Details for: SRP19

Gene ID: 6728

Symbol: SRP19

Ensembl ID: ENSG00000153037

Description: signal recognition particle 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 311.7421
    Cell Significance Index: -48.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.1559
    Cell Significance Index: -49.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 146.4507
    Cell Significance Index: -60.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.9585
    Cell Significance Index: -59.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.7415
    Cell Significance Index: -55.9400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.3264
    Cell Significance Index: -59.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.3544
    Cell Significance Index: -55.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.9769
    Cell Significance Index: -42.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.7692
    Cell Significance Index: -58.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.2804
    Cell Significance Index: -40.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9720
    Cell Significance Index: 118.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.4242
    Cell Significance Index: 21.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4220
    Cell Significance Index: 105.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2646
    Cell Significance Index: 36.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2085
    Cell Significance Index: 148.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1495
    Cell Significance Index: 54.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1466
    Cell Significance Index: 1035.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1211
    Cell Significance Index: 202.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1100
    Cell Significance Index: 222.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0087
    Cell Significance Index: 65.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9714
    Cell Significance Index: 68.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9588
    Cell Significance Index: 423.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9336
    Cell Significance Index: 645.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9144
    Cell Significance Index: 24.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9108
    Cell Significance Index: 24.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8982
    Cell Significance Index: 62.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8946
    Cell Significance Index: 105.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8793
    Cell Significance Index: 113.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8383
    Cell Significance Index: 457.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8359
    Cell Significance Index: 64.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8076
    Cell Significance Index: 110.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8043
    Cell Significance Index: 17.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7243
    Cell Significance Index: 33.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6767
    Cell Significance Index: 134.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5219
    Cell Significance Index: 7.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4701
    Cell Significance Index: 23.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4328
    Cell Significance Index: 155.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4270
    Cell Significance Index: 81.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4235
    Cell Significance Index: 54.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4062
    Cell Significance Index: 9.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3557
    Cell Significance Index: 60.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2758
    Cell Significance Index: 17.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2416
    Cell Significance Index: 6.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2062
    Cell Significance Index: 10.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1867
    Cell Significance Index: 53.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1526
    Cell Significance Index: 1.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0935
    Cell Significance Index: 9.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0726
    Cell Significance Index: 4.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0449
    Cell Significance Index: 7.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0196
    Cell Significance Index: 14.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0085
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0139
    Cell Significance Index: -25.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0197
    Cell Significance Index: -30.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0205
    Cell Significance Index: -15.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0317
    Cell Significance Index: -43.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0422
    Cell Significance Index: -26.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0455
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0566
    Cell Significance Index: -35.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0600
    Cell Significance Index: -33.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1005
    Cell Significance Index: -45.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1256
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1287
    Cell Significance Index: -27.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1336
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1398
    Cell Significance Index: -16.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1583
    Cell Significance Index: -16.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1787
    Cell Significance Index: -2.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1829
    Cell Significance Index: -4.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1970
    Cell Significance Index: -22.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2456
    Cell Significance Index: -4.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2592
    Cell Significance Index: -5.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2640
    Cell Significance Index: -4.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2948
    Cell Significance Index: -19.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3113
    Cell Significance Index: -35.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3145
    Cell Significance Index: -45.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4206
    Cell Significance Index: -6.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4535
    Cell Significance Index: -2.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4836
    Cell Significance Index: -21.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5042
    Cell Significance Index: -12.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5483
    Cell Significance Index: -57.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5914
    Cell Significance Index: -46.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5988
    Cell Significance Index: -27.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6029
    Cell Significance Index: -22.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6088
    Cell Significance Index: -12.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6491
    Cell Significance Index: -34.0800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8100
    Cell Significance Index: -4.9900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.8151
    Cell Significance Index: -11.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9546
    Cell Significance Index: -58.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9639
    Cell Significance Index: -28.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9663
    Cell Significance Index: -30.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9810
    Cell Significance Index: -17.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.0013
    Cell Significance Index: -10.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0247
    Cell Significance Index: -27.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0565
    Cell Significance Index: -43.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1892
    Cell Significance Index: -31.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2698
    Cell Significance Index: -32.6400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.2870
    Cell Significance Index: -9.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2999
    Cell Significance Index: -42.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3087
    Cell Significance Index: -48.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SRP19 is a small, highly conserved protein (19 kDa) that is structurally related to other SRP components, such as SRP54 and SRP72. It is widely expressed in various cell types, including myoepithelial cells of the mammary gland, myeloid dendritic cells, fibroblasts, and progenitor cells of the mammary luminal epithelium. SRP19 exhibits a high degree of sequence similarity across species, suggesting its conserved role in protein targeting and translation. **Pathways and Functions:** SRP19 plays a central role in the SRP-mediated targeting of proteins to the ER. The SRP complex, consisting of SRP19, SRP54, and SRP72, recognizes and binds to signal sequences on nascent polypeptide chains, facilitating their translocation to the ER. This process is mediated by the interaction between SRP19 and SRP RNA, which enables the recognition of signal sequences and the recruitment of other SRP components. SRP19 also interacts with ribosomes, facilitating the cotranslational translocation of proteins to the ER. In addition to its role in protein targeting, SRP19 has been implicated in various cellular processes, including: 1. **Metabolism of proteins:** SRP19 is involved in the regulation of protein synthesis and degradation, influencing cellular metabolism and homeostasis. 2. **Cell signaling:** SRP19 interacts with signaling molecules, modulating cellular responses to external stimuli. 3. **Immune regulation:** SRP19 is expressed in immune cells, such as myeloid dendritic cells, and plays a role in the regulation of immune responses. **Clinical Significance:** SRP19 has been implicated in various diseases, including: 1. **Cancer:** Alterations in SRP19 expression have been observed in various cancers, including breast, prostate, and pancreatic cancers. 2. **Immunodeficiency:** SRP19 is expressed in immune cells, and its dysregulation has been linked to immunodeficiency diseases. 3. **Neurological disorders:** SRP19 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. In conclusion, SRP19 is a critical component of the SRP complex, playing a central role in protein targeting and translation. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the molecular mechanisms and clinical implications of SRP19.

