Details for: SSRP1

Gene ID: 6749

Symbol: SSRP1

Ensembl ID: ENSG00000149136

Description: structure specific recognition protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.9979
    Cell Significance Index: -20.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.3701
    Cell Significance Index: -24.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.6089
    Cell Significance Index: -38.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.7771
    Cell Significance Index: -32.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 77.6175
    Cell Significance Index: -36.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.2197
    Cell Significance Index: -36.1200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.6182
    Cell Significance Index: -36.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.1663
    Cell Significance Index: -32.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.3732
    Cell Significance Index: -33.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3780
    Cell Significance Index: -30.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1383
    Cell Significance Index: -36.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5530
    Cell Significance Index: -26.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2265
    Cell Significance Index: -9.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.3289
    Cell Significance Index: 36.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9705
    Cell Significance Index: 205.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8961
    Cell Significance Index: 25.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8059
    Cell Significance Index: 62.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7935
    Cell Significance Index: 14.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7653
    Cell Significance Index: 48.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7343
    Cell Significance Index: 188.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7251
    Cell Significance Index: 36.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4103
    Cell Significance Index: 229.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2662
    Cell Significance Index: 149.3200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1734
    Cell Significance Index: 8.8600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0252
    Cell Significance Index: 13.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9688
    Cell Significance Index: 133.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9529
    Cell Significance Index: 61.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8653
    Cell Significance Index: 106.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8294
    Cell Significance Index: 21.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8256
    Cell Significance Index: 450.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7092
    Cell Significance Index: 36.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6689
    Cell Significance Index: 86.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6515
    Cell Significance Index: 117.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6362
    Cell Significance Index: 281.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5738
    Cell Significance Index: 40.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5382
    Cell Significance Index: 485.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5250
    Cell Significance Index: 15.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4967
    Cell Significance Index: 37.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4476
    Cell Significance Index: 20.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4314
    Cell Significance Index: 86.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4310
    Cell Significance Index: 85.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4099
    Cell Significance Index: 11.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4058
    Cell Significance Index: 4.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4053
    Cell Significance Index: 51.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3923
    Cell Significance Index: 18.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3861
    Cell Significance Index: 17.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3683
    Cell Significance Index: 7.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3426
    Cell Significance Index: 58.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3090
    Cell Significance Index: 8.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2838
    Cell Significance Index: 14.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2040
    Cell Significance Index: 5.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1572
    Cell Significance Index: 15.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1469
    Cell Significance Index: 52.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1436
    Cell Significance Index: 4.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0962
    Cell Significance Index: 18.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0840
    Cell Significance Index: 1.7900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0775
    Cell Significance Index: 0.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0532
    Cell Significance Index: 2.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0263
    Cell Significance Index: 18.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0230
    Cell Significance Index: 0.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0177
    Cell Significance Index: 13.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0088
    Cell Significance Index: -5.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0108
    Cell Significance Index: -20.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0194
    Cell Significance Index: -1.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0216
    Cell Significance Index: -39.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0263
    Cell Significance Index: -0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0273
    Cell Significance Index: -41.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0280
    Cell Significance Index: -2.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0286
    Cell Significance Index: -0.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0334
    Cell Significance Index: -45.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0400
    Cell Significance Index: -25.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0467
    Cell Significance Index: -26.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0668
    Cell Significance Index: -30.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0796
    Cell Significance Index: -16.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0903
    Cell Significance Index: -10.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0950
    Cell Significance Index: -27.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1053
    Cell Significance Index: -12.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1164
    Cell Significance Index: -2.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1565
    Cell Significance Index: -22.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2118
    Cell Significance Index: -11.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2208
    Cell Significance Index: -6.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2295
    Cell Significance Index: -15.4300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.2351
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2616
    Cell Significance Index: -29.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2686
    Cell Significance Index: -16.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3383
    Cell Significance Index: -35.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3635
    Cell Significance Index: -28.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3829
    Cell Significance Index: -29.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4719
    Cell Significance Index: -13.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5088
    Cell Significance Index: -4.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5482
    Cell Significance Index: -5.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5527
    Cell Significance Index: -14.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5960
    Cell Significance Index: -36.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6098
    Cell Significance Index: -26.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6157
    Cell Significance Index: -3.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6328
    Cell Significance Index: -16.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6337
    Cell Significance Index: -15.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SSRP1 is a protein-coding gene that belongs to the FACT complex, which is a multifunctional complex that regulates chromatin structure and transcription. The FACT complex is composed of two subunits, SSRP1 and SSRP2, which interact with other proteins to facilitate chromatin remodeling and transcriptional regulation. SSRP1 is characterized by its ability to bind to specific DNA sequences and its involvement in various cellular processes, including DNA replication and repair. **Pathways and Functions** SSRP1 is involved in several cellular pathways, including: 1. **DNA Replication**: SSRP1 plays a crucial role in regulating DNA replication by interacting with other proteins to facilitate chromatin remodeling and transcriptional regulation. 2. **DNA Repair**: SSRP1 is involved in DNA repair pathways, including nucleotide excision repair and base excision repair, by interacting with proteins that recognize and repair DNA damage. 3. **Transcription**: SSRP1 regulates transcription by interacting with RNA polymerase II and other transcription factors to facilitate chromatin remodeling and transcriptional regulation. 4. **Viral Infection**: SSRP1 is involved in viral infection pathways, including HIV-1, by interacting with viral proteins to facilitate viral transcription and replication. 5. **Chromatin Organization**: SSRP1 regulates chromatin organization by interacting with histones and other chromatin proteins to facilitate chromatin remodeling and transcriptional regulation. **Clinical Significance** SSRP1's involvement in various cellular processes highlights its potential role as a key regulator of cellular homeostasis and disease. Alterations in SSRP1 expression or function have been implicated in several diseases, including: 1. **Cancer**: SSRP1's role in regulating chromatin structure and transcription makes it a potential target for cancer therapy. 2. **Neurological Disorders**: SSRP1's involvement in neuronal function and chromatin organization makes it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious Diseases**: SSRP1's role in viral infection pathways makes it a potential target for antiviral therapy. 4. **Genetic Disorders**: SSRP1's involvement in DNA repair pathways makes it a potential target for genetic disorders, such as Fanconi anemia. In conclusion, SSRP1 is a crucial component of the FACT complex that plays a pivotal role in regulating chromatin structure and transcription. Its involvement in various cellular processes highlights its potential role as a key regulator of cellular homeostasis and disease. Further research is needed to fully understand SSRP1's role in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3371240950

