Details for: SSRP1
Gene ID: 6749
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SSRP1
Ensembl ID: ENSG00000149136
Description: structure specific recognition protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 36.8rCSI 36.73%PRS 48.67
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CSI 34.23rCSI 30.91%PRS 51.87
-
CSI 32.91rCSI 26.61%PRS 56.28
-
CSI 22.12rCSI 27.76%PRS 65.48
-
CSI 20.11rCSI 17.41%PRS 59.75
-
CSI 19.34rCSI 22.14%PRS 75.79
-
CSI 17.96rCSI 51.26%PRS 68.3
-
CSI 15.47rCSI 13.74%PRS 53.3
-
CSI 13.66rCSI 9.5%PRS 65.5
-
CSI 13.28rCSI 17.74%PRS 77.39
-
CSI 13.22rCSI 42.89%PRS 56.57
-
CSI 12.62rCSI 9.93%PRS 61.85
-
CSI 12.09rCSI 18.68%PRS 53.12
-
CSI 11.02rCSI 10.83%PRS 78.56
-
CSI 10.27rCSI 14.56%PRS 51.39
-
CSI 9.4rCSI 7.78%PRS 56.78
-
CSI 9.02rCSI 10.6%PRS 58.05
-
CSI 8.24rCSI 7.93%PRS 55.45
-
CSI 7.82rCSI 11.79%PRS 58.24
-
CSI 7.72rCSI 10.54%PRS 57.24
-
CSI 7.51rCSI 17.04%PRS 60.1
-
CSI 7.42rCSI 32.99%PRS 54.19
-
CSI 7.26rCSI 16.22%PRS 62.57
-
CSI 7.13rCSI 14.73%PRS 58.13
-
CSI 7.09rCSI 38.27%PRS 68.81
-
CSI 6.2rCSI 4.31%PRS 69.57
-
CSI 6.07rCSI 8.43%PRS 54.02
-
CSI 5.96rCSI 6.88%PRS 48.7
-
CSI 5.85rCSI 8.44%PRS 64.87
-
CSI 5.73rCSI 5.02%PRS 65.38
-
CSI 5.6rCSI 29.9%PRS 87.62
-
CSI 5.49rCSI 5.07%PRS 75.11
-
CSI 5.44rCSI 18.38%PRS 61.11
-
CSI 5.34rCSI 3.83%PRS 69.11
-
CSI 5.29rCSI 3.52%PRS 58.57
-
CSI 5.28rCSI 5.38%PRS 68.58
-
CSI 5.14rCSI 4.86%PRS 54.94
-
CSI 5.07rCSI 26.17%PRS 77.67
-
CSI 4.94rCSI 21.72%PRS 46.67
-
CSI 4.83rCSI 20.96%PRS 69.27
-
CSI 4.74rCSI 3.74%PRS 42.11
-
CSI 4.72rCSI 4.55%PRS 45.54
-
CSI 4.71rCSI 30.9%PRS 83.12
-
CSI 4.68rCSI 6.48%PRS 57.58
-
CSI 4.67rCSI 13.47%PRS 70.27
-
CSI 4.46rCSI 3.74%PRS 59.85
-
CSI 4.22rCSI 16.42%PRS 75.68
-
CSI 4.18rCSI 5.58%PRS 55.93
-
CSI 4.12rCSI 3.13%PRS 67.72
-
CSI 4.11rCSI 4.23%PRS 72.71
-
CSI 3.95rCSI 11.65%PRS 58.53
-
CSI 3.91rCSI 3.24%PRS 53.97
-
CSI 3.74rCSI 3.23%PRS 61.64
-
CSI 3.69rCSI 5.67%PRS 52.98
-
CSI 3.63rCSI 4.94%PRS 67.34
-
CSI 3.62rCSI 4.95%PRS 60.68
-
CSI 3.59rCSI 3.31%PRS 56.19
-
CSI 3.48rCSI 4.97%PRS 57.62
-
CSI 3.44rCSI 3.59%PRS 55.51
-
CSI 3.41rCSI 3.17%PRS 55.01
-
