Details for: SURF4
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 53.86rCSI 56.42%PRS 23.86
-
CSI 43.73rCSI 54.1%PRS 19.72
-
CSI 28.14rCSI 62.31%PRS 20.75
-
CSI 26.33rCSI 40.68%PRS 21.01
-
CSI 20.18rCSI 21.1%PRS 23.4
-
CSI 19.15rCSI 25.45%PRS 24.66
-
CSI 12.61rCSI 24.28%PRS 50
-
CSI 12.12rCSI 19.63%PRS 22.65
-
CSI 12.02rCSI 47.85%PRS 37.96
-
CSI 11.43rCSI 17.55%PRS 27.12
-
CSI 11.36rCSI 11.63%PRS 40.63
-
CSI 10.09rCSI 17.46%PRS 17.17
-
CSI 9.23rCSI 14.66%PRS 28.86
-
CSI 9.12rCSI 14.7%PRS 33.76
-
CSI 9.08rCSI 11.41%PRS 34.36
-
CSI 8.21rCSI 23.02%PRS 34.68
-
CSI 8.13rCSI 8%PRS 24.19
-
CSI 8.03rCSI 11.93%PRS 26.45
-
CSI 8.02rCSI 15.59%PRS 23.1
-
CSI 7.86rCSI 9.39%PRS 13.15
-
CSI 7.74rCSI 18.41%PRS 33.25
-
CSI 7.57rCSI 13.35%PRS 21.93
-
CSI 7.54rCSI 5.93%PRS 27.35
-
CSI 7.4rCSI 5.63%PRS 29.9
-
CSI 7.16rCSI 17.4%PRS 13.06
-
CSI 6.95rCSI 20.02%PRS 40.58
-
CSI 6.89rCSI 40.07%PRS 33
-
CSI 6.35rCSI 69.52%PRS 39.11
-
CSI 6.32rCSI 8.94%PRS 31.59
-
CSI 6.17rCSI 12.74%PRS 33.38
-
CSI 5.84rCSI 6.09%PRS 23.05
-
CSI 5.82rCSI 4.71%PRS 22.69
-
CSI 5.63rCSI 5.53%PRS 35.04
-
CSI 5.06rCSI 11.56%PRS 21.97
-
CSI 5.04rCSI 11.26%PRS 26.45
-
CSI 4.92rCSI 6.7%PRS 50.87
-
CSI 4.6rCSI 4.89%PRS 37.89
-
CSI 4.45rCSI 11.52%PRS 20.91
-
CSI 4.37rCSI 3.28%PRS 24.14
-
CSI 4.35rCSI 12.47%PRS 33.97
-
CSI 4.21rCSI 13.66%PRS 26.9
-
CSI 4.2rCSI 5.42%PRS 13.92
-
CSI 4.19rCSI 2.91%PRS 31.92
-
CSI 4.18rCSI 45.51%PRS 42.19
-
CSI 4.17rCSI 6.13%PRS 20.69
-
CSI 4.05rCSI 5.04%PRS 23.96
-
CSI 4.04rCSI 6.38%PRS 22.58
-
CSI 4rCSI 2.69%PRS 27.95
-
CSI 3.9rCSI 4.08%PRS 58.69
-
CSI 3.9rCSI 5.3%PRS 33.9
-
CSI 3.79rCSI 2.53%PRS 51.58
-
CSI 3.73rCSI 3.14%PRS 35.58
-
CSI 3.72rCSI 30.25%PRS 22.21
-
CSI 3.66rCSI 8.69%PRS 27.81
-
CSI 3.46rCSI 3.07%PRS 22.68
-
CSI 3.46rCSI 6.59%PRS 35.15
-
CSI 3.43rCSI 12.85%PRS 18.85
-
CSI 3.4rCSI 5.96%PRS 17.2
-
CSI 3.37rCSI 2.68%PRS 40.17
-
CSI 3.27rCSI 3.04%PRS 22.57
-
CSI 3.25rCSI 18.63%PRS 33.18
-
CSI 3.17rCSI 2.74%PRS 34.23
-
CSI 3.16rCSI 3.67%PRS 56.45
-
CSI 3.15rCSI 4.82%PRS 22.67
-
CSI 3.14rCSI 5.59%PRS 36.92
-
CSI 3.13rCSI 3.53%PRS 35.76
-
CSI 3.11rCSI 3.96%PRS 25.94
