Details for: SUPT5H

Gene ID: 6829

Symbol: SUPT5H

Ensembl ID: ENSG00000196235

Description: SPT5 homolog, DSIF elongation factor subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 251.1488
    Cell Significance Index: -39.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 150.8023
    Cell Significance Index: -38.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 112.4051
    Cell Significance Index: -46.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.3399
    Cell Significance Index: -37.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.3232
    Cell Significance Index: -44.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.4868
    Cell Significance Index: -42.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.5865
    Cell Significance Index: -44.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.0003
    Cell Significance Index: -38.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.5900
    Cell Significance Index: -41.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.8683
    Cell Significance Index: -39.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8841
    Cell Significance Index: -33.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7981
    Cell Significance Index: -42.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2930
    Cell Significance Index: -18.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1202
    Cell Significance Index: 215.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5689
    Cell Significance Index: 170.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5509
    Cell Significance Index: 21.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1715
    Cell Significance Index: 1057.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9710
    Cell Significance Index: 192.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9116
    Cell Significance Index: 24.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8795
    Cell Significance Index: 108.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8730
    Cell Significance Index: 157.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8051
    Cell Significance Index: 161.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7980
    Cell Significance Index: 36.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7804
    Cell Significance Index: 40.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6906
    Cell Significance Index: 32.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6884
    Cell Significance Index: 35.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6846
    Cell Significance Index: 94.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6746
    Cell Significance Index: 368.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5944
    Cell Significance Index: 17.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5635
    Cell Significance Index: 66.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4738
    Cell Significance Index: 22.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4542
    Cell Significance Index: 29.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4138
    Cell Significance Index: 21.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3744
    Cell Significance Index: 233.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3723
    Cell Significance Index: 257.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3687
    Cell Significance Index: 3.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3462
    Cell Significance Index: 124.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3433
    Cell Significance Index: 151.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3005
    Cell Significance Index: 38.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2837
    Cell Significance Index: 17.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2790
    Cell Significance Index: 45.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2637
    Cell Significance Index: 7.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2537
    Cell Significance Index: 43.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2252
    Cell Significance Index: 6.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1742
    Cell Significance Index: 12.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1551
    Cell Significance Index: 29.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1161
    Cell Significance Index: 15.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1062
    Cell Significance Index: 6.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1043
    Cell Significance Index: 2.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0934
    Cell Significance Index: 7.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0798
    Cell Significance Index: 2.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0430
    Cell Significance Index: 80.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0393
    Cell Significance Index: 2.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0333
    Cell Significance Index: 45.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0195
    Cell Significance Index: 35.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0080
    Cell Significance Index: 12.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0130
    Cell Significance Index: -1.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0195
    Cell Significance Index: -14.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0293
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0354
    Cell Significance Index: -16.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0456
    Cell Significance Index: -25.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0578
    Cell Significance Index: -5.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0720
    Cell Significance Index: -10.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0842
    Cell Significance Index: -5.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0960
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0997
    Cell Significance Index: -21.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1264
    Cell Significance Index: -36.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1348
    Cell Significance Index: -15.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1618
    Cell Significance Index: -18.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1692
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2183
    Cell Significance Index: -24.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2205
    Cell Significance Index: -3.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2214
    Cell Significance Index: -1.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2462
    Cell Significance Index: -10.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2596
    Cell Significance Index: -6.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2605
    Cell Significance Index: -7.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2630
    Cell Significance Index: -14.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2646
    Cell Significance Index: -4.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3184
    Cell Significance Index: -7.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3306
    Cell Significance Index: -8.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3746
    Cell Significance Index: -39.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3766
    Cell Significance Index: -14.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3883
    Cell Significance Index: -9.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3988
    Cell Significance Index: -9.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4556
    Cell Significance Index: -36.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4763
    Cell Significance Index: -10.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5077
    Cell Significance Index: -16.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5183
    Cell Significance Index: -14.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5334
    Cell Significance Index: -10.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5509
    Cell Significance Index: -19.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6067
    Cell Significance Index: -12.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6091
    Cell Significance Index: -37.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6753
    Cell Significance Index: -4.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7520
    Cell Significance Index: -7.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7621
    Cell Significance Index: -11.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7660
    Cell Significance Index: -18.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8072
    Cell Significance Index: -23.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure:** The SUPT5H gene is a single-exon gene, encoding a 75-kDa protein that belongs to the SPT5 family of transcription elongation factors. 2. **Cellular expression:** SUPT5H is expressed in various cell types, including choroid plexus epithelial cells, glandular epithelial cells, male germ cells, and bladder urothelial cells. 3. **Protein interactions:** SUPT5H interacts with other proteins, such as DHX9 and TRF1, to form the DSIF complex, which regulates RNAPII-mediated transcription elongation. 4. **Disease associations:** SUPT5H has been implicated in several diseases, including cancer (e.g., breast cancer and lung cancer), autoimmune disorders (e.g., rheumatoid arthritis and lupus), and infectious diseases (e.g., HIV-1). **Pathways and Functions:** 1. **Transcription elongation:** SUPT5H regulates RNAPII-mediated transcription elongation by interacting with the DSIF complex, which modulates the activity of the transcriptional machinery. 2. **Chromatin binding:** SUPT5H binds to chromatin and regulates gene expression by modulating the accessibility of transcription factors to specific DNA sequences. 3. **RNA processing:** SUPT5H is involved in the regulation of RNA processing, including splicing and export of RNAs. 4. **Cell cycle regulation:** SUPT5H has been implicated in the regulation of cell cycle progression, particularly in the G2/M phase. **Clinical Significance:** 1. **Cancer:** SUPT5H is overexpressed in several types of cancer, including breast cancer and lung cancer, and has been associated with poor prognosis. 2. **Autoimmune disorders:** SUPT5H has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus, and has been identified as a potential therapeutic target. 3. **Infectious diseases:** SUPT5H has been shown to play a role in the regulation of HIV-1 transcription elongation and has been associated with the progression of HIV-1 infection. 4. **Immunological regulation:** SUPT5H is involved in the regulation of immune responses, including the activation of B cells and dendritic cells, and has been implicated in the pathogenesis of autoimmune disorders. In conclusion, the SUPT5H gene plays a crucial role in regulating transcription elongation by RNAPII and has significant implications for our understanding of immunological regulation and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which SUPT5H regulates transcription elongation and its role in disease.

