Details for: TRAPPC2

Gene ID: 6399

Symbol: TRAPPC2

Ensembl ID: ENSG00000196459

Description: trafficking protein particle complex subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.7366
    Cell Significance Index: -18.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.6951
    Cell Significance Index: -18.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.8317
    Cell Significance Index: -20.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.7408
    Cell Significance Index: -17.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.1712
    Cell Significance Index: -19.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9397
    Cell Significance Index: -20.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6647
    Cell Significance Index: -17.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3834
    Cell Significance Index: -20.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2508
    Cell Significance Index: -20.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4058
    Cell Significance Index: 228.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2550
    Cell Significance Index: 80.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0535
    Cell Significance Index: 122.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0027
    Cell Significance Index: 288.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9340
    Cell Significance Index: 56.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9216
    Cell Significance Index: 100.2500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9054
    Cell Significance Index: 14.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8020
    Cell Significance Index: 50.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6373
    Cell Significance Index: 127.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4780
    Cell Significance Index: 33.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4439
    Cell Significance Index: 242.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3709
    Cell Significance Index: 5.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3661
    Cell Significance Index: 36.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3623
    Cell Significance Index: 71.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3264
    Cell Significance Index: 20.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3044
    Cell Significance Index: 35.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2807
    Cell Significance Index: 100.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2702
    Cell Significance Index: 48.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2608
    Cell Significance Index: 13.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2293
    Cell Significance Index: 31.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2196
    Cell Significance Index: 41.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2174
    Cell Significance Index: 4.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1876
    Cell Significance Index: 23.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1750
    Cell Significance Index: 8.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1583
    Cell Significance Index: 7.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1557
    Cell Significance Index: 68.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1414
    Cell Significance Index: 9.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0816
    Cell Significance Index: 3.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0709
    Cell Significance Index: 1.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0699
    Cell Significance Index: 3.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0539
    Cell Significance Index: 6.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0485
    Cell Significance Index: 2.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0482
    Cell Significance Index: 1.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0460
    Cell Significance Index: 3.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0429
    Cell Significance Index: 1.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0290
    Cell Significance Index: 1.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0263
    Cell Significance Index: 0.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0220
    Cell Significance Index: 1.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0166
    Cell Significance Index: 31.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0086
    Cell Significance Index: 13.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0075
    Cell Significance Index: 0.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0051
    Cell Significance Index: 9.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0019
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0117
    Cell Significance Index: -1.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0136
    Cell Significance Index: -10.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.6900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0182
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0208
    Cell Significance Index: -15.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0286
    Cell Significance Index: -16.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0338
    Cell Significance Index: -21.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0418
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0525
    Cell Significance Index: -1.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0591
    Cell Significance Index: -6.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0674
    Cell Significance Index: -1.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0813
    Cell Significance Index: -2.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0901
    Cell Significance Index: -13.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0983
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1000
    Cell Significance Index: -21.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1191
    Cell Significance Index: -4.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1213
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1225
    Cell Significance Index: -14.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1311
    Cell Significance Index: -3.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1570
    Cell Significance Index: -16.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1615
    Cell Significance Index: -1.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1621
    Cell Significance Index: -4.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1723
    Cell Significance Index: -4.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1837
    Cell Significance Index: -11.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1875
    Cell Significance Index: -3.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1942
    Cell Significance Index: -3.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2060
    Cell Significance Index: -5.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2130
    Cell Significance Index: -16.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2187
    Cell Significance Index: -5.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2295
    Cell Significance Index: -2.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2416
    Cell Significance Index: -3.6200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2661
    Cell Significance Index: -3.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2689
    Cell Significance Index: -6.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2735
    Cell Significance Index: -5.7300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2743
    Cell Significance Index: -3.8500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3412
    Cell Significance Index: -2.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3431
    Cell Significance Index: -9.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3443
    Cell Significance Index: -7.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3516
    Cell Significance Index: -11.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3622
    Cell Significance Index: -11.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3652
    Cell Significance Index: -11.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3821
    Cell Significance Index: -8.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAPPC2 is a conserved protein that is widely expressed across various cell types, including early pro-B cells, pancreatic A cells, and neurons. Its expression is also observed in immune cells, such as CD8-positive, alpha-beta cytokine-secreting effector T cells. TRAPPC2 is a component of the TRAPP complex, which is a large protein complex involved in regulating vesicle trafficking. The TRAPPC2 protein is characterized by its ability to interact with Rab GTPases, specifically Rab GEFs, to regulate their GTPase activity and facilitate vesicle trafficking. **Pathways and Functions:** TRAPPC2 participates in various cellular pathways, including: 1. **Asparagine N-linked Glycosylation:** TRAPPC2 is involved in the regulation of asparagine N-linked glycosylation, a post-translational modification that is crucial for protein stability and function. 2. **Copii-mediated Vesicle Transport:** TRAPPC2 is a component of the Copii complex, which is involved in regulating vesicle trafficking between the ER and Golgi apparatus. 3. **Vesicle Coating and Tethering:** TRAPPC2 regulates the formation and coating of vesicles, facilitating their transport to the Golgi apparatus. 4. **Protein Binding:** TRAPPC2 interacts with various proteins, including Rab GTPases, to regulate their activity and facilitate protein trafficking. **Clinical Significance:** Dysregulation of TRAPPC2 has been implicated in various diseases, including: 1. **Immunodeficiency Disorders:** Mutations in TRAPPC2 have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Neurological Disorders:** TRAPPC2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** TRAPPC2 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer. In conclusion, TRAPPC2 plays a critical role in regulating protein trafficking and modification within cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of TRAPPC2. **Recommendations:** 1. **Further Research:** Additional studies are needed to elucidate the specific mechanisms by which TRAPPC2 regulates protein trafficking and modification. 2. **Therapeutic Applications:** Targeting TRAPPC2 may provide a novel therapeutic strategy for treating diseases associated with its dysregulation. 3. **Cellular and Molecular Studies:** Further investigation into the cellular and molecular mechanisms underlying TRAPPC2 function will provide a deeper understanding of its role in cellular biology.

