Details for: SNRPF
Gene ID: 6636
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SNRPF
Ensembl ID: ENSG00000139343
Description: small nuclear ribonucleoprotein polypeptide F
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 93.66rCSI 75.73%PRS 12.24
-
CSI 85.5rCSI 56.83%PRS 14.78
-
CSI 82.16rCSI 74.2%PRS 10.96
-
CSI 80.53rCSI 69.73%PRS 13.8
-
CSI 73.55rCSI 58.13%PRS 8.51
-
CSI 69.32rCSI 66.84%PRS 8.48
-
CSI 67.4rCSI 64.88%PRS 12.82
-
CSI 67.24rCSI 59.06%PRS 13.93
-
CSI 64.45rCSI 54.02%PRS 14.8
-
CSI 62.5rCSI 65.33%PRS 13.03
-
CSI 62.16rCSI 73.01%PRS 14.56
-
CSI 57.05rCSI 71.6%PRS 15.78
-
CSI 56.49rCSI 64.66%PRS 25.41
-
CSI 56.04rCSI 80.83%PRS 17.24
-
CSI 48.62rCSI 40.27%PRS 12.39
-
CSI 47.98rCSI 57.59%PRS 12.24
-
CSI 45.42rCSI 45.33%PRS 10.58
-
CSI 42.52rCSI 37.74%PRS 12.4
-
CSI 40.72rCSI 47.03%PRS 10.86
-
CSI 39.54rCSI 31.11%PRS 14.72
-
CSI 38.82rCSI 66.5%PRS 16.58
-
CSI 36.86rCSI 36.25%PRS 13.41
-
CSI 35.59rCSI 29.5%PRS 11.68
-
CSI 35.39rCSI 37.07%PRS 11.53
-
CSI 34.62rCSI 30.44%PRS 8.98
-
CSI 34.21rCSI 47.52%PRS 12.75
-
CSI 33.93rCSI 41.98%PRS 10.86
-
CSI 31.89rCSI 49.28%PRS 11.6
-
CSI 30.97rCSI 47.38%PRS 20.14
-
CSI 29.29rCSI 39.91%PRS 11.04
-
CSI 28.6rCSI 40.82%PRS 13.98
-
CSI 26.11rCSI 62.08%PRS 18.64
-
CSI 25.44rCSI 54.09%PRS 21.6
-
CSI 24.2rCSI 69.1%PRS 21.44
-
CSI 23.82rCSI 31.67%PRS 13.53
-
CSI 23.05rCSI 30.81%PRS 23.62
-
CSI 23.04rCSI 41.08%PRS 20.95
-
CSI 22.16rCSI 23.22%PRS 13.19
-
CSI 20.91rCSI 32.13%PRS 17.64
-
CSI 20.65rCSI 19.52%PRS 12.94
-
CSI 20.36rCSI 14.16%PRS 14.51
-
CSI 20.12rCSI 64.55%PRS 18.15
-
CSI 19.25rCSI 50.67%PRS 24.2
-
CSI 19.18rCSI 27.65%PRS 19.94
-
CSI 17.49rCSI 59.12%PRS 20.82
-
CSI 17.47rCSI 61.28%PRS 22.45
-
CSI 17.32rCSI 50.15%PRS 14.02
-
CSI 16.99rCSI 15.67%PRS 12.57
-
CSI 16.54rCSI 31.22%PRS 15.35
-
CSI 16.35rCSI 20.97%PRS 14.3
-
CSI 16.1rCSI 13.44%PRS 36.17
-
CSI 16.01rCSI 32.86%PRS 29.03
-
CSI 15.87rCSI 69.68%PRS 23.03
-
CSI 15.21rCSI 36.59%PRS 19.58
-
CSI 14.93rCSI 77.11%PRS 24.37
-
CSI 14.78rCSI 39.83%PRS 15.94
-
CSI 13.98rCSI 14.59%PRS 12.69
-
CSI 13.83rCSI 17.75%PRS 12.04
-
CSI 13.14rCSI 27.97%PRS 19.94
-
CSI 12.99rCSI 11.38%PRS 16.43
-
CSI 12.39rCSI 36.59%PRS 15.14
-
