Details for: SNRPA

Gene ID: 6626

Symbol: SNRPA

Ensembl ID: ENSG00000077312

Description: small nuclear ribonucleoprotein polypeptide A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 156.8676
    Cell Significance Index: -24.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.9584
    Cell Significance Index: -19.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.0136
    Cell Significance Index: -33.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.5066
    Cell Significance Index: -34.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.5438
    Cell Significance Index: -33.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.7755
    Cell Significance Index: -31.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8288
    Cell Significance Index: -26.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5047
    Cell Significance Index: -33.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2674
    Cell Significance Index: -19.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1122
    Cell Significance Index: -9.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.6417
    Cell Significance Index: 39.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3324
    Cell Significance Index: 48.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.3250
    Cell Significance Index: 29.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7725
    Cell Significance Index: 209.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5004
    Cell Significance Index: 90.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4754
    Cell Significance Index: 43.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3889
    Cell Significance Index: 18.9500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3001
    Cell Significance Index: 10.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2413
    Cell Significance Index: 80.0900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1873
    Cell Significance Index: 8.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0474
    Cell Significance Index: 27.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9466
    Cell Significance Index: 122.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8493
    Cell Significance Index: 39.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8427
    Cell Significance Index: 760.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8328
    Cell Significance Index: 114.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8252
    Cell Significance Index: 22.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8045
    Cell Significance Index: 55.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7863
    Cell Significance Index: 6.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7625
    Cell Significance Index: 20.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7260
    Cell Significance Index: 396.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6319
    Cell Significance Index: 17.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5764
    Cell Significance Index: 20.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5516
    Cell Significance Index: 109.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5204
    Cell Significance Index: 63.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4836
    Cell Significance Index: 25.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4717
    Cell Significance Index: 85.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4591
    Cell Significance Index: 34.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4494
    Cell Significance Index: 198.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4122
    Cell Significance Index: 29.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4014
    Cell Significance Index: 11.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3865
    Cell Significance Index: 18.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2838
    Cell Significance Index: 4.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2636
    Cell Significance Index: 5.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2570
    Cell Significance Index: 32.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2067
    Cell Significance Index: 2.1400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.2005
    Cell Significance Index: 0.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1754
    Cell Significance Index: 7.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1751
    Cell Significance Index: 35.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1672
    Cell Significance Index: 3.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1242
    Cell Significance Index: 3.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1079
    Cell Significance Index: 38.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0985
    Cell Significance Index: 18.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0831
    Cell Significance Index: 2.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0393
    Cell Significance Index: 1.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0085
    Cell Significance Index: 6.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0062
    Cell Significance Index: 0.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0055
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0042
    Cell Significance Index: -0.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0104
    Cell Significance Index: -1.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0119
    Cell Significance Index: -22.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0165
    Cell Significance Index: -25.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0168
    Cell Significance Index: -0.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0189
    Cell Significance Index: -1.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0211
    Cell Significance Index: -0.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0264
    Cell Significance Index: -35.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0277
    Cell Significance Index: -20.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0281
    Cell Significance Index: -17.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0366
    Cell Significance Index: -27.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0547
    Cell Significance Index: -30.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0551
    Cell Significance Index: -25.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0657
    Cell Significance Index: -18.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0663
    Cell Significance Index: -3.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0724
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0729
    Cell Significance Index: -45.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0772
    Cell Significance Index: -4.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1065
    Cell Significance Index: -15.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1503
    Cell Significance Index: -17.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1556
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1818
    Cell Significance Index: -38.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1836
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2013
    Cell Significance Index: -23.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2121
    Cell Significance Index: -2.4100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2253
    Cell Significance Index: -3.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2266
    Cell Significance Index: -14.2800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2492
    Cell Significance Index: -1.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2518
    Cell Significance Index: -19.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2540
    Cell Significance Index: -15.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2629
    Cell Significance Index: -3.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3162
    Cell Significance Index: -32.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3763
    Cell Significance Index: -25.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3787
    Cell Significance Index: -8.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3840
    Cell Significance Index: -30.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4092
    Cell Significance Index: -25.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5120
    Cell Significance Index: -4.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5225
    Cell Significance Index: -13.4300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5929
    Cell Significance Index: -8.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6326
    Cell Significance Index: -27.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6787
    Cell Significance Index: -19.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7117
    Cell Significance Index: -4.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **RNA Splicing**: SNRPA is a critical component of the spliceosome complex, which is responsible for the precise splicing of pre-mRNA into mature mRNA. The U1 snRNP A recognizes the 5' splice site of the intron and facilitates the removal of the intron, resulting in the creation of a mature mRNA molecule. 2. **DNA Binding**: SNRPA has been shown to bind to DNA, suggesting a potential role in regulating gene expression or DNA repair mechanisms. 3. **Protein Interactions**: The U1 snRNP A interacts with various proteins, including other snRNPs, to form the spliceosome complex, which is essential for the efficient splicing of pre-mRNA. **Pathways and Functions** 1. **RNA Splicing via Spliceosome**: SNRPA is involved in the spliceosome-mediated splicing of pre-mRNA, which is a critical process for the generation of mature mRNA molecules. 2. **Metabolism of RNA**: SNRPA plays a role in the metabolism of RNA, including the regulation of RNA splicing and the degradation of aberrant RNA molecules. 3. **DNA Binding and Repair**: SNRPA's ability to bind to DNA suggests a potential role in DNA repair mechanisms or the regulation of gene expression. **Clinical Significance** 1. **Immune System Disorders**: SNRPA has been implicated in various immune system disorders, including autoimmune diseases and immune deficiencies. Mutations in the SNRPA gene have been associated with increased susceptibility to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: Aberrant expression of SNRPA has been observed in certain types of cancer, including leukemia and lymphoma. The U1 snRNP A has been shown to interact with oncogenic proteins, suggesting a potential role in the development and progression of cancer. 3. **Neurological Disorders**: SNRPA has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. The U1 snRNP A has been shown to interact with proteins involved in neurodegeneration, suggesting a potential role in the pathogenesis of these diseases. In conclusion, the SNRPA gene plays a critical role in various cellular processes, including RNA splicing, DNA binding, and protein interactions. The expression of SNRPA is widespread, with significant levels detected in hematopoietic cells, ovarian surface epithelial cells, and other cell types involved in immune responses. Further research is needed to fully elucidate the role of SNRPA in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3720224021

