Details for: SLC9A1

Gene ID: 6548

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SLC9A1

Ensembl ID: ENSG00000090020

Description: solute carrier family 9 member A1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • foveolar cell of stomach CL0002179
    CSI 6.03
    rCSI 12.84%
    PRS 94.02
  • CD14-positive monocyte CL0001054
    CSI 5.79
    rCSI 7.22%
    PRS 96.98
  • paneth cell of epithelium of small intestine CL1000343
    CSI 4.51
    rCSI 12.64%
    PRS 94.77
  • intestinal tuft cell CL0019032
    CSI 3.85
    rCSI 5.88%
    PRS 93.89
  • regular atrial cardiac myocyte CL0002129
    CSI 3.66
    rCSI 11.79%
    PRS 89.68
  • conjunctival epithelial cell CL1000432
    CSI 3.48
    rCSI 5.32%
    PRS 91.84
  • secretory cell CL0000151
    CSI 3.47
    rCSI 3.62%
    PRS 91.95
  • melanocyte CL0000148
    CSI 3.31
    rCSI 2.45%
    PRS 90.03
  • intestine goblet cell CL0019031
    CSI 3.28
    rCSI 2.91%
    PRS 90.69
  • placental villous trophoblast CL2000060
    CSI 3.27
    rCSI 5.05%
    PRS 91.14
  • goblet cell CL0000160
    CSI 3.21
    rCSI 3.04%
    PRS 90.73
  • lung secretory cell CL1000272
    CSI 3.17
    rCSI 7.85%
    PRS 93.8
  • dopaminergic neuron CL0000700
    CSI 3.06
    rCSI 17.27%
    PRS 83.64
  • endothelial cell of placenta CL0009092
    CSI 3.05
    rCSI 15.03%
    PRS 95.33
  • epithelial cell of lung CL0000082
    CSI 2.97
    rCSI 2.46%
    PRS 93.7
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.95
    rCSI 18.44%
    PRS 87.36
  • colon epithelial cell CL0011108
    CSI 2.9
    rCSI 3.04%
    PRS 90.74
  • bronchus fibroblast of lung CL2000093
    CSI 2.88
    rCSI 2.34%
    PRS 92.24
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.75
    rCSI 6.98%
    PRS 88.16
  • mucous neck cell CL0000651
    CSI 2.75
    rCSI 3.96%
    PRS 94.82
  • small intestine goblet cell CL1000495
    CSI 2.68
    rCSI 5.87%
    PRS 94.28
  • myeloid leukocyte CL0000766
    CSI 2.64
    rCSI 2.43%
    PRS 93.88
  • hepatic stellate cell CL0000632
    CSI 2.63
    rCSI 9.86%
    PRS 89.56
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.58
    rCSI 6.66%
    PRS 90.88
  • cardiac muscle cell CL0000746
    CSI 2.57
    rCSI 3.69%
    PRS 85.86
  • granulocyte CL0000094
    CSI 2.46
    rCSI 3.76%
    PRS 95.9
  • Mueller cell CL0000636
    CSI 2.45
    rCSI 5.6%
    PRS 87.36
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.45
    rCSI 6.61%
    PRS 94.31
  • choroid plexus epithelial cell CL0000706
    CSI 2.42
    rCSI 3.96%
    PRS 87.01
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 2.35
    rCSI 3.94%
    PRS 82.19
  • colonocyte CL1000347
    CSI 2.34
    rCSI 3.36%
    PRS 90.95
  • blood vessel endothelial cell CL0000071
    CSI 2.28
    rCSI 4.72%
    PRS 91.46
  • BEST4+ enteroycte CL4030026
    CSI 2.23
    rCSI 2.77%
    PRS 92.27
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.22
    rCSI 2.87%
    PRS 83.2
  • mucus secreting cell CL0000319
    CSI 2.14
    rCSI 3.41%
    PRS 96.03
  • colon goblet cell CL0009039
    CSI 2.02
    rCSI 4.79%
    PRS 93.79
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.01
    rCSI 2.41%
    PRS 82.23
  • extravillous trophoblast CL0008036
    CSI 1.95
    rCSI 2.42%
    PRS 91.41
  • basal cell CL0000646
    CSI 1.92
    rCSI 2.57%
    PRS 90.37
  • stem cell CL0000034
    CSI 1.9
    rCSI 1.83%
    PRS 89.54
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.86
    rCSI 2.31%
    PRS 80
  • vascular associated smooth muscle cell CL0000359
    CSI 1.82
    rCSI 5.92%
    PRS 91.25
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.81
    rCSI 2.92%
    PRS 83.17
  • tuft cell of colon CL0009041
    CSI 1.73
    rCSI 4.02%
    PRS 93.78
  • club cell CL0000158
    CSI 1.65
    rCSI 2.41%
    PRS 89.09
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.63
    rCSI 2.88%
    PRS 81.49
  • corneal epithelial cell CL0000575
    CSI 1.62
    rCSI 4.62%
    PRS 93.72
  • keratocyte CL0002363
    CSI 1.61
    rCSI 3.87%
    PRS 93.41
  • squamous epithelial cell CL0000076
    CSI 1.42
    rCSI 3.38%
    PRS 89.84
  • medium spiny neuron CL1001474
    CSI 1.41
    rCSI 12.18%
    PRS 86.12
  • syncytiotrophoblast cell CL0000525
    CSI 1.27
    rCSI 3.66%
    PRS 93.54
  • enteroglial cell CL4040002
    CSI 1.24
    rCSI 6.52%
    PRS 92.86
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.17
    rCSI 28.29%
    PRS 80.08
  • retinal ganglion cell CL0000740
    CSI 1.07
    rCSI 2.36%
    PRS 84.08
  • endothelial cell of vascular tree CL0002139
    CSI 0.93
    rCSI 5.08%
    PRS 89.3
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.92
    rCSI 2.24%
    PRS 80.03
  • direct pathway medium spiny neuron CL4023026
    CSI 0.72
    rCSI 17.34%
    PRS 79.99
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.72
    rCSI 2.24%
    PRS 85
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.69
    rCSI 2.16%
    PRS 83.27
  • blood vessel smooth muscle cell CL0019018
    CSI 0.66
    rCSI 5.36%
    PRS 91.23
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.65
    rCSI 2.47%
    PRS 82.36
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.62
    rCSI 2.24%
    PRS 80.31
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.4
    rCSI 2.33%
    PRS 82.59

