI 1.5rCSI 3.4%PRS 48.3%
-
CSI 1.5rCSI 2.1%PRS 51.7%
-
CSI 1.6rCSI 1.9%PRS 46.3%
-
CSI 1.6rCSI 2.4%PRS 67.5%
-
CSI 1.6rCSI 1.4%PRS 60.7%
-
CSI 1.6rCSI 2.3%PRS 63.4%
-
CSI 1.6rCSI 2.2%PRS 55.7%
-
CSI 1.6rCSI 7.8%PRS 50.5%
-
CSI 1.6rCSI 1.6%PRS 53.0%
-
CSI 1.6rCSI 4.0%PRS 45.4%
-
CSI 1.7rCSI 2.5%PRS 58.3%
-
CSI 1.7rCSI 1.1%PRS 62.1%
-
CSI 1.7rCSI 2.5%PRS 48.8%
-
CSI 1.8rCSI 1.2%PRS 54.2%
-
CSI 1.8rCSI 7.9%PRS 86.1%
-
CSI 1.8rCSI 3.5%PRS 72.9%
-
CSI 1.8rCSI 2.6%PRS 53.9%
-
CSI 1.8rCSI 4.2%PRS 55.7%
-
CSI 1.8rCSI 3.2%PRS 43.7%
-
CSI 1.8rCSI 3.1%PRS 60.0%
-
CSI 1.8rCSI 2.9%PRS 35.9%
-
CSI 1.8rCSI 2.7%PRS 61.9%
-
CSI 1.8rCSI 1.9%PRS 53.7%
-
CSI 1.9rCSI 4.5%PRS 51.9%
-
CSI 1.9rCSI 2.7%PRS 58.2%
-
CSI 1.9rCSI 4.7%PRS 32.7%
-
CSI 1.9rCSI 3.0%PRS 48.3%
-
CSI 1.9rCSI 5.8%PRS 61.1%
-
CSI 1.9rCSI 1.6%PRS 49.2%
-
CSI 2.0rCSI 1.7%PRS 54.8%
-
CSI 2.0rCSI 8.1%PRS 58.7%
-
CSI 2.0rCSI 1.6%PRS 51.4%
-
CSI 2.0rCSI 3.0%PRS 59.9%
-
CSI 2.0rCSI 2.1%PRS 47.4%
-
CSI 2.0rCSI 6.4%PRS 49.3%
-
CSI 2.0rCSI 9.2%PRS 66.1%
-
CSI 2.0rCSI 7.0%PRS 40.8%
-
CSI 2.1rCSI 4.8%PRS 69.6%
-
CSI 2.1rCSI 3.8%PRS 65.7%
-
CSI 2.2rCSI 12.0%PRS 60.8%
-
CSI 2.2rCSI 3.2%PRS 53.2%
-
CSI 2.2rCSI 2.7%PRS 63.9%
-
CSI 2.2rCSI 3.1%PRS 47.0%
-
CSI 2.2rCSI 3.7%PRS 76.4%
-
CSI 2.2rCSI 11.0%PRS 62.3%
-
CSI 2.2rCSI 3.7%PRS 56.0%
-
CSI 2.2rCSI 3.3%PRS 45.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1134845603
Symbol: S14L1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8697811
Title: Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region.
PubMed ID: 8697811
DOI: 10.1159/000134342
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9110174
PubMed ID: 17092608
Title: SEC14-like protein 1 interacts with cholinergic transporters.
PubMed ID: 17092608
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23843640
Title: Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1.
PubMed ID: 23843640
DOI: 10.1128/jvi.01073-13
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 715
- Mass: 81250
- Checksum: A0B840F8FFF01D13
- Sequence:
MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG AIHVIERRCK LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE TFSNRVIINE HCCYTVHPEN EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK QYTSNIKKGK EIIEYYLRQL EEEGITFVPR WSPPSITTSS ETSSSSSKKQ AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD ADYIKRYLGD LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD TKGLVRALGE EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG LNMRHLWRPG VKALLRIIEV VEANYPETLG RLLILRAPRV FPVLWTLVSP FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK EIIPDFLSGE CMCEVPEGGL VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI QIVDASSVIT WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP RVDDVLASLQ VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA TTSSSQSHSS SMISR
Genular Protein ID: 1948058434
Symbol: Q59HE8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 723
- Mass: 82039
- Checksum: 12332B991F6CE5E0
- Sequence:
EGCCCIAIMV QKYQSPVRVY KYPFELIMAA YERRFPTCPL IPMFVGSDTV NEFKSEDGAI HVIERRCKLD VDAPRLLKKI AGVDYVYFVQ KNSLNSRERT LHIEAYNETF SNRVIINEHC CYTVHPENED WTCFEQSASL DIKSFFGFES TVEKIAMKQY TSNIKKGKEI IEYYLRQLEE EGITFVPRWS PPSITPSSET SSSSSKKQAA SMAVVIPEAA LKEGLSGDAL SSPSAPEPVV GTPDDKLDAD YIKRYLGDLT PLQESCLIRL RQWLQETHKG KIPKDEHILR FLRARDFNID KAREIMCQSL TWRKQHQVDY ILETWTPPQV LQDYYAGGWH HHDKDGRPLY VLRLGQMDTK GLVRALGEEA LLRYVLSINE EGLRRCEENT KVFGRPISSW TCLVDLEGLN MRHLWRPGVK ALLRIIEVVE ANYPETLGRL LILRAPRVFP VLWTLVSPFI DDNTRRKFLI YAGNDYQGPG GLLDYIDKEI IPDFLSGECM CEVPEGGLVP KSLYRTAEEL ENEDLKLWTE TIYQSASVFK GAPHEILIQI VDASSVITWD FDVCKGDIVF NIYHSKRSPQ PPKKDSLGAH SITSPGGNNV QLIDKVWQLG RDYSMVESPL ICKEGESVQG SHVTRWPGFY ILQWKFHSMP ACAASSLPRV DDVLASLQVS SHKCKVMYYT EVIGSEDFRG SMTSLESSHS GFSQLSAATT SSSQSHSSSM ISR
Genular Protein ID: 1570574735
Symbol: A5PLM6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 719
- Mass: 81856
- Checksum: 89B51A96A680E42C
- Sequence:
MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG AIHVIERRCK LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE TFSNRVIINE HCCYTVHPEN EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK QYTSNIKKGK EIIEYYLRQL EEEGITFVPR WSPPSITPSS ETSSSSSKKQ AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD ADYIKRYLGD LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD TKGLVRALGE EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG LNMRHLWRPG VKALLRIMEV VEANYPETLG RLLILRAPRV FPVLWTLVSP FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK EIIPDFLSGE CMCEVPEGGL VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI QIVDASSVIT WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP RVDDVLASLQ VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA TTSSSQSHSS SMISRWRFC
Genular Protein ID: 48398315
Symbol: Q7Z3R7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 715
- Mass: 81216
- Checksum: D166D53A8C2ADBC8
- Sequence:
MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG AIHVIERRCK LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE TFSNRVIINE HCCYTVHPEN EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK QYTSNIKKGK EIIEYYLRQL EEEGITFVPR WSPPSITPSS ETSSSSSKKQ AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD ADYIKRYLGD LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD TKGLVRALGE EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG LNMRHLRRPG VKALLRIIEV VEANYPETLG RLLILRAPRV FPVLWTLVSP FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK EIIPDFLSGE CMCEVPEGGL VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI QIVDASSVIT WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP RVDDVLASLQ VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA TTSSSQSHSS SMISR