TAF1 | ENSG00000147133 | NCBI 6872

Details for: TAF1

Gene ID: 6872

Symbol: TAF1

Ensembl ID: ENSG00000147133

Description: TATA-box binding protein associated factor 1

Associated with

Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Acetyl-coa binding
(GO:1905502)
Atp binding
(GO:0005524)
Cellular response to atp
(GO:0071318)
Cellular response to uv
(GO:0034644)
Chromatin
(GO:0000785)
Chromatin remodeling
(GO:0006338)
Dna damage response
(GO:0006974)
H3k27me3 modified histone binding
(GO:0061628)
Histone acetyltransferase activity
(GO:0004402)
Histone h2as1 kinase activity
(GO:0044024)
Histone reader activity
(GO:0140566)
Kinase activity
(GO:0016301)
Lysine-acetylated histone binding
(GO:0070577)
Midbrain development
(GO:0030901)
Mll1 complex
(GO:0071339)
Mrna transcription by rna polymerase ii
(GO:0042789)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein autoubiquitination
(GO:1905524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Nuclear receptor binding
(GO:0016922)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Positive regulation of androgen receptor activity
(GO:2000825)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein polyubiquitination
(GO:0000209)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein stabilization
(GO:0050821)
Regulation of cell cycle g1/s phase transition
(GO:1902806)
Regulation of signal transduction by p53 class mediator
(GO:1901796)
Rna polymerase i general transcription initiation factor activity
(GO:0001181)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Rna polymerase ii preinitiation complex assembly
(GO:0051123)
Sequence-specific dna binding
(GO:0043565)
Tbp-class protein binding
(GO:0017025)
Transcription by rna polymerase ii
(GO:0006366)
Transcription factor tfiid complex
(GO:0005669)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Transcription initiation at rna polymerase i promoter
(GO:0006361)
Transcription regulator complex
(GO:0005667)
Transcription regulator inhibitor activity
(GO:0140416)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin conjugating enzyme activity
(GO:0061631)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 233.6298
Cell Significance Index: -36.3400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 143.1932
Cell Significance Index: -36.3200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 76.5691
Cell Significance Index: -36.1500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 74.3125
Cell Significance Index: -30.1900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 53.8879
Cell Significance Index: -36.1600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 31.8306
Cell Significance Index: -30.3900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 30.6013
Cell Significance Index: -37.7300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.9570
Cell Significance Index: -34.7100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.8315
Cell Significance Index: -36.3400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.3544
Cell Significance Index: -24.8500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.6907
Cell Significance Index: -38.2400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.0553
Cell Significance Index: 52.8300
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.9237
Cell Significance Index: 31.7000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.8644
Cell Significance Index: 128.9400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8099
Cell Significance Index: 363.0700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6280
Cell Significance Index: 161.0500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5704
Cell Significance Index: 311.6600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.2460
Cell Significance Index: 17.9200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1263
Cell Significance Index: 404.0000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0789
Cell Significance Index: 82.8000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0155
Cell Significance Index: 28.3800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9519
Cell Significance Index: 103.5400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9342
Cell Significance Index: 41.3200
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.9233
Cell Significance Index: 18.0200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9201
Cell Significance Index: 55.2400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8391
Cell Significance Index: 97.7900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8081
Cell Significance Index: 30.6000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.7892
Cell Significance Index: 16.8700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.7644
Cell Significance Index: 13.1000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7627
Cell Significance Index: 39.7300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7282
Cell Significance Index: 44.7600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7233
Cell Significance Index: 117.6300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.7043
Cell Significance Index: 39.5200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6527
Cell Significance Index: 8.9100
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.5964
Cell Significance Index: 7.1100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5793
Cell Significance Index: 38.9500
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.5373
Cell Significance Index: 13.1100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5209
Cell Significance Index: 13.0200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4595
Cell Significance Index: 82.8400
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.4582
Cell Significance Index: 10.9900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3872
Cell Significance Index: 47.6100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3711
Cell Significance Index: 8.0400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3182
Cell Significance Index: 43.7000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2686
Cell Significance Index: 7.7400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2474
Cell Significance Index: 11.2100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2443
Cell Significance Index: 460.0300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2248
Cell Significance Index: 102.0500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1991
Cell Significance Index: 108.7600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1896
Cell Significance Index: 12.2300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1561
Cell Significance Index: 140.9900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1433
Cell Significance Index: 9.0300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1376
Cell Significance Index: 211.7900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1347