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Solute Carrier Family 9 Member A1, [SLC9A1](/details-gene/6548), encodes the ubiquitously expressed Sodium/Hydrogen Exchanger 1 (NHE1). This integral membrane protein is a critical regulator of intracellular pH (pHi) by mediating the electroneutral exchange of one intracellular proton for one extracellular sodium ion. Beyond its primary housekeeping role in pHi and cell volume homeostasis, [SLC9A1](/details-gene/6548) is involved in a diverse array of cellular processes, including cell migration, proliferation, and apoptosis. **Overall**, expression data reveals its particular significance in secretory epithelial cells such as the [foveolar cell of stomach](/details-cell/CL0002179), immune cells like the [CD14-positive monocyte](/details-cell/CL0001054), and contractile cells like the [regular atrial cardiac myocyte](/details-cell/CL0002129), highlighting its specialized importance in tissues with high metabolic, secretory, or mechanical demands. Clinically, dysfunction of [SLC9A1](/details-gene/6548) has been associated with various pathologies, as noted in OMIM ([107310](https://omim.org/entry/107310)). ## Cellular Roles and Expression Landscape The expression profile of [SLC9A1](/details-gene/6548) underscores its fundamental role in cellular physiology across multiple organ systems. Its high significance is most pronounced in several distinct functional cell groups: * **Epithelial and Secretory Cells:** [SLC9A1](/details-gene/6548) shows exceptionally high significance in a wide range of epithelial cells responsible for secretion and absorption. This includes the [foveolar cell of stomach](/details-cell/CL0002179), [paneth cell of epithelium of small intestine](/details-cell/CL1000343), [intestine goblet cell](/details-cell/CL0019031), and [lung secretory cell](/details-cell/CL1000272). This pattern suggests a crucial role in maintaining the steep ion gradients and pH homeostasis necessary for producing and secreting substances like mucus, digestive enzymes, and antimicrobial peptides. * **Immune System:** The gene is a significant marker for [CD14-positive monocyte](/details-cell/CL0001054). In these cells, rapid changes in cell shape and volume are required for processes like chemotaxis, extravasation, and phagocytosis. The activity of [SLC9A1](/details-gene/6548) is likely essential for regulating the localized pHi and cytoskeletal dynamics that drive these motile functions. * **Cardiac Muscle:** A high CSI score in the [regular atrial cardiac myocyte](/details-cell/CL0002129) is consistent with the well-documented role of [SLC9A1](/details-gene/6548) in the heart. It is critical for pHi recovery following the metabolic acidosis associated with cardiac muscle contraction and is implicated in the pathophysiology of cardiac hypertrophy and ischemia-reperfusion injury [Link](https://doi.org/10.1007/bf00936442). * **Other Specialized Tissues:** High significance is also noted in diverse cell types such as [melanocyte](/details-cell/CL0000148), [placental villous trophoblast](/details-cell/CL2000060), and [dopaminergic neuron](/details-cell/CL0000700), indicating its broad importance in maintaining cellular integrity and function across the body. ## Pathways and Molecular Function The primary molecular function of [SLC9A1](/details-gene/6548) is [sodium:proton antiporter activity](/details-go/GO:0015385), a process central to the [Sodium/proton exchangers](/details-reactome/R-HSA-425986) and broader [Slc-mediated transmembrane transport](/details-reactome/R-HSA-425407) pathways. This core activity supports several fundamental biological processes. Its canonical role is the [Regulation of intracellular ph](/details-go/GO:0051453), allowing cells to extrude excess acid and respond to conditions like [hypoxia](/details-go/GO:0071456) or an [acidic ph](/details-go/GO:0071468). This function is critical for cell survival and proliferation. The protein's activity is tightly regulated