Details for: SH3BGRL

Gene ID: 6451

Symbol: SH3BGRL

Ensembl ID: ENSG00000131171

Description: SH3 domain binding glutamate rich protein like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 425.6640
    Cell Significance Index: -66.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.0939
    Cell Significance Index: -59.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 215.0273
    Cell Significance Index: -88.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 182.2737
    Cell Significance Index: -74.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 176.7337
    Cell Significance Index: -83.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 157.0613
    Cell Significance Index: -80.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 125.4802
    Cell Significance Index: -84.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 78.8170
    Cell Significance Index: -75.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.8652
    Cell Significance Index: -77.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.2226
    Cell Significance Index: -77.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.0778
    Cell Significance Index: -87.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.3188
    Cell Significance Index: -57.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.5410
    Cell Significance Index: -38.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.3861
    Cell Significance Index: 252.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.9487
    Cell Significance Index: 54.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8069
    Cell Significance Index: 181.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3999
    Cell Significance Index: 329.5700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.1413
    Cell Significance Index: 12.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7598
    Cell Significance Index: 207.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7543
    Cell Significance Index: 36.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7135
    Cell Significance Index: 308.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6642
    Cell Significance Index: 204.6300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.4827
    Cell Significance Index: 9.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4523
    Cell Significance Index: 157.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3586
    Cell Significance Index: 174.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1617
    Cell Significance Index: 513.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1609
    Cell Significance Index: 20.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0676
    Cell Significance Index: 65.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9874
    Cell Significance Index: 354.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9399
    Cell Significance Index: 513.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8468
    Cell Significance Index: 24.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6531
    Cell Significance Index: 34.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6157
    Cell Significance Index: 16.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5805
    Cell Significance Index: 39.0300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.5397
    Cell Significance Index: 2.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5058
    Cell Significance Index: 101.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4770
    Cell Significance Index: 61.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3151
    Cell Significance Index: 4.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2467
    Cell Significance Index: 6.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2320
    Cell Significance Index: 13.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2309
    Cell Significance Index: 104.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2289
    Cell Significance Index: 6.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2017
    Cell Significance Index: 7.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1901
    Cell Significance Index: 32.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1784
    Cell Significance Index: 12.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1541
    Cell Significance Index: 15.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1229
    Cell Significance Index: 23.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0894
    Cell Significance Index: 168.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0697
    Cell Significance Index: 3.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0280
    Cell Significance Index: 43.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0176
    Cell Significance Index: 12.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0090
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0102
    Cell Significance Index: -0.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0198
    Cell Significance Index: -0.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0206
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0274
    Cell Significance Index: -17.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0348
    Cell Significance Index: -26.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0552
    Cell Significance Index: -34.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0558
    Cell Significance Index: -1.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0621
    Cell Significance Index: -84.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0980
    Cell Significance Index: -5.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1109
    Cell Significance Index: -62.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1668
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2433
    Cell Significance Index: -51.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2530
    Cell Significance Index: -50.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2561
    Cell Significance Index: -73.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3285
    Cell Significance Index: -14.5300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3312
    Cell Significance Index: -5.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3594
    Cell Significance Index: -52.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4147
    Cell Significance Index: -9.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4475
    Cell Significance Index: -52.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5331
    Cell Significance Index: -61.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5593
    Cell Significance Index: -15.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5845
    Cell Significance Index: -46.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6306
    Cell Significance Index: -16.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6346
    Cell Significance Index: -24.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6366
    Cell Significance Index: -72.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6380
    Cell Significance Index: -66.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7344
    Cell Significance Index: -12.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7446
    Cell Significance Index: -23.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7679
    Cell Significance Index: -6.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7730
    Cell Significance Index: -17.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8181
    Cell Significance Index: -23.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8312
    Cell Significance Index: -43.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0112
    Cell Significance Index: -27.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0882
    Cell Significance Index: -23.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1062
    Cell Significance Index: -84.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.1672
    Cell Significance Index: -13.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.2262
    Cell Significance Index: -13.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3665
    Cell Significance Index: -83.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3866
    Cell Significance Index: -87.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5914
    Cell Significance Index: -39.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.6137
    Cell Significance Index: -14.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7753
    Cell Significance Index: -52.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9210
    Cell Significance Index: -26.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9645
    Cell Significance Index: -42.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9648
    Cell Significance Index: -29.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9818
    Cell Significance Index: -72.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SH3BGRL is a glutamate-rich protein that interacts with the SH3 domain of SH3L1, a protein involved in signaling pathways. The protein is expressed in various cell types, including uterine smooth muscle cells, supporting cells, blood cells, and immune cells such as monocytes and macrophages. Its expression is also observed in mesodermal cells, progenitor cells of mammary luminal epithelium, and kidney interstitial cells. **Pathways and Functions:** SH3BGRL is involved in several cellular and immune-related pathways, including: 1. **Positive regulation of cytoplasmic translational initiation**: SH3BGRL interacts with the SH3 domain of SH3L1 to regulate the translation of mRNAs, which is essential for protein synthesis and cellular adaptation. 2. **Proteasome-mediated ubiquitin-dependent protein catabolic process**: SH3BGRL is involved in the regulation of protein degradation, which is crucial for maintaining cellular homeostasis and immune function. 3. **Protein-rna adaptor activity**: SH3BGRL acts as a protein-RNA adapter, facilitating the interaction between proteins and RNAs, which is essential for gene expression and regulation. 4. **Sh3 domain binding**: SH3BGRL interacts with the SH3 domain of SH3L1, which is involved in signaling pathways and protein-protein interactions. **Clinical Significance:** SH3BGRL has been implicated in various diseases and disorders, including: 1. **Immune-related disorders**: SH3BGRL is involved in the regulation of immune responses, and its dysregulation may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: SH3BGRL has been observed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological disorders**: SH3BGRL has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuronal dysfunction and degeneration. 4. **Cardiovascular disease**: SH3BGRL may play a role in the development of cardiovascular disease, particularly in the context of immune-mediated inflammation. In conclusion, SH3BGRL is a multifunctional protein involved in various cellular and immune-related pathways. Its dysregulation may contribute to various diseases and disorders, highlighting the importance of further research into the functional significance of SH3BGRL.

