Details for: SIAH1

Gene ID: 6477

Symbol: SIAH1

Ensembl ID: ENSG00000196470

Description: siah E3 ubiquitin protein ligase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 206.3708
    Cell Significance Index: -32.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 129.0000
    Cell Significance Index: -32.7200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 73.2132
    Cell Significance Index: -30.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.8124
    Cell Significance Index: -32.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.7650
    Cell Significance Index: -27.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.9973
    Cell Significance Index: -27.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8355
    Cell Significance Index: -34.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2361
    Cell Significance Index: -30.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7885
    Cell Significance Index: -34.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1590
    Cell Significance Index: -25.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8720
    Cell Significance Index: -15.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 6.3719
    Cell Significance Index: 170.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0441
    Cell Significance Index: 29.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9556
    Cell Significance Index: 26.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9439
    Cell Significance Index: 187.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9212
    Cell Significance Index: 32.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7358
    Cell Significance Index: 147.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6570
    Cell Significance Index: 34.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6486
    Cell Significance Index: 29.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5672
    Cell Significance Index: 31.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4964
    Cell Significance Index: 12.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4806
    Cell Significance Index: 61.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4674
    Cell Significance Index: 206.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4550
    Cell Significance Index: 62.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4185
    Cell Significance Index: 31.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4151
    Cell Significance Index: 26.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3584
    Cell Significance Index: 128.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3460
    Cell Significance Index: 188.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3367
    Cell Significance Index: 41.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3320
    Cell Significance Index: 42.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3318
    Cell Significance Index: 17.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3303
    Cell Significance Index: 59.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3250
    Cell Significance Index: 9.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3022
    Cell Significance Index: 21.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2987
    Cell Significance Index: 7.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2496
    Cell Significance Index: 15.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2476
    Cell Significance Index: 15.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2434
    Cell Significance Index: 12.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2248
    Cell Significance Index: 10.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2155
    Cell Significance Index: 16.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2126
    Cell Significance Index: 4.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1683
    Cell Significance Index: 16.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1433
    Cell Significance Index: 269.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1131
    Cell Significance Index: 21.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1090
    Cell Significance Index: 5.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0717
    Cell Significance Index: 2.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0500
    Cell Significance Index: 31.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0396
    Cell Significance Index: 61.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0372
    Cell Significance Index: 1.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0340
    Cell Significance Index: 15.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0254
    Cell Significance Index: 46.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0101
    Cell Significance Index: 13.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0161
    Cell Significance Index: -1.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0212
    Cell Significance Index: -3.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0291
    Cell Significance Index: -21.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0317
    Cell Significance Index: -23.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0434
    Cell Significance Index: -7.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0475
    Cell Significance Index: -26.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0555
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0585
    Cell Significance Index: -36.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0589
    Cell Significance Index: -0.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0807
    Cell Significance Index: -1.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0888
    Cell Significance Index: -5.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0946
    Cell Significance Index: -27.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0973
    Cell Significance Index: -1.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1021
    Cell Significance Index: -1.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1092
    Cell Significance Index: -12.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1527
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1637
    Cell Significance Index: -34.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1683
    Cell Significance Index: -19.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1930
    Cell Significance Index: -6.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2228
    Cell Significance Index: -3.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2350
    Cell Significance Index: -1.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2363
    Cell Significance Index: -10.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2389
    Cell Significance Index: -24.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2869
    Cell Significance Index: -5.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2892
    Cell Significance Index: -10.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3282
    Cell Significance Index: -7.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3408
    Cell Significance Index: -26.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3454
    Cell Significance Index: -5.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3550
    Cell Significance Index: -7.6900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3727
    Cell Significance Index: -3.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3744
    Cell Significance Index: -8.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4554
    Cell Significance Index: -27.9200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4752
    Cell Significance Index: -3.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4778
    Cell Significance Index: -12.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4892
    Cell Significance Index: -7.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5179
    Cell Significance Index: -11.3400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.5212
    Cell Significance Index: -8.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5378
    Cell Significance Index: -14.4100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5590
    Cell Significance Index: -3.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5829
    Cell Significance Index: -14.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5872
    Cell Significance Index: -7.5200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6516
    Cell Significance Index: -4.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6781
    Cell Significance Index: -19.3500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6794
    Cell Significance Index: -4.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6972
    Cell Significance Index: -22.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIAH1 is a member of the Siah family of E3 ubiquitin ligases, which are characterized by their ability to interact with specific ubiquitin ligases and modulate their activity. SIAH1 is distinct from other Siah family members due to its unique substrate specificity and tissue distribution. The gene is highly expressed in cells involved in immune responses, including mononuclear cells and peripheral nervous system neurons, suggesting its critical role in regulating immune cell function and neuronal survival. **Pathways and Functions:** SIAH1 is involved in various cellular pathways, including: 1. **Adaptive Immune System:** SIAH1 regulates the activity of immune cells by targeting proteins involved in antigen presentation, cytokine signaling, and immune cell survival. 2. **Apoptotic Process:** SIAH1 modulates apoptosis by targeting pro-apoptotic proteins, thereby regulating cell death and survival. 3. **Protein Degradation:** SIAH1 mediates the ubiquitination and degradation of target proteins, regulating their activity and localization. 4. **Canonical Wnt Signaling Pathway:** SIAH1 interacts with β-catenin to regulate Wnt signaling, thereby modulating cell proliferation and differentiation. 5. **Cell Cycle Regulation:** SIAH1 targets proteins involved in the cell cycle, regulating cell growth and division. **Clinical Significance:** Dysregulation of SIAH1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** SIAH1 dysfunction has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, highlighting its potential as a therapeutic target. 2. **Cancer:** SIAH1 overexpression has been observed in various cancers, suggesting its role in tumor progression and metastasis. 3. **Neurodegenerative Diseases:** SIAH1 dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlighting its potential as a therapeutic target. In conclusion, SIAH1 is a multifunctional gene that plays a critical role in regulating immune responses, apoptosis, and protein metabolism. Its dysregulation has been implicated in various diseases, underscoring its potential as a therapeutic target. Further research is needed to elucidate the mechanisms underlying SIAH1 function and to explore its therapeutic applications.

