Details for: SRSF1

Gene ID: 6426

Symbol: SRSF1

Ensembl ID: ENSG00000136450

Description: serine and arginine rich splicing factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 196.9202
    Cell Significance Index: -30.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.3729
    Cell Significance Index: -31.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.0181
    Cell Significance Index: -42.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 90.4426
    Cell Significance Index: -42.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.7505
    Cell Significance Index: -43.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.7833
    Cell Significance Index: -42.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.9290
    Cell Significance Index: -40.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8637
    Cell Significance Index: -34.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6459
    Cell Significance Index: -35.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8032
    Cell Significance Index: -42.6300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.3874
    Cell Significance Index: 26.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.9025
    Cell Significance Index: 100.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5982
    Cell Significance Index: 70.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3534
    Cell Significance Index: 18.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2417
    Cell Significance Index: 24.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1080
    Cell Significance Index: 126.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8360
    Cell Significance Index: 38.4300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.7628
    Cell Significance Index: 18.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5574
    Cell Significance Index: 253.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5523
    Cell Significance Index: 183.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5049
    Cell Significance Index: 43.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4143
    Cell Significance Index: 37.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3994
    Cell Significance Index: 252.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3576
    Cell Significance Index: 63.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3113
    Cell Significance Index: 1184.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2998
    Cell Significance Index: 30.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2994
    Cell Significance Index: 178.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2714
    Cell Significance Index: 82.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2365
    Cell Significance Index: 64.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1219
    Cell Significance Index: 137.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1065
    Cell Significance Index: 13.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0596
    Cell Significance Index: 13.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0131
    Cell Significance Index: 56.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9460
    Cell Significance Index: 189.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9098
    Cell Significance Index: 496.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8101
    Cell Significance Index: 103.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8068
    Cell Significance Index: 23.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8017
    Cell Significance Index: 79.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7694
    Cell Significance Index: 53.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7107
    Cell Significance Index: 254.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6983
    Cell Significance Index: 52.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6669
    Cell Significance Index: 42.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6515
    Cell Significance Index: 84.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6195
    Cell Significance Index: 28.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5885
    Cell Significance Index: 12.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5536
    Cell Significance Index: 244.7700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4550
    Cell Significance Index: 2.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4247
    Cell Significance Index: 22.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4195
    Cell Significance Index: 32.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4074
    Cell Significance Index: 25.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3656
    Cell Significance Index: 105.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3550
    Cell Significance Index: 70.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3362
    Cell Significance Index: 23.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2517
    Cell Significance Index: 12.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2472
    Cell Significance Index: 11.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2209
    Cell Significance Index: 42.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1752
    Cell Significance Index: 4.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1021
    Cell Significance Index: 3.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1005
    Cell Significance Index: 17.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0798
    Cell Significance Index: 1.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0792
    Cell Significance Index: 0.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0580
    Cell Significance Index: 0.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0212
    Cell Significance Index: 16.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0184
    Cell Significance Index: 0.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0146
    Cell Significance Index: 1.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0098
    Cell Significance Index: 7.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0037
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0075
    Cell Significance Index: -4.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0209
    Cell Significance Index: -39.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0219
    Cell Significance Index: -40.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0267
    Cell Significance Index: -1.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0268
    Cell Significance Index: -41.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0324
    Cell Significance Index: -44.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0456
    Cell Significance Index: -25.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0457
    Cell Significance Index: -4.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0611
    Cell Significance Index: -38.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0646
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0783
    Cell Significance Index: -2.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0898
    Cell Significance Index: -40.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0915
    Cell Significance Index: -9.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1214
    Cell Significance Index: -2.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1406
    Cell Significance Index: -4.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1534
    Cell Significance Index: -5.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1555
    Cell Significance Index: -18.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1806
    Cell Significance Index: -4.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1861
    Cell Significance Index: -21.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1947
    Cell Significance Index: -4.6700
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2060
    Cell Significance Index: -1.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2088
    Cell Significance Index: -2.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2448
    Cell Significance Index: -3.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2519
    Cell Significance Index: -2.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2781
    Cell Significance Index: -40.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3804
    Cell Significance Index: -9.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4104
    Cell Significance Index: -42.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4222
    Cell Significance Index: -33.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5169
    Cell Significance Index: -7.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5296
    Cell Significance Index: -3.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5499
    Cell Significance Index: -8.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRSF1 is a serine and arginine-rich protein that belongs to the SR family of splicing factors. It contains a characteristic arginine-rich domain that mediates its interactions with other proteins and RNA molecules. SRSF1 is a multifunctional protein that plays a central role in the regulation of alternative RNA splicing, including the recognition of 5' splice sites, the removal of introns, and the joining of exons. It also interacts with other proteins involved in RNA processing, including RNA polymerase II and DNA topoisomerase. **Pathways and Functions** SRSF1 is involved in several key pathways, including: 1. **Alternative RNA Splicing**: SRSF1 plays a crucial role in the recognition of 5' splice sites and the removal of introns, allowing for the generation of diverse protein isoforms from a single gene. 2. **Gene Expression (Transcription)**: SRSF1 interacts with RNA polymerase II to regulate the transcription of genes involved in RNA processing. 3. **Liver Regeneration**: SRSF1 is involved in the regulation of liver regeneration, where it plays a key role in the activation of genes involved in cell proliferation and differentiation. 4. **Metabolism of RNA**: SRSF1 interacts with RNA-binding proteins to regulate the metabolism of RNA, including the processing of capped intron-containing pre-mRNAs. **Clinical Significance** Dysregulation of SRSF1 has been implicated in several diseases, including: 1. **Cancer**: SRSF1 mutations have been identified in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders**: SRSF1 mutations have been implicated in neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Liver Regeneration**: SRSF1 is involved in the regulation of liver regeneration, and its dysregulation may contribute to liver dysfunction in certain diseases. In conclusion, SRSF1 is a crucial gene involved in the regulation of alternative RNA splicing, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the role of SRSF1 in human disease and to develop therapeutic strategies to target this gene in the treatment of various disorders.

