Details for: TAF11

Gene ID: 6882

Symbol: TAF11

Ensembl ID: ENSG00000064995

Description: TATA-box binding protein associated factor 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 215.4357
    Cell Significance Index: -33.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 130.1828
    Cell Significance Index: -33.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.0020
    Cell Significance Index: -37.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.3091
    Cell Significance Index: -38.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.1801
    Cell Significance Index: -32.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.2416
    Cell Significance Index: -37.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.7319
    Cell Significance Index: -33.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.4610
    Cell Significance Index: -38.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.6322
    Cell Significance Index: -33.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1735
    Cell Significance Index: -40.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.3278
    Cell Significance Index: -28.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6801
    Cell Significance Index: -14.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6237
    Cell Significance Index: 181.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7138
    Cell Significance Index: 199.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1493
    Cell Significance Index: 15.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8820
    Cell Significance Index: 121.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7611
    Cell Significance Index: 34.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7131
    Cell Significance Index: 389.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7109
    Cell Significance Index: 45.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7067
    Cell Significance Index: 114.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6573
    Cell Significance Index: 17.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6455
    Cell Significance Index: 129.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6312
    Cell Significance Index: 18.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6256
    Cell Significance Index: 13.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6096
    Cell Significance Index: 120.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5886
    Cell Significance Index: 16.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5867
    Cell Significance Index: 259.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5708
    Cell Significance Index: 67.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5399
    Cell Significance Index: 66.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5083
    Cell Significance Index: 91.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4652
    Cell Significance Index: 16.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4462
    Cell Significance Index: 84.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4288
    Cell Significance Index: 9.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4114
    Cell Significance Index: 19.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4009
    Cell Significance Index: 361.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3872
    Cell Significance Index: 10.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3727
    Cell Significance Index: 9.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3611
    Cell Significance Index: 129.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3500
    Cell Significance Index: 16.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3455
    Cell Significance Index: 44.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3344
    Cell Significance Index: 21.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2963
    Cell Significance Index: 20.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2486
    Cell Significance Index: 6.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2417
    Cell Significance Index: 12.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2344
    Cell Significance Index: 13.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2264
    Cell Significance Index: 29.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2124
    Cell Significance Index: 13.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2035
    Cell Significance Index: 2.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1725
    Cell Significance Index: 17.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1641
    Cell Significance Index: 12.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1340
    Cell Significance Index: 6.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0939
    Cell Significance Index: 4.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0725
    Cell Significance Index: 136.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0618
    Cell Significance Index: 2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0576
    Cell Significance Index: 106.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0553
    Cell Significance Index: 4.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0496
    Cell Significance Index: 76.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0271
    Cell Significance Index: 4.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0085
    Cell Significance Index: 5.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0042
    Cell Significance Index: -1.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0196
    Cell Significance Index: -14.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0247
    Cell Significance Index: -18.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0374
    Cell Significance Index: -27.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0571
    Cell Significance Index: -32.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0594
    Cell Significance Index: -6.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0689
    Cell Significance Index: -43.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0978
    Cell Significance Index: -28.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1225
    Cell Significance Index: -17.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1384
    Cell Significance Index: -1.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1464
    Cell Significance Index: -4.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1588
    Cell Significance Index: -3.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1613
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1784
    Cell Significance Index: -20.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1915
    Cell Significance Index: -40.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2103
    Cell Significance Index: -9.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2271
    Cell Significance Index: -15.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2369
    Cell Significance Index: -4.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2851
    Cell Significance Index: -10.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3073
    Cell Significance Index: -8.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3245
    Cell Significance Index: -8.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3332
    Cell Significance Index: -34.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3596
    Cell Significance Index: -9.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3658
    Cell Significance Index: -2.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3748
    Cell Significance Index: -9.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3804
    Cell Significance Index: -12.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3901
    Cell Significance Index: -7.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3918
    Cell Significance Index: -31.0300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4047
    Cell Significance Index: -3.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5266
    Cell Significance Index: -12.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5558
    Cell Significance Index: -34.0800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6068
    Cell Significance Index: -4.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6430
    Cell Significance Index: -18.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6470
    Cell Significance Index: -9.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6482
    Cell Significance Index: -9.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6715
    Cell Significance Index: -17.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8016
    Cell Significance Index: -18.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8177
    Cell Significance Index: -7.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization**: TAF11 is primarily found in the nucleus, where it associates with the TATA-binding protein and RNA polymerase II to regulate transcription. 2. **Protein binding**: TAF11 exhibits protein heterodimerization activity, interacting with other transcription factors, such as TFIID and p53, to modulate gene expression. 3. **Regulatory functions**: TAF11 is involved in positive regulation of transcription initiation by RNA polymerase II, as well as positive regulation of transcription by p53. 4. **Viral interactions**: TAF11 has been implicated in the regulation of HIV transcription, suggesting its potential as a therapeutic target in HIV infection. **Pathways and Functions:** 1. **Transcriptional regulation**: TAF11 plays a critical role in regulating gene expression by facilitating the recruitment of RNA polymerase II to promoters, enabling the transcription of essential genes involved in immune cell development and function. 2. **Immune response**: TAF11 is involved in the regulation of immune cell development, function, and survival, highlighting its importance in the context of immune responses. 3. **Viral infection pathways**: TAF11 has been implicated in the regulation of HIV transcription, suggesting its potential as a therapeutic target in HIV infection. 4. **Cellular differentiation**: TAF11 may also play a role in regulating cellular differentiation, particularly in the context of pancreatic acinar cell development. **Clinical Significance:** 1. **HIV infection**: TAF11's role in HIV transcription regulation makes it a potential therapeutic target for the treatment of HIV infection. 2. **Immune disorders**: Dysregulation of TAF11 expression may contribute to the development of immune disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Cancer**: TAF11's involvement in p53 regulation may also contribute to the development of cancer, particularly in the context of p53-mediated transcriptional regulation. 4. **Basic research**: Further studies on TAF11's role in transcriptional regulation and immune response may provide insights into the mechanisms underlying various diseases and disorders. In conclusion, TAF11 is a multifunctional transcription factor that plays a crucial role in regulating gene expression, particularly in the context of immune responses and viral infections. Further research on TAF11's role in disease pathways and its potential as a therapeutic target may provide valuable insights into the development of novel treatments for various diseases.

Genular Protein ID: 4006922714

Symbol: TAF11_HUMAN

Name: Transcription initiation factor TFIID subunit 11

UniProtKB Accession Codes:

Q15544 B2R8R3 B4DY18 Q9UHS0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 28 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7729427

Title: Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

PubMed ID: 7729427

DOI: 10.1002/j.1460-2075.1995.tb07138.x

PubMed ID: 8820923

Title: Isolation and characterization of a cDNA encoding a human TFIID subunit containing a variety of putative structural motifs including direct repeats.

PubMed ID: 8820923

DOI: 10.1248/bpb.19.122

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 9695952

Title: Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.

PubMed ID: 9695952

DOI: 10.1016/s0092-8674(00)81423-3

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 211
  • Mass: 23307
  • Checksum: 77C7BDC667D19A8F
  • Sequence:
    • MDDAHESPSD KGGETGESDE TAAVPGDPGA TDTDGIPEET DGDADVDLKE AAAEEGELES 
QDVSDLTTVE REDSSLLNPA AKKLKIDTKE KKEKKQKVDE DEIQKMQILV SSFSEEQLNR 
YEMYRRSAFP KAAIKRLIQS ITGTSVSQNV VIAMSGISKV FVGEVVEEAL DVCEKWGEMP 
PLQPKHMREA VRRLKSKGQI PNSKHKKIIF F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.