CSI 3.4rCSI 2.86%PRS 72.93
-
CSI 3.37rCSI 4.11%PRS 62.92
-
CSI 3.35rCSI 11.75%PRS 68.73
-
CSI 3.3rCSI 5.88%PRS 69.52
-
CSI 3.24rCSI 11.72%PRS 74.96
-
CSI 3.16rCSI 5.12%PRS 52.37
-
CSI 3.14rCSI 4%PRS 61.44
-
CSI 3.13rCSI 15.72%PRS 67.59
-
CSI 3.11rCSI 3.6%PRS 63.84
-
CSI 3.07rCSI 2.44%PRS 77.22
-
CSI 3.06rCSI 8.78%PRS 74.47
-
CSI 2.92rCSI 2.56%PRS 60.27
-
CSI 2.92rCSI 2.26%PRS 56.33
-
CSI 2.91rCSI 7.39%PRS 49.83
-
CSI 2.9rCSI 2.85%PRS 70.92
-
CSI 2.89rCSI 3.47%PRS 53.3
-
CSI 2.88rCSI 4.21%PRS 58.97
-
CSI 2.78rCSI 4.91%PRS 36.65
-
CSI 2.74rCSI 1.84%PRS 67.51
-
CSI 2.71rCSI 3.48%PRS 52.56
-
CSI 2.69rCSI 5.39%PRS 44.26
-
CSI 2.69rCSI 1.59%PRS 72.01
-
CSI 2.67rCSI 4.16%PRS 80.37
-
CSI 2.59rCSI 7.28%PRS 52.76
-
CSI 2.56rCSI 2.25%PRS 43.35
-
CSI 2.52rCSI 2.64%PRS 53.62
-
CSI 2.52rCSI 4.36%PRS 45.21
-
CSI 2.51rCSI 4.79%PRS 70.9
-
CSI 2.48rCSI 5.89%PRS 65.38
-
CSI 2.47rCSI 3.67%PRS 57.15
-
CSI 2.4rCSI 6.94%PRS 56.87
-
CSI 2.37rCSI 15.28%PRS 74.56
-
CSI 2.37rCSI 1.76%PRS 68.94
-
CSI 2.36rCSI 3.61%PRS 69.88
-
CSI 2.35rCSI 1.76%PRS 72.77
-
CSI 2.34rCSI 2.51%PRS 53.8
-
CSI 2.33rCSI 2.44%PRS 51.86
-
CSI 2.28rCSI 24.95%PRS 69.14
-
CSI 2.27rCSI 2.81%PRS 51.07
-
CSI 2.27rCSI 2.97%PRS 68.6
-
CSI 0.6rCSI 2.6%PRS 69.0%
-
CSI 0.6rCSI 3.0%PRS 66.5%
-
CSI 0.6rCSI 2.0%PRS 39.1%
-
CSI 0.8rCSI 2.7%PRS 86.6%
-
CSI 0.8rCSI 2.5%PRS 61.2%
-
CSI 0.8rCSI 4.6%PRS 64.9%
-
CSI 0.8rCSI 4.5%PRS 81.3%
-
CSI 0.9rCSI 2.4%PRS 68.9%
-
CSI 0.9rCSI 1.9%PRS 67.8%
-
CSI 0.9rCSI 1.4%PRS 63.6%
-
CSI 1.0rCSI 0.8%PRS 65.8%
-
CSI 1.0rCSI 1.1%PRS 58.9%
-
CSI 1.0rCSI 4.6%PRS 84.8%
-
CSI 1.0rCSI 1.4%PRS 63.2%
-
CSI 1.1rCSI 2.5%PRS 71.2%
-
CSI 1.2rCSI 2.0%PRS 37.6%
-
CSI 1.2rCSI 1.9%PRS 45.0%
-
CSI 1.3rCSI 22.0%PRS 80.2%
-
CSI 1.4rCSI 2.2%PRS 47.5%
-
CSI 1.4rCSI 4.0%PRS 79.7%
-
CSI 1.4rCSI 1.5%PRS 71.4%
-
CSI 1.4rCSI 42.7%PRS 76.4%
-
CSI 1.5rCSI 2.0%PRS 80.6%
-
CSI 1.5rCSI 3.0%PRS 74.8%
-
CSI 1.5rCSI 3.3%PRS 52.2%
-
CSI 1.5rCSI 2.9%PRS 73.4%
-
CSI 1.5rCSI 1.2%PRS 54.8%
-
CSI 1.6rCSI 1.9%PRS 57.1%
-
CSI 1.6rCSI 2.8%PRS 48.1%
-
CSI 1.6rCSI 1.3%PRS 55.5%
-
CSI 1.6rCSI 2.0%PRS 38.8%
-
CSI 1.6rCSI 6.4%PRS 50.6%
-
CSI 1.6rCSI 4.0%PRS 63.6%
-