-
CSI 3.09rCSI 4.28%PRS 31.12
-
CSI 3.04rCSI 3.64%PRS 39.02
-
CSI 3.01rCSI 2.44%PRS 23.64
-
CSI 2.93rCSI 5.88%PRS 16.56
-
CSI 2.91rCSI 2.18%PRS 58.4
-
CSI 2.88rCSI 2.23%PRS 21.68
-
CSI 2.87rCSI 4.12%PRS 30.12
-
CSI 2.83rCSI 2.03%PRS 31.2
-
CSI 2.78rCSI 11.11%PRS 45.94
-
CSI 2.74rCSI 2.64%PRS 23.27
-
CSI 2.74rCSI 8.12%PRS 31.38
-
CSI 2.71rCSI 4.16%PRS 30.21
-
CSI 2.69rCSI 2.59%PRS 16.4
-
CSI 2.68rCSI 6.01%PRS 13.94
-
CSI 2.59rCSI 2.45%PRS 23.63
-
CSI 2.58rCSI 2.26%PRS 29.95
-
CSI 2.57rCSI 1.79%PRS 27.23
-
CSI 2.57rCSI 3.51%PRS 25.39
-
CSI 2.57rCSI 6.52%PRS 22.42
-
CSI 2.55rCSI 39.5%PRS 51.89
-
CSI 2.53rCSI 4.05%PRS 24.64
-
CSI 2.53rCSI 10.3%PRS 22.91
-
CSI 2.52rCSI 11.07%PRS 40.78
-
CSI 2.48rCSI 2.72%PRS 25.25
-
CSI 2.47rCSI 1.95%PRS 15.43
-
CSI 2.46rCSI 2.27%PRS 40.43
-
CSI 2.42rCSI 2.53%PRS 21
-
CSI 2.39rCSI 1.81%PRS 30.99
-
CSI 2.39rCSI 1.79%PRS 35.5
-
CSI 2.38rCSI 10.58%PRS 21.88
-
CSI 2.36rCSI 3.22%PRS 22.25
-
CSI 2.32rCSI 5.44%PRS 32.06
-
CSI 2.29rCSI 8.25%PRS 12.54
-
CSI 0.1rCSI 0.2%PRS 17.3%
-
CSI 0.1rCSI 0.3%PRS 65.9%
-
CSI 0.2rCSI 1.6%PRS 54.0%
-
CSI 0.2rCSI 1.2%PRS 33.2%
-
CSI 0.3rCSI 1.8%PRS 43.2%
-
CSI 0.4rCSI 2.1%PRS 62.7%
-
CSI 0.4rCSI 2.5%PRS 54.4%
-
CSI 0.4rCSI 2.3%PRS 49.8%
-
CSI 0.4rCSI 2.9%PRS 61.9%
-
CSI 0.5rCSI 1.0%PRS 16.0%
-
CSI 0.5rCSI 2.5%PRS 37.7%
-
CSI 0.5rCSI 2.5%PRS 36.8%
-
CSI 0.5rCSI 1.8%PRS 38.7%
-
CSI 0.5rCSI 1.3%PRS 17.1%
-
CSI 0.5rCSI 0.8%PRS 17.1%
-
CSI 0.5rCSI 3.6%PRS 42.5%
-
CSI 0.6rCSI 2.4%PRS 40.4%
-
CSI 0.6rCSI 2.9%PRS 29.9%
-
CSI 0.6rCSI 3.5%PRS 14.0%
-
CSI 0.6rCSI 3.4%PRS 38.8%
-
CSI 0.7rCSI 1.8%PRS 36.5%
-
CSI 0.7rCSI 4.4%PRS 62.8%
-
CSI 0.7rCSI 5.4%PRS 40.7%
-
CSI 0.7rCSI 8.2%PRS 63.4%
-
CSI 0.8rCSI 7.5%PRS 54.9%
-
CSI 0.8rCSI 1.4%PRS 13.2%
-
CSI 0.8rCSI 2.5%PRS 14.2%
-
CSI 0.8rCSI 3.1%PRS 21.6%
-
CSI 0.8rCSI 1.6%PRS 28.6%
-
CSI 0.8rCSI 3.6%PRS 38.6%
-
CSI 0.9rCSI 1.9%PRS 30.0%
-
CSI 0.9rCSI 1.2%PRS 19.7%
-
CSI 0.9rCSI 3.1%PRS 36.2%
-
CSI 0.9rCSI 21.1%PRS 12.8%
-
CSI 0.9rCSI 3.2%PRS 38.5%
-
CSI 0.9rCSI 4.9%PRS 68.1%
-
CSI 0.9rCSI 1.3%PRS 17.4%
-
CSI 0.9rCSI 1.4%PRS 23.0%
-
CSI 0.9rCSI 1.1%PRS 38.9%