Cell Significance Index: 85.5500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1305
Cell Significance Index: 240.6600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1287
Cell Significance Index: 24.4900
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1279
Cell Significance Index: 2.8000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1217
Cell Significance Index: 53.7900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1072
Cell Significance Index: 145.8000
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0536
Cell Significance Index: 1.5300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0414
Cell Significance Index: 0.2500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0333
Cell Significance Index: 1.1700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0271
Cell Significance Index: 0.7300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0196
Cell Significance Index: 1.0200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0022
Cell Significance Index: -0.0600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0077
Cell Significance Index: -0.3600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0236
Cell Significance Index: -3.4300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0271
Cell Significance Index: -19.8400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0336
Cell Significance Index: -24.9000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0366
Cell Significance Index: -4.3200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0393
Cell Significance Index: -29.7200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0408
Cell Significance Index: -6.9600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0474
Cell Significance Index: -0.6800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0534
Cell Significance Index: -30.1300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0638
Cell Significance Index: -39.8200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0899
Cell Significance Index: -11.5300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0915
Cell Significance Index: -4.3000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1031
Cell Significance Index: -10.5300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1101
Cell Significance Index: -31.6800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1223
Cell Significance Index: -12.7300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1484
Cell Significance Index: -2.5000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1524
Cell Significance Index: -2.2500
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.1584
Cell Significance Index: -2.3700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1661
Cell Significance Index: -19.0300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1816
Cell Significance Index: -38.2600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2225
Cell Significance Index: -28.7500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2325
Cell Significance Index: -16.4400
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.2343
Cell Significance Index: -2.0800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3423
Cell Significance Index: -7.2900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3592
Cell Significance Index: -26.7700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3806
Cell Significance Index: -12.1900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4062
Cell Significance Index: -32.1700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4173
Cell Significance Index: -6.1600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4196
Cell Significance Index: -11.4200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4270
Cell Significance Index: -22.4200
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4491
Cell Significance Index: -5.5700
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.4574
Cell Significance Index: -5.7600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4843
Cell Significance Index: -29.6900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5814
Cell Significance Index: -12.3400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5949
Cell Significance Index: -12.3400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6038
Cell Significance Index: -19.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TAF1 is a multi-functional transcription factor with several key characteristics: 1. **TAF1 is a component of the TFIID complex**: TAF1 works in conjunction with TBP to bind to the TATA box, recruiting RNA polymerase II to initiate transcription. 2. **Regulates cell cycle progression**: TAF1 is involved in the regulation of the G1/S phase transition, a critical checkpoint in the cell cycle. 3. **Regulates transcriptional regulation by p53**: TAF1 interacts with p53, a tumor suppressor protein, to regulate its activity. 4. **Involvement in DNA damage response**: TAF1 is involved in the regulation of the DNA damage response, including the activation of genes involved in DNA repair. 5. **Expression in various cell types**: TAF1 is expressed in a wide range of cell types, including ciliary muscle cells, skeletal muscle fibers, and corneal epithelial cells. **Pathways and Functions** TAF1 is involved in several key pathways and functions: 1. **Transcriptional regulation**: TAF1 regulates the expression of genes involved in cell cycle progression, DNA damage response, and transcriptional regulation by p53. 2. **Cell cycle regulation**: TAF1 is involved in the regulation of the G1/S phase transition, a critical checkpoint in the cell cycle. 3. **DNA damage response**: TAF1 is involved in the regulation of the DNA damage response, including the activation of genes involved in DNA repair. 4. **Transcriptional initiation**: TAF1 works in conjunction with TBP to recruit RNA polymerase II to initiate transcription. 5. **HIV life cycle**: TAF1 is involved in the regulation of the HIV life cycle, including transcriptional regulation and viral replication. **Clinical Significance** Dysregulation of TAF1 has been implicated in various diseases, including: 1. **Cancer**: TAF1 dysregulation has been linked to several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders**: TAF1 dysregulation has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: TAF1 is involved in the regulation of the HIV life cycle, and dysregulation of TAF1 has been linked to HIV infection and disease progression. In conclusion, TAF1 is a multi-functional transcription factor that plays a crucial role in the regulation of gene expression in various cellular processes. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases. Further research is needed to fully understand the role of TAF1 in human disease and to develop therapeutic strategies to target TAF1 in disease prevention and treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cell cycle gene 1 protein

