Details for: SRI

Gene ID: 6717

Symbol: SRI

Ensembl ID: ENSG00000075142

Description: sorcin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 325.8216
    Cell Significance Index: -50.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 225.1192
    Cell Significance Index: -57.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 191.1408
    Cell Significance Index: -78.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 169.5970
    Cell Significance Index: -68.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 168.4944
    Cell Significance Index: -79.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 152.0456
    Cell Significance Index: -78.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 118.6846
    Cell Significance Index: -79.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 73.6010
    Cell Significance Index: -70.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.0370
    Cell Significance Index: -72.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.0935
    Cell Significance Index: -79.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4873
    Cell Significance Index: -50.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.1748
    Cell Significance Index: -43.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9821
    Cell Significance Index: 222.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.7644
    Cell Significance Index: 72.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.7508
    Cell Significance Index: 272.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7168
    Cell Significance Index: 334.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7166
    Cell Significance Index: 1483.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.6996
    Cell Significance Index: 24.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5842
    Cell Significance Index: 70.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.5082
    Cell Significance Index: 452.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1707
    Cell Significance Index: 63.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0665
    Cell Significance Index: 107.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0663
    Cell Significance Index: 283.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9936
    Cell Significance Index: 93.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9343
    Cell Significance Index: 44.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8984
    Cell Significance Index: 86.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7843
    Cell Significance Index: 228.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6251
    Cell Significance Index: 24.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4644
    Cell Significance Index: 15.9200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3259
    Cell Significance Index: 8.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2808
    Cell Significance Index: 26.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1475
    Cell Significance Index: 24.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0246
    Cell Significance Index: 205.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9236
    Cell Significance Index: 119.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9038
    Cell Significance Index: 106.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8686
    Cell Significance Index: 384.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7280
    Cell Significance Index: 8.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7237
    Cell Significance Index: 33.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6617
    Cell Significance Index: 46.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3527
    Cell Significance Index: 22.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3158
    Cell Significance Index: 53.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3132
    Cell Significance Index: 10.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2897
    Cell Significance Index: 55.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2436
    Cell Significance Index: 4.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2289
    Cell Significance Index: 82.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2074
    Cell Significance Index: 2.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1346
    Cell Significance Index: 4.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1054
    Cell Significance Index: 5.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0801
    Cell Significance Index: 60.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0624
    Cell Significance Index: 45.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0412
    Cell Significance Index: 1.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0242
    Cell Significance Index: 0.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0062
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0225
    Cell Significance Index: -1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0236
    Cell Significance Index: -44.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0351
    Cell Significance Index: -54.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0379
    Cell Significance Index: -69.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0410
    Cell Significance Index: -25.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0472
    Cell Significance Index: -4.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0527
    Cell Significance Index: -71.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0864
    Cell Significance Index: -54.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0886
    Cell Significance Index: -4.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0906
    Cell Significance Index: -51.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0910
    Cell Significance Index: -18.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0999
    Cell Significance Index: -69.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1023
    Cell Significance Index: -7.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1253
    Cell Significance Index: -3.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1467
    Cell Significance Index: -66.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1541
    Cell Significance Index: -32.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1800
    Cell Significance Index: -5.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1891
    Cell Significance Index: -22.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2268
    Cell Significance Index: -65.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2320
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2973
    Cell Significance Index: -34.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2988
    Cell Significance Index: -7.4700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4077
    Cell Significance Index: -3.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4452
    Cell Significance Index: -11.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4659
    Cell Significance Index: -67.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4978
    Cell Significance Index: -56.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5031
    Cell Significance Index: -14.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5259
    Cell Significance Index: -29.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5761
    Cell Significance Index: -45.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6563
    Cell Significance Index: -44.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7358
    Cell Significance Index: -13.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7507
    Cell Significance Index: -78.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8816
    Cell Significance Index: -67.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0397
    Cell Significance Index: -10.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0542
    Cell Significance Index: -66.4400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.2262
    Cell Significance Index: -7.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2716
    Cell Significance Index: -56.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2895
    Cell Significance Index: -79.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3217
    Cell Significance Index: -38.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3757
    Cell Significance Index: -23.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5319
    Cell Significance Index: -58.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.5543
    Cell Significance Index: -19.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5907
    Cell Significance Index: -58.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.6441
    Cell Significance Index: -83.0900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.7140
    Cell Significance Index: -10.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.7145
    Cell Significance Index: -44.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Calcium-binding protein**: Sorcin is a calcium-binding protein that regulates calcium homeostasis within cells. 2. **Muscle contraction and relaxation**: Sorcin plays a crucial role in regulating muscle contraction and relaxation by modulating the activity of calcium channels and the release of calcium ions from the sarcoplasmic reticulum. 3. **Sarcoplasmic reticulum**: Sorcin is specifically expressed in the sarcoplasmic reticulum, a type of smooth endoplasmic reticulum found in muscle cells. 4. **Regulation of calcium ion transport**: Sorcin regulates the transport of calcium ions across cellular membranes, affecting various cellular processes. 5. **Regulation of cardiac muscle contraction**: Sorcin is significantly expressed in the heart and plays a crucial role in regulating cardiac muscle contraction and relaxation. **Pathways and Functions** 1. **Calcium signaling pathway**: Sorcin is involved in regulating calcium signaling pathways, including the release of calcium ions from the sarcoplasmic reticulum and the activity of calcium channels. 2. **Muscle contraction and relaxation pathway**: Sorcin regulates muscle contraction and relaxation by modulating the activity of calcium channels and the release of calcium ions from the sarcoplasmic reticulum. 3. **Cardiac conduction pathway**: Sorcin is involved in regulating cardiac conduction by modulating the activity of calcium channels and the release of calcium ions from the sarcoplasmic reticulum. 4. **Ion homeostasis pathway**: Sorcin regulates ion homeostasis by modulating the transport of calcium ions across cellular membranes. 5. **Cell communication pathway**: Sorcin regulates cell communication by electrical coupling, which is essential for maintaining proper muscle function and cardiac conduction. **Clinical Significance** 1. **Cardiac arrhythmias**: Alterations in sorcin expression or function may contribute to cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. 2. **Muscle disorders**: Sorcin dysfunction has been implicated in various muscle disorders, including muscular dystrophy and hypertrophic cardiomyopathy. 3. **Cancer**: Sorcin expression has been altered in certain types of cancer, including prostate cancer and breast cancer. 4. **Neurological disorders**: Sorcin has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease. 5. **Infectious diseases**: Sorcin has been shown to play a role in regulating the immune response to infections, such as tuberculosis and malaria. In conclusion, sorcin is a crucial protein involved in regulating calcium homeostasis within cells, particularly in muscle contraction and relaxation. Its dysregulation has been implicated in various diseases, including cardiac arrhythmias, muscle disorders, cancer, neurological disorders, and infectious diseases. Further research is needed to fully understand the role of sorcin in human health and disease.