Genular Protein ID: 667492531

Symbol: SPT5H_HUMAN

Name: Transcription elongation factor SPT5

UniProtKB Accession Codes:

O00267 O43279 Q59G52 Q99639

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 7 CORUM 1 CTD 1 ChEBI 2 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 30 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 33 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 18 RefSeq 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8975720

Title: Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5.

PubMed ID: 8975720

DOI: 10.1006/geno.1996.0646

PubMed ID: 9199507

Title: Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis.

PubMed ID: 9199507

DOI: 10.1016/s0014-5793(97)00486-9

PubMed ID: 9450929

Title: DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.

PubMed ID: 9450929

DOI: 10.1101/gad.12.3.343

PubMed ID: 9514752

Title: Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation.

PubMed ID: 9514752

DOI: 10.1006/jmbi.1997.1601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9857195

Title: Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.

PubMed ID: 9857195

DOI: 10.1093/emboj/17.24.7395

PubMed ID: 10199401

Title: NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

PubMed ID: 10199401

DOI: 10.1016/s0092-8674(00)80713-8

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10421630

Title: Transcription elongation factor hSPT5 stimulates mRNA capping.

PubMed ID: 10421630

DOI: 10.1101/gad.13.14.1774

PubMed ID: 10075709

Title: Structure and function of the human transcription elongation factor DSIF.

PubMed ID: 10075709

DOI: 10.1074/jbc.274.12.8085

PubMed ID: 10454543

Title: Tat-SF1 protein associates with RAP30 and human SPT5 proteins.

PubMed ID: 10454543

DOI: 10.1128/mcb.19.9.5960

PubMed ID: 10912001

Title: FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

PubMed ID: 10912001

DOI: 10.1016/s1097-2765(00)80272-5

PubMed ID: 10757782

Title: Domains in the SPT5 protein that modulate its transcriptional regulatory properties.

PubMed ID: 10757782

DOI: 10.1128/mcb.20.9.2970-2983.2000

PubMed ID: 11145967

Title: Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

PubMed ID: 11145967

DOI: 10.1074/jbc.m010908200

PubMed ID: 11112772

Title: DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.

PubMed ID: 11112772

DOI: 10.1074/jbc.m006130200

PubMed ID: 11553615

Title: A highly purified RNA polymerase II elongation control system.

PubMed ID: 11553615

DOI: 10.1074/jbc.m104967200

PubMed ID: 11575923

Title: The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.

PubMed ID: 11575923

DOI: 10.1006/jmbi.2001.4991

PubMed ID: 11809800

Title: Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences.

PubMed ID: 11809800

DOI: 10.1128/mcb.22.4.1079-1093.2002

PubMed ID: 11940650

Title: Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.

PubMed ID: 11940650

DOI: 10.1128/mcb.22.9.2918-2927.2002

PubMed ID: 12653964

Title: Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex.

