Details for: SELENOW

Gene ID: 6415

Symbol: SELENOW

Ensembl ID: ENSG00000178980

Description: selenoprotein W

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 6.5
    Marker Score: 86449
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.67
    Marker Score: 3796
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 4.76
    Marker Score: 4662.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.06
    Marker Score: 1189
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.65
    Marker Score: 1515
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.62
    Marker Score: 2573
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.6
    Marker Score: 2539
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.57
    Marker Score: 18759
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.56
    Marker Score: 3178
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.48
    Marker Score: 1145
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.3
    Marker Score: 6974
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.27
    Marker Score: 113302
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.25
    Marker Score: 2762
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.23
    Marker Score: 7740
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.23
    Marker Score: 2123
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.2
    Marker Score: 3854
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.19
    Marker Score: 4155
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.19
    Marker Score: 27675
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.16
    Marker Score: 6317.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.11
    Marker Score: 5841
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.05
    Marker Score: 1050.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.93
    Marker Score: 7155
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.93
    Marker Score: 2792
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.86
    Marker Score: 1734
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.85
    Marker Score: 21250
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.85
    Marker Score: 2621
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.84
    Marker Score: 8913
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.84
    Marker Score: 3427
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.81
    Marker Score: 5720
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.81
    Marker Score: 4666
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.8
    Marker Score: 18183
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.77
    Marker Score: 1049.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.77
    Marker Score: 7421
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.77
    Marker Score: 36519.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.76
    Marker Score: 18014
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.73
    Marker Score: 31779.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.73
    Marker Score: 2579
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.72
    Marker Score: 3777
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.72
    Marker Score: 4604
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.69
    Marker Score: 1568
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.68
    Marker Score: 1784
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.63
    Marker Score: 7502.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.63
    Marker Score: 4043
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.62
    Marker Score: 6612
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.61
    Marker Score: 2459
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.61
    Marker Score: 2500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.59
    Marker Score: 25656.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.59
    Marker Score: 4245
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.58
    Marker Score: 1459.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.54
    Marker Score: 1989.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.54
    Marker Score: 2575
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.51
    Marker Score: 55992
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.5
    Marker Score: 10732
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.5
    Marker Score: 1969.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.5
    Marker Score: 1293
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.49
    Marker Score: 2683
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.48
    Marker Score: 1321.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.48
    Marker Score: 1177
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.47
    Marker Score: 3976
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.46
    Marker Score: 1268
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.46
    Marker Score: 7771
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.46
    Marker Score: 19226
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.46
    Marker Score: 5607.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.46
    Marker Score: 3618
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.43
    Marker Score: 2576
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.41
    Marker Score: 4578
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.4
    Marker Score: 2324
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.4
    Marker Score: 2694
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.39
    Marker Score: 9230.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.39
    Marker Score: 5630
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.39
    Marker Score: 10310
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.39
    Marker Score: 686
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.38
    Marker Score: 4225
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.38
    Marker Score: 8445
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.38
    Marker Score: 9875
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.37
    Marker Score: 820.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.37
    Marker Score: 2078
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.36
    Marker Score: 3247
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.35
    Marker Score: 2024
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.35
    Marker Score: 1476
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.33
    Marker Score: 4243
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.33
    Marker Score: 694
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.33
    Marker Score: 2103
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.32
    Marker Score: 26181
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.32
    Marker Score: 2410.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.32
    Marker Score: 14836
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.32
    Marker Score: 1316
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.31
    Marker Score: 1552
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.3
    Marker Score: 11048
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.3
    Marker Score: 1910
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.3
    Marker Score: 5838.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.29
    Marker Score: 121119
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.29
    Marker Score: 735
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.29
    Marker Score: 19714
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.29
    Marker Score: 2478.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.28
    Marker Score: 1043
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.28
    Marker Score: 545
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.28
    Marker Score: 1790
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.28
    Marker Score: 2034
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.28
    Marker Score: 1064

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Other Information

**Key Characteristics:** SELENOW is a selenoprotein, a class of proteins that incorporate selenocysteine, a sulfur-containing amino acid, into their structure. This unique amino acid is essential for the enzyme activity of selenoproteins. SELENOW exhibits a high degree of expression in various cell types, including cardiac muscle cells, skeletal muscle satellite cells, and epithelial cells of the lung. Its localization in the cytoplasm and response to selenium ions underscore its role in antioxidant defense mechanisms. The protein's expression is also observed in immune cells, such as monocytes and extravillous trophoblasts, suggesting a potential role in immune function. **Pathways and Functions:** SELENOW is involved in several key pathways that regulate cellular homeostasis: 1. **Antioxidant activity:** SELENOW plays a crucial role in protecting cells from oxidative stress by scavenging reactive oxygen species (ROS) and detoxifying cellular oxidants. 2. **Cellular oxidant detoxification:** SELENOW is involved in the detoxification of cellular oxidants, which helps maintain cellular homeostasis and prevent oxidative damage. 3. **Cytoplasmic localization:** SELENOW is localized in the cytoplasm, where it can interact with other proteins and regulate cellular processes. 4. **Response to selenium ion:** SELENOW responds to selenium ions, which is essential for its antioxidant activity and detoxification functions. **Clinical Significance:** The dysregulation of SELENOW has been implicated in various diseases, including: 1. **Cardiovascular disease:** SELENOW's antioxidant activity and detoxification functions may contribute to the development of cardiovascular disease by preventing oxidative damage to cardiac cells. 2. **Muscular dystrophy:** SELENOW's expression in skeletal muscle satellite cells suggests a potential role in muscular dystrophy, a group of diseases characterized by progressive muscle degeneration. 3. **Cancer:** SELENOW's expression in epithelial cells of the lung and immune cells suggests a potential role in cancer prevention and treatment. 4. **Neurodegenerative diseases:** SELENOW's antioxidant activity and detoxification functions may contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, SELENOW is a critical player in maintaining cellular homeostasis through its antioxidant defense mechanisms and detoxification functions. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of SELENOW in human health and disease.

Genular Protein ID: 1151100556

Symbol: SELW_HUMAN

Name: N/A

UniProtKB Accession Codes:

P63302 A8MRR7 O15532 O19096 Q86TI9 Q96KM5

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256076

Title: Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species.

PubMed ID: 9256076

DOI: 10.1016/s0378-1119(97)00113-3

PubMed ID: 12818432

Title: Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P.

PubMed ID: 12818432

DOI: 10.1016/s0167-4781(03)00078-2

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10718624

Title: Selenoprotein W accumulates primarily in primate skeletal muscle, heart, brain and tongue.

PubMed ID: 10718624

DOI: 10.1023/a:1007065829068

PubMed ID: 27645994

Title: Selenoprotein gene nomenclature.

PubMed ID: 27645994

DOI: 10.1074/jbc.m116.756155

Sequence Information:

  • Length: 87
  • Mass: 9448
  • Checksum: F8FDF3194B0654E9
  • Sequence:
    • MALAVRVVYC GAUGYKSKYL QLKKKLEDEF PGRLDICGEG TPQATGFFEV MVAGKLIHSK 
KKGDGYVDTE SKFLKLVAAI KAALAQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.