Details for: SSR3

Gene ID: 6747

Symbol: SSR3

Ensembl ID: ENSG00000114850

Description: signal sequence receptor subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 358.4809
    Cell Significance Index: -55.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.3206
    Cell Significance Index: -50.8100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 177.8381
    Cell Significance Index: -73.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 150.0035
    Cell Significance Index: -60.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.7428
    Cell Significance Index: -66.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 129.2805
    Cell Significance Index: -66.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 99.6912
    Cell Significance Index: -66.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.3210
    Cell Significance Index: -61.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.3076
    Cell Significance Index: -63.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.6095
    Cell Significance Index: -55.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.5427
    Cell Significance Index: -50.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.4038
    Cell Significance Index: -64.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.5317
    Cell Significance Index: 127.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.9741
    Cell Significance Index: 185.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.2371
    Cell Significance Index: 86.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0471
    Cell Significance Index: 82.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.9339
    Cell Significance Index: 477.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7625
    Cell Significance Index: 379.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5507
    Cell Significance Index: 119.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3900
    Cell Significance Index: 68.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.2987
    Cell Significance Index: 67.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.1076
    Cell Significance Index: 359.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1019
    Cell Significance Index: 1147.8800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8666
    Cell Significance Index: 23.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8412
    Cell Significance Index: 38.5400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.5515
    Cell Significance Index: 9.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5186
    Cell Significance Index: 273.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4896
    Cell Significance Index: 192.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4573
    Cell Significance Index: 179.1900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.4279
    Cell Significance Index: 29.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4204
    Cell Significance Index: 105.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4090
    Cell Significance Index: 12.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3970
    Cell Significance Index: 98.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2466
    Cell Significance Index: 32.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1930
    Cell Significance Index: 129.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1741
    Cell Significance Index: 519.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1029
    Cell Significance Index: 995.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0805
    Cell Significance Index: 138.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0459
    Cell Significance Index: 54.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9498
    Cell Significance Index: 188.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8460
    Cell Significance Index: 50.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8428
    Cell Significance Index: 58.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7764
    Cell Significance Index: 14.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7505
    Cell Significance Index: 20.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7055
    Cell Significance Index: 7.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5285
    Cell Significance Index: 7.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4963
    Cell Significance Index: 58.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4452
    Cell Significance Index: 15.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4284
    Cell Significance Index: 85.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3918
    Cell Significance Index: 296.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3882
    Cell Significance Index: 4.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3139
    Cell Significance Index: 112.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2251
    Cell Significance Index: 14.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2096
    Cell Significance Index: 39.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1962
    Cell Significance Index: 5.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1310
    Cell Significance Index: 12.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1238
    Cell Significance Index: 5.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1079
    Cell Significance Index: 79.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0606
    Cell Significance Index: 1.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0593
    Cell Significance Index: 111.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0233
    Cell Significance Index: 0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0037
    Cell Significance Index: 0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0219
    Cell Significance Index: -13.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0317
    Cell Significance Index: -58.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0344
    Cell Significance Index: -21.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0352
    Cell Significance Index: -54.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0426
    Cell Significance Index: -0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0469
    Cell Significance Index: -63.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0797
    Cell Significance Index: -44.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0845
    Cell Significance Index: -38.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0963
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1240
    Cell Significance Index: -26.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1434
    Cell Significance Index: -16.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1762
    Cell Significance Index: -50.7000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1797
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2386
    Cell Significance Index: -27.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2920
    Cell Significance Index: -42.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3038
    Cell Significance Index: -19.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3065
    Cell Significance Index: -16.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3752
    Cell Significance Index: -43.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4391
    Cell Significance Index: -22.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4689
    Cell Significance Index: -11.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4731
    Cell Significance Index: -26.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4780
    Cell Significance Index: -15.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5175
    Cell Significance Index: -31.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5645
    Cell Significance Index: -14.1100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.5653
    Cell Significance Index: -2.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5804
    Cell Significance Index: -16.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6055
    Cell Significance Index: -63.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6325
    Cell Significance Index: -3.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6472
    Cell Significance Index: -51.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7659
    Cell Significance Index: -51.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7701
    Cell Significance Index: -11.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7844
    Cell Significance Index: -39.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9510
    Cell Significance Index: -18.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0597
    Cell Significance Index: -10.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0827
    Cell Significance Index: -66.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0885
    Cell Significance Index: -16.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Function:** SSR3 is localized to the endoplasmic reticulum membrane and is involved in the targeting of proteins to this compartment. 2. **Expression Pattern:** SSR3 is significantly expressed in cells of the immune system, including IgA plasma cells, IgG plasmablasts, and fibroblasts of the mammary gland. 3. **Protein Interactions:** SSR3 interacts with other proteins, such as Translocon-associated protein subunit gamma (SSRG_HUMAN), to facilitate protein targeting to the ER membrane. 4. **Cellular Context:** SSR3 is expressed in various cell types, including acinar cells of the salivary gland, myoepithelial cells of the mammary gland, and pneumocytes of the lung. **Pathways and Functions:** 1. **Srp-dependent Cotranslational Protein Targeting to Membrane:** SSR3 is involved in the cotranslational targeting of proteins to the ER membrane, mediated by the SRP (Signal Recognition Particle) complex. 2. **Metabolism of Proteins:** SSR3 contributes to the proper folding and secretion of proteins, ensuring their correct targeting to the ER membrane. 3. **Protein Binding:** SSR3 interacts with other proteins to facilitate protein targeting and secretion. 4. **Translation:** SSR3 is involved in the translation process, ensuring the accurate translation of mRNAs into proteins. **Clinical Significance:** 1. **Immune System Regulation:** SSR3 plays a crucial role in regulating immune responses, particularly in the context of immune cell function and differentiation. 2. **Disease Association:** Alterations in SSR3 expression or function may contribute to the development of immune-related diseases, such as autoimmune disorders or immunodeficiency conditions. 3. **Cancer Association:** SSR3 expression has been linked to various types of cancer, including breast cancer, highlighting its potential as a prognostic biomarker. 4. **Therapeutic Targeting:** Understanding the mechanisms of SSR3 may provide novel therapeutic targets for the treatment of immune-related disorders and cancer. In conclusion, SSR3 is a critical gene that plays a pivotal role in protein targeting and immune function. Its expression in immune cells and tissues highlights its significance in regulating immune responses and its potential as a biomarker for disease. Further research is needed to fully elucidate the functions and clinical significance of SSR3, but its importance in the immune system is undeniable.