by various stimuli, including growth factors, which can induce its phosphorylation [Link](https://doi.org/10.1126/science.2154036). In the context of its expression in cardiac myocytes, [SLC9A1](/details-gene/6548) is directly involved in [Cardiac muscle cell contraction](/details-go/GO:0086003) and the [Positive regulation of the force of heart contraction](/details-go/GO:0098735). Its activity helps mitigate the acid load generated during intense metabolic activity, thereby protecting the myocyte from ion imbalance and contractile dysfunction. Beyond ion transport, [SLC9A1](/details-gene/6548) functions as a signaling scaffold. It participates in processes such as [Cell migration](/details-go/GO:0016477) and the [Regulation of focal adhesion assembly](/details-go/GO:0051893). Through its C-terminal cytoplasmic domain, it binds to various proteins, including calmodulin ([Calmodulin binding](/details-go/GO:0005516)) and phospholipids like PIP2 ([Phosphatidylinositol-4,5-bisphosphate binding](/details-go/GO:0005546)), linking pH regulation directly to cytoskeletal organization and cell signaling cascades. ## Research Directions Given its ubiquitous yet contextually critical roles, research on [SLC9A1](/details-gene/6548) can be pursued in several directions focusing on its tissue-specific functions. **Proposed Hypotheses:** 1. Given its high expression in secretory epithelial cells of the gut ([foveolar cell of stomach](/details-cell/CL0002179), [paneth cell](/details-cell/CL1000343)), it is hypothesized that [SLC9A1](/details-gene/6548) is indispensable for establishing the specific luminal and intracellular pH conditions required for proper protein folding and exocytosis of secreted products like mucins and antimicrobial peptides. Its dysregulation may therefore be a key factor in the pathogenesis of mucosal barrier defects seen in inflammatory bowel disease. 2. Based on its significance in [CD14-positive monocyte](/details-cell/CL0001054) and its documented role in motility, it is hypothesized that the polarized activity of [SLC9A1](/details-gene/6548) at the leading edge of migrating monocytes creates localized alkaline pHi microdomains that are essential for promoting actin polymerization and focal adhesion turnover, thereby driving efficient chemotaxis. **Experimental Approach:** To test the second hypothesis regarding monocyte migration, the following experiment could be conducted: * Primary human [CD14-positive monocyte](/details-cell/CL0001054) could be treated with a highly specific NHE1 inhibitor (e.g., Cariporide). * Cell migration could be quantitatively assessed using a 3D microfluidic chemotaxis chamber with a stable gradient of a chemoattractant like C-C motif chemokine 2 (CCL2). * Advanced imaging techniques, such as live-cell lattice light-sheet microscopy, could be employed using cells expressing a genetically encoded pHi sensor and a fluorescent actin probe. This would allow for simultaneous visualization of intracellular pH dynamics, cytoskeletal reorganization, and cell motility at high spatiotemporal resolution, directly testing the link between localized [SLC9A1](/details-gene/6548) activity and the mechanics of migration. **Therapeutic Potential:** [SLC9A1](/details-gene/6548) is a well-established therapeutic target, primarily for **inhibition**. Its role in extruding acid makes it a pro-survival factor for cancer cells in the acidic tumor microenvironment and a driver of maladaptive growth in cardiac hypertrophy. Pharmacological inhibitors of NHE1 have been extensively studied for cardioprotection against ischemia-reperfusion injury and as potential anti-cancer agents. The main challenge remains the ubiquitous expression of the protein, which raises concerns about off-target effects of systemic inhibition. Future therapeutic strategies may rely on developing inhibitors with greater specificity or employing targeted delivery systems to concentrate the drug in pathological tissues while sparing healthy ones.

