Details for: SRP72

Gene ID: 6731

Symbol: SRP72

Ensembl ID: ENSG00000174780

Description: signal recognition particle 72

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 316.1781
    Cell Significance Index: -49.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 163.6550
    Cell Significance Index: -41.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.7428
    Cell Significance Index: -66.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 134.2500
    Cell Significance Index: -54.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 133.7549
    Cell Significance Index: -55.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 122.9040
    Cell Significance Index: -63.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 100.0116
    Cell Significance Index: -67.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.5862
    Cell Significance Index: -54.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.7690
    Cell Significance Index: -60.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9227
    Cell Significance Index: -53.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8538
    Cell Significance Index: -62.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.1143
    Cell Significance Index: -40.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.8046
    Cell Significance Index: 676.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.3784
    Cell Significance Index: 117.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9190
    Cell Significance Index: 208.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8214
    Cell Significance Index: 117.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6402
    Cell Significance Index: 225.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4299
    Cell Significance Index: 38.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3325
    Cell Significance Index: 216.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2922
    Cell Significance Index: 17.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0554
    Cell Significance Index: 211.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0166
    Cell Significance Index: 47.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0115
    Cell Significance Index: 71.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9941
    Cell Significance Index: 46.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9789
    Cell Significance Index: 432.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9365
    Cell Significance Index: 511.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9010
    Cell Significance Index: 18.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8829
    Cell Significance Index: 159.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8578
    Cell Significance Index: 170.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8504
    Cell Significance Index: 63.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8350
    Cell Significance Index: 107.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8242
    Cell Significance Index: 28.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8200
    Cell Significance Index: 22.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8179
    Cell Significance Index: 100.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7060
    Cell Significance Index: 90.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6738
    Cell Significance Index: 241.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6694
    Cell Significance Index: 78.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6365
    Cell Significance Index: 6.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5959
    Cell Significance Index: 101.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5727
    Cell Significance Index: 15.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3739
    Cell Significance Index: 25.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3136
    Cell Significance Index: 8.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2756
    Cell Significance Index: 7.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2616
    Cell Significance Index: 180.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2564
    Cell Significance Index: 7.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2324
    Cell Significance Index: 209.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2008
    Cell Significance Index: 10.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1731
    Cell Significance Index: 3.7500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1238
    Cell Significance Index: 1.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1171
    Cell Significance Index: 6.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1118
    Cell Significance Index: 21.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0976
    Cell Significance Index: 6.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0216
    Cell Significance Index: 16.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0143
    Cell Significance Index: 26.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0185
    Cell Significance Index: -11.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0235
    Cell Significance Index: -36.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0250
    Cell Significance Index: -46.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0360
    Cell Significance Index: -2.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0457
    Cell Significance Index: -62.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0472
    Cell Significance Index: -0.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0483
    Cell Significance Index: -4.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0632
    Cell Significance Index: -35.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0707
    Cell Significance Index: -3.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0712
    Cell Significance Index: -1.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0761
    Cell Significance Index: -34.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0845
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1361
    Cell Significance Index: -28.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1535
    Cell Significance Index: -15.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1756
    Cell Significance Index: -50.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1887
    Cell Significance Index: -1.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2089
    Cell Significance Index: -6.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2364
    Cell Significance Index: -4.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2407
    Cell Significance Index: -34.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2578
    Cell Significance Index: -19.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2635
    Cell Significance Index: -16.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2956
    Cell Significance Index: -33.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3053
    Cell Significance Index: -34.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3128
    Cell Significance Index: -7.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3610
    Cell Significance Index: -8.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4127
    Cell Significance Index: -3.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4912
    Cell Significance Index: -33.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5766
    Cell Significance Index: -6.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5781
    Cell Significance Index: -60.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6129
    Cell Significance Index: -10.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6220
    Cell Significance Index: -49.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6617
    Cell Significance Index: -11.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7121
    Cell Significance Index: -31.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7443
    Cell Significance Index: -19.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7602
    Cell Significance Index: -19.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8067
    Cell Significance Index: -15.7500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.8071
    Cell Significance Index: -5.0200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8351
    Cell Significance Index: -10.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8640
    Cell Significance Index: -18.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8820
    Cell Significance Index: -33.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8970
    Cell Significance Index: -55.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9434
    Cell Significance Index: -33.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3077
    Cell Significance Index: -19.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRP72 is a relatively small protein, with an estimated molecular weight of approximately 72 kDa. It is a component of the SRP complex, which is composed of several subunits, including SRP54, SRP68, and SRP9. SRP72 is highly conserved across species, suggesting its importance in maintaining cellular function. Its expression is widespread, with significant levels detected in various cell types, including hematopoietic cells, epithelial cells, and fibroblasts. **Pathways and Functions** The SRP72 gene is involved in several key pathways, including: 1. **Cytosol-to-ER targeting**: SRP72 plays a critical role in the recognition and binding of ribosomes to the ER membrane, facilitating the cotranslational targeting of proteins to the ER. 2. **Protein folding**: SRP72 is essential for the proper folding of proteins in the ER, ensuring that proteins are correctly folded and secreted or retained in the ER. 3. **Signal recognition particle binding**: SRP72 binds to the signal recognition particle, which recognizes and binds to the ER membrane, facilitating the targeting of proteins to the ER. 4. **Metabolism of proteins**: SRP72 is involved in the regulation of protein metabolism, including protein synthesis, folding, and secretion. **Clinical Significance** Dysregulation of the SRP72 gene has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the SRP72 gene have been associated with immunodeficiency disorders, such as primary immunodeficiency diseases. 2. **Cancer**: Overexpression of SRP72 has been observed in various types of cancer, including breast cancer and lymphoma. 3. **Infectious diseases**: SRP72 has been shown to play a role in the regulation of immune responses to infectious diseases, such as HIV and influenza. 4. **Neurological disorders**: SRP72 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the SRP72 gene is a critical component of the signal recognition particle complex, playing a vital role in the targeting of proteins to the endoplasmic reticulum for proper folding and secretion. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular function and overall health.

