Details for: SNRPF

Gene ID: 6636

Symbol: SNRPF

Ensembl ID: ENSG00000139343

Description: small nuclear ribonucleoprotein polypeptide F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 356.6165
    Cell Significance Index: -55.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 196.6027
    Cell Significance Index: -80.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 187.8622
    Cell Significance Index: -47.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 165.6137
    Cell Significance Index: -78.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 144.8379
    Cell Significance Index: -74.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 116.7622
    Cell Significance Index: -78.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.7345
    Cell Significance Index: -73.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.1297
    Cell Significance Index: -64.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.9744
    Cell Significance Index: -78.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4111
    Cell Significance Index: -38.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5672
    Cell Significance Index: -18.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 5.6891
    Cell Significance Index: 152.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.2634
    Cell Significance Index: 57.2200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.8633
    Cell Significance Index: 38.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5988
    Cell Significance Index: 96.2600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.4631
    Cell Significance Index: 36.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.0924
    Cell Significance Index: 218.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6745
    Cell Significance Index: 70.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6208
    Cell Significance Index: 123.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.5317
    Cell Significance Index: 298.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5126
    Cell Significance Index: 68.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.4888
    Cell Significance Index: 1100.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4145
    Cell Significance Index: 27.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.2462
    Cell Significance Index: 78.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2239
    Cell Significance Index: 273.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1584
    Cell Significance Index: 1178.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1479
    Cell Significance Index: 294.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0452
    Cell Significance Index: 122.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0164
    Cell Significance Index: 363.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9473
    Cell Significance Index: 251.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8969
    Cell Significance Index: 141.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7737
    Cell Significance Index: 114.4300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.7514
    Cell Significance Index: 15.0500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.4901
    Cell Significance Index: 8.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4822
    Cell Significance Index: 43.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2877
    Cell Significance Index: 60.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2307
    Cell Significance Index: 63.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2153
    Cell Significance Index: 155.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1176
    Cell Significance Index: 25.8200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0520
    Cell Significance Index: 18.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9639
    Cell Significance Index: 27.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9328
    Cell Significance Index: 268.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8015
    Cell Significance Index: 36.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7789
    Cell Significance Index: 154.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7625
    Cell Significance Index: 9.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7368
    Cell Significance Index: 6.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7366
    Cell Significance Index: 665.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5124
    Cell Significance Index: 11.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4794
    Cell Significance Index: 12.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3301
    Cell Significance Index: 62.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3243
    Cell Significance Index: 245.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2941
    Cell Significance Index: 105.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2795
    Cell Significance Index: 56.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2466
    Cell Significance Index: 40.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1439
    Cell Significance Index: 4.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1093
    Cell Significance Index: 1.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0863
    Cell Significance Index: 8.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0448
    Cell Significance Index: 2.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0151
    Cell Significance Index: 0.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0050
    Cell Significance Index: 3.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0166
    Cell Significance Index: -31.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0361
    Cell Significance Index: -49.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0445
    Cell Significance Index: -81.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0472
    Cell Significance Index: -72.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0651
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0729
    Cell Significance Index: -53.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0855
    Cell Significance Index: -54.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1155
    Cell Significance Index: -19.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1258
    Cell Significance Index: -70.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1448
    Cell Significance Index: -8.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1448
    Cell Significance Index: -90.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1491
    Cell Significance Index: -67.6500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1560
    Cell Significance Index: -0.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1715
    Cell Significance Index: -6.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1777
    Cell Significance Index: -20.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2411
    Cell Significance Index: -6.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2705
    Cell Significance Index: -15.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3596
    Cell Significance Index: -10.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3672
    Cell Significance Index: -9.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3711
    Cell Significance Index: -5.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3793
    Cell Significance Index: -43.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4115
    Cell Significance Index: -86.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4288
    Cell Significance Index: -62.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5389
    Cell Significance Index: -9.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5883
    Cell Significance Index: -12.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6346
    Cell Significance Index: -50.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7022
    Cell Significance Index: -9.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7454
    Cell Significance Index: -77.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8067
    Cell Significance Index: -54.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8350
    Cell Significance Index: -5.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8731
    Cell Significance Index: -60.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8779
    Cell Significance Index: -10.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9274
    Cell Significance Index: -71.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0409
    Cell Significance Index: -10.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1034
    Cell Significance Index: -67.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3363
    Cell Significance Index: -34.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3451
    Cell Significance Index: -39.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.3762
    Cell Significance Index: -39.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4532
    Cell Significance Index: -64.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.5102
    Cell Significance Index: -25.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** SNRPF is primarily expressed in cells involved in hematopoiesis, muscle development, and neural differentiation. Its expression is also detected in various types of epithelial cells, including those lining the pancreas, prostate, and nephron. 2. **Function:** SNRPF is a key component of the spliceosome, responsible for the recognition and processing of introns in pre-mRNA transcripts. It interacts with other spliceosomal components, such as U1, U2, U4, U5, and U6 snRNPs, to facilitate the removal of introns and the generation of mature mRNAs. 3. **Regulation:** SNRPF is subject to post-translational modifications, including phosphorylation and ubiquitination, which regulate its activity and interactions with other proteins. **Pathways and Functions:** 1. **RNA Splicing:** SNRPF plays a crucial role in the recognition and processing of introns in pre-mRNA transcripts, ensuring the accurate production of mature mRNAs. 2. **Spliceosome Assembly:** SNRPF interacts with other spliceosomal components to facilitate the assembly of the spliceosome, a complex molecular machine responsible for the recognition and processing of introns. 3. **Catalytic Step 2 Spliceosome:** SNRPF is involved in the catalytic step 2 of the spliceosome, where the intron is removed and the exons are joined. 4. **SARS-CoV-2 Translation and Host Interactions:** SNRPF has been shown to modulate SARS-CoV-2 translation and host interactions, highlighting its potential as a target for therapeutic interventions. **Clinical Significance:** 1. **Immune Response:** SNRPF plays a critical role in the regulation of the immune response, particularly in the context of SARS-CoV-2 infection. Its dysregulation may contribute to the development of immune-related diseases. 2. **Cancer:** Alterations in SNRPF expression and function have been observed in various types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Neurological Disorders:** SNRPF has been implicated in the pathogenesis of neurological disorders, including autism and schizophrenia, highlighting its potential as a therapeutic target. 4. **Infectious Diseases:** SNRPF's role in SARS-CoV-2 translation and host interactions highlights its potential as a target for therapeutic interventions in infectious diseases. In conclusion, SNRPF is a crucial gene involved in the regulation of RNA splicing and immune response. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and infectious diseases. Further research is necessary to fully elucidate the role of SNRPF in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 1367816488

Symbol: RUXF_HUMAN

Name: Small nuclear ribonucleoprotein F

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7744013

Title: snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions.

PubMed ID: 7744013

DOI: 10.1002/j.1460-2075.1995.tb07199.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11574479

Title: Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

PubMed ID: 11574479

DOI: 10.1093/emboj/20.19.5470

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12975319

Title: Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

PubMed ID: 12975319

DOI: 10.1101/gad.274403

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21816274

Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.

PubMed ID: 21816274

DOI: 10.1016/j.cell.2011.06.043

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 23333303

Title: Structural basis of assembly chaperone-mediated snRNP formation.

PubMed ID: 23333303

DOI: 10.1016/j.molcel.2012.12.009

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 31799625

Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.

PubMed ID: 31799625

DOI: 10.1093/nar/gkz1135

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 86
  • Mass: 9725
  • Checksum: 416B88D575DAE58A
  • Sequence:
  • MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG 
    EVLIRCNNVL YIRGVEEEEE DGEMRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.