Details for: SMARCE1

Gene ID: 6605

Symbol: SMARCE1

Ensembl ID: ENSG00000073584

Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.03
    Marker Score: 3454.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.02
    Marker Score: 2262
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2
    Marker Score: 1047
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.98
    Marker Score: 2121
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.96
    Marker Score: 1310
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.92
    Marker Score: 2038
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.91
    Marker Score: 5199
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.82
    Marker Score: 11852
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.81
    Marker Score: 7826
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.78
    Marker Score: 20010
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.78
    Marker Score: 6573.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.74
    Marker Score: 60397
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.74
    Marker Score: 7115.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.72
    Marker Score: 1814
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.68
    Marker Score: 16882
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.67
    Marker Score: 6560.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.63
    Marker Score: 3054
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.6
    Marker Score: 2622.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.59
    Marker Score: 1122
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.55
    Marker Score: 1126
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.52
    Marker Score: 838
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.52
    Marker Score: 2153
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.52
    Marker Score: 612
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.52
    Marker Score: 356
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.52
    Marker Score: 486.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.48
    Marker Score: 1494
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.44
    Marker Score: 531
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.41
    Marker Score: 3835.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.4
    Marker Score: 954
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.39
    Marker Score: 1749
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.39
    Marker Score: 2777
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.39
    Marker Score: 12202
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.38
    Marker Score: 399
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.38
    Marker Score: 666.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.38
    Marker Score: 726.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.38
    Marker Score: 16020
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.37
    Marker Score: 3232
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.37
    Marker Score: 2866
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.34
    Marker Score: 1440.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.33
    Marker Score: 261
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.33
    Marker Score: 1307
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.32
    Marker Score: 425
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.32
    Marker Score: 267
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.32
    Marker Score: 336
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.32
    Marker Score: 893
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.31
    Marker Score: 1890
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.3
    Marker Score: 691
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.28
    Marker Score: 363
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.28
    Marker Score: 16897
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.25
    Marker Score: 1664
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.25
    Marker Score: 1502
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.24
    Marker Score: 7926.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.24
    Marker Score: 902.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.24
    Marker Score: 1612.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.23
    Marker Score: 1185.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.23
    Marker Score: 41694.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.22
    Marker Score: 913
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.22
    Marker Score: 2173
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.21
    Marker Score: 3338
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.21
    Marker Score: 2365
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.2
    Marker Score: 620
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.2
    Marker Score: 296
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.2
    Marker Score: 1843
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.19
    Marker Score: 853
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.19
    Marker Score: 4960
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.18
    Marker Score: 1876
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.17
    Marker Score: 411
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.17
    Marker Score: 1416.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.16
    Marker Score: 2025.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.16
    Marker Score: 10082
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.16
    Marker Score: 1119
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.16
    Marker Score: 2050
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.14
    Marker Score: 2323
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.14
    Marker Score: 1411
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.13
    Marker Score: 832
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.13
    Marker Score: 2376
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.13
    Marker Score: 678.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.12
    Marker Score: 485
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.12
    Marker Score: 704
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.11
    Marker Score: 11016
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1
    Marker Score: 263
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.1
    Marker Score: 502
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.09
    Marker Score: 565
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.09
    Marker Score: 534.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.09
    Marker Score: 2854
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.09
    Marker Score: 775
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.09
    Marker Score: 14632
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.09
    Marker Score: 939
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.08
    Marker Score: 3219
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.08
    Marker Score: 676
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.08
    Marker Score: 3406
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.08
    Marker Score: 8031
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.08
    Marker Score: 1262
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.08
    Marker Score: 380.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.07
    Marker Score: 3015
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.07
    Marker Score: 507
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.07
    Marker Score: 1499
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.06
    Marker Score: 261.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.05
    Marker Score: 9030
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.05
    Marker Score: 255