Genular Protein ID: 2264970851

Symbol: SORCN_HUMAN

Name: Sorcin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7873602

Title: Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells.

PubMed ID: 7873602

DOI: 10.1016/0167-4781(94)00206-i

PubMed ID: 8561500

Title: Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines.

PubMed ID: 8561500

DOI: 10.1006/abbi.1996.0027

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16341674

Title: Transcriptome analysis of human gastric cancer.

PubMed ID: 16341674

DOI: 10.1007/s00335-005-0075-2

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 12804766

Title: The PEF family proteins sorcin and grancalcin interact in vivo and in vitro.

PubMed ID: 12804766

DOI: 10.1016/s0014-5793(03)00518-0

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11714909

Title: Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family.

PubMed ID: 11714909

DOI: 10.1110/ps.36701

PubMed ID: 17699613

Title: Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor.

PubMed ID: 17699613

DOI: 10.1096/fj.07-8988com

Sequence Information:

  • Length: 198
  • Mass: 21676
  • Checksum: A4829C7650A5E3FA
  • Sequence:
  • MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID ADELQRCLTQ 
    SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA VLNGWRQHFI SFDTDRSGTV 
    DPQELQKALT TMGFRLSPQA VNSIAKRYST NGKITFDDYI ACCVKLRALT DSFRRRDTAQ 
    QGVVNFPYDD FIQCVMSV

Genular Protein ID: 2738445498

Symbol: B4DHQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 158
  • Mass: 17145
  • Checksum: 76EF6548F0B6C53E
  • Sequence:
  • MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID ADELQRCLTQ 
    SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA VNSIAKRYST NGKITFDDYI 
    ACCVKLRALT DSFRRRDTAQ QGVVNFPYDD FIQCVMSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.