Genular Protein ID: 192110314

Symbol: SRP72_HUMAN

Name: Signal recognition particle subunit SRP72

UniProtKB Accession Codes:

O76094 G5E9Z8 Q7Z3C0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 16672232

Title: Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.

PubMed ID: 16672232

DOI: 10.1110/ps.051861406

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21073748

Title: Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA.

PubMed ID: 21073748

DOI: 10.1186/1471-2199-11-83

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28369529

Title: Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.

PubMed ID: 28369529

DOI: 10.1093/jmcb/mjx010

PubMed ID: 27899666

Title: Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.

PubMed ID: 27899666

DOI: 10.1093/nar/gkw1124

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

PubMed ID: 22541560

Title: Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia.

PubMed ID: 22541560

DOI: 10.1016/j.ajhg.2012.03.020

Sequence Information:

  • Length: 671
  • Mass: 74606
  • Checksum: CC0BA17AC52E3613
  • Sequence:
    • MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKDDVTALHC KVVCLIQNGS 
FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT IESANQQTDK LKELYGQVLY 
RLERYDECLA VYRDLVRNSQ DDYDEERKTN LSAVVAAQSN WEKVVPENLG LQEGTHELCY 
NTACALIGQG QLNQAMKILQ KAEDLCRRSL SEDTDGTEED PQAELAIIHG QMAYILQLQG 
RTEEALQLYN QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK 
KQLQAIEFNK ALLAMYTNQA EQCRKISASL QSQSPEHLLP VLIQAAQLCR EKQHTKAIEL 
LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE ELKHKPGMVS ALVTMYSHEE 
DIDSAIEVFT QAIQWYQNHQ PKSPAHLSLI REAANFKLKY GRKKEAISDL QQLWKQNPKD 
IHTLAQLISA YSLVDPEKAK ALSKHLPSSD SMSLKVDVEA LENSAGATYI RKKGGKVTGD 
SQPKEQGQGD LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK 
GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA GAPATKKKQQ 
QKKKKGGKGG W

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.