Genular Protein ID: 2600647395

Symbol: SIAH1_HUMAN

Name: E3 ubiquitin-protein ligase SIAH1

UniProtKB Accession Codes:

Q8IUQ4 A0FKF3 O43269 Q49A58 Q92880

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8799150

Title: Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.

PubMed ID: 8799150

DOI: 10.1073/pnas.93.17.9039

PubMed ID: 9403064

Title: Characterization of human homologs of the Drosophila seven in absentia (sina) gene.

PubMed ID: 9403064

DOI: 10.1006/geno.1997.4997

PubMed ID: 10956387

Title: Lack of somatic mutation in the coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene.

PubMed ID: 10956387

DOI: 10.1002/1097-0215(20000915)87:6<794::aid-ijc5>3.3.co;2-2

PubMed ID: 17420721

Title: Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin.

PubMed ID: 17420721

DOI: 10.1038/sj.onc.1210449

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9334332

Title: Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.

PubMed ID: 9334332

DOI: 10.1101/gad.11.20.2701

PubMed ID: 9582267

Title: p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

PubMed ID: 9582267

DOI: 10.1093/emboj/17.10.2736

PubMed ID: 9858595

Title: Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.

PubMed ID: 9858595

DOI: 10.1128/mcb.19.1.724

PubMed ID: 11146551

Title: SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.

PubMed ID: 11146551

DOI: 10.1038/sj.onc.1204002

PubMed ID: 10747903

Title: p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.

PubMed ID: 10747903

DOI: 10.1074/jbc.m000372200

PubMed ID: 11389839

Title: Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.

PubMed ID: 11389839

DOI: 10.1016/s1097-2765(01)00242-8

PubMed ID: 11389840

Title: Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.

PubMed ID: 11389840

DOI: 10.1016/s1097-2765(01)00241-6

PubMed ID: 11483517

Title: The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.

PubMed ID: 11483517

DOI: 10.1093/emboj/20.15.4143

PubMed ID: 11483518

Title: Regulation of BOB.1/OBF.1 stability by SIAH.

PubMed ID: 11483518

DOI: 10.1093/emboj/20.15.4153

PubMed ID: 11752454

Title: Siah-1 binds and regulates the function of Numb.

PubMed ID: 11752454

DOI: 10.1073/pnas.261571998

PubMed ID: 12072443

Title: Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.

PubMed ID: 12072443

DOI: 10.1074/jbc.m204812200

PubMed ID: 14506261

Title: Siah-1 facilitates ubiquitination and degradation of synphilin-1.

PubMed ID: 14506261

DOI: 10.1074/jbc.m306347200

PubMed ID: 12810624

Title: Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.

PubMed ID: 12810624

PubMed ID: 12557228

Title: SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas.

PubMed ID: 12557228

DOI: 10.1002/gcc.10170

PubMed ID: 14654780

Title: SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.

PubMed ID: 14654780

DOI: 10.1038/sj.onc.1206994

PubMed ID: 12421809

Title: Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP).

PubMed ID: 12421809

DOI: 10.1074/jbc.m210263200

PubMed ID: 15163637

Title: SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome.

PubMed ID: 15163637

DOI: 10.1093/hmg/ddh165

PubMed ID: 14645235

Title: The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.

PubMed ID: 14645235

DOI: 10.1074/jbc.m306407200

PubMed ID: 15064394

Title: Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

PubMed ID: 15064394

DOI: 10.1073/pnas.0401081101

PubMed ID: 18536714

Title: Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

PubMed ID: 18536714

DOI: 10.1038/ncb1743

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19224863

Title: Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.

PubMed ID: 19224863

DOI: 10.1074/jbc.m805990200

PubMed ID: 20508617

Title: Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.

PubMed ID: 20508617

DOI: 10.1038/leu.2010.114

PubMed ID: 22483617

Title: The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.

PubMed ID: 22483617

DOI: 10.1016/j.molcel.2012.03.007

PubMed ID: 33591310

Title: DAZAP2 acts as specifier of the p53 response to DNA damage.

PubMed ID: 33591310

DOI: 10.1093/nar/gkab084

PubMed ID: 16085652

Title: Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.

PubMed ID: 16085652

DOI: 10.1074/jbc.m506707200

PubMed ID: 28546513

Title: The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation.

PubMed ID: 28546513

DOI: 10.1101/gad.300053.117

PubMed ID: 32430360

Title: De novo variants in SIAH1, encoding an E3 ubiquitin ligase, are associated with developmental delay, hypotonia and dysmorphic features.

PubMed ID: 32430360

DOI: 10.1136/jmedgenet-2019-106335

Sequence Information:

  • Length: 282
  • Mass: 31123
  • Checksum: FA0698D0DC1B0A15
  • Sequence:
    • MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL 
VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY ASSGCEITLP HTEKADHEEL 
CEFRPYSCPC PGASCKWQGS LDAVMPHLMH QHKSITTLQG EDIVFLATDI NLPGAVDWVM 
MQSCFGFHFM LVLEKQEKYD GHQQFFAIVQ LIGTRKQAEN FAYRLELNGH RRRLTWEATP 
RSIHEGIATA IMNSDCLVFD TSIAQLFAEN GNLGINVTIS MC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.