Genular Protein ID: 1160642897

Symbol: SL9A1_HUMAN

Name: Sodium/hydrogen exchanger 1

UniProtKB Accession Codes:

P19634 B1ALD6 D3DPL4 Q96EM2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 DrugCentral 1 EMBL 27 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 66 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2536298

Title: Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

PubMed ID: 2536298

DOI: 10.1016/0092-8674(89)90901-x

PubMed ID: 2154036

Title: Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD.

PubMed ID: 2154036

DOI: 10.1126/science.2154036

PubMed ID: 1712287

Title: Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

PubMed ID: 1712287

DOI: 10.1002/j.1460-2075.1991.tb07725.x

PubMed ID: 8283968

Title: Cloning and analysis of the human myocardial Na+/H+ exchanger.

PubMed ID: 8283968

DOI: 10.1007/bf00936442

PubMed ID: 10913675

Title: Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: a comparison with healthy controls.

PubMed ID: 10913675

DOI: 10.1016/s0165-4608(99)00246-0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7110335

Title: Modifier role of internal H+ in activating the Na+-H+ exchanger in renal microvillus membrane vesicles.

PubMed ID: 7110335

DOI: 10.1038/299161a0

PubMed ID: 8068684

Title: The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain.

PubMed ID: 8068684

DOI: 10.1021/bi00200a030

PubMed ID: 7603840

Title: Expression of the human sodium/proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium/proton exchange activity and establishes sodium/lithium countertransport.

PubMed ID: 7603840

DOI: 10.1007/bf00374811

PubMed ID: 8967452

Title: Coimmunoprecipitation of a 24-kDa protein with NHE1, the ubiquitous isoform of the Na+/H+ exchanger.

PubMed ID: 8967452

DOI: 10.1152/ajpcell.1996.270.5.c1493

PubMed ID: 8901634

Title: A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.

PubMed ID: 8901634

DOI: 10.1073/pnas.93.22.12631

PubMed ID: 9688597

Title: Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage.

PubMed ID: 9688597

DOI: 10.1152/ajpcell.1998.275.2.c431

PubMed ID: 10713111

Title: A novel topology model of the human Na(+)/H(+) exchanger isoform 1.

PubMed ID: 10713111

DOI: 10.1074/jbc.275.11.7942

PubMed ID: 11532004

Title: Functional analysis of polar amino-acid residues in membrane associated regions of the NHE1 isoform of the mammalian Na+/H+ exchanger.

PubMed ID: 11532004

DOI: 10.1046/j.1432-1327.2001.02391.x

PubMed ID: 11412833

Title: Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559.