Genular Protein ID: 3901753864

Symbol: SRSF1_HUMAN

Name: Alternative-splicing factor 1

UniProtKB Accession Codes:

Q07955 B2R6Z7 D3DTZ3 Q13809

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 9 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1855257

Title: Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators.

PubMed ID: 1855257

DOI: 10.1016/0092-8674(91)90626-a

PubMed ID: 1830244

Title: Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators.

PubMed ID: 1830244

DOI: 10.1016/0092-8674(91)90627-b

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 1741384

Title: Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

PubMed ID: 1741384

DOI: 10.1073/pnas.89.4.1301

PubMed ID: 8261509

Title: Specific interactions between proteins implicated in splice site selection and regulated alternative splicing.

PubMed ID: 8261509

DOI: 10.1016/0092-8674(93)90316-i

PubMed ID: 8223481

Title: Functional domains of the human splicing factor ASF/SF2.

PubMed ID: 8223481

DOI: 10.1002/j.1460-2075.1993.tb06161.x

PubMed ID: 8139654

Title: Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.

PubMed ID: 8139654

DOI: 10.1038/368119a0

PubMed ID: 7512732

Title: The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.

PubMed ID: 7512732

DOI: 10.1073/pnas.91.8.3363

PubMed ID: 7543047

Title: The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

PubMed ID: 7543047

DOI: 10.1002/j.1460-2075.1995.tb07360.x

PubMed ID: 9237760

Title: A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.

PubMed ID: 9237760

DOI: 10.1038/41137

PubMed ID: 9420331

Title: A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm.

PubMed ID: 9420331

DOI: 10.1101/gad.12.1.55

PubMed ID: 9885563

Title: A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2.