CSI 1.6rCSI 1.7%PRS 67.1%
-
CSI 1.6rCSI 2.0%PRS 35.9%
-
CSI 1.6rCSI 7.2%PRS 71.5%
-
CSI 1.7rCSI 3.6%PRS 58.9%
-
CSI 1.7rCSI 3.9%PRS 75.9%
-
CSI 1.7rCSI 1.3%PRS 59.8%
-
CSI 1.7rCSI 4.6%PRS 63.7%
-
CSI 1.8rCSI 4.4%PRS 53.1%
-
CSI 1.8rCSI 2.7%PRS 59.6%
-
CSI 1.8rCSI 1.9%PRS 60.7%
-
CSI 1.8rCSI 2.1%PRS 71.6%
-
CSI 1.9rCSI 2.7%PRS 71.6%
-
CSI 1.9rCSI 5.3%PRS 53.4%
-
CSI 1.9rCSI 34.6%PRS 85.8%
-
CSI 1.9rCSI 3.0%PRS 56.7%
-
CSI 1.9rCSI 2.5%PRS 60.7%
-
CSI 1.9rCSI 1.4%PRS 57.8%
-
CSI 1.9rCSI 4.1%PRS 56.2%
-
CSI 1.9rCSI 2.6%PRS 47.5%
-
CSI 2.0rCSI 3.1%PRS 48.0%
-
CSI 2.0rCSI 2.9%PRS 66.8%
-
CSI 2.0rCSI 2.9%PRS 66.7%
-
CSI 2.0rCSI 3.1%PRS 51.4%
-
CSI 2.0rCSI 4.9%PRS 36.4%
-
CSI 2.0rCSI 4.5%PRS 52.9%
-
CSI 2.1rCSI 5.5%PRS 67.6%
-
CSI 2.1rCSI 6.3%PRS 74.6%
-
CSI 2.1rCSI 4.3%PRS 35.5%
-
CSI 2.1rCSI 3.1%PRS 52.3%
-
CSI 2.2rCSI 12.3%PRS 65.3%
-
CSI 2.2rCSI 3.7%PRS 64.5%
-
CSI 2.2rCSI 4.2%PRS 57.6%
-
CSI 2.2rCSI 2.6%PRS 63.5%
-
CSI 2.2rCSI 29.2%PRS 84.1%
-
CSI 2.2rCSI 4.2%PRS 76.2%
-
CSI 2.3rCSI 2.6%PRS 45.0%
-
CSI 2.3rCSI 3.0%PRS 68.6%
-
CSI 2.3rCSI 2.8%PRS 51.1%
-
CSI 2.3rCSI 25.0%PRS 69.1%
-
CSI 2.3rCSI 2.4%PRS 51.9%
-
CSI 2.3rCSI 2.5%PRS 53.8%
-
CSI 2.4rCSI 1.8%PRS 72.8%
-
CSI 2.4rCSI 3.6%PRS 69.9%
-
CSI 2.4rCSI 1.8%PRS 68.9%
-
CSI 2.4rCSI 15.3%PRS 74.6%
-
CSI 2.4rCSI 6.9%PRS 56.9%
-
CSI 2.5rCSI 3.7%PRS 57.2%
-
CSI 2.5rCSI 5.9%PRS 65.4%
-
CSI 2.5rCSI 4.8%PRS 70.9%
-
CSI 2.5rCSI 4.4%PRS 45.2%
-
CSI 2.5rCSI 2.6%PRS 53.6%
-
CSI 2.6rCSI 2.3%PRS 43.4%
-
CSI 2.6rCSI 7.3%PRS 52.8%
-
CSI 2.7rCSI 4.2%PRS 80.4%
-
CSI 2.7rCSI 1.6%PRS 72.0%
-
CSI 2.7rCSI 5.4%PRS 44.3%
-
CSI 2.7rCSI 3.5%PRS 52.6%
-
CSI 2.7rCSI 1.8%PRS 67.5%
-
CSI 2.8rCSI 4.9%PRS 36.7%
-
CSI 2.9rCSI 4.2%PRS 59.0%
-
CSI 2.9rCSI 3.5%PRS 53.3%
-
CSI 2.9rCSI 2.9%PRS 70.9%
-
CSI 2.9rCSI 7.4%PRS 49.8%
-
CSI 2.9rCSI 2.3%PRS 56.3%
-
CSI 2.9rCSI 2.6%PRS 60.3%
-
CSI 3.1rCSI 8.8%PRS 74.5%
-
CSI 3.1rCSI 2.4%PRS 77.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3371240950
Symbol: SSRP1_HUMAN
Name: FACT complex subunit SSRP1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1372440
Title: Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.