Genular Protein ID: 2198114248

Symbol: TAF1_HUMAN

Name: Cell cycle gene 1 protein

UniProtKB Accession Codes:

P21675 A5CVC8 A5CVC9 A5CVD0 A5CVD1 B1Q2X3 Q59FZ3 Q6IUZ1 Q70Q86 Q70Q87 Q70T00 Q70T01 Q70T02 Q70T03

Database IDs:

Citations:

PubMed ID: 2038334

Title: The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein.

PubMed ID: 2038334

DOI: 10.1128/mcb.11.6.3317-3325.1991

PubMed ID: 7680771

Title: Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation.

PubMed ID: 7680771

DOI: 10.1038/362175a0

PubMed ID: 17273961

Title: Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism.

PubMed ID: 17273961

DOI: 10.1086/512129

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 3169001

Title: Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complements the temperature-sensitive G1 mutants, tsBN462 and ts13, of the BHK cell line.

PubMed ID: 3169001

DOI: 10.1002/j.1460-2075.1988.tb02996.x

PubMed ID: 12928496

Title: Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism.

PubMed ID: 12928496

DOI: 10.1073/pnas.1831949100

PubMed ID: 17952504

Title: Structural and functional analysis of the human TAF1/DYT3 multiple transcript system.

PubMed ID: 17952504

DOI: 10.1007/s00335-007-9063-z

PubMed ID: 8450888

Title: The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1.

PubMed ID: 8450888

DOI: 10.1038/362179a0

PubMed ID: 8625415

Title: TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74.

PubMed ID: 8625415

DOI: 10.1016/s0092-8674(00)81055-7

PubMed ID: 8647434

Title: TAF-like function of SV40 large T antigen.

PubMed ID: 8647434

DOI: 10.1101/gad.10.11.1369

PubMed ID: 8649420

Title: Interaction of the viral activator protein ICP4 with TFIID through TAF250.

PubMed ID: 8649420

DOI: 10.1128/mcb.16.6.3085

PubMed ID: 9660973

Title: Functional analysis of the human TAFII250 N-terminal kinase domain.

PubMed ID: 9660973

DOI: 10.1016/s1097-2765(00)80089-1

PubMed ID: 9858607

Title: Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250.

PubMed ID: 9858607

DOI: 10.1128/mcb.19.1.846

PubMed ID: 10759893

Title: A human homologue of yeast anti-silencing factor has histone chaperone activity.

PubMed ID: 10759893

DOI: 10.1046/j.1365-2443.2000.00319.x

PubMed ID: 11278496

Title: Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity.

PubMed ID: 11278496

DOI: 10.1074/jbc.m009385200

PubMed ID: 11592977

Title: TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.

PubMed ID: 11592977

DOI: 10.1073/pnas.211444798

PubMed ID: 12093919

Title: Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID.

PubMed ID: 12093919

DOI: 10.1073/pnas.142627899

PubMed ID: 12842904

Title: Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis.

PubMed ID: 12842904

DOI: 10.1074/jbc.m303549200

PubMed ID: 15053879

Title: Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.

PubMed ID: 15053879

DOI: 10.1016/s1097-2765(04)00123-6

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 15870300

Title: TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.