Symbol: SNRPA_HUMAN

Name: U1 small nuclear ribonucleoprotein A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1831431

Title: Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein.

PubMed ID: 1831431

DOI: 10.1016/0378-1119(91)90077-o

PubMed ID: 2962859

Title: cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins.

PubMed ID: 2962859

DOI: 10.1002/j.1460-2075.1987.tb02721.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9848648

Title: The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor.

PubMed ID: 9848648

DOI: 10.1017/s1355838298981183

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19561594

Title: Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.

PubMed ID: 19561594

DOI: 10.1038/nbt.1550

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 30538201

Title: Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

PubMed ID: 30538201

DOI: 10.1073/pnas.1818012115

PubMed ID: 2147232

Title: Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A.

PubMed ID: 2147232

DOI: 10.1038/348515a0

PubMed ID: 7984237

Title: Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.

PubMed ID: 7984237

DOI: 10.1038/372432a0

PubMed ID: 1826055

Title: RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.

PubMed ID: 1826055

DOI: 10.1073/pnas.88.6.2495

PubMed ID: 8070414

Title: NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein.

PubMed ID: 8070414

DOI: 10.1002/j.1460-2075.1994.tb06698.x

PubMed ID: 8602269

Title: Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation.

PubMed ID: 8602269

DOI: 10.1038/380646a0

PubMed ID: 8609632

Title: Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.

PubMed ID: 8609632

DOI: 10.1006/jmbi.1996.0171

PubMed ID: 9312034

Title: Structural basis of the RNA-binding specificity of human U1A protein.

PubMed ID: 9312034

DOI: 10.1093/emboj/16.18.5764

PubMed ID: 9265619

Title: Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy.

PubMed ID: 9265619

DOI: 10.1021/bi9709811

PubMed ID: 1833186

Title: Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.

PubMed ID: 1833186

DOI: 10.1002/j.1460-2075.1991.tb04909.x

Sequence Information:

  • Length: 282
  • Mass: 31280
  • Checksum: 9426E83EE5A22894
  • Sequence:
  • MAVPETRPNH TIYINNLNEK IKKDELKKSL YAIFSQFGQI LDILVSRSLK MRGQAFVIFK 
    EVSSATNALR SMQGFPFYDK PMRIQYAKTD SDIIAKMKGT FVERDRKREK RKPKSQETPA 
    TKKAVQGGGA TPVVGAVQGP VPGMPPMTQA PRIMHHMPGQ PPYMPPPGMI PPPGLAPGQI 
    PPGAMPPQQL MPGQMPPAQP LSENPPNHIL FLTNLPEETN ELMLSMLFNQ FPGFKEVRLV 
    PGRHDIAFVE FDNEVQAGAA RDALQGFKIT QNNAMKISFA KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.