Details for: STX4

Gene ID: 6810

Symbol: STX4

Ensembl ID: ENSG00000103496

Description: syntaxin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.5970
    Cell Significance Index: -26.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.8075
    Cell Significance Index: -23.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.4654
    Cell Significance Index: -29.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.9496
    Cell Significance Index: -25.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.8907
    Cell Significance Index: -29.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.9697
    Cell Significance Index: -28.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.2311
    Cell Significance Index: -27.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.3804
    Cell Significance Index: -22.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2506
    Cell Significance Index: -22.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1616
    Cell Significance Index: -28.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0665
    Cell Significance Index: -8.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8336
    Cell Significance Index: 52.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5388
    Cell Significance Index: 21.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3931
    Cell Significance Index: 137.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7558
    Cell Significance Index: 52.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7370
    Cell Significance Index: 20.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7138
    Cell Significance Index: 37.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6346
    Cell Significance Index: 29.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6124
    Cell Significance Index: 75.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5585
    Cell Significance Index: 25.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5520
    Cell Significance Index: 11.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5341
    Cell Significance Index: 96.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4750
    Cell Significance Index: 13.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4627
    Cell Significance Index: 204.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4626
    Cell Significance Index: 63.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4448
    Cell Significance Index: 20.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3994
    Cell Significance Index: 25.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3985
    Cell Significance Index: 217.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3617
    Cell Significance Index: 9.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3265
    Cell Significance Index: 6.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3050
    Cell Significance Index: 21.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2974
    Cell Significance Index: 8.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2721
    Cell Significance Index: 245.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1962
    Cell Significance Index: 39.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1922
    Cell Significance Index: 24.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1821
    Cell Significance Index: 23.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1740
    Cell Significance Index: 34.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1698
    Cell Significance Index: 3.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1522
    Cell Significance Index: 2.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1363
    Cell Significance Index: 3.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1257
    Cell Significance Index: 9.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0975
    Cell Significance Index: 18.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0768
    Cell Significance Index: 2.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0728
    Cell Significance Index: 0.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0541
    Cell Significance Index: 1.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0531
    Cell Significance Index: 36.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0496
    Cell Significance Index: 1.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0443
    Cell Significance Index: 1.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0413
    Cell Significance Index: 0.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0277
    Cell Significance Index: 3.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0274
    Cell Significance Index: 9.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0238
    Cell Significance Index: 0.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0151
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0080
    Cell Significance Index: 15.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0075
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0098
    Cell Significance Index: -7.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0106
    Cell Significance Index: -1.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -20.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0125
    Cell Significance Index: -9.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0160
    Cell Significance Index: -21.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0223
    Cell Significance Index: -14.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0296
    Cell Significance Index: -4.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0326
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0342
    Cell Significance Index: -25.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0380
    Cell Significance Index: -5.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0479
    Cell Significance Index: -27.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0487
    Cell Significance Index: -22.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0518
    Cell Significance Index: -32.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0759
    Cell Significance Index: -3.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0824
    Cell Significance Index: -23.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1203
    Cell Significance Index: -13.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1341
    Cell Significance Index: -2.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1394
    Cell Significance Index: -3.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1418
    Cell Significance Index: -16.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1548
    Cell Significance Index: -32.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1737
    Cell Significance Index: -9.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1742
    Cell Significance Index: -13.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2011
    Cell Significance Index: -10.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2587
    Cell Significance Index: -5.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2642
    Cell Significance Index: -16.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2654
    Cell Significance Index: -27.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2717
    Cell Significance Index: -6.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2731
    Cell Significance Index: -17.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2859
    Cell Significance Index: -22.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3221
    Cell Significance Index: -21.6600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3578
    Cell Significance Index: -2.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3742
    Cell Significance Index: -22.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4788
    Cell Significance Index: -26.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4803
    Cell Significance Index: -16.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4811
    Cell Significance Index: -4.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4897
    Cell Significance Index: -10.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5226
    Cell Significance Index: -21.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5272
    Cell Significance Index: -23.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5356
    Cell Significance Index: -15.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6380
    Cell Significance Index: -24.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6652
    Cell Significance Index: -24.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6866
    Cell Significance Index: -17.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6879
    Cell Significance Index: -24.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6947
    Cell Significance Index: -16.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STX4 is a member of the syntaxin family, which is characterized by its ability to facilitate vesicle fusion and exocytosis. It is a soluble protein that interacts with other SNARE proteins to form the SNARE complex, which is essential for the regulation of membrane fusion and vesicle transport. STX4 is also known for its ability to modulate the activity of other proteins, including those involved in immune response and synaptic transmission. Some key characteristics of STX4 include: * Soluble protein with SNARE complex-forming ability * Essential component of the SNARE complex * Involved in regulation of exocytosis, endocytosis, and intracellular protein transport * Widespread expression across different cell types, including immune cells, epithelial cells, and neurons * Implicated in various physiological and pathological processes, including immune system regulation, synaptic transmission, and cancer development **Pathways and Functions** STX4 is involved in several cellular pathways, including: 1. **Adaptive Immune System**: STX4 plays a crucial role in the regulation of immune cell function, including the activation and proliferation of T cells and B cells. 2. **Antigen Processing-Cross Presentation**: STX4 is involved in the processing and presentation of antigens to CD8+ T cells, which is essential for the activation of cytotoxic T cells. 3. **Extracellular Exosome**: STX4 is involved in the formation and regulation of exosomes, which are small vesicles that play a crucial role in intercellular communication. 4. **Neurotransmitter Transport**: STX4 is involved in the regulation of neurotransmitter transport and synaptic transmission, which is essential for neuronal function and behavior. 5. **Endocytosis**: STX4 is involved in the regulation of endocytosis, which is the process by which cells internalize external molecules and signals. Some key functions of STX4 include: * Regulation of exocytosis and endocytosis * Modulation of immune cell function * Regulation of synaptic transmission and neurotransmitter transport * Formation and regulation of exosomes * Involvement in cancer development and progression **Clinical Significance** STX4 has been implicated in various diseases and disorders, including: 1. **Autoimmune Disorders**: STX4 has been implicated in the development of autoimmune disorders, including rheumatoid arthritis and lupus. 2. **Neurological Disorders**: STX4 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: STX4 has been implicated in the development and progression of cancer, including breast cancer and lung cancer. 4. **Immune System Disorders**: STX4 has been implicated in the development of immune system disorders, including immunodeficiency diseases and autoimmune disorders. Overall, STX4 is a critical protein that plays a pivotal role in various cellular processes, including immune response, neurotransmission, and vesicle trafficking. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of understanding its function and regulation.