CSI 12.35rCSI 12.59%PRS 17.7
-
CSI 12.34rCSI 19.89%PRS 19.8
-
CSI 12.17rCSI 21.79%PRS 11.52
-
CSI 12.11rCSI 55.05%PRS 42.84
-
CSI 11.67rCSI 33.75%PRS 27.49
-
CSI 11.63rCSI 8.09%PRS 17.59
-
CSI 11.6rCSI 31.86%PRS 20.42
-
CSI 11.18rCSI 60.34%PRS 23.16
-
CSI 11.14rCSI 14.19%PRS 14.39
-
CSI 10.97rCSI 14.99%PRS 13.73
-
CSI 10.48rCSI 60.06%PRS 19.14
-
CSI 10.43rCSI 55.68%PRS 44.61
-
CSI 10.43rCSI 16.01%PRS 14.46
-
CSI 10.29rCSI 30.68%PRS 30.67
-
CSI 9.98rCSI 65.47%PRS 31.99
-
CSI 9.91rCSI 18.91%PRS 29.15
-
CSI 9.75rCSI 37.94%PRS 20.31
-
CSI 9.66rCSI 14.99%PRS 18.84
-
CSI 9.3rCSI 18.54%PRS 20.54
-
CSI 9.28rCSI 26.02%PRS 19.12
-
CSI 9.07rCSI 52.77%PRS 18.62
-
CSI 8.97rCSI 8.86%PRS 46.47
-
CSI 8.89rCSI 13.56%PRS 11.55
-
CSI 8.87rCSI 25.92%PRS 39.73
-
CSI 8.86rCSI 10.25%PRS 9.07
-
CSI 8.84rCSI 13.5%PRS 15.65
-
CSI 8.83rCSI 43.53%PRS 16.85
-
CSI 8.81rCSI 12.04%PRS 14.06
-
CSI 8.73rCSI 6.13%PRS 32.03
-
CSI 8.64rCSI 64.86%PRS 22.74
-
CSI 8.53rCSI 12.23%PRS 16.97
-
CSI 8.49rCSI 11.76%PRS 17.82
-
CSI 8.44rCSI 8.74%PRS 14.54
-
CSI 8.29rCSI 15.81%PRS 19.79
-
CSI 8.11rCSI 5.66%PRS 12.99
-
CSI 7.99rCSI 10.05%PRS 52.65
-
CSI 7.76rCSI 13.71%PRS 7.22
-
CSI 7.69rCSI 11.25%PRS 13.09
-
CSI 7.29rCSI 5.52%PRS 17.13
-
CSI -7.9rCSI -9.2%PRS 18.3%
-
CSI -5.7rCSI -18.4%PRS 15.2%
-
CSI -5.2rCSI -8.6%PRS 14.4%
-
CSI -2.7rCSI -7.9%PRS 18.3%
-
CSI -2.0rCSI -14.8%PRS 6.3%
-
CSI -1.1rCSI -1.3%PRS 18.9%
-
CSI -1.0rCSI -1.5%PRS 14.2%
-
CSI -0.9rCSI -1.5%PRS 9.5%
-
CSI -0.3rCSI -0.4%PRS 21.5%
-
CSI -0.3rCSI -1.1%PRS 12.6%
-
CSI -0.2rCSI -1.4%PRS 64.5%
-
CSI 0.0rCSI 0.1%PRS 19.9%
-
CSI 0.1rCSI 0.6%PRS 12.8%
-
CSI 0.1rCSI 0.9%PRS 36.3%
-
CSI 0.1rCSI 0.6%PRS 30.6%
-
CSI 0.2rCSI 3.7%PRS 74.1%
-
CSI 0.2rCSI 1.2%PRS 18.1%
-
CSI 0.3rCSI 0.7%PRS 14.8%
-
CSI 0.3rCSI 1.0%PRS 7.8%
-
CSI 0.4rCSI 0.5%PRS 17.3%
-
CSI 0.4rCSI 7.1%PRS 38.8%
-
CSI 0.4rCSI 0.9%PRS 36.0%
-
CSI 0.4rCSI 0.8%PRS 8.9%
-
CSI 0.4rCSI 6.1%PRS 38.5%
-
CSI 0.4rCSI 1.3%PRS 9.6%
-
CSI 0.4rCSI 1.3%PRS 18.0%
-
CSI 0.5rCSI 10.7%PRS 22.1%
-
CSI 0.5rCSI 2.2%PRS 54.8%
-
CSI 0.5rCSI 1.3%PRS 15.4%
-
CSI 0.5rCSI 8.6%PRS 58.3%
-
CSI 0.6rCSI 1.2%PRS 25.0%
-
CSI 0.6rCSI 3.4%PRS 34.0%
-
CSI 0.6rCSI 2.1%PRS 7.4%
-
CSI 0.6rCSI 14.7%PRS 54.6%