PubMed ID: 15870300

DOI: 10.1128/mcb.25.10.4321-4332.2005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22711989

Title: Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.

PubMed ID: 22711989

DOI: 10.1128/mcb.00416-12

PubMed ID: 23184149

Title: X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism.

PubMed ID: 23184149

DOI: 10.1093/hmg/dds499

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10827952

Title: Structure and function of a human TAFII250 double bromodomain module.

PubMed ID: 10827952

DOI: 10.1126/science.288.5470.1422

PubMed ID: 22464331

Title: Histone recognition and large-scale structural analysis of the human bromodomain family.

PubMed ID: 22464331

DOI: 10.1016/j.cell.2012.02.013

PubMed ID: 25412659

Title: Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.

PubMed ID: 25412659

DOI: 10.1038/cr.2014.148

PubMed ID: 26365797

Title: A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications.

PubMed ID: 26365797

DOI: 10.1016/j.str.2015.08.004

PubMed ID: 27007846

Title: Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

PubMed ID: 27007846

DOI: 10.1038/nature17394

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 26637982

Title: TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations.

PubMed ID: 26637982

DOI: 10.1016/j.ajhg.2015.11.005

PubMed ID: 25644381

Title: X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.

PubMed ID: 25644381

DOI: 10.1038/mp.2014.193

Sequence Information:

Length: 1893
Mass: 214714
Checksum: AE148C222B418BB4
Sequence:

MGPGCDLLLR TAATITAAAI MSDTDSDEDS AGGGPFSLAG FLFGNINGAG QLEGESVLDD 
ECKKHLAGLG ALGLGSLITE LTANEELTGT DGALVNDEGW VRSTEDAVDY SDINEVAEDE 
SRRYQQTMGS LQPLCHSDYD EDDYDADCED IDCKLMPPPP PPPGPMKKDK DQDSITGVSE 
NGEGIILPSI IAPSSLASEK VDFSSSSDSE SEMGPQEATQ AESEDGKLTL PLAGIMQHDA 
TKLLPSVTEL FPEFRPGKVL RFLRLFGPGK NVPSVWRSAR RKRKKKHREL IQEEQIQEVE 
CSVESEVSQK SLWNYDYAPP PPPEQCLSDD EITMMAPVES KFSQSTGDID KVTDTKPRVA 
EWRYGPARLW YDMLGVPEDG SGFDYGFKLR KTEHEPVIKS RMIEEFRKLE ENNGTDLLAD 
ENFLMVTQLH WEDDIIWDGE DVKHKGTKPQ RASLAGWLPS SMTRNAMAYN VQQGFAATLD 
DDKPWYSIFP IDNEDLVYGR WEDNIIWDAQ AMPRLLEPPV LTLDPNDENL ILEIPDEKEE 
ATSNSPSKES KKESSLKKSR ILLGKTGVIK EEPQQNMSQP EVKDPWNLSN DEYYYPKQQG 
LRGTFGGNII QHSIPAVELR QPFFPTHMGP IKLRQFHRPP LKKYSFGALS QPGPHSVQPL 
LKHIKKKAKM REQERQASGG GEMFFMRTPQ DLTGKDGDLI LAEYSEENGP LMMQVGMATK 
IKNYYKRKPG KDPGAPDCKY GETVYCHTSP FLGSLHPGQL LQAFENNLFR APIYLHKMPE 
TDFLIIRTRQ GYYIRELVDI FVVGQQCPLF EVPGPNSKRA NTHIRDFLQV FIYRLFWKSK 
DRPRRIRMED IKKAFPSHSE SSIRKRLKLC ADFKRTGMDS NWWVLKSDFR LPTEEEIRAM 
VSPEQCCAYY SMIAAEQRLK DAGYGEKSFF APEEENEEDF QMKIDDEVRT APWNTTRAFI 
AAMKGKCLLE VTGVADPTGC GEGFSYVKIP NKPTQQKDDK EPQPVKKTVT GTDADLRRLS 
LKNAKQLLRK FGVPEEEIKK LSRWEVIDVV RTMSTEQARS GEGPMSKFAR GSRFSVAEHQ 
ERYKEECQRI FDLQNKVLSS TEVLSTDTDS SSAEDSDFEE MGKNIENMLQ NKKTSSQLSR 
EREEQERKEL QRMLLAAGSA ASGNNHRDDD TASVTSLNSS ATGRCLKIYR TFRDEEGKEY 
VRCETVRKPA VIDAYVRIRT TKDEEFIRKF ALFDEQHREE MRKERRRIQE QLRRLKRNQE 
KEKLKGPPEK KPKKMKERPD LKLKCGACGA IGHMRTNKFC PLYYQTNAPP SNPVAMTEEQ 
EEELEKTVIH NDNEELIKVE GTKIVLGKQL IESADEVRRK SLVLKFPKQQ LPPKKKRRVG 
TTVHCDYLNR PHKSIHRRRT DPMVTLSSIL ESIINDMRDL PNTYPFHTPV NAKVVKDYYK 
IITRPMDLQT LRENVRKRLY PSREEFREHL ELIVKNSATY NGPKHSLTQI SQSMLDLCDE 
KLKEKEDKLA RLEKAINPLL DDDDQVAFSF ILDNIVTQKM MAVPDSWPFH HPVNKKFVPD 
YYKVIVNPMD LETIRKNISK HKYQSRESFL DDVNLILANS VKYNGPESQY TKTAQEIVNV 
CYQTLTEYDE HLTQLEKDIC TAKEAALEEA ELESLDPMTP GPYTPQPPDL YDTNTSLSMS 
RDASVFQDES NMSVLDIPSA TPEKQVTQEG EDGDGDLADE EEGTVQQPQA SVLYEDLLMS 
EGEDDEEDAG SDEEGDNPFS AIQLSESGSD SDVGSGGIRP KQPRMLQENT RMDMENEESM 
MSYEGDGGEA SHGLEDSNIS YGSYEEPDPK SNTQDTSFSS IGGYEVSEEE EDEEEEEQRS 
GPSVLSQVHL SEDEEDSEDF HSIAGDSDLD SDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TAF1