Genular Protein ID: 3431163339

Symbol: SSRG_HUMAN

Name: Translocon-associated protein subunit gamma

UniProtKB Accession Codes:

Q9UNL2 B2R7D0 B4E2P2 D3DNK5 Q549M4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 185
  • Mass: 21080
  • Checksum: DEE0B14BF524F62A
  • Sequence:
    • MAPKGSSKQQ SEEDLLLQDF SRNLSAKSSA LFFGNAFIVS AIPIWLYWRI WHMDLIQSAV 
LYSVMTLVST YLVAFAYKNV KFVLKHKVAQ KREDAVSKEV TRKLSEADNR KMSRKEKDER 
ILWKKNEVAD YEATTFSIFY NNTLFLVVVI VASFFILKNF NPTVNYILSI SASSGLIALL 
STGSK

Genular Protein ID: 3084284176

Symbol: C9J365_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J365

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 133
  • Mass: 15113
  • Checksum: B053A7EEF645D1A4
  • Sequence:
    • MDLIQSAVLY SVMTLVSTYL VAFAYKNVKF VLKHKVAQKR EDAVSKEVTR KLSEADNRKM 
SRKEKDERIL WKKNEVADYE ATTFSIFYNN TLFLVVVIVA SFFILKNFNP TVNYILSISA 
SSGLIALLST GSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.