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CSI 0.9rCSI 2.3%PRS 32.8%
-
CSI 1.0rCSI 1.4%PRS 31.4%
-
CSI 1.0rCSI 1.2%PRS 12.5%
-
CSI 1.0rCSI 3.3%PRS 35.2%
-
CSI 1.0rCSI 24.0%PRS 83.5%
-
CSI 1.0rCSI 7.1%PRS 55.9%
-
CSI 1.0rCSI 1.2%PRS 27.7%
-
CSI 1.0rCSI 1.5%PRS 25.7%
-
CSI 1.0rCSI 1.2%PRS 25.8%
-
CSI 1.0rCSI 1.5%PRS 35.2%
-
CSI 1.0rCSI 0.8%PRS 33.2%
-
CSI 1.0rCSI 4.7%PRS 47.6%
-
CSI 1.0rCSI 2.3%PRS 33.9%
-
CSI 1.0rCSI 1.6%PRS 39.2%
-
CSI 1.1rCSI 1.3%PRS 28.1%
-
CSI 1.1rCSI 2.7%PRS 27.6%
-
CSI 1.1rCSI 2.0%PRS 34.2%
-
CSI 1.1rCSI 1.3%PRS 27.3%
-
CSI 1.1rCSI 1.7%PRS 36.1%
-
CSI 1.1rCSI 1.3%PRS 21.9%
-
CSI 1.1rCSI 2.1%PRS 47.3%
-
CSI 1.2rCSI 3.0%PRS 33.8%
-
CSI 1.2rCSI 1.8%PRS 20.7%
-
CSI 1.2rCSI 0.9%PRS 21.1%
-
CSI 1.2rCSI 3.4%PRS 45.8%
-
CSI 1.2rCSI 3.5%PRS 25.3%
-
CSI 1.2rCSI 1.8%PRS 25.5%
-
CSI 1.2rCSI 6.2%PRS 67.3%
-
CSI 1.3rCSI 1.4%PRS 20.7%
-
CSI 1.3rCSI 1.2%PRS 20.4%
-
CSI 1.3rCSI 3.2%PRS 20.8%
-
CSI 1.3rCSI 3.4%PRS 28.7%
-
CSI 1.3rCSI 2.4%PRS 16.2%
-
CSI 1.3rCSI 2.5%PRS 57.5%
-
CSI 1.3rCSI 2.5%PRS 43.0%
-
CSI 1.4rCSI 2.1%PRS 19.0%
-
CSI 1.4rCSI 1.2%PRS 26.7%
-
CSI 1.4rCSI 3.2%PRS 29.7%
-
CSI 1.4rCSI 2.5%PRS 52.4%
-
CSI 1.5rCSI 2.9%PRS 51.9%
-
CSI 1.5rCSI 3.6%PRS 33.6%
-
CSI 1.5rCSI 2.6%PRS 30.5%
-
CSI 1.5rCSI 2.3%PRS 49.9%
-
CSI 1.5rCSI 3.5%PRS 43.2%
-
CSI 1.5rCSI 1.3%PRS 16.4%
-
CSI 1.5rCSI 3.7%PRS 39.6%
-
CSI 1.6rCSI 1.3%PRS 21.4%
-
CSI 1.6rCSI 1.4%PRS 28.4%
-
CSI 1.6rCSI 2.0%PRS 29.3%
-
CSI 1.6rCSI 2.2%PRS 43.2%
-
CSI 1.6rCSI 2.6%PRS 17.2%
-
CSI 1.6rCSI 1.7%PRS 26.6%
-
CSI 1.6rCSI 4.3%PRS 26.9%
-
CSI 1.7rCSI 4.3%PRS 53.8%
-
CSI 1.7rCSI 3.2%PRS 46.3%
-
CSI 1.7rCSI 7.1%PRS 51.8%
-
CSI 1.7rCSI 3.1%PRS 18.6%
-
CSI 1.7rCSI 4.5%PRS 43.3%
-
CSI 1.7rCSI 2.5%PRS 29.5%
-
CSI 1.7rCSI 8.5%PRS 30.3%
-
CSI 1.8rCSI 2.5%PRS 25.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 647388776
Symbol: SURF4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7540914
Title: The surf-4 gene encodes a novel 30 kDa integral membrane protein.
PubMed ID: 7540914
PubMed ID: 9740673
PubMed ID: 15308636
Title: Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.
