Details for: SNRPA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 156.8676
Cell Significance Index: -24.4000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 76.9584
Cell Significance Index: -19.5200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 70.0136
Cell Significance Index: -33.0600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 66.5066
Cell Significance Index: -34.2100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 49.5438
Cell Significance Index: -33.2500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 25.7755
Cell Significance Index: -31.7800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.8288
Cell Significance Index: -26.3300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.5047
Cell Significance Index: -33.5600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.2674
Cell Significance Index: -19.2500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.1122
Cell Significance Index: -9.0000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 3.6417
Cell Significance Index: 39.5900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.3324
Cell Significance Index: 48.8200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.3250
Cell Significance Index: 29.7800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.7725
Cell Significance Index: 209.0300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5004
Cell Significance Index: 90.0800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.4754
Cell Significance Index: 43.3300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3889
Cell Significance Index: 18.9500 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.3001
Cell Significance Index: 10.3800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2413
Cell Significance Index: 80.0900 - Cell Name: germ cell (CL0000586)
Fold Change: 1.1873
Cell Significance Index: 8.9700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.0474
Cell Significance Index: 27.5400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.9466
Cell Significance Index: 122.3000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8493
Cell Significance Index: 39.9200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8427
Cell Significance Index: 760.9200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8328
Cell Significance Index: 114.3700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8252
Cell Significance Index: 22.4600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8045
Cell Significance Index: 55.6400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.7863
Cell Significance Index: 6.6100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7625
Cell Significance Index: 20.3600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7260
Cell Significance Index: 396.5000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6319
Cell Significance Index: 17.6600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5764
Cell Significance Index: 20.0300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5516
Cell Significance Index: 109.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5204
Cell Significance Index: 63.9900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4836
Cell Significance Index: 25.1200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4717
Cell Significance Index: 85.0300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4591
Cell Significance Index: 34.2200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4494
Cell Significance Index: 198.6700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4122
Cell Significance Index: 29.1500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4014
Cell Significance Index: 11.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3865
Cell Significance Index: 18.0200 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.2838
Cell Significance Index: 4.3100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2636
Cell Significance Index: 5.7100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2570
Cell Significance Index: 32.9500 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.2067
Cell Significance Index: 2.1400 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.2005
Cell Significance Index: 0.9800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1754
Cell Significance Index: 7.9500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1751
Cell Significance Index: 35.1300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1672
Cell Significance Index: 3.5600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1242
Cell Significance Index: 3.5600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1079
Cell Significance Index: 38.7000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0985
Cell Significance Index: 18.7500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0831
Cell Significance Index: 2.6600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0393
Cell Significance Index: 1.0500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0085
Cell Significance Index: 6.4500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0062
Cell Significance Index: 0.1100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0055
Cell Significance Index: 0.0900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0005
Cell Significance Index: 0.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0042
Cell Significance Index: -0.7200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0104
Cell Significance Index: -1.0600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0119
Cell Significance Index: -22.0100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0165
Cell Significance Index: -25.3900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0168
Cell Significance Index: -0.3100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0189
Cell Significance Index: -1.8700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0211
Cell Significance Index: -0.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0264
Cell Significance Index: -35.8900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0277
Cell Significance Index: -20.3200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0281
Cell Significance Index: -17.8600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0366
Cell Significance Index: -27.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0547
Cell Significance Index: -30.8700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0551
Cell Significance Index: -25.0100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0657
Cell Significance Index: -18.9100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0663
Cell Significance Index: -3.4800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0724
Cell Significance Index: -2.5500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0729
Cell Significance Index: -45.5000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0772
Cell Significance Index: -4.3300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1065
Cell Significance Index: -15.4800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1503
Cell Significance Index: -17.5100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1556
Cell Significance Index: -3.8900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1818
Cell Significance Index: -38.2900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1836
Cell Significance Index: -4.9200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2013
Cell Significance Index: -23.0700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2121
Cell Significance Index: -2.4100 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2253
Cell Significance Index: -3.1600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2266
Cell Significance Index: -14.2800 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.2492
Cell Significance Index: -1.5600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2518
Cell Significance Index: -19.3200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2540
Cell Significance Index: -15.6100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2629
Cell Significance Index: -3.9400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3162
Cell Significance Index: -32.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3763
Cell Significance Index: -25.3000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3787
Cell Significance Index: -8.7500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3840
Cell Significance Index: -30.4100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4092
Cell Significance Index: -25.0900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.5120
Cell Significance Index: -4.7200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5225
Cell Significance Index: -13.4300 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.5929
Cell Significance Index: -8.3100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6326
Cell Significance Index: -27.9800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6787
Cell Significance Index: -19.9900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.7117
Cell Significance Index: -4.3000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3720224021
Symbol: SNRPA_HUMAN
Name: U1 small nuclear ribonucleoprotein A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1831431
Title: Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein.
PubMed ID: 1831431
PubMed ID: 2962859
Title: cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins.
PubMed ID: 2962859
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9848648
Title: The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor.
PubMed ID: 9848648
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19561594
Title: Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.
PubMed ID: 19561594
DOI: 10.1038/nbt.1550
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 30538201
Title: Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
PubMed ID: 30538201
PubMed ID: 2147232
Title: Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A.
PubMed ID: 2147232
DOI: 10.1038/348515a0
PubMed ID: 7984237
Title: Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.
PubMed ID: 7984237
DOI: 10.1038/372432a0
PubMed ID: 1826055
Title: RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.
PubMed ID: 1826055
PubMed ID: 8070414
Title: NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein.
PubMed ID: 8070414
PubMed ID: 8602269
Title: Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation.
PubMed ID: 8602269
DOI: 10.1038/380646a0
PubMed ID: 8609632
Title: Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.
PubMed ID: 8609632
PubMed ID: 9312034
Title: Structural basis of the RNA-binding specificity of human U1A protein.
PubMed ID: 9312034
PubMed ID: 9265619
Title: Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy.
PubMed ID: 9265619
DOI: 10.1021/bi9709811
PubMed ID: 1833186
Title: Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.
PubMed ID: 1833186
Sequence Information:
- Length: 282
- Mass: 31280
- Checksum: 9426E83EE5A22894
- Sequence:
MAVPETRPNH TIYINNLNEK IKKDELKKSL YAIFSQFGQI LDILVSRSLK MRGQAFVIFK EVSSATNALR SMQGFPFYDK PMRIQYAKTD SDIIAKMKGT FVERDRKREK RKPKSQETPA TKKAVQGGGA TPVVGAVQGP VPGMPPMTQA PRIMHHMPGQ PPYMPPPGMI PPPGLAPGQI PPGAMPPQQL MPGQMPPAQP LSENPPNHIL FLTNLPEETN ELMLSMLFNQ FPGFKEVRLV PGRHDIAFVE FDNEVQAGAA RDALQGFKIT QNNAMKISFA KK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.