Details for: SELENOW

Gene ID: 6415

Symbol: SELENOW

Ensembl ID: ENSG00000178980

Description: selenoprotein W

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 334.4782
    Cell Significance Index: -137.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 289.9617
    Cell Significance Index: -136.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 256.3254
    Cell Significance Index: -131.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 205.8129
    Cell Significance Index: -138.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 38.6060
    Cell Significance Index: -103.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 30.5783
    Cell Significance Index: -93.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.2117
    Cell Significance Index: -44.2400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.2816
    Cell Significance Index: 40.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.6847
    Cell Significance Index: 1347.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.4212
    Cell Significance Index: 2414.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.4121
    Cell Significance Index: 40.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.1893
    Cell Significance Index: 74.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.1064
    Cell Significance Index: 46.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.0751
    Cell Significance Index: 734.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.0071
    Cell Significance Index: 492.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.6712
    Cell Significance Index: 54.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2011
    Cell Significance Index: 149.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0332
    Cell Significance Index: 209.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9120
    Cell Significance Index: 399.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6848
    Cell Significance Index: 140.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.4484
    Cell Significance Index: 1082.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2034
    Cell Significance Index: 114.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8653
    Cell Significance Index: 25.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7658
    Cell Significance Index: 354.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7582
    Cell Significance Index: 40.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7075
    Cell Significance Index: 120.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4684
    Cell Significance Index: 109.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2748
    Cell Significance Index: 36.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2451
    Cell Significance Index: 33.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1515
    Cell Significance Index: 54.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0103
    Cell Significance Index: 129.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9974
    Cell Significance Index: 11.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9629
    Cell Significance Index: 124.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9352
    Cell Significance Index: 71.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9317
    Cell Significance Index: 13.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8399
    Cell Significance Index: 17.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7813
    Cell Significance Index: 77.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7312
    Cell Significance Index: 21.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7307
    Cell Significance Index: 33.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7133
    Cell Significance Index: 255.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4162
    Cell Significance Index: 26.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3739
    Cell Significance Index: 74.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3606
    Cell Significance Index: 68.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3089
    Cell Significance Index: 18.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2487
    Cell Significance Index: 188.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1360
    Cell Significance Index: 99.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0924
    Cell Significance Index: 2.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0706
    Cell Significance Index: 4.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0669
    Cell Significance Index: 11.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0331
    Cell Significance Index: -1.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0649
    Cell Significance Index: -119.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0798
    Cell Significance Index: -108.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0811
    Cell Significance Index: -124.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0867
    Cell Significance Index: -8.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0869
    Cell Significance Index: -2.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1170
    Cell Significance Index: -74.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1206
    Cell Significance Index: -54.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1710
    Cell Significance Index: -11.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1747
    Cell Significance Index: -129.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2123
    Cell Significance Index: -119.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2269
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2819
    Cell Significance Index: -176.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4748
    Cell Significance Index: -16.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4773
    Cell Significance Index: -56.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5109
    Cell Significance Index: -74.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5518
    Cell Significance Index: -22.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5695
    Cell Significance Index: -9.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7194
    Cell Significance Index: -151.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7199