PubMed ID: 15308636
PubMed ID: 18287528
Title: The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.
PubMed ID: 18287528
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30251625
Title: The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9.
PubMed ID: 30251625
DOI: 10.7554/elife.38839
PubMed ID: 29643117
Title: SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization.
PubMed ID: 29643117
PubMed ID: 29251827
Title: Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.
PubMed ID: 29251827
PubMed ID: 32989016
Title: The endoplasmic reticulum cargo receptor SURF4 facilitates efficient erythropoietin secretion.
PubMed ID: 32989016
DOI: 10.1128/mcb.00180-20
PubMed ID: 33186557
Title: Receptor-mediated ER export of lipoproteins controls lipid homeostasis in mice and humans.
PubMed ID: 33186557
PubMed ID: 34015269
Title: TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
PubMed ID: 34015269
Sequence Information:
- Length: 269
- Mass: 30394
- Checksum: 03366E29882B97A5
- Sequence:
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE QRDYIDTTWN CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIVQNIVGTA LMILVAIGFK TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL LVVALGPGGV SMDEKKKEW
Genular Protein ID: 1198704673
Symbol: B7Z7A8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 260
- Mass: 29458
- Checksum: 795E288F8EA30C02
- Sequence:
MRSLATEFLR VTKQYLPHVA RLCLISTFLE DGIRMWFQWS EQRDYIDTTW NCGYLLASSF VFLNLLGQLT GCVLVLSRNF VQYACFGLFG IIALQTIAYS ILWDLKFLMR NLALGGGLLL LLAESRSEGK SMFAGVPTMR ESSPKQYMQL GGRVLLVLMF MTLLHFDASF FSIVQNIVGT ALMILVAIGF KTKLAALTLV VWLFAINVYF NAFWTIPVYK PMHDFLKYDF FQTMSVIGGL LLVVALGPGG VSMDEKKKEW
Genular Protein ID: 516839150
Symbol: B7Z1G8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 226
- Mass: 25497
- Checksum: 13E6BAC55DA33F5D
- Sequence:
MWFQWSEQRD YIDTTWNCGY LLASSFVFLN LLGQLTGCVL VLSRNFVQYA CFGLFGIIAL QTIAYSILWD LKFLMRNLAL GGGLLLLLAE SRSEGKSMFA GVPTMRESSP KQYMQLGGRV LLVLMFMTLL HFDASFFSIV QNIVGTALMI LVAIGFKTKL AALTLVVWLF AINVYFNAFW TIPVYKPMHD FLKYDFFQTM SVIGGLLLVV ALGPGGVSMD EKKKEW