Associated with

Cells (max top 100)

Other Information

The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. PubMed ID: 2038334

Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation. PubMed ID: 7680771

Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. PubMed ID: 17273961

The DNA sequence of the human X chromosome. PubMed ID: 15772651

Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complements the temperature-sensitive G1 mutants, tsBN462 and ts13, of the BHK cell line. PubMed ID: 3169001

Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism. PubMed ID: 12928496

Structural and functional analysis of the human TAF1/DYT3 multiple transcript system. PubMed ID: 17952504

The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1. PubMed ID: 8450888

TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74. PubMed ID: 8625415

TAF-like function of SV40 large T antigen. PubMed ID: 8647434

Interaction of the viral activator protein ICP4 with TFIID through TAF250. PubMed ID: 8649420

Functional analysis of the human TAFII250 N-terminal kinase domain. PubMed ID: 9660973

Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250. PubMed ID: 9858607

A human homologue of yeast anti-silencing factor has histone chaperone activity. PubMed ID: 10759893

Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. PubMed ID: 11278496

TAFII55 binding to TAFII250 inhibits its acetyltransferase activity. PubMed ID: 11592977

Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID. PubMed ID: 12093919

Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis. PubMed ID: 12842904

Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. PubMed ID: 15053879

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. PubMed ID: 15960975

TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter. PubMed ID: 15870300

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7. PubMed ID: 22711989

X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism. PubMed ID: 23184149

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. PubMed ID: 25593309

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structure and function of a human TAFII250 double bromodomain module. PubMed ID: 10827952

Histone recognition and large-scale structural analysis of the human bromodomain family. PubMed ID: 22464331

Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. PubMed ID: 25412659

A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications. PubMed ID: 26365797

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. PubMed ID: 27007846

Structural insights into preinitiation complex assembly on core promoters. PubMed ID: 33795473

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations. PubMed ID: 26637982

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes. PubMed ID: 25644381