PubMed ID: 9885563

DOI: 10.1016/s1097-2765(00)80290-7

PubMed ID: 9671816

Title: SAF-B couples transcription and pre-mRNA splicing to SAR/MAR elements.

PubMed ID: 9671816

DOI: 10.1093/nar/26.15.3542

PubMed ID: 10757789

Title: Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

PubMed ID: 10757789

DOI: 10.1128/mcb.20.9.3049-3057.2000

PubMed ID: 12215544

Title: Nuclear export and retention signals in the RS domain of SR proteins.

PubMed ID: 12215544

DOI: 10.1128/mcb.22.19.6871-6882.2002

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12667464

Title: SR splicing factors serve as adapter proteins for TAP-dependent mRNA export.

PubMed ID: 12667464

DOI: 10.1016/s1097-2765(03)00089-3

PubMed ID: 14555757

Title: Processive phosphorylation of alternative splicing factor/splicing factor 2.

PubMed ID: 14555757

DOI: 10.1073/pnas.1635129100

PubMed ID: 15798186

Title: A novel SR-related protein is required for the second step of pre-mRNA splicing.

PubMed ID: 15798186

DOI: 10.1128/mcb.25.8.2969-2980.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18216018

Title: Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.

PubMed ID: 18216018

DOI: 10.1074/jbc.m708188200

PubMed ID: 18155240

Title: Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1.

PubMed ID: 18155240

DOI: 10.1016/j.jmb.2007.08.029

PubMed ID: 18687337

Title: Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1.

PubMed ID: 18687337

DOI: 10.1016/j.jmb.2008.07.055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19886675

Title: Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1.

PubMed ID: 19886675

DOI: 10.1021/bi901107q

PubMed ID: 19477182

Title: Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1.

PubMed ID: 19477182

DOI: 10.1016/j.jmb.2009.05.060

PubMed ID: 19561594

Title: Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.

PubMed ID: 19561594

DOI: 10.1038/nbt.1550

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20308322

Title: Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF.

PubMed ID: 20308322

DOI: 10.1128/mcb.01270-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21296756

Title: NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo.

PubMed ID: 21296756

DOI: 10.1093/nar/gkq1267

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24644279

Title: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.

PubMed ID: 24644279

DOI: 10.1074/jbc.m113.530717

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 23604122

Title: RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1.

PubMed ID: 23604122

DOI: 10.1038/onc.2013.133

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18342604

Title: A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1.

PubMed ID: 18342604

DOI: 10.1016/j.molcel.2007.12.017

PubMed ID: 24449914

Title: Structural basis for nuclear import of splicing factors by human Transportin 3.

PubMed ID: 24449914

DOI: 10.1073/pnas.1320755111

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 37071997

Title: SRSF1 haploinsufficiency is responsible for a syndromic developmental disorder associated with intellectual disability.

PubMed ID: 37071997

DOI: 10.1016/j.ajhg.2023.03.016

Sequence Information:

  • Length: 248
  • Mass: 27745
  • Checksum: C28A0B2F112EA713
  • Sequence:
    • MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE 
FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE 
NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF 
RSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR 
HSRSRSRT

Genular Protein ID: 2826477565

Symbol: Q59FA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FA2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 233
  • Mass: 25625
  • Checksum: BA479BDF0C40D0CD
  • Sequence:
    • GRGRRGAAAG SLCRALGLVG RPVLESALFV TAMSGGGVIR GPAGNNDCRI YVGNLPPDIR 
TKDIEDVFYK YGAIRDIDLK NRRGGPPFAF VEFEDPRDAE DAVYGRDGYD YDGYRLRVEF 
PRSGRGTGRG GGGGGGGGAP RGRYGPPSRR SENRVVVSGL PPSGSWQDLK DHMREAGDVC 
YADVYRDGTG VVEFVRKEDM TYAVRKLDNT KFRSHEVGYT RILFFDQNWI QWS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.