Genular Protein ID: 2138134875

Symbol: SH3L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75368 Q3SYL1 Q5JT50 Q6FIE8 Q9H0N8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9642120

Title: Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene.

PubMed ID: 9642120

DOI: 10.1006/bbrc.1998.8763

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16511048

Title: Expression, purification and crystallization of a human protein SH3BGRL at atomic resolution.

PubMed ID: 16511048

DOI: 10.1107/s174430910500730x

PubMed ID: 32381043

Title: SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.

PubMed ID: 32381043

DOI: 10.1186/s13046-020-01577-z

PubMed ID: 34870550

Title: Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers.

PubMed ID: 34870550

DOI: 10.1080/15548627.2021.2002108

PubMed ID: 34331014

Title: Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation.

PubMed ID: 34331014

DOI: 10.1038/s41388-021-01970-8

PubMed ID: 34930999

Title: Correction to: Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation.

PubMed ID: 34930999

DOI: 10.1038/s41388-021-02129-1

PubMed ID: 16080146

Title: Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins.

PubMed ID: 16080146

DOI: 10.1002/prot.20523

Sequence Information:

  • Length: 114
  • Mass: 12774
  • Checksum: D72AC2A095F1AA8B
  • Sequence:
    • MVIRVYIASS SGSTAIKKKQ QDVLGFLEAN KIGFEEKDIA ANEENRKWMR ENVPENSRPA 
TGYPLPPQIF NESQYRGDYD AFFEARENNA VYAFLGLTAP PGSKEAEVQA KQQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.