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** SMARCE1 is a 27-kDa protein that belongs to the SWI/SNF subfamily of chromatin remodeling complexes. Its structure consists of a C-terminal domain that interacts with the SWI/SNF complex and a N-terminal domain that binds to histone H3. SMARCE1 exhibits a unique enzymatic activity, which includes: 1. **Chromatin remodeling**: SMARCE1 participates in the ATP-dependent remodeling of chromatin structure, allowing for the regulation of gene expression. 2. **Histone modification**: SMARCE1 is involved in the methylation of histone arginine 3 (H3R3) and the trimethylation of histone arginine 17 (H3R17). 3. **Transcriptional regulation**: SMARCE1 modulates the expression of target genes by interacting with transcription factors, such as Runx1. **Pathways and Functions** SMARCE1 is involved in various cellular processes, including: 1. **Cell differentiation**: SMARCE1 regulates the expression of genes involved in cell differentiation, including myoblast differentiation and stem cell population maintenance. 2. **Gene expression (transcription)**: SMARCE1 modulates the expression of target genes by interacting with transcription factors and RNA polymerase II. 3. **DNA repair**: SMARCE1 is involved in the regulation of DNA repair pathways, including double-strand break repair and nucleotide-excision repair. 4. **Cell cycle regulation**: SMARCE1 regulates the cell cycle by controlling the expression of genes involved in the G0 to G1 transition and the G1/S transition of the mitotic cell cycle. **Clinical Significance** Dysregulation of SMARCE1 has been implicated in several human diseases, including: 1. **Cancer**: SMARCE1 loss is observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: SMARCE1 is involved in the regulation of gene expression in neurons, and its loss has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Immunological disorders**: SMARCE1 plays a crucial role in regulating immune cell function, and its loss has been implicated in autoimmune diseases, such as lupus and rheumatoid arthritis. In conclusion, SMARCE1 is a critical regulator of chromatin structure and gene expression, and its dysregulation has significant implications for human health. Further research is needed to fully understand the mechanisms by which SMARCE1 regulates chromatin and to develop therapeutic strategies for the treatment of diseases associated with SMARCE1 loss.

Genular Protein ID: 2112138246

Symbol: SMCE1_HUMAN

Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

UniProtKB Accession Codes:

Q969G3 B3KMC1 B4DFR4 C0IMW4 C0IMW5 C0IMW7 H7C3F6 O43539

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 31 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 15 EMDB 3 EPD 1 Ensembl 10 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9435219

Title: Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.

PubMed ID: 9435219

DOI: 10.1073/pnas.95.2.492

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12192000

Title: REST repression of neuronal genes requires components of the hSWI.SNF complex.

PubMed ID: 12192000

DOI: 10.1074/jbc.m205691200

PubMed ID: 12110891

Title: Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.

PubMed ID: 12110891

DOI: 10.1038/nature00876

PubMed ID: 12145209

Title: Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes.

PubMed ID: 12145209

DOI: 10.1093/emboj/cdf412

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12672490

Title: Recent advances in understanding chromatin remodeling by SWI/SNF complexes.

PubMed ID: 12672490

DOI: 10.1016/s0959-437x(03)00022-4

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 16051670

Title: hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes.

PubMed ID: 16051670

DOI: 10.1210/me.2005-0097

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 20829358

Title: Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex.

PubMed ID: 20829358

DOI: 10.1074/jbc.m110.173997

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 22426308

Title: Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.

PubMed ID: 22426308

DOI: 10.1038/ng.2219

PubMed ID: 23377182

Title: Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas.

PubMed ID: 23377182

DOI: 10.1038/ng.2552

PubMed ID: 23906836

Title: A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling.

PubMed ID: 23906836

DOI: 10.1093/hmg/ddt366

PubMed ID: 25249420

Title: Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case.

PubMed ID: 25249420

DOI: 10.1007/s00381-014-2558-5

Sequence Information:

  • Length: 411
  • Mass: 46649
  • Checksum: 6F1C1B7917BAD506
  • Sequence:
    • MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP 
KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII GGMWRDLTDE EKQEYLNEYE 
AEKIEYNESM KAYHNSPAYL AYINAKSRAE AALEEESRQR QSRMEKGEPY MSIQPAEDPD 
DYDDGFSMKH TATARFQRNH RLISEILSES VVPDVRSVVT TARMQVLKRQ VQSLMVHQRK 
LEAELLQIEE RHQEKKRKFL ESTDSFNNEL KRLCGLKVEV DMEKIAAEIA QAEEQARKRQ 
EEREKEAAEQ AERSQSSIVP EEEQAANKGE EKKDDENIPM ETEETHLEET TESQQNGEEG 
TSTPEDKESG QEGVDSMAEE GTSDSNTGSE SNSATVEEPP TDPIPEDEKK E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.