Details for: STC1

Gene ID: 6781

Symbol: STC1

Ensembl ID: ENSG00000159167

Description: stanniocalcin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.2146
    Cell Significance Index: -17.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.0101
    Cell Significance Index: -17.2000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 8.4574
    Cell Significance Index: 60.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.0013
    Cell Significance Index: 106.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.4830
    Cell Significance Index: 21.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.9413
    Cell Significance Index: 68.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2896
    Cell Significance Index: 41.3100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.0612
    Cell Significance Index: 4.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8966
    Cell Significance Index: 19.4300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8253
    Cell Significance Index: 11.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7994
    Cell Significance Index: 8.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6203
    Cell Significance Index: 46.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5616
    Cell Significance Index: 9.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5538
    Cell Significance Index: 302.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3644
    Cell Significance Index: 69.3500
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.3349
    Cell Significance Index: 1.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1925
    Cell Significance Index: 10.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1862
    Cell Significance Index: 2.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1829
    Cell Significance Index: 1.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1049
    Cell Significance Index: 94.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0629
    Cell Significance Index: 0.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0505
    Cell Significance Index: 5.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0502
    Cell Significance Index: 9.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0441
    Cell Significance Index: 27.5400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0439
    Cell Significance Index: 0.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0429
    Cell Significance Index: 2.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0208
    Cell Significance Index: 3.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0205
    Cell Significance Index: 2.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0173
    Cell Significance Index: 0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0159
    Cell Significance Index: 7.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0128
    Cell Significance Index: 9.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0126
    Cell Significance Index: 1.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0053
    Cell Significance Index: 0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0025
    Cell Significance Index: 0.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0010
    Cell Significance Index: -0.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0016
    Cell Significance Index: -1.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0162
    Cell Significance Index: -29.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0192
    Cell Significance Index: -29.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0226
    Cell Significance Index: -30.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0228
    Cell Significance Index: -0.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0245
    Cell Significance Index: -17.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0262
    Cell Significance Index: -9.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0265
    Cell Significance Index: -16.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0278
    Cell Significance Index: -0.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0333
    Cell Significance Index: -0.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0345
    Cell Significance Index: -2.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0397
    Cell Significance Index: -11.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0464
    Cell Significance Index: -21.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0536
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0585
    Cell Significance Index: -12.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0595
    Cell Significance Index: -2.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0718
    Cell Significance Index: -4.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0723
    Cell Significance Index: -8.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0729
    Cell Significance Index: -9.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0777
    Cell Significance Index: -14.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0847
    Cell Significance Index: -16.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0977
    Cell Significance Index: -2.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1000
    Cell Significance Index: -10.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1008
    Cell Significance Index: -5.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1034
    Cell Significance Index: -12.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1129
    Cell Significance Index: -16.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1297
    Cell Significance Index: -14.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1457
    Cell Significance Index: -8.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1722
    Cell Significance Index: -17.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2029
    Cell Significance Index: -5.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2045
    Cell Significance Index: -15.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2263
    Cell Significance Index: -1.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2371
    Cell Significance Index: -18.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2556
    Cell Significance Index: -6.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2570
    Cell Significance Index: -17.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2598
    Cell Significance Index: -12.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2809
