Details for: SUPT5H

Gene ID: 6829

Symbol: SUPT5H

Ensembl ID: ENSG00000196235

Description: SPT5 homolog, DSIF elongation factor subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.06
    Marker Score: 1890.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.88
    Marker Score: 4614
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.53
    Marker Score: 442
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.52
    Marker Score: 3460
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.48
    Marker Score: 1008
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.46
    Marker Score: 589
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.44
    Marker Score: 2115
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.43
    Marker Score: 955
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.37
    Marker Score: 4710
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.37
    Marker Score: 15920
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.3
    Marker Score: 1723
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.24
    Marker Score: 726
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.23
    Marker Score: 381
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.22
    Marker Score: 291
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.22
    Marker Score: 3410
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2
    Marker Score: 12440
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.2
    Marker Score: 2134
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2
    Marker Score: 1262
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.2
    Marker Score: 1653
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.19
    Marker Score: 63144
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.19
    Marker Score: 268
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.19
    Marker Score: 1112
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.17
    Marker Score: 40370
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.16
    Marker Score: 573
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.16
    Marker Score: 2629
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.15
    Marker Score: 7355
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.15
    Marker Score: 782
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.14
    Marker Score: 534
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.14
    Marker Score: 9911
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.13
    Marker Score: 38616
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.13
    Marker Score: 884
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.12
    Marker Score: 484
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.1
    Marker Score: 1198
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.1
    Marker Score: 832
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.1
    Marker Score: 520
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.09
    Marker Score: 381
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.09
    Marker Score: 1363
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.08
    Marker Score: 267
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.08
    Marker Score: 2109
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.08
    Marker Score: 537
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.07
    Marker Score: 9426
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.07
    Marker Score: 10150
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.07
    Marker Score: 9170
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.07
    Marker Score: 643
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.07
    Marker Score: 1108
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.07
    Marker Score: 752
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.07
    Marker Score: 3947
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.07
    Marker Score: 2165
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.06
    Marker Score: 895
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.06
    Marker Score: 433
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.06
    Marker Score: 3343
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16552
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.06
    Marker Score: 231.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.06
    Marker Score: 291
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.05
    Marker Score: 1515
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.05
    Marker Score: 768
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.05
    Marker Score: 58902
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.05
    Marker Score: 2000.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.05
    Marker Score: 5169
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.05
    Marker Score: 1358
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.05
    Marker Score: 713
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.05
    Marker Score: 332
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.05
    Marker Score: 1053
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.05
    Marker Score: 4264
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.04
    Marker Score: 2205
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.04
    Marker Score: 274
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.04
    Marker Score: 1120
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.04
    Marker Score: 3071
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63519
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 388
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.03
    Marker Score: 918
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.03
    Marker Score: 355
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.03
    Marker Score: 1106
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.03
    Marker Score: 229
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.02
    Marker Score: 1233
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.02
    Marker Score: 5360
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 1.02
    Marker Score: 267
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.02
    Marker Score: 642
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.02
    Marker Score: 1567
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.01
    Marker Score: 653
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.01
    Marker Score: 11407
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.01
    Marker Score: 220
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.01
    Marker Score: 243
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.01
    Marker Score: 876
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.01
    Marker Score: 702
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1
    Marker Score: 9948
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1
    Marker Score: 1081
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1
    Marker Score: 220
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1
    Marker Score: 1104
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1
    Marker Score: 226
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71550
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47771
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.99
    Marker Score: 351
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.99
    Marker Score: 3837
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.99
    Marker Score: 342
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.99
    Marker Score: 262
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.99
    Marker Score: 1437
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.99
    Marker Score: 283
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.99
    Marker Score: 275
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.99
    Marker Score: 199