-
CSI 0.6rCSI 0.7%PRS 17.3%
-
CSI 0.6rCSI 0.9%PRS 18.2%
-
CSI 0.7rCSI 1.7%PRS 11.5%
-
CSI 0.7rCSI 1.5%PRS 13.7%
-
CSI 0.7rCSI 6.3%PRS 36.4%
-
CSI 0.7rCSI 4.5%PRS 18.8%
-
CSI 0.7rCSI 3.2%PRS 12.2%
-
CSI 0.7rCSI 0.8%PRS 11.4%
-
CSI 0.8rCSI 2.0%PRS 48.9%
-
CSI 0.8rCSI 14.4%PRS 70.2%
-
CSI 0.8rCSI 9.0%PRS 46.3%
-
CSI 0.8rCSI 7.2%PRS 72.9%
-
CSI 0.8rCSI 18.8%PRS 70.0%
-
CSI 0.8rCSI 1.1%PRS 18.9%
-
CSI 0.8rCSI 2.3%PRS 15.0%
-
CSI 0.8rCSI 2.6%PRS 8.4%
-
CSI 0.9rCSI 1.0%PRS 16.5%
-
CSI 0.9rCSI 0.9%PRS 25.6%
-
CSI 0.9rCSI 4.0%PRS 12.1%
-
CSI 1.0rCSI 2.5%PRS 9.5%
-
CSI 1.0rCSI 1.0%PRS 19.5%
-
CSI 1.1rCSI 11.4%PRS 81.1%
-
CSI 1.1rCSI 5.8%PRS 22.3%
-
CSI 1.1rCSI 2.6%PRS 18.6%
-
CSI 1.1rCSI 3.8%PRS 47.7%
-
CSI 1.1rCSI 2.0%PRS 9.4%
-
CSI 1.2rCSI 1.6%PRS 20.2%
-
CSI 1.2rCSI 1.3%PRS 14.2%
-
CSI 1.2rCSI 2.9%PRS 60.8%
-
CSI 1.2rCSI 5.2%PRS 31.8%
-
CSI 1.3rCSI 27.0%PRS 59.8%
-
CSI 1.3rCSI 1.8%PRS 16.4%
-
CSI 1.3rCSI 3.0%PRS 11.9%
-
CSI 1.4rCSI 4.9%PRS 6.7%
-
CSI 1.4rCSI 2.1%PRS 12.2%
-
CSI 1.4rCSI 2.5%PRS 16.3%
-
CSI 1.4rCSI 2.7%PRS 8.9%
-
CSI 1.4rCSI 5.6%PRS 25.4%
-
CSI 1.5rCSI 2.8%PRS 32.8%
-
CSI 1.5rCSI 2.4%PRS 10.6%
-
CSI 1.6rCSI 3.2%PRS 18.9%
-
CSI 1.6rCSI 1.2%PRS 20.8%
-
CSI 1.6rCSI 4.0%PRS 12.4%
-
CSI 1.6rCSI 7.3%PRS 48.4%
-
CSI 1.7rCSI 3.1%PRS 26.9%
-
CSI 1.7rCSI 2.4%PRS 11.5%
-
CSI 1.7rCSI 2.7%PRS 8.0%
-
CSI 1.7rCSI 3.4%PRS 13.1%
-
CSI 1.7rCSI 2.3%PRS 29.8%
-
CSI 1.8rCSI 3.7%PRS 25.1%
-
CSI 1.8rCSI 7.9%PRS 35.2%
-
CSI 1.8rCSI 7.0%PRS 17.4%
-
CSI 1.8rCSI 4.5%PRS 7.1%
-
CSI 1.9rCSI 3.3%PRS 24.8%
-
CSI 1.9rCSI 7.7%PRS 27.1%
-
CSI 2.0rCSI 4.6%PRS 18.9%
-
CSI 2.0rCSI 51.2%PRS 56.3%
-
CSI 2.0rCSI 7.0%PRS 45.9%
-
CSI 2.1rCSI 3.6%PRS 24.9%
-
CSI 2.2rCSI 33.5%PRS 30.5%
-
CSI 2.2rCSI 8.1%PRS 10.5%
-
CSI 2.3rCSI 3.9%PRS 7.3%
-
CSI 2.3rCSI 16.4%PRS 37.9%
-
CSI 2.3rCSI 2.8%PRS 7.1%
-
CSI 2.4rCSI 6.8%PRS 58.0%
-
CSI 2.4rCSI 14.9%PRS 48.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1367816488
Symbol: RUXF_HUMAN
Name: Small nuclear ribonucleoprotein F
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7744013
Title: snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions.
PubMed ID: 7744013
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11574479