Genular Protein ID: 314775246

Symbol: TPC2A_HUMAN

Name: Trafficking protein particle complex subunit 2

UniProtKB Accession Codes:

P0DI81 A6NEG0 O14582 Q9HD16

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 6 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10431248

Title: Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.

PubMed ID: 10431248

DOI: 10.1038/11976

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11031107

Title: Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda.

PubMed ID: 11031107

DOI: 10.1006/geno.2000.6326

PubMed ID: 11805826

Title: Functional organization of the yeast proteome by systematic analysis of protein complexes.

PubMed ID: 11805826

DOI: 10.1038/415141a

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21525244

Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.

PubMed ID: 21525244

DOI: 10.1091/mbc.e10-11-0873

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25918224

Title: TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.

PubMed ID: 25918224

DOI: 10.1083/jcb.201501090

PubMed ID: 14597397

Title: Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.

PubMed ID: 14597397

DOI: 10.1016/s0378-1119(03)00819-9

PubMed ID: 19416478

Title: TRAPPC2L is a novel, highly conserved TRAPP-interacting protein.

PubMed ID: 19416478

DOI: 10.1111/j.1600-0854.2009.00906.x

PubMed ID: 20498720

Title: SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1.

PubMed ID: 20498720

DOI: 10.1371/journal.pone.0010646

PubMed ID: 11349230

Title: The molecular basis of X-linked spondyloepiphyseal dysplasia tarda.

PubMed ID: 11349230

DOI: 10.1086/320592

PubMed ID: 11424925

Title: A missense mutation in the SEDL gene results in delayed onset of X linked spondyloepiphyseal dysplasia in a large pedigree.

PubMed ID: 11424925

DOI: 10.1136/jmg.38.6.409

Sequence Information:

  • Length: 140
  • Mass: 16445
  • Checksum: B099943C6F88952C
  • Sequence:
    • MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY 
LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP 
IRSSAFDRKV QFLGKKHLLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.