PubMed ID: 11412833

DOI: 10.1016/s0014-2999(01)00991-8

PubMed ID: 11696366

Title: Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1.

PubMed ID: 11696366

DOI: 10.1016/s0014-5793(01)02986-6

PubMed ID: 11350981

Title: Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.

PubMed ID: 11350981

DOI: 10.1074/jbc.m100296200

PubMed ID: 12226101

Title: Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.

PubMed ID: 12226101

DOI: 10.1074/jbc.m208313200

PubMed ID: 12809501

Title: The Na+/H+ exchanger cytoplasmic tail: structure, function, and interactions with tescalcin.

PubMed ID: 12809501

DOI: 10.1021/bi027143d

PubMed ID: 12947095

Title: Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition.

PubMed ID: 12947095

DOI: 10.1074/jbc.m308099200

PubMed ID: 15035633

Title: Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements.

PubMed ID: 15035633

DOI: 10.1021/bi0360004

PubMed ID: 15323573

Title: Dimeric interaction between the cytoplasmic domains of the Na+/H+ exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation.

PubMed ID: 15323573

DOI: 10.1021/bi049367x

PubMed ID: 14680478

Title: Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1.

PubMed ID: 14680478

DOI: 10.1042/bj20030884

PubMed ID: 15096511

Title: The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

PubMed ID: 15096511

DOI: 10.1074/jbc.m400814200

PubMed ID: 17073455

Title: Dimerization is crucial for the function of the Na+/H+ exchanger NHE1.

PubMed ID: 17073455

DOI: 10.1021/bi0608616

PubMed ID: 17493937

Title: NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.

PubMed ID: 17493937

DOI: 10.1074/jbc.m701637200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18757828

Title: Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1.

PubMed ID: 18757828

DOI: 10.1161/circresaha.108.175877

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369449

Title: Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.

PubMed ID: 19369449

DOI: 10.1152/ajpcell.00062.2009

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21392185

Title: Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.

PubMed ID: 21392185

DOI: 10.1111/j.1365-2443.2011.01497.x

PubMed ID: 22020933

Title: Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival.

PubMed ID: 22020933

DOI: 10.1074/jbc.m110.212845

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27650500

Title: A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.

PubMed ID: 27650500

DOI: 10.1074/jbc.m116.736215

PubMed ID: 30287853

Title: Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1.

PubMed ID: 30287853

DOI: 10.1038/s41598-018-33096-5

PubMed ID: 25205112

Title: Mutation of SLC9A1, encoding the major Na[?]/H[?] exchanger, causes ataxia-deafness Lichtenstein-Knorr syndrome.

PubMed ID: 25205112

DOI: 10.1093/hmg/ddu461

PubMed ID: 15677483

Title: Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger.

PubMed ID: 15677483

DOI: 10.1074/jbc.m409608200

PubMed ID: 16511206

Title: Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.

PubMed ID: 16511206

DOI: 10.1107/s1744309105030836

PubMed ID: 16710297

Title: Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.

PubMed ID: 16710297

DOI: 10.1038/sj.emboj.7601145

PubMed ID: 17050540

Title: Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.

PubMed ID: 17050540

DOI: 10.1074/jbc.m604092200

PubMed ID: 32130622

Title: Acidic residues of extracellular loop 3 of the Na+/H+ exchanger type 1 are important in cation transport.

PubMed ID: 32130622

DOI: 10.1007/s11010-020-03707-9

PubMed ID: 31375679

Title: Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin.

PubMed ID: 31375679

DOI: 10.1038/s41467-019-11391-7

PubMed ID: 34108458

Title: Structure and mechanism of the human NHE1-CHP1 complex.