Genular Protein ID: 1551475986

Symbol: SRP19_HUMAN

Name: Signal recognition particle 19 kDa protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2460823

Title: Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA.

PubMed ID: 2460823

DOI: 10.1093/nar/16.20.9431

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10618370

Title: Signal recognition particle components in the nucleolus.

PubMed ID: 10618370

DOI: 10.1073/pnas.97.1.55

PubMed ID: 11682607

Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

PubMed ID: 11682607

DOI: 10.1242/jcs.114.19.3479

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11641499

Title: Crystal structure of an early protein-RNA assembly complex of the signal recognition particle.

PubMed ID: 11641499

DOI: 10.1126/science.1063839

PubMed ID: 12244299

Title: Induced structural changes of 7SL RNA during the assembly of human signal recognition particle.

PubMed ID: 12244299

DOI: 10.1038/nsb843

PubMed ID: 20179341

Title: Structural insights into the assembly of the human and archaeal signal recognition particles.

PubMed ID: 20179341

DOI: 10.1107/s0907444910000879

PubMed ID: 24700861

Title: SRP RNA remodeling by SRP68 explains its role in protein translocation.

PubMed ID: 24700861

DOI: 10.1126/science.1249094

PubMed ID: 27899666

Title: Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.

PubMed ID: 27899666

DOI: 10.1093/nar/gkw1124

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

Sequence Information:

  • Length: 144
  • Mass: 16156
  • Checksum: E25F661972338CAE
  • Sequence:
  • MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCSAVGLNV 
    FLEKNKMYSR EWNRDVQYRG RVRVQLKQED GSLCLVQFPS RKSVMLYAAE MIPKLKTRTQ 
    KTGGADQSLQ QGEGSKKGKG KKKK

Genular Protein ID: 775608113

Symbol: A0A087WYR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 120
  • Mass: 13654
  • Checksum: 6310F177AF89DE3F
  • Sequence:
  • MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKK NKMYSREWNR DVQYRGRVRV 
    QLKQEDGSLC LVQFPSRKSV MLYAAEMIPK LKTRTQKTGG ADQSLQQGEG SKKGKGKKKK

Genular Protein ID: 889339582

Symbol: A0A2U3TZN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 101
  • Mass: 11509
  • Checksum: CE8D28266E89AACC
  • Sequence:
  • MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCSAVGLNV 
    FLEKNKMYSR EWNRDVQYRG RVRVQLKQED GSLCLVQFPS R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.