PubMed ID: 12653964

DOI: 10.1046/j.1365-2443.2003.00638.x

PubMed ID: 12718890

Title: Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

PubMed ID: 12718890

DOI: 10.1016/s1097-2765(03)00101-1

PubMed ID: 12612062

Title: Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.

PubMed ID: 12612062

DOI: 10.1128/mcb.23.6.1863-1873.2003

PubMed ID: 15380072

Title: Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila.

PubMed ID: 15380072

DOI: 10.1016/j.cub.2004.08.066

PubMed ID: 15564463

Title: Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.

PubMed ID: 15564463

DOI: 10.1128/jvi.78.24.13522-13533.2004

PubMed ID: 14701750

Title: Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element.

PubMed ID: 14701750

DOI: 10.1128/mcb.24.2.787-795.2004

PubMed ID: 15060154

Title: Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.

PubMed ID: 15060154

DOI: 10.1128/mcb.24.8.3324-3336.2004

PubMed ID: 15136722

Title: Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II.

PubMed ID: 15136722

DOI: 10.1073/pnas.0401493101

PubMed ID: 16214896

Title: A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS.

PubMed ID: 16214896

DOI: 10.1073/pnas.0409405102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16327805

Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

PubMed ID: 16327805

DOI: 10.1038/nsmb1028

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23652018

Title: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

PubMed ID: 23652018

DOI: 10.1038/ncomms2823

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 37478862

Title: Orphan quality control shapes network dynamics and gene expression.

PubMed ID: 37478862

DOI: 10.1016/j.cell.2023.06.015

PubMed ID: 19860741

Title: Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface.

PubMed ID: 19860741

DOI: 10.1042/bj20091422

PubMed ID: 28892040

Title: Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp.

PubMed ID: 28892040

DOI: 10.1038/nsmb.3465

Sequence Information:

  • Length: 1087
  • Mass: 121000
  • Checksum: EC3F402A670A5B7D
  • Sequence:
    • MSDSEDSNFS EEEDSERSSD GEEAEVDEER RSAAGSEKEE EPEDEEEEEE EEEYDEEEEE 
EDDDRPPKKP RHGGFILDEA DVDDEYEDED QWEDGAEDIL EKEEIEASNI DNVVLDEDRS 
GARRLQNLWR DQREEELGEY YMKKYAKSSV GETVYGGSDE LSDDITQQQL LPGVKDPNLW 
TVKCKIGEER ATAISLMRKF IAYQFTDTPL QIKSVVAPEH VKGYIYVEAY KQTHVKQAIE 
GVGNLRLGYW NQQMVPIKEM TDVLKVVKEV ANLKPKSWVR LKRGIYKDDI AQVDYVEPSQ 
NTISLKMIPR IDYDRIKARM SLKDWFAKRK KFKRPPQRLF DAEKIRSLGG DVASDGDFLI 
FEGNRYSRKG FLFKSFAMSA VITEGVKPTL SELEKFEDQP EGIDLEVVTE STGKEREHNF 
QPGDNVEVCE GELINLQGKI LSVDGNKITI MPKHEDLKDM LEFPAQELRK YFKMGDHVKV 
IAGRFEGDTG LIVRVEENFV ILFSDLTMHE LKVLPRDLQL CSETASGVDV GGQHEWGELV 
QLDPQTVGVI VRLERETFQV LNMYGKVVTV RHQAVTRKKD NRFAVALDSE QNNIHVKDIV 
KVIDGPHSGR EGEIRHLFRS FAFLHCKKLV ENGGMFVCKT RHLVLAGGSK PRDVTNFTVG 
GFAPMSPRIS SPMHPSAGGQ RGGFGSPGGG SGGMSRGRGR RDNELIGQTV RISQGPYKGY 
IGVVKDATES TARVELHSTC QTISVDRQRL TTVGSRRPGG MTSTYGRTPM YGSQTPMYGS 
GSRTPMYGSQ TPLQDGSRTP HYGSQTPLHD GSRTPAQSGA WDPNNPNTPS RAEEEYEYAF 
DDEPTPSPQA YGGTPNPQTP GYPDPSSPQV NPQYNPQTPG TPAMYNTDQF SPYAAPSPQG 
SYQPSPSPQS YHQVAPSPAG YQNTHSPASY HPTPSPMAYQ ASPSPSPVGY SPMTPGAPSP 
GGYNPHTPGS GIEQNSSDWV TTDIQVKVRD TYLDTQVVGQ TGVIRSVTGG MCSVYLKDSE 
KVVSISSEHL EPITPTKNNK VKVILGEDRE ATGVLLSIDG EDGIVRMDLD EQLKILNLRF 
LGKLLEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.