PubMed ID: 34108458

DOI: 10.1038/s41467-021-23496-z

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 815
  • Mass: 90763
  • Checksum: 02EC748C79DF6526
  • Sequence:
    • MVLRSGICGL SPHRIFPSLL VVVALVGLLP VLRSHGLQLS PTASTIRSSE PPRERSIGDV 
TTAPPEVTPE SRPVNHSVTD HGMKPRKAFP VLGIDYTHVR TPFEISLWIL LACLMKIGFH 
VIPTISSIVP ESCLLIVVGL LVGGLIKGVG ETPPFLQSDV FFLFLLPPII LDAGYFLPLR 
QFTENLGTIL IFAVVGTLWN AFFLGGLMYA VCLVGGEQIN NIGLLDNLLF GSIISAVDPV 
AVLAVFEEIH INELLHILVF GESLLNDAVT VVLYHLFEEF ANYEHVGIVD IFLGFLSFFV 
VALGGVLVGV VYGVIAAFTS RFTSHIRVIE PLFVFLYSYM AYLSAELFHL SGIMALIASG 
VVMRPYVEAN ISHKSHTTIK YFLKMWSSVS ETLIFIFLGV STVAGSHHWN WTFVISTLLF 
CLIARVLGVL GLTWFINKFR IVKLTPKDQF IIAYGGLRGA IAFSLGYLLD KKHFPMCDLF 
LTAIITVIFF TVFVQGMTIR PLVDLLAVKK KQETKRSINE EIHTQFLDHL LTGIEDICGH 
YGHHHWKDKL NRFNKKYVKK CLIAGERSKE PQLIAFYHKM EMKQAIELVE SGGMGKIPSA 
VSTVSMQNIH PKSLPSERIL PALSKDKEEE IRKILRNNLQ KTRQRLRSYN RHTLVADPYE 
EAWNQMLLRR QKARQLEQKI NNYLTVPAHK LDSPTMSRAR IGSDPLAYEP KEDLPVITID 
PASPQSPESV DLVNEELKGK VLGLSRDPAK VAEEDEDDDG GIMMRSKETS SPGTDDVFTP 
APSDSPSSQR IQRCLSDPGP HPEPGEGEPF FPKGQ

Genular Protein ID: 4224461109

Symbol: B2RAH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RAH2

Database IDs:

ARBA 23 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 5 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 3

Sequence Information:

  • Length: 815
  • Mass: 90793
  • Checksum: 0FE61589EAD78EC5
  • Sequence:
    • MVLRSGICGL SPHRIFPSLL VVVALVGLLP VLRSHGLQLS PTASTIRSSE PPRERSIGDV 
TTAPPEVTPE SRPVNHSVTD HGMKPRKAFP VLGIDYTHVR TPFEISLWIL LACLMKIGFH 
VIPTISSIVP ESCLLIVVGL LVGGLIKGVG ETPPFLQSDV FFLFLLPPII LDAGYFLPLR 
QFTENLGTIL IFAVVGTLWN AFFLGGLMYA VCLVGGEQIN NIGLLDNLLF GSIISTVDPV 
AVLAVFEEIH INELLHILVF GESLLNDAVT VVLYHLFEEF ANYEHVGIVD IFLGFLSFFV 
VALGGVLVGV VYGVIAAFTS RFTSHIRVIE PLFVFLYSYM AYLSAELFHL SGIMALIASG 
VVMRPYVEAN ISHKSHTTIK YFLKMWSSVS ETLIFIFLGV STVAGSHHWN WTFVISTLLF 
CLIARVLGVL GLTWFINKFR IVKLTPKDQF IIAYGGLRGA IAFSLGYLLD KKHFPMCDLF 
LTAIITVIFF TVFVQGMTIR PLVDLLAVKK KQETKRSINE EIHTQFLDHL LTGIEDICGH 
YGHHHWKDKL NRFNKKYVKK CLIAGERSKE PQLIAFYHKM EMKQAIELVE SGGMGKIPSA 
VSTVSMQNIH PKSLPSERIL PALSKDKEEE IRKILRNNLQ KTRQRLRSYN RHTLVADPYE 
EAWNQMLLRR QKARQLEQKI NNYLTVPAHK LDSPTMSRAR IGSDPLAYEP KEDLPVITID 
PASPQSPESV DLVNEELKGK VLGLSRDPAK VAEEDEDDDG GIMMRSKETS SPGTDDVFTP 
APSDSPSSQR IQRCLSDPGP HPEPGEGEPF FPKGQ