Title: Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.
PubMed ID: 11574479
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 12975319
Title: Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.
PubMed ID: 12975319
DOI: 10.1101/gad.274403
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15146077
Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
PubMed ID: 15146077
DOI: 10.1261/rna.7320604
PubMed ID: 16314521
Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.
PubMed ID: 16314521
PubMed ID: 18984161
Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
PubMed ID: 18984161
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 19325628
Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
PubMed ID: 19325628
DOI: 10.1038/nature07851
PubMed ID: 21816274
Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.
PubMed ID: 21816274
PubMed ID: 21516107
Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
PubMed ID: 21516107
DOI: 10.1038/nature09956
PubMed ID: 23333303
Title: Structural basis of assembly chaperone-mediated snRNP formation.
PubMed ID: 23333303
PubMed ID: 25555158
Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
PubMed ID: 25555158
DOI: 10.7554/elife.04986
PubMed ID: 26912367
Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.
PubMed ID: 26912367
PubMed ID: 28502770
Title: An Atomic Structure of the Human Spliceosome.
PubMed ID: 28502770
PubMed ID: 28781166
Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
PubMed ID: 28781166
PubMed ID: 28076346
Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
PubMed ID: 28076346
DOI: 10.1038/nature21079
PubMed ID: 31799625
Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.
PubMed ID: 31799625
DOI: 10.1093/nar/gkz1135
PubMed ID: 32494006
Title: Molecular architecture of the human 17S U2 snRNP.
PubMed ID: 32494006
PubMed ID: 33509932
Title: Structure of the activated human minor spliceosome.
PubMed ID: 33509932
PubMed ID: 36797247
Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.
PubMed ID: 36797247
Sequence Information:
- Length: 86
- Mass: 9725
- Checksum: 416B88D575DAE58A
- Sequence:
MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE