Details for: SNRPC

Gene ID: 6631

Symbol: SNRPC

Ensembl ID: ENSG00000124562

Description: small nuclear ribonucleoprotein polypeptide C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 275.4826
    Cell Significance Index: -42.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 155.6319
    Cell Significance Index: -39.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 130.7933
    Cell Significance Index: -53.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.1428
    Cell Significance Index: -56.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.8047
    Cell Significance Index: -53.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.9317
    Cell Significance Index: -56.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.1727
    Cell Significance Index: -53.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4144
    Cell Significance Index: -56.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0914
    Cell Significance Index: -35.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3073
    Cell Significance Index: -34.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8126
    Cell Significance Index: -14.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.2652
    Cell Significance Index: 26.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9527
    Cell Significance Index: 32.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.6118
    Cell Significance Index: 156.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4790
    Cell Significance Index: 51.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1989
    Cell Significance Index: 57.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1485
    Cell Significance Index: 74.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8692
    Cell Significance Index: 220.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6317
    Cell Significance Index: 105.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5922
    Cell Significance Index: 46.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5310
    Cell Significance Index: 12.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3164
    Cell Significance Index: 718.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2314
    Cell Significance Index: 169.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1555
    Cell Significance Index: 142.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1131
    Cell Significance Index: 51.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1130
    Cell Significance Index: 492.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0647
    Cell Significance Index: 13.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0453
    Cell Significance Index: 188.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0003
    Cell Significance Index: 70.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9510
    Cell Significance Index: 122.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9266
    Cell Significance Index: 69.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6991
    Cell Significance Index: 19.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6401
    Cell Significance Index: 127.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6303
    Cell Significance Index: 7.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6295
    Cell Significance Index: 32.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5196
    Cell Significance Index: 13.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5154
    Cell Significance Index: 148.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4732
    Cell Significance Index: 21.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3940
    Cell Significance Index: 50.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3688
    Cell Significance Index: 62.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3295
    Cell Significance Index: 66.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3203
    Cell Significance Index: 7.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3177
    Cell Significance Index: 14.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2815
    Cell Significance Index: 8.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1727
    Cell Significance Index: 4.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1705
    Cell Significance Index: 1.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1590
    Cell Significance Index: 25.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1431
    Cell Significance Index: 14.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1288
    Cell Significance Index: 6.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0943
    Cell Significance Index: 33.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0801
    Cell Significance Index: 1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0601
    Cell Significance Index: 45.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0550
    Cell Significance Index: 1.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0547
    Cell Significance Index: 0.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0538
    Cell Significance Index: 3.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0126
    Cell Significance Index: 0.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0019
    Cell Significance Index: 0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0154
    Cell Significance Index: -28.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0229
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0267
    Cell Significance Index: -16.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0274
    Cell Significance Index: -5.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0334
    Cell Significance Index: -61.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0407
    Cell Significance Index: -62.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0461
    Cell Significance Index: -62.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0598
    Cell Significance Index: -33.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0665
    Cell Significance Index: -42.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0810
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0932
    Cell Significance Index: -19.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1004
    Cell Significance Index: -45.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1261
    Cell Significance Index: -14.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1483
    Cell Significance Index: -5.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1554
    Cell Significance Index: -3.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1608
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1815
    Cell Significance Index: -20.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2137
    Cell Significance Index: -3.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2353
    Cell Significance Index: -18.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3140
    Cell Significance Index: -45.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3981
    Cell Significance Index: -45.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4289
    Cell Significance Index: -26.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4405
    Cell Significance Index: -24.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4562
    Cell Significance Index: -36.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5328
    Cell Significance Index: -7.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5372
    Cell Significance Index: -55.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5514
    Cell Significance Index: -16.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5641
    Cell Significance Index: -6.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5747
    Cell Significance Index: -12.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6420
    Cell Significance Index: -43.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6764
    Cell Significance Index: -18.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7746
    Cell Significance Index: -4.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7907
    Cell Significance Index: -19.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8040
    Cell Significance Index: -49.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.8615
    Cell Significance Index: -6.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0414
    Cell Significance Index: -26.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0537
    Cell Significance Index: -18.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1084
    Cell Significance Index: -40.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1487
    Cell Significance Index: -50.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.1811
    Cell Significance Index: -20.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2293
    Cell Significance Index: -35.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNRPC is a polypeptide, specifically a small nuclear ribonucleoprotein (snRNP), which is a complex of RNA and protein that plays a central role in the splicing of pre-mRNA. The SNRPC gene is encoded by a single gene, ENSG00000124562, and is highly conserved across species. The protein product of this gene, RU1C, is a homodimer, consisting of two identical subunits that interact with other snRNPs to form the spliceosome. The SNRPC protein exhibits high affinity for single-stranded RNA, which is essential for its function in the spliceosome. **Pathways and Functions** The SNRPC protein is integral to several key pathways involved in RNA processing, including: 1. **Spliceosome Assembly**: SNRPC is a critical component of the spliceosome, which is responsible for the recognition and removal of introns from pre-mRNA. The SNRPC protein interacts with other snRNPs to form the spliceosome, a complex molecular machine that facilitates the splicing of pre-mRNA. 2. **mRNA Splicing**: SNRPC is involved in the recognition of 5'-splice sites on pre-mRNA, which is essential for the initiation of splicing. The protein's ability to bind to single-stranded RNA allows it to interact with the pre-mRNA, facilitating the recognition of splice sites. 3. **Pre-mRNA Processing**: SNRPC is involved in the processing of capped intron-containing pre-mRNA, which is essential for the production of mature mRNA. **Clinical Significance** The SNRPC gene has been implicated in several diseases, including: 1. **Splice site mutations**: Mutations in the SNRPC gene can lead to aberrant splicing of pre-mRNA, resulting in the production of aberrant mRNAs and proteins. 2. **Developmental disorders**: SNRPC is highly expressed in embryonic stem cells and is involved in the regulation of cellular differentiation. Mutations in the SNRPC gene can lead to developmental disorders, such as embryonic lethality or abnormal development of tissues. 3. **Cancer**: SNRPC has been implicated in the development of certain types of cancer, including leukemia and lymphoma, where aberrant splicing of pre-mRNA can lead to the production of aberrant proteins. In conclusion, the SNRPC gene plays a critical role in the regulation of gene expression and the production of functional proteins. Its involvement in various diseases highlights the importance of this gene in human health and disease. Further research is needed to fully elucidate the functions and clinical significance of the SNRPC gene.