    Cell Significance Index: -82.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7675
    Cell Significance Index: -26.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7930
    Cell Significance Index: -92.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8393
    Cell Significance Index: -23.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8923
    Cell Significance Index: -70.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0353
    Cell Significance Index: -22.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.1022
    Cell Significance Index: -14.1200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1024
    Cell Significance Index: -9.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2416
    Cell Significance Index: -129.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5211
    Cell Significance Index: -48.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5576
    Cell Significance Index: -44.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.8829
    Cell Significance Index: -105.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.9519
    Cell Significance Index: -49.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.1542
    Cell Significance Index: -61.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.2179
    Cell Significance Index: -135.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.2578
    Cell Significance Index: -99.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -2.3536
    Cell Significance Index: -43.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -2.4772
    Cell Significance Index: -26.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.4920
    Cell Significance Index: -66.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.7166
    Cell Significance Index: -102.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.7358
    Cell Significance Index: -80.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.8147
    Cell Significance Index: -72.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.8197
    Cell Significance Index: -68.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.8569
    Cell Significance Index: -29.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.9001
    Cell Significance Index: -94.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.9602
    Cell Significance Index: -103.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.9734
    Cell Significance Index: -94.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.9933
    Cell Significance Index: -109.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -3.0526
    Cell Significance Index: -73.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.3732
    Cell Significance Index: -20.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -3.4863
    Cell Significance Index: -44.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SELENOW is a selenoprotein, a class of proteins that incorporate selenocysteine, a sulfur-containing amino acid, into their structure. This unique amino acid is essential for the enzyme activity of selenoproteins. SELENOW exhibits a high degree of expression in various cell types, including cardiac muscle cells, skeletal muscle satellite cells, and epithelial cells of the lung. Its localization in the cytoplasm and response to selenium ions underscore its role in antioxidant defense mechanisms. The protein's expression is also observed in immune cells, such as monocytes and extravillous trophoblasts, suggesting a potential role in immune function. **Pathways and Functions:** SELENOW is involved in several key pathways that regulate cellular homeostasis: 1. **Antioxidant activity:** SELENOW plays a crucial role in protecting cells from oxidative stress by scavenging reactive oxygen species (ROS) and detoxifying cellular oxidants. 2. **Cellular oxidant detoxification:** SELENOW is involved in the detoxification of cellular oxidants, which helps maintain cellular homeostasis and prevent oxidative damage. 3. **Cytoplasmic localization:** SELENOW is localized in the cytoplasm, where it can interact with other proteins and regulate cellular processes. 4. **Response to selenium ion:** SELENOW responds to selenium ions, which is essential for its antioxidant activity and detoxification functions. **Clinical Significance:** The dysregulation of SELENOW has been implicated in various diseases, including: 1. **Cardiovascular disease:** SELENOW's antioxidant activity and detoxification functions may contribute to the development of cardiovascular disease by preventing oxidative damage to cardiac cells. 2. **Muscular dystrophy:** SELENOW's expression in skeletal muscle satellite cells suggests a potential role in muscular dystrophy, a group of diseases characterized by progressive muscle degeneration. 3. **Cancer:** SELENOW's expression in epithelial cells of the lung and immune cells suggests a potential role in cancer prevention and treatment. 4. **Neurodegenerative diseases:** SELENOW's antioxidant activity and detoxification functions may contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, SELENOW is a critical player in maintaining cellular homeostasis through its antioxidant defense mechanisms and detoxification functions. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of SELENOW in human health and disease.

Genular Protein ID: 1151100556

Symbol: SELW_HUMAN

Name: N/A

UniProtKB Accession Codes:

P63302 A8MRR7 O15532 O19096 Q86TI9 Q96KM5

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256076

Title: Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species.

PubMed ID: 9256076

DOI: 10.1016/s0378-1119(97)00113-3

PubMed ID: 12818432

Title: Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P.

PubMed ID: 12818432

DOI: 10.1016/s0167-4781(03)00078-2

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10718624

Title: Selenoprotein W accumulates primarily in primate skeletal muscle, heart, brain and tongue.

PubMed ID: 10718624

DOI: 10.1023/a:1007065829068

PubMed ID: 27645994

Title: Selenoprotein gene nomenclature.

PubMed ID: 27645994

DOI: 10.1074/jbc.m116.756155

Sequence Information:

  • Length: 87
  • Mass: 9448
  • Checksum: F8FDF3194B0654E9
  • Sequence:
    • MALAVRVVYC GAUGYKSKYL QLKKKLEDEF PGRLDICGEG TPQATGFFEV MVAGKLIHSK 
KKGDGYVDTE SKFLKLVAAI KAALAQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.