Genular Protein ID: 3044278225

Symbol: STX4_HUMAN

Name: Syntaxin-4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8206394

Title: Isolation and sequence analysis of the human syntaxin-encoding gene.

PubMed ID: 8206394

DOI: 10.1016/0378-1119(94)90117-1

PubMed ID: 8760387

Title: Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.

PubMed ID: 8760387

DOI: 10.1042/bj3170945

PubMed ID: 10080545

Title: Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1.

PubMed ID: 10080545

DOI: 10.1002/jlb.65.3.397

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36355422

Title: Syntaxin 4 is essential for hearing in human and zebrafish.

PubMed ID: 36355422

DOI: 10.1093/hmg/ddac257

Sequence Information:

  • Length: 297
  • Mass: 34180
  • Checksum: 5084FD1C49A86BAA
  • Sequence:
  • MRDRTHELRQ GDDSSDEEDK ERVALVVHPG TARLGSPDEE FFHKVRTIRQ TIVKLGNKVQ 
    ELEKQQVTIL ATPLPEESMK QELQNLRDEI KQLGREIRLQ LKAIEPQKEE ADENYNSVNT 
    RMRKTQHGVL SQQFVELINK CNSMQSEYRE KNVERIRRQL KITNAGMVSD EELEQMLDSG 
    QSEVFVSNIL KDTQVTRQAL NEISARHSEI QQLERSIREL HDIFTFLATE VEMQGEMINR 
    IEKNILSSAD YVERGQEHVK TALENQKKAR KKKVLIAICV SITVVLLAVI IGVTVVG

Genular Protein ID: 1213771306

Symbol: B7Z425_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 219
  • Mass: 25262
  • Checksum: 4062706AB6A41D45
  • Sequence:
  • MKQELQNLRD EIKQLGREIR LQLKAIEPQK EEADENYNSV NTRMRKTQHG VLSQQFVELI 
    NKCNSMQSEY REKNVERIRR QLKITNAGMV SDEELEQMLD SGQSEVFVSN ILKDTQVTRQ 
    ALNEISARHS EIQQLERSIR ELHDIFTFLA TEVEMQGEMI NRIEKNILSS ADYVERGQEH 
    VKTALENQKK ARKKKVLIAI CVSITVVLLA VIIGVTVVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.