Genular Protein ID: 2474932120

Symbol: RU1C_HUMAN

Name: N/A

UniProtKB Accession Codes:

P09234 Q5TAL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2971157

Title: Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals.

PubMed ID: 2971157

DOI: 10.1093/nar/16.17.8307

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 2961811

Title: Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide.

PubMed ID: 2961811

PubMed ID: 2136774

Title: U1-specific protein C needed for efficient complex formation of U1 snRNP with a 5' splice site.

PubMed ID: 2136774

DOI: 10.1126/science.2136774

PubMed ID: 1826349

Title: Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP.

PubMed ID: 1826349

DOI: 10.1093/nar/19.3.449

PubMed ID: 8798632

Title: Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction.

PubMed ID: 8798632

DOI: 10.1074/jbc.271.39.23985

PubMed ID: 12486009

Title: The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.

PubMed ID: 12486009

DOI: 10.1093/emboj/cdf668

PubMed ID: 15525645

Title: Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry.

PubMed ID: 15525645

DOI: 10.1074/jbc.m409587200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15312772

Title: The structure and biochemical properties of the human spliceosomal protein U1C.

PubMed ID: 15312772

DOI: 10.1016/j.jmb.2004.04.078

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

Sequence Information:

  • Length: 159
  • Mass: 17394
  • Checksum: EC313A57DEC79D95
  • Sequence:
    • MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI DKTTAAFQQG 
KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP PMMPMMGPPP PGMMPVGPAP 
GMRPPMGGHM PMMPGPPMMR PPARPMMVPT RPGMTRPDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.