    Cell Significance Index: -9.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2866
    Cell Significance Index: -3.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2919
    Cell Significance Index: -18.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3112
    Cell Significance Index: -12.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3129
    Cell Significance Index: -6.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3194
    Cell Significance Index: -19.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3372
    Cell Significance Index: -18.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3578
    Cell Significance Index: -10.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3743
    Cell Significance Index: -5.6400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3759
    Cell Significance Index: -4.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3807
    Cell Significance Index: -5.8900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3983
    Cell Significance Index: -5.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4099
    Cell Significance Index: -20.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4266
    Cell Significance Index: -8.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4273
    Cell Significance Index: -9.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4288
    Cell Significance Index: -11.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4365
    Cell Significance Index: -11.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4368
    Cell Significance Index: -19.3200
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.4550
    Cell Significance Index: -2.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4816
    Cell Significance Index: -17.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4848
    Cell Significance Index: -13.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4976
    Cell Significance Index: -8.2000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5121
    Cell Significance Index: -10.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5139
    Cell Significance Index: -19.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5438
    Cell Significance Index: -17.3200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.5706
    Cell Significance Index: -4.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STC1 is a small, secreted protein belonging to the stanniocalcin family, which consists of four members in humans (STC1-4). STC1 is primarily expressed in epithelial cells, endothelial cells, and hematopoietic stem cells, suggesting its involvement in tissue-specific functions. The protein is characterized by its unique structure, which includes a characteristic disulfide-linked dimeric form and a unique C-terminal domain. **Pathways and Functions:** STC1 is involved in various signaling pathways, including: 1. **Apical plasma membrane**: STC1 interacts with the apical plasma membrane, influencing cell migration, differentiation, and survival. 2. **Bone development**: STC1 regulates bone mineralization, osteoblast differentiation, and bone growth plate development. 3. **Cellular response to camp**: STC1 modulates the cellular response to cyclic AMP (cAMP), a key signaling molecule involved in various physiological processes. 4. **Intracellular calcium ion homeostasis**: STC1 regulates calcium ion transport, influencing cell signaling, differentiation, and survival. 5. **Negative regulation of calcium ion transport**: STC1 inhibits calcium ion transport, which is essential for maintaining calcium homeostasis in cells. STC1 also interacts with various proteins, including hormones, growth factors, and receptors, to regulate cellular functions. These interactions include: 1. **Regulation of cardiac muscle cell contraction**: STC1 modulates cardiac muscle contraction and relaxation. 2. **Regulation of monoatomic anion transport**: STC1 regulates the transport of monoatomic anions, such as chloride and phosphate. 3. **Response to vitamin D**: STC1 interacts with vitamin D, influencing bone development and mineralization. **Clinical Significance:** STC1 has been implicated in various diseases, including: 1. **Osteoporosis**: STC1 regulates bone mineralization and density, making it a potential therapeutic target for osteoporosis treatment. 2. **Cardiovascular disease**: STC1 modulates cardiac muscle contraction and relaxation, suggesting its involvement in cardiovascular disease. 3. **Cancer**: STC1 has been shown to inhibit cancer cell migration and invasion, suggesting its potential as an anti-cancer therapeutic agent. 4. **Neurological disorders**: STC1 may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, due to its involvement in calcium homeostasis and neuronal signaling. In conclusion, STC1 is a multifunctional protein that plays a crucial role in various physiological processes, including immune regulation, bone development, and cellular response to stress. Its involvement in various diseases highlights its potential as a therapeutic target for the treatment of osteoporosis, cardiovascular disease, cancer, and neurological disorders. Further research is needed to fully elucidate the mechanisms of STC1 and its potential applications in human health and disease.

Genular Protein ID: 3155414555

Symbol: STC1_HUMAN

Name: Stanniocalcin-1

UniProtKB Accession Codes:

P52823 B4DN22 Q71UE5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 25 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7489828

Title: A novel human cDNA highly homologous to the fish hormone stanniocalcin.

PubMed ID: 7489828

DOI: 10.1016/0303-7207(95)03601-3

PubMed ID: 8700837

Title: Human stanniocalcin: a possible hormonal regulator of mineral metabolism.

PubMed ID: 8700837

DOI: 10.1073/pnas.93.5.1792

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9794484

Title: Comparative analysis of mammalian stanniocalcin genes.

PubMed ID: 9794484

DOI: 10.1210/endo.139.11.6313

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 247
  • Mass: 27621
  • Checksum: 1E4A8BD861B49AED
  • Sequence:
    • MLQNSAVLLV LVISASATHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL QVGCGAFACL 
ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGVTSKVFLA IRRCSTFQRM 
IAEVQEECYS KLNVCSIAKR NPEAITEVVQ LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD 
SLMEKIGPNM ASLFHILQTD HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEEDSPSHIK 
RTSHESA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.