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Other Information

**Key Characteristics:** 1. **Gene structure:** The SUPT5H gene is a single-exon gene, encoding a 75-kDa protein that belongs to the SPT5 family of transcription elongation factors. 2. **Cellular expression:** SUPT5H is expressed in various cell types, including choroid plexus epithelial cells, glandular epithelial cells, male germ cells, and bladder urothelial cells. 3. **Protein interactions:** SUPT5H interacts with other proteins, such as DHX9 and TRF1, to form the DSIF complex, which regulates RNAPII-mediated transcription elongation. 4. **Disease associations:** SUPT5H has been implicated in several diseases, including cancer (e.g., breast cancer and lung cancer), autoimmune disorders (e.g., rheumatoid arthritis and lupus), and infectious diseases (e.g., HIV-1). **Pathways and Functions:** 1. **Transcription elongation:** SUPT5H regulates RNAPII-mediated transcription elongation by interacting with the DSIF complex, which modulates the activity of the transcriptional machinery. 2. **Chromatin binding:** SUPT5H binds to chromatin and regulates gene expression by modulating the accessibility of transcription factors to specific DNA sequences. 3. **RNA processing:** SUPT5H is involved in the regulation of RNA processing, including splicing and export of RNAs. 4. **Cell cycle regulation:** SUPT5H has been implicated in the regulation of cell cycle progression, particularly in the G2/M phase. **Clinical Significance:** 1. **Cancer:** SUPT5H is overexpressed in several types of cancer, including breast cancer and lung cancer, and has been associated with poor prognosis. 2. **Autoimmune disorders:** SUPT5H has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus, and has been identified as a potential therapeutic target. 3. **Infectious diseases:** SUPT5H has been shown to play a role in the regulation of HIV-1 transcription elongation and has been associated with the progression of HIV-1 infection. 4. **Immunological regulation:** SUPT5H is involved in the regulation of immune responses, including the activation of B cells and dendritic cells, and has been implicated in the pathogenesis of autoimmune disorders. In conclusion, the SUPT5H gene plays a crucial role in regulating transcription elongation by RNAPII and has significant implications for our understanding of immunological regulation and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which SUPT5H regulates transcription elongation and its role in disease.

Genular Protein ID: 667492531

Symbol: SPT5H_HUMAN

Name: Transcription elongation factor SPT5

UniProtKB Accession Codes:

O00267 O43279 Q59G52 Q99639

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 7 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 21 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 25 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 18 RefSeq 6 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8975720

Title: Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5.

PubMed ID: 8975720

DOI: 10.1006/geno.1996.0646

PubMed ID: 9199507

Title: Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis.

PubMed ID: 9199507

DOI: 10.1016/s0014-5793(97)00486-9

PubMed ID: 9450929

Title: DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.

PubMed ID: 9450929

DOI: 10.1101/gad.12.3.343

PubMed ID: 9514752

Title: Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation.

PubMed ID: 9514752

DOI: 10.1006/jmbi.1997.1601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9857195

Title: Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.

PubMed ID: 9857195

DOI: 10.1093/emboj/17.24.7395

PubMed ID: 10199401

Title: NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

PubMed ID: 10199401

DOI: 10.1016/s0092-8674(00)80713-8

PubMed ID: 10393184

Title: A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.

PubMed ID: 10393184

DOI: 10.1093/emboj/18.13.3688

PubMed ID: 10421630

Title: Transcription elongation factor hSPT5 stimulates mRNA capping.

PubMed ID: 10421630

DOI: 10.1101/gad.13.14.1774

PubMed ID: 10075709

Title: Structure and function of the human transcription elongation factor DSIF.

PubMed ID: 10075709

DOI: 10.1074/jbc.274.12.8085

PubMed ID: 10454543

Title: Tat-SF1 protein associates with RAP30 and human SPT5 proteins.

PubMed ID: 10454543

DOI: 10.1128/mcb.19.9.5960

PubMed ID: 10912001

Title: FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

PubMed ID: 10912001

DOI: 10.1016/s1097-2765(00)80272-5

PubMed ID: 10757782

Title: Domains in the SPT5 protein that modulate its transcriptional regulatory properties.

PubMed ID: 10757782

DOI: 10.1128/mcb.20.9.2970-2983.2000

PubMed ID: 11145967

Title: Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

PubMed ID: 11145967

DOI: 10.1074/jbc.m010908200

PubMed ID: 11112772

Title: DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.

PubMed ID: 11112772

DOI: 10.1074/jbc.m006130200

PubMed ID: 11553615

Title: A highly purified RNA polymerase II elongation control system.

PubMed ID: 11553615

DOI: 10.1074/jbc.m104967200

PubMed ID: 11575923

Title: The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.

PubMed ID: 11575923

DOI: 10.1006/jmbi.2001.4991

PubMed ID: 11809800

Title: Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences.

PubMed ID: 11809800

DOI: 10.1128/mcb.22.4.1079-1093.2002

PubMed ID: 11940650

Title: Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.

PubMed ID: 11940650

DOI: 10.1128/mcb.22.9.2918-2927.2002

PubMed ID: 12653964

Title: Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex.