PubMed ID: 1372440
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9489704
Title: FACT, a factor that facilitates transcript elongation through nucleosomes.
PubMed ID: 9489704
PubMed ID: 9566881
Title: The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene.
PubMed ID: 9566881
PubMed ID: 9836642
Title: Requirement of RSF and FACT for transcription of chromatin templates in vitro.
PubMed ID: 9836642
PubMed ID: 10421373
Title: The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.
PubMed ID: 10421373
DOI: 10.1038/22350
PubMed ID: 10912001
Title: FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.
PubMed ID: 10912001
PubMed ID: 11344167
Title: Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin.
PubMed ID: 11344167
PubMed ID: 11239457
Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
PubMed ID: 11239457
PubMed ID: 12374749
Title: SSRP1 functions as a co-activator of the transcriptional activator p63.
PubMed ID: 12374749
DOI: 10.1093/emboj/cdf540
PubMed ID: 12393879
Title: p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.
PubMed ID: 12393879
PubMed ID: 11824977
Title: High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases.
PubMed ID: 11824977
PubMed ID: 12934006
Title: FACT facilitates transcription-dependent nucleosome alteration.
PubMed ID: 12934006
PubMed ID: 14660563
Title: Nek9, a novel FACT-associated protein, modulates interphase progression.
PubMed ID: 14660563
PubMed ID: 15561718
Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.
PubMed ID: 15561718
PubMed ID: 15659405
Title: CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity.
PubMed ID: 15659405
PubMed ID: 16713563
Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
PubMed ID: 16713563
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16498457
Title: Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis.
PubMed ID: 16498457
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19836239
Title: UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.
PubMed ID: 19836239
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22002106
Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.
PubMed ID: 22002106
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27499292
Title: The flexible ends of CENP-A nucleosome are required for mitotic fidelity.
PubMed ID: 27499292
PubMed ID: 28611249
Title: A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.
PubMed ID: 28611249
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 709
- Mass: 81075
- Checksum: 4E7EE3735EB41082
- Sequence:
MAETLEFNDV YQEVKGSMND GRLRLSRQGI IFKNSKTGKV DNIQAGELTE GIWRRVALGH GLKLLTKNGH VYKYDGFRES EFEKLSDFFK THYRLELMEK DLCVKGWNWG TVKFGGQLLS FDIGDQPVFE IPLSNVSQCT TGKNEVTLEF HQNDDAEVSL MEVRFYVPPT QEDGVDPVEA FAQNVLSKAD VIQATGDAIC IFRELQCLTP RGRYDIRIYP TFLHLHGKTF DYKIPYTTVL RLFLLPHKDQ RQMFFVISLD PPIKQGQTRY HFLILLFSKD EDISLTLNMN EEEVEKRFEG RLTKNMSGSL YEMVSRVMKA LVNRKITVPG NFQGHSGAQC ITCSYKASSG LLYPLERGFI YVHKPPVHIR FDEISFVNFA RGTTTTRSFD FEIETKQGTQ YTFSSIEREE YGKLFDFVNA KKLNIKNRGL KEGMNPSYDE YADSDEDQHD AYLERMKEEG KIREENANDS SDDSGEETDE SFNPGEEEED VAEEFDSNAS ASSSSNEGDS DRDEKKRKQL KKAKMAKDRK SRKKPVEVKK GKDPNAPKRP MSAYMLWLNA SREKIKSDHP GISITDLSKK AGEIWKGMSK EKKEEWDRKA EDARRDYEKA MKEYEGGRGE SSKRDKSKKK KKVKVKMEKK STPSRGSSSK SSSRQLSESF KSKEFVSSDE SSSGENKSKK KRRRSEDSEE EELASTPPSS EDSASGSDE