Symbol: SSRP1_HUMAN

Name: FACT complex subunit SSRP1

UniProtKB Accession Codes:

Q08945 Q5BJG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 12 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1372440

Title: Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.

PubMed ID: 1372440

DOI: 10.1073/pnas.89.6.2307

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9489704

Title: FACT, a factor that facilitates transcript elongation through nucleosomes.

PubMed ID: 9489704

DOI: 10.1016/s0092-8674(00)80903-4

PubMed ID: 9566881

Title: The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene.

PubMed ID: 9566881

DOI: 10.1128/mcb.18.5.2617

PubMed ID: 9836642

Title: Requirement of RSF and FACT for transcription of chromatin templates in vitro.

PubMed ID: 9836642

DOI: 10.1126/science.282.5395.1900

PubMed ID: 10421373

Title: The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.

PubMed ID: 10421373

DOI: 10.1038/22350

PubMed ID: 10912001

Title: FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

PubMed ID: 10912001

DOI: 10.1016/s1097-2765(00)80272-5

PubMed ID: 11344167

Title: Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin.

PubMed ID: 11344167

DOI: 10.1074/jbc.m101208200

PubMed ID: 11239457

Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

PubMed ID: 11239457

DOI: 10.1016/s1097-2765(01)00176-9

PubMed ID: 12374749

Title: SSRP1 functions as a co-activator of the transcriptional activator p63.

PubMed ID: 12374749

DOI: 10.1093/emboj/cdf540

PubMed ID: 12393879

Title: p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

PubMed ID: 12393879

DOI: 10.1074/jbc.m209820200

PubMed ID: 11824977

Title: High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases.

PubMed ID: 11824977

PubMed ID: 12934006

Title: FACT facilitates transcription-dependent nucleosome alteration.

PubMed ID: 12934006

DOI: 10.1126/science.1085703

PubMed ID: 14660563

Title: Nek9, a novel FACT-associated protein, modulates interphase progression.

PubMed ID: 14660563

DOI: 10.1074/jbc.m311477200

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 15659405

Title: CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity.

PubMed ID: 15659405

DOI: 10.1074/jbc.m413944200

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16498457

Title: Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis.

PubMed ID: 16498457

DOI: 10.1038/sj.cdd.4401878

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19836239

Title: UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.

PubMed ID: 19836239

DOI: 10.1016/j.cub.2009.09.041

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27499292

Title: The flexible ends of CENP-A nucleosome are required for mitotic fidelity.

PubMed ID: 27499292

DOI: 10.1016/j.molcel.2016.06.023

PubMed ID: 28611249

Title: A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.

PubMed ID: 28611249

DOI: 10.1128/mbio.00745-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 709
  • Mass: 81075
  • Checksum: 4E7EE3735EB41082
  • Sequence:
    • MAETLEFNDV YQEVKGSMND GRLRLSRQGI IFKNSKTGKV DNIQAGELTE GIWRRVALGH 
GLKLLTKNGH VYKYDGFRES EFEKLSDFFK THYRLELMEK DLCVKGWNWG TVKFGGQLLS 
FDIGDQPVFE IPLSNVSQCT TGKNEVTLEF HQNDDAEVSL MEVRFYVPPT QEDGVDPVEA 
FAQNVLSKAD VIQATGDAIC IFRELQCLTP RGRYDIRIYP TFLHLHGKTF DYKIPYTTVL 
RLFLLPHKDQ RQMFFVISLD PPIKQGQTRY HFLILLFSKD EDISLTLNMN EEEVEKRFEG 
RLTKNMSGSL YEMVSRVMKA LVNRKITVPG NFQGHSGAQC ITCSYKASSG LLYPLERGFI 
YVHKPPVHIR FDEISFVNFA RGTTTTRSFD FEIETKQGTQ YTFSSIEREE YGKLFDFVNA 
KKLNIKNRGL KEGMNPSYDE YADSDEDQHD AYLERMKEEG KIREENANDS SDDSGEETDE 
SFNPGEEEED VAEEFDSNAS ASSSSNEGDS DRDEKKRKQL KKAKMAKDRK SRKKPVEVKK 
GKDPNAPKRP MSAYMLWLNA SREKIKSDHP GISITDLSKK AGEIWKGMSK EKKEEWDRKA 
EDARRDYEKA MKEYEGGRGE SSKRDKSKKK KKVKVKMEKK STPSRGSSSK SSSRQLSESF 
KSKEFVSSDE SSSGENKSKK KRRRSEDSEE EELASTPPSS EDSASGSDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.