PubMed ID: 12653964

DOI: 10.1046/j.1365-2443.2003.00638.x

PubMed ID: 12718890

Title: Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

PubMed ID: 12718890

DOI: 10.1016/s1097-2765(03)00101-1

PubMed ID: 12612062

Title: Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.

PubMed ID: 12612062

DOI: 10.1128/mcb.23.6.1863-1873.2003

PubMed ID: 15380072

Title: Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila.

PubMed ID: 15380072

DOI: 10.1016/j.cub.2004.08.066

PubMed ID: 15564463

Title: Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.

PubMed ID: 15564463

DOI: 10.1128/jvi.78.24.13522-13533.2004

PubMed ID: 14701750

Title: Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element.

PubMed ID: 14701750

DOI: 10.1128/mcb.24.2.787-795.2004

PubMed ID: 15060154

Title: Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.

PubMed ID: 15060154

DOI: 10.1128/mcb.24.8.3324-3336.2004

PubMed ID: 15136722

Title: Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II.

PubMed ID: 15136722

DOI: 10.1073/pnas.0401493101

PubMed ID: 16214896

Title: A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS.

PubMed ID: 16214896

DOI: 10.1073/pnas.0409405102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16327805

Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

PubMed ID: 16327805

DOI: 10.1038/nsmb1028

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23652018

Title: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

PubMed ID: 23652018

DOI: 10.1038/ncomms2823

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 19860741

Title: Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface.

PubMed ID: 19860741

DOI: 10.1042/bj20091422

Sequence Information:

  • Length: 1087
  • Mass: 121000
  • Checksum: EC3F402A670A5B7D
  • Sequence:
    • MSDSEDSNFS EEEDSERSSD GEEAEVDEER RSAAGSEKEE EPEDEEEEEE EEEYDEEEEE 
EDDDRPPKKP RHGGFILDEA DVDDEYEDED QWEDGAEDIL EKEEIEASNI DNVVLDEDRS 
GARRLQNLWR DQREEELGEY YMKKYAKSSV GETVYGGSDE LSDDITQQQL LPGVKDPNLW 
TVKCKIGEER ATAISLMRKF IAYQFTDTPL QIKSVVAPEH VKGYIYVEAY KQTHVKQAIE 
GVGNLRLGYW NQQMVPIKEM TDVLKVVKEV ANLKPKSWVR LKRGIYKDDI AQVDYVEPSQ 
NTISLKMIPR IDYDRIKARM SLKDWFAKRK KFKRPPQRLF DAEKIRSLGG DVASDGDFLI 
FEGNRYSRKG FLFKSFAMSA VITEGVKPTL SELEKFEDQP EGIDLEVVTE STGKEREHNF 
QPGDNVEVCE GELINLQGKI LSVDGNKITI MPKHEDLKDM LEFPAQELRK YFKMGDHVKV 
IAGRFEGDTG LIVRVEENFV ILFSDLTMHE LKVLPRDLQL CSETASGVDV GGQHEWGELV 
QLDPQTVGVI VRLERETFQV LNMYGKVVTV RHQAVTRKKD NRFAVALDSE QNNIHVKDIV 
KVIDGPHSGR EGEIRHLFRS FAFLHCKKLV ENGGMFVCKT RHLVLAGGSK PRDVTNFTVG 
GFAPMSPRIS SPMHPSAGGQ RGGFGSPGGG SGGMSRGRGR RDNELIGQTV RISQGPYKGY 
IGVVKDATES TARVELHSTC QTISVDRQRL TTVGSRRPGG MTSTYGRTPM YGSQTPMYGS 
GSRTPMYGSQ TPLQDGSRTP HYGSQTPLHD GSRTPAQSGA WDPNNPNTPS RAEEEYEYAF 
DDEPTPSPQA YGGTPNPQTP GYPDPSSPQV NPQYNPQTPG TPAMYNTDQF SPYAAPSPQG 
SYQPSPSPQS YHQVAPSPAG YQNTHSPASY HPTPSPMAYQ ASPSPSPVGY SPMTPGAPSP 
GGYNPHTPGS GIEQNSSDWV TTDIQVKVRD TYLDTQVVGQ TGVIRSVTGG MCSVYLKDSE 
KVVSISSEHL EPITPTKNNK VKVILGEDRE ATGVLLSIDG EDGIVRMDLD